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29101por Moledina, Dennis G., Mansour, Sherry G., Jia, Yaqi, Obeid, Wassim, Thiessen-Philbrook, Heather, Koyner, Jay L., McArthur, Eric, Garg, Amit X., Wilson, F. Perry, Shlipak, Michael G., Coca, Steven G., Parikh, Chirag R.“…INTRODUCTION: Animal models of renal ischemia-reperfusion injury (IRI) demonstrate that interferon (IFN)-γ producing T-helper (Th)-1 cells worsen acute kidney injury (AKI), whereas interleukin (IL)-4– and IL-13–producing Th2 cells lead to repair. …”
Publicado 2019
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29102por Bo, Marco, Erre, Gian Luca, Bach, Horacio, Slavin, Yael N, Manchia, Piera Angela, Passiu, Giuseppe, Sechi, Leonardo A“…Moreover, we analyzed the correlation of immune response to both proteins with the following homologous peptides: BOLF1(305–320), MAP_4027(18–32) and IRF5(424–434) to understand how the synergic role of Epstein–Barr virus (EBV) and MAP infection in genetically predisposed subjects may lead to a possible deregulation of interferon regulatory factor 5 (IRF5). MATERIALS AND METHODS: The presence of Abs against protein tyrosine phosphatase A (PtpA) and protein kinase G (PknG) in sera from Sardinian RA patients (n=84) and healthy volunteers (HCs, n=79) was tested by indirect ELISA. …”
Publicado 2019
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29103por Chou, Wei-Ling, Lee, Tzong-Huei, Huang, Tse-Hung, Wang, Pei-Wen, Chen, Ya-Ping, Chen, Chin-Chang, Chang, Zi-Yu, Fang, Jia-You, Yang, Shih-Chun“…The erythema, barrier function, and epidermal thickness of the AD-like wounds were improved by CoQ(0) through the reduction of IL-1β, IL-4, IL-6, IL-10, interferon (IFN)-γ, and by neutrophil infiltration in the lesional skin. …”
Publicado 2019
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29104por Zeng, Yukun, Gong, Zuxin, Wu, Binbin, Guan, Wenchao, Yu, Shenyi, An, Yajuan, Lu, Rongbin, Zhao, Jinrong, Wu, Yijian, Huang, Yifan, Wu, Xiaoping“…BLP injection in mock chickens enhanced the levels of serum cytokines (IL-2, IL-4 and interferon-γ) (P < 0.05). Surprisingly, the novel BLP significantly inhibited expression of the ALV gp85 gene in the thymus (P < 0.05), kidney (P < 0.05) and bursa of Fabricius (BF) (P < 0.01) of ALV-infected chickens. …”
Publicado 2019
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29105por Zou, Wenbin, Yu, Hailiang, Wang, Xiaohui, Dai, Guojun, Sun, Mingming, Zhang, Genxi, Zhang, Tao, Shi, Huiqiang, Xie, Kaizhou, Wang, Jinyu“…The following six different parameters were identified: body weight gain 3–5 days post infection and catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA) and γ-interferon (IFN-γ) concentrations on the eight day post inoculation. …”
Publicado 2019
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29106“…CD8(+) T cells activity was evaluated by investigation of cytotoxic molecules, target cell death, and interferon-γ (IFN-γ) secretion. IL-24 was decreasingly expressed in both peripheral bloods and cancer tissues in colorectal adenocarcinoma patients. …”
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29107por Zhang, Zongwang, Wu, Yanwei, Wu, Bing, Qi, Qing, Li, Heng, Lu, Huimin, Fan, Chen, Feng, Chunlan, Zuo, Jianping, Niu, Lili, Tang, Wei“…Consistently, DZ2002 inhibited the expression of various molecules associated with dermal fibrosis, including transforming growth factor β1, connective tissue growth factor, tumor necrosis factor-α, interferon-γ, IL-1β, IL-4, IL-6, IL-10, IL-12p40, IL-17A, and monocyte chemotactic protein 1 in the lesional skin of BLM-induced mice. …”
Publicado 2019
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29108por Salvetat, N., Van der Laan, S., Vire, B., Chimienti, F., Cleophax, S., Bronowicki, J. P., Doffoel, M., Bourlière, M., Schwan, R., Lang, J. P., Pujol, J. F., Weissmann, D.“…We show that PDE8A RNA editing is increased in all patients following interferon treatment, but differently in 30% of patients. …”
Publicado 2019
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29109por Leaker, Brian R., Singh, Dave, Lindgren, Sam, Almqvist, Gun, Eriksson, Leif, Young, Barbara, O’Connor, Brian“…CONCLUSIONS AND CLINICAL RELEVANCE: In patients with allergic asthma, TLR7 agonists could potentially reduce allergen responsiveness by stimulating Type 1 interferon responses to down-regulate the dominant Th2 responses. …”
Publicado 2019
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29110por Hashimoto, Mamoru, Minami, Takafumi, Hamaguchi, Mamoru, Fujimoto, Saizo, Takahashi, Tomoki, Kikuchi, Takashi, Adomi, Shogo, Banno, Eri, Ohzeki, Takayuki, Shimizu, Nobutaka, Mori, Yasunori, Nozawa, Masahiro, Nose, Kazuhiro, Yoshimura, Kazuhiro, Uemura, Hirotsugu“…Computed tomography (CT) revealed distribution of small nodules in the bilateral lungs, for which miliary TB was included in the differential diagnosis. T-Spot, interferon-gamma-release assay, and bronchoscopy yielded no significant findings; however, sputum and urine culture confirmed the diagnosis of TB. …”
Publicado 2019
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29111“…MATERIALS AND METHODS: From February to August 2017, we conducted a retrospective study at a referral university hospital in Korea, to screen the interferon-gamma release assay (IGRA) tests conducted for all HCWs for detecting and treating LTBI. …”
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29112por Chuang, Wen Yang., Lin, Wei Chih., Hsieh, Yun Chen., Huang, Chung Ming., Chang, Shen Chang., Lee, Tzu-Tai“…SCFP, SAFP, and AOFP significantly reduced the amount of interleukin-1β, inducible nitric oxide synthases, interferon-γ, and nuclear factor kappa B mRNA expression in PBMCs, especially in the AOFP group. …”
Publicado 2019
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29113por Freedman, Mark S., Brod, Staley, Singer, Barry A., Cohen, Bruce A., Hayward, Brooke, Dangond, Fernando, Coyle, Patricia K.“…This study evaluated efficacy of subcutaneous (sc) interferon beta-1a (IFN β-1a) 44 µg 3 × weekly (tiw) in patients appearing to transition from relapsing–remitting multiple sclerosis (RRMS) to secondary progressive MS (SPMS). …”
Publicado 2019
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29114“…The concentration of interferon-inducible protein 10 decreased significantly in the rifaximin group compared with that in the control group (P = 0.024). …”
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29115por Ávila-Pérez, Gines, Nogales, Aitor, Park, Jun-Gyu, Vasquez, Desarey Morales, Dean, David A., Barravecchia, Michael, Perez, Daniel R., Almazán, Fernando, Martínez-Sobrido, Luis“…A bacterial artificial chromosome containing the sequence of ZIKV strain Paraiba/2015 under the control of the cytomegalovirus promoter was complexed with a commercial transfection reagent and administrated using different routes in type-I interferon receptor deficient A129 mice. Clinical signs and death associated with ZIKV viremia were observed in mice. …”
Publicado 2020
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29116por Pang, Qing, Jin, Hao, Ke, Xiquan, Man, Zhongran, Wang, Yong, Tan, Yi, Lu, Zheng, Liu, Huichun“…Serotonin significantly facilitated the release of serum and intrahepatic inflammatory cytokines, including interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-17A (IL-17A), interferon-gamma (IFN-γ), and tumor necrosis-alpha (TNF-α), after the administration of Con A. …”
Publicado 2020
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29117“…Inhibition by SPSB1 was specific to NF-κB, because other transcription factors related to innate immunity and interferon (IFN) responses such as IRF-3, AP-1, and STATs remained unaffected by SPSB1. …”
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29118por Fu, Runzhong, Guo, Hao, Janga, Srikanth, Choi, Minchang, Klinngam, Wannita, Edman, Maria C., Hamm-Alvarez, Sarah F.“…Primary mouse LGAC and human corneal epithelial cells (HCE-T cells) exposed to interferon-gamma, a cytokine elevated in SS, showed up to 9.6-fold (p ≤ 0.0001) and 25-fold (p ≤ 0.0001) increases in CX3CL1 gene expression, and 1.9-fold (p = 0.0005) and 196-fold (p ≤ 0.0001) increases in CX3CL1 protein expression, respectively. …”
Publicado 2020
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29119por Gao, Nannan, Xu, Wenshuai, Ji, Jiadong, Yang, Yanli, Wang, Shao-Ting, Wang, Jun, Chen, Xiang, Meng, Shuzhen, Tian, Xinlun, Xu, Kai-Feng“…Further analyses illustrated that among COPD patients, air pollution exposure was associated with reduced levels of serum eotaxin, interleukin 4 (IL-4) and IL-13 and was correlated with increased serum IL-2, IL-12, IL-17A, interferon γ (IFNγ), monocyte displacing protein 1 (MCP-1) and soluble CD40 ligand (sCD40L). …”
Publicado 2020
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29120por Grunewald, Matthew E., Shaban, Mohamed G., Mackin, Samantha R., Fehr, Anthony R., Perlman, Stanley“…Knockdown of TiPARP reduced viral replication and increased interferon expression, suggesting that TiPARP functions in a proviral manner during MHV infection. …”
Publicado 2020
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