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  1. 29061
    “…The present study was performed to investigate whether VD alleviates rotavirus (RV) infection through a microRNA-155-5p (miR-155-5p)-mediated regulation of TANK-binding kinase 1 (TBK1)/interferon regulatory factors 3 (IRF3) signaling pathway in vivo and in vitro. (2) Methods: The efficacy of VD treatment was evaluated in DLY pig and IPEC-J2. …”
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    Vitamin D Alleviates Rotavirus Infection through a Microrna-155-5p Mediated Regulation of the TBK1/IRF3 Signaling Pathway In Vivo and In Vitro
  2. 29062
    “…BACKGROUND & AIMS: The toll‐like receptor‐interferon (TLR–IFN) signalling pathway plays a crucial role in HBV infection. …”
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    Interaction of TLR–IFN and HLA polymorphisms on susceptibility of chronic HBV infection in Southwest Han Chinese
  3. 29063
    “…Viral loads in tissues of the older group were significantly higher than those of the younger group. The levels of interferon (IFN)-γ, interleukin (IL)-2 and neutralizing antibody in the 15-week-old ducks were higher than in the 55-week-old ducks at the early stage of the DTMUV infection, suggesting the immune response in the younger ducks to DTMUV was stronger than in the older ducks. …”
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    Pathogenicity comparison of duck Tembusu virus in different aged Cherry Valley breeding ducks
  4. 29064
    “…Regulation of the receptor was determined using STAT inhibitors (STAT1, STAT3 and PanSTAT inhibitors), TLR3 inhibition, and neutralization of interferon alpha receptor 2 (IFNAR2). Significance was determined by a p-value of greater than 0.05. …”
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    IL-22Ra1 is induced during influenza infection by direct and indirect TLR3 induction of STAT1
  5. 29065
    “…Moreover, hsa-miR-1975 was secreted in exosomes and taken up by the neighboring cells to induce interferon expression. CONCLUSIONS: Our findings unravel a critical role of Y-class small RNA in host’s defense against influenza virus infection and reveal its antiviral mechanism through exosome delivery. …”
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    Exosome-delivered and Y RNA-derived small RNA suppresses influenza virus replication
  6. 29066
    “…Here, we evaluated the performance of two alternative bTB-diagnostic tools, the interferon-gamma assay, IGRA, and the enzyme-linked immunosorbent assay (ELISA), which had never been used in Uruguay in the absence of a gold standard. …”
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    Modeling the Accuracy of Two in-vitro Bovine Tuberculosis Tests Using a Bayesian Approach
  7. 29067
    “…Achieving sustained viral response with interferon (IFN) treatment reduces the risk from 3%-5% to 0.5%-1% annually. …”
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    No evidence for higher rates of hepatocellular carcinoma after direct-acting antiviral treatment: a meta-analysis
  8. 29068
    “…Patients undergoing primary therapy with topical 5-fluorouracil 1% (5-FU) (4 times a day for 7 days with a 21-day break) or interferon-alpha-2b (IFN) (4 times a day) were reviewed. …”
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    Utility of high-resolution anterior segment optical coherence tomography in the diagnosis and management of sub-clinical ocular surface squamous neoplasia
  9. 29069
    “…Through in vitro experiments, we proved that m6A suppression (represented by METTL14 knockdown) promoted GC cell proliferation and invasiveness through activating Wnt and PI3K‐Akt signaling, while m6A elevation (represented by FTO knockdown) reversed these phenotypical and molecular changes. m6A may also be involved in interferon signaling and immune responses of GC. CONCLUSIONS: Our work demonstrated that low‐m6A signatures predicted adverse clinicopathological features of GC, while the reduction of RNA m6A methylation activated oncogenic Wnt/PI3K‐Akt signaling and promoted malignant phenotypes of GC cells.…”
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    Reduced m6A modification predicts malignant phenotypes and augmented Wnt/PI3K‐Akt signaling in gastric cancer
  10. 29070
    por Hernandez, Nicholas, Bucciol, Giorgia, Moens, Leen, Le Pen, Jérémie, Shahrooei, Mohammad, Goudouris, Ekaterini, Shirkani, Afshin, Changi-Ashtiani, Majid, Rokni-Zadeh, Hassan, Sayar, Esra Hazar, Reisli, Ismail, Lefevre-Utile, Alain, Zijlmans, Dick, Jurado, Andrea, Pholien, Ruben, Drutman, Scott, Belkaya, Serkan, Cobat, Aurelie, Boudewijns, Robbert, Jochmans, Dirk, Neyts, Johan, Seeleuthner, Yoann, Lorenzo-Diaz, Lazaro, Enemchukwu, Chibuzo, Tietjen, Ian, Hoffmann, Hans-Heinrich, Momenilandi, Mana, Pöyhönen, Laura, Siqueira, Marilda M., de Lima, Sheila M. Barbosa, de Souza Matos, Denise C., Homma, Akira, Maia, Maria de Lourdes S., da Costa Barros, Tamiris Azamor, de Oliveira, Patricia Mouta Nunes, Mesquita, Emersom Ciclini, Gijsbers, Rik, Zhang, Shen-Ying, Seligman, Stephen J., Abel, Laurent, Hertzog, Paul, Marr, Nico, Martins, Reinaldo de Menezes, Meyts, Isabelle, Zhang, Qian, MacDonald, Margaret R., Rice, Charles M., Casanova, Jean-Laurent, Jouanguy, Emmanuelle, Bossuyt, Xavier
    Publicado 2019
    “…Severe illness by MMR vaccines can be caused by inborn errors of type I and/or III interferon (IFN) immunity (mutations in IFNAR2, STAT1, or STAT2). …”
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    Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines
  11. 29071
    “…This was most apparent in the high dose group, with significant co-suppression of pro-inflammatory interleukin (IL)-1β, IL-4, IL-6, IL-13, IL-17, monocytes chemotactic protein (MCP)1, granulocyte-macrophage colony-stimulating factor (GM-CSF), vascular endothelial growth factor (VEGF), tumor growth factor (TGF)-β1, interferon (IFN)-γ, and immune suppressors IL-10 and IL-12. …”
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    Astragalus polysaccharide (PG2) Ameliorates Cancer Symptom Clusters, as well as Improves Quality of Life in Patients with Metastatic Disease, through Modulation of the Inflammatory Cascade
  12. 29072
    “…Neither MP nor MP-IC induced interferon (IFN)-γ+ and tumor necrosis factor (TNF)-α+ T cells in patients with RA. …”
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    Proinflammatory Differentiation of Macrophages Through Microparticles That Form Immune Complexes Leads to T- and B-Cell Activation in Systemic Autoimmune Diseases
  13. 29073
    “…The multifunctional viral VP35 protein is involved in this process by exerting an antagonistic action against the early antiviral alpha/beta interferon (IFN-α/β) response, and represents a suitable target for the development of strategies to control EBOV infection. …”
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    Intracellular human antibody fragments recognizing the VP35 protein of Zaire Ebola filovirus inhibit the protein activity
  14. 29074
    “…LPS induced changes in expression of specific genes related to embryo-maternal interactions including under-expression of eight members of the cadherin superfamily, over-expression of six members of the mucin family, and differential expression of a large set of genes binding the above molecules and of more than 20 transcripts coding for cytokines and their receptors. Type I interferon-τ dependent genes were also over-expressed. …”
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    Differential gene expression in bovine endometrial epithelial cells after challenge with LPS; specific implications for genes involved in embryo maternal interactions
  15. 29075
    “…Further investigation of the proviral mechanism of CALCOCO2 revealed that CALCOCO2, but not SQSTM1, suppresses the antiviral type I interferon signaling by promoting autophagy-mediated degradation of the mitochondrial antiviral signaling (MAVS) protein. …”
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    CALCOCO2/NDP52 and SQSTM1/p62 differentially regulate coxsackievirus B3 propagation
  16. 29076
    “…RNA-sequencing (RNA-seq) profiling revealed a marked enhancement of interferon (IFN)-α and IFN-γ signatures in Stat5b(−/−) cells. …”
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    Twins with different personalities: STAT5B—but not STAT5A—has a key role in BCR/ABL-induced leukemia
  17. 29077
    “…Considering the controls as a reference, the group with IBD endoscopic activity showed higher serum levels of granulocyte colony-stimulating factor (G-CSF), interleukin 1 receptor antagonist (IL-1Ra), and platelet-derived growth factor BB (PDGF-BB) (P < .05). Interferon-induced protein 10 (IP-10) was associated with extraintestinal symptoms of disease (P = .041). …”
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    Serum cytokine, chemokine, and growth factor profiles and their modulation in inflammatory bowel disease
  18. 29078
    “…The serum effects of RBTP were: (1) decreases in alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AKP), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), D-lactate (D-LA), diamine oxidase (DAO), lipopolysaccharide (LPS), and an increase of high density lipoprotein cholesterol (HDL-C) levels; (2) a decrease of inflammatory cytokines such as interleukin 1 beta (IL-1β), interleukin 4 (IL-4), interleukin 6 (IL-6), interleukin 10 (IL-10), tumor necrosis factor alpha (TNF-α), and interferon gamma (INF-γ); (3) a decrease the reactive oxygen species (ROS) level in liver tissue; and (4) alleviation of pathological injuries of liver, epididymis, and small intestinal tissues caused by NAFLD and protection of body tissues. qPCR and Western blot results showed that RBTP could up-regulate the mRNA and protein expressions of LPL, PPAR-α, CYP7A1, and CPT1, and down-regulate PPAR-γ and C/EBP-α in the liver of NAFLD mice. …”
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    Raw Bowl Tea (Tuocha) Polyphenol Prevention of Nonalcoholic Fatty Liver Disease by Regulating Intestinal Function in Mice
  19. 29079
    “…Furthermore, 155.5 μg 25(OH)D(3)/kg supplementation downregulated the mRNA abundance of inflammatory cytokines and interferon signal pathway-related genes (p < 0.05) compared with CON-PEDV. …”
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    Dietary 25-Hydroxyvitamin D(3) Supplementation Alleviates Porcine Epidemic Diarrhea Virus Infection by Improving Intestinal Structure and Immune Response in Weaned Pigs
  20. 29080
    “…T-helper (Th)1 [CD4(+); interferon (IFN)-γ(+)] and Th2 [CD4(+); interleukin (IL)-4(+)] expression in peripheral blood mononuclear cells was evaluated using flow cytometry. …”
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    MicroRNA-146a as a potential regulator involved in the pathogenesis of atopic dermatitis
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