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29121por Rosenthal, Philip, Schwarz, Kathleen B., Gonzalez‐Peralta, Regino P., Lin, Chuan‐Hao, Kelly, Deidre A., Nightingale, Scott, Balistreri, William F., Bansal, Sanjay, Jonas, Maureen M., Massetto, Benedetta, Brainard, Diana M., Hsueh, Chia‐Hsiang, Shao, Jiang, Parhy, Bandita, Davison, Suzanne, Feiterna‐Sperling, Cornelia, Gillis, Lynette A., Indolfi, Giuseppe, Sokal, Etienne M., Murray, Karen F., Wirth, Stefan“…Currently, the only approved hepatitis C virus (HCV) treatment for children aged <12 years is pegylated interferon plus ribavirin. In an open‐label study, we evaluated the safety and efficacy of sofosbuvir plus ribavirin for 12 weeks in children aged 3 to <12 years chronically infected with genotype 2 or for 24 weeks in patients with genotype 3. …”
Publicado 2019
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29122por González-Corvillo, Carmen, Beneyto, Isabel, Sánchez-Fructuoso, Ana, Perelló, Manel, Alonso, Angel, Mazuecos, Auxiliadora, Jiménez, Carlos, Zárraga, Sofía, Paul, Javier, Lauzurica, Ricardo, Hernández, Domingo, Guirado, Luis, Franco, Antonio, Ruiz, Juan Carlos, Llorente, Santiago, Crespo, Marta, Rodríguez-Benot, Alberto, de Gracia Guindo, María del Carmen, Díaz-Corte, Carmen, Gentil, Miguel Ángel“…There are limited data on the long-term effects of all-oral, interferon-free DAA combination therapies in kidney transplant (KT) patients infected with HCV. …”
Publicado 2019
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29123por Amado, Tiago, Amorim, Ana, Enguita, Francisco J., Romero, Paula V., Inácio, Daniel, de Miranda, Marta Pires, Winter, Samantha J., Simas, J. Pedro, Krueger, Andreas, Schmolka, Nina, Silva-Santos, Bruno, Gomes, Anita Q.“…The main cytokine associated with these protective responses is interferon-γ (IFN-γ), whose production is known to be regulated at the transcriptional level during CD8(+) T cell differentiation. …”
Publicado 2020
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29124por Li, Tete, Wu, Jing, Zhu, Shan, Zang, Guoxia, Li, Shuang, Lv, Xinping, Yue, Wenjun, Qiao, Yuan, Cui, Jiuwei, Shao, Yan, Zhang, Jun, Liu, Yong-Jun, Chen, Jingtao“…METHODS: Twenty potential CpG-C ODNs were screened for their ability to secrete interferon (IFN)-α, and interleukin (IL)-6 and tumor necrosis factor (TNF)-α production for the three most promising sequences were assayed in human peripheral blood mononuclear cells (PBMCs) by enzyme-linked immunosorbent assay (ELISA) or cytometric bead array assay. …”
Publicado 2020
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29125por Tani, Joji, Morishita, Asahiro, Sakamoto, Teppei, Takuma, Kei, Nakahara, Mai, Fujita, Koji, Oura, Kyoko, Tadokoro, Tomoko, Mimura, Shima, Nomura, Takako, Yoneyama, Hirohito, Kobara, Hideki, Himoto, Takashi, Tsutsui, Akemi, Senoh, Tomonori, Nagano, Takuya, Ogawa, Chikara, Moriya, Akio, Deguchi, Akihiro, Takaguchi, Kouichi, Masaki, Tsutomu“…Direct acting antivirals (DAA) have recently been developed to treat patients with hepatitis C virus (HCV) infection, and interferon-free DAA treatment has improved the cure rate of patients. …”
Publicado 2020
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29126por Goto, Shinya, Konnai, Satoru, Hirano, Yuki, Kohara, Junko, Okagawa, Tomohiro, Maekawa, Naoya, Sajiki, Yamato, Watari, Kei, Minato, Erina, Kobayashi, Atsuhi, Gondaira, Satoshi, Higuchi, Hidetoshi, Koiwa, Masateru, Tajima, Motoshi, Taguchi, Eiji, Uemura, Ryoko, Yamada, Shinji, Kaneko, Mika K., Kato, Yukinari, Yamamoto, Keiichi, Toda, Mikihiro, Suzuki, Yasuhiko, Murata, Shiro, Ohashi, Kazuhiko“…Additionally, plasma PGE(2) production in infected cattle was negatively correlated with M. bovis-specific interferon (IFN)-γ production from PBMCs. These results suggest that PGE(2) could be one of the inducers of PD-L1 expression and could be involved in immunosuppression during M. bovis infection. …”
Publicado 2020
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29127“…In addition, NaB increased the AR-associated low expression of interleukin 2 (IL-2), interferon γ and IL-17 and decreased the expression of IL-4, IL-5 and transforming growth factor β1. …”
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29128“…Ovalbumin-induced increased levels of interleukin (IL)-4, IL-5, IL-13, and interferon (IFN)-γ in nasal lavage fluid were significantly decreased (P < .05) by apigenin. …”
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29129por Alizadeh, Mohammadali, Shojadoost, Bahram, Astill, Jake, Taha-Abdelaziz, Khaled, Karimi, Seyed Hossein, Bavananthasivam, Jegarubee, Kulkarni, Raveendra R., Sharif, Shayan“…The results demonstrated that lactobacilli inoculation increased the splenic expression of cytokines, including interferon (IFN)-α, IFN-β, IFN-γ, interleukin (IL)-8, and IL-12 on day 5 post-hatch compared to the control group (PBS). …”
Publicado 2020
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29130“…RESULTS: In our study, the LPS-induced inflammation in k562 cells was reflected by increases in levels of diverse inflammatory cytokines, including interleukin (IL)-10, IL-1β, IL-6, interferon-γ, tumor necrosis factor (TNF)-α and TNF-β. …”
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29131por Yin, Peidi, Li, Huifeng, Ke, Chao, Cao, Guangxu, Xin, Xiaoqian, Hu, Junjiao, Cai, Xiangran, Li, Lingfeng, Liu, Xiaowen, Du, Bin“…PURPOSE: Some chemotherapeutics have been shown to induce both the release of damage-associated molecular patterns (DAMPs) and the production of type I interferon (IFN-I), leading to immunogenic cell death (ICD). …”
Publicado 2020
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29132“…Previous studies have found that interferon-γ-inducible protein (IP)-10 and interleukin (IL)-17 can be elevated and may play a role in KD development and coronary artery lesion formation. …”
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29133“…CD4(+) cells and CD8(+) cells were isolated from peripheral blood of COPD patients respectively and treated with BAFF or BAFF plus BR3-Fc. Interferon-γ (IFN-γ) and interleukin-4 (IL-4) were detected in the CD4(+) cells, and perforin and granzyme B were detected in the CD8(+) cells. …”
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29134“…The only available therapy before 2008 was interferon alpha-2A (INFa2A), targeted agents added from 2008. …”
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29135por Kim, Yong-seok, Sun, Der Sheng, Yoon, Jung-sook, Ko, Yoon Ho, Won, Hye Sung, Kim, Jeong Soo“…The serum concentrations of soluble programmed death-ligand 1 (sPD-L1) and interferon gamma were determined using enzyme-linked immunosorbent assays. …”
Publicado 2020
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29136por de Beijer, Monique T. A., Jansen, Diahann T. S. L., Dou, Yingying, van Esch, Wim J. E., Mok, Juk Yee, Maas, Mariëlle J. P., Brasser, Giso, de Man, Robert A., Woltman, Andrea M., Buschow, Sonja I.“…Subsequently, we demonstrated interferon gamma (IFN-γ) production in response to 5 of the novel HBx-derived binders and 17 of the novel Pol-derived binders. …”
Publicado 2020
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29137por Lu, Shuang, Zhu, Ni, Guo, Weiwei, Wang, Xin, Li, Kaiji, Yan, Jie, Jiang, Cuiping, Han, Shiyu, Xiang, Hanmin, Wu, Xiaohan, Liu, Yuanyuan, Xiong, Hairong, Chen, Liangjun, Gong, Zuojiong, Luo, Fan, Hou, Wei“…Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis demonstrated that the host genes of differentially expressed circRNAs were principally involved in the innate immune response, the type I interferon (IFN) signaling pathway, and the cytokine-mediated signaling pathway. …”
Publicado 2020
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29138por Zheng, Qisheng, Chen, Desheng, Li, Peng, Bi, Zhixiang, Cao, Ruibing, Zhou, Bin, Chen, Puyan“…The production of gamma interferon (IFN-γ), interleukin-2 (IL-2), and interleukin-4 (IL-4) was detected in splenocytes of rMVA-inoculated mice at 30, 60, and 90 days post inoculation to evaluate the cellular immune response. …”
Publicado 2007
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29139por Colmant, Agathe M. G., Bielefeldt-Ohmann, Helle, Vet, Laura J., O’Brien, Caitlin A., Bowen, Richard A., Hartwig, Airn E., Davis, Steven, Piyasena, Thisun B. H., Habarugira, Gervais, Harrison, Jessica J., Hobson-Peters, Jody, Hall, Roy A.“…We determined that the mechanisms involved in BgV host-restriction were independent of the type-1 interferon response and RNAse L activity. Using a BgV infectious clone and two chimeric viruses generated as hybrids between BgV and West Nile virus, we demonstrated that BgV host-restriction occurred post-cell entry. …”
Publicado 2020
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29140“…Expression of genes encoding inflammatory cytokines and chemokines, including interleukin (IL)-1β, IL-6, IL-15, tumour necrosis factor (TNF)-α, CXCL10, CCL8, interferon (IFN)-α, IFN-β and IFN-γ, was higher in cats with FIP, consistent with inflammatory pathway activation. …”
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