“…PRINCIPAL FINDINGS: To test if TRIM genes are up-regulated during antiviral immune responses, we performed a systematic analysis of TRIM gene expression in human primary lymphocytes and monocyte-derived macrophages in response to interferons (IFNs, type I and II) or following FcγR-mediated activation of macrophages. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In the current studies, we report that activation of type I interferon (IFN) signaling in tumor cells is primarily due to elevated secretion of the type I interferon, IFN-β. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Several lines of evidence implicate the impairment of the host interferon (IFN) antiviral innate immune response by MARV or EBOV as an important determinant of virulence. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Recent studies indicate that interferon modulation is an important factor in the development of severe flaviviral illness. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Many viruses trigger the type I interferon (IFN) system, leading to the transcription of hundreds of interferon-stimulated genes (ISGs). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Interferon-beta is widely used for the treatment of relapsing multiple sclerosis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Chimeric T cells directed to the γ-subunit of the fetal acetylcholine receptor (fAChR) produce large amounts of interferon-γ (IFNγ) on coculture with fAChR-expressing rhabdomyosarcoma (RMS) cells prior to RMS cell death. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Early addition of Type I interferon (IFN) to ECs blocks hantavirus replication and thus for hantaviruses to be pathogenic they need to prevent early interferon induction. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Interferon inducible transmembrane proteins (IFITMs) have diverse roles, including the control of cell proliferation, promotion of homotypic cell adhesion, protection against viral infection, promotion of bone matrix maturation and mineralisation, and mediating germ cell development. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Systemic Sclerosis (Scleroderma, SSc) is an autoimmune disease characterized by vasculopathy, inflammation, and fibrosis that can lead to loss of organ function. Type I interferons (IFNs) are family of cytokines that mitigate the deleterious effects of viral and bacterial infections in the innate immunity system. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Overexpression of transcripts induced by interferons (IFN), termed as an “IFN signature,” has been found in SS patients. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The intricacies involving the role of interferon-gamma (IFN-γ) in herpesvirus infection and persistence are complex. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A hallmark of the antiviral response is the induction of interferons. First discovered in 1957 by Issac and Lindeman, interferons are noted for their ability to interfere with viral replication. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Interferon lambda (IFN-λ) is a member of the class II cytokine family, and like the other members of this family, they are small helical proteins. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Interferon-stimulated genes (ISGs) are critical for controlling virus infections. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…[Image: see text] A series of novel, saccharin-based antagonists have been identified for the interferon signaling pathway. Through in vitro high-throughput screening with the Colorado Center for Drug Discovery (C2D2) Pilot Library, we identified hit compound 1, which was the basis for extensive structure–activity relationship studies. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Human lupus is strongly associated with a gene expression signature characterized by over-expression of Type I interferon-regulated genes. A strong interferon signature generally is not seen in the standard mouse models of lupus, despite considerable evidence for the involvement of toll-like receptor-driven interferon production. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Interferon (IFN) in combination with ribavirin has been the standard of care (SOC) for chronic hepatitis C for the past few decades. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Microarray studies with interferon gamma-treated human macrophages identified more than 160 interferon-stimulated genes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso