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29161por Cai, Helen Q., Catts, Vibeke S., Webster, Maree J., Galletly, Cherrie, Liu, Dennis, O’Donnell, Maryanne, Weickert, Thomas W, Weickert, Cynthia Shannon“…The “high inflammation” schizophrenia subgroup had lower ABCG2 and higher ICAM1, VE-cadherin, occludin and interferon-induced transmembrane protein mRNAs compared to both “low inflammation” schizophrenia and “low inflammation” control subgroups. …”
Publicado 2018
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29162por Ficarelli, Mattia, Antzin-Anduetza, Irati, Hugh-White, Rupert, Firth, Andrew E., Sertkaya, Helin, Wilson, Harry, Neil, Stuart J. D., Schulz, Reiner, Swanson, Chad M.“…Interestingly, CpGs inserted into some regions of the genome sensitize the virus to ZAP antiviral activity more efficiently than insertions into other regions, and this sensitivity can be modulated by interferon treatment or ZAP overexpression. Furthermore, the sensitivity of the virus to endogenous ZAP was correlated with its sensitivity to the ZAP cofactor KHNYN. …”
Publicado 2020
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29163por Mizuno, Hiroya, Arce, Lorena, Tomotsune, Kae, Albarracin, Leonardo, Funabashi, Ryutaro, Vera, Daniela, Islam, Md. Aminul, Vizoso-Pinto, Maria Guadalupe, Takahashi, Hideki, Sasaki, Yasuko, Kitazawa, Haruki, Villena, Julio“…The challenge of PIE cells with the TLR3 agonist poly(I:C) significantly increased interferon (IFN)-β, interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1 expressions. …”
Publicado 2020
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29164“…The success of virus elimination by antiviral treatment is determined by the SVR when the HCV is no longer detectable in serum. Interferon-alpha (IFN-α) and its analogs, pegylated IFN-α (PEG-IFN-α) alone with ribavirin (RBV), have been the primary antiviral treatment of HCV for many years with a low cure rate. …”
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29165“…GRP78-positive clones correlated with increased serum levels of interferon gamma (IFNγ). CONCLUSIONS: The presence of GRP78-positive clones in certain PBMC subpopulations in pCR patients suggests a dynamic interaction between ER stress and immune responsiveness. …”
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29166por Rossi, Alessandro, Melone, Velia, Turco, Rossella, Camera, Luigi, Bruzzese, Eugenia, Miele, Erasmo, Staiano, Annamaria, Guarino, Alfredo, Lo Vecchio, Andrea“…Positive tuberculin skin test and Interferon Gamma release assay (IGRA) as well as increased Ca125 serum concentrations were found. …”
Publicado 2020
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29167“…In the MHW group, insulin, homeostatic model assessment of insulin resistance (HOMA-IR), γ-glutamyltransferase (GGT), high-sensitivity C-reactive protein (hs-CRP), and interferon (IFN)-γ showed significant increases compared to those in the other groups. …”
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29168por Uher, Tomas, Schaedelin, Sabine, Srpova, Barbora, Barro, Christian, Bergsland, Niels, Dwyer, Michael, Tyblova, Michaela, Vodehnalova, Karolina, Benkert, Pascal, Oechtering, Johanna, Leppert, David, Naegelin, Yvonne, Krasensky, Jan, Vaneckova, Manuela, Kubala Havrdova, Eva, Kappos, Ludwig, Zivadinov, Robert, Horakova, Dana, Kuhle, Jens, Kalincik, Tomas“…METHODS: This observational study included 163 patients (405 samples) with early RRMS from the Study of Early interferon-beta1a (IFN-β1a) Treatment (SET) cohort and 179 patients (664 samples) with more advanced RRMS from the Genome-Wide Association Study of Multiple Sclerosis (GeneMSA) cohort. …”
Publicado 2020
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29169por Isaiah, Simon, Loots, Du Toit, Solomons, Regan, van der Kuip, Martijn, Tutu Van Furth, A. Marceline, Mason, Shayne“…Furthermore, we take a severe chronic neuroinflammatory infectious disease – tuberculous meningitis (TBM), caused by Mycobacterium tuberculosis, and examine three previously validated CSF immunological biomarkers – vascular endothelial growth factor, interferon-gamma and myeloperoxidase – in terms of the expected changes in normal brain metabolism. …”
Publicado 2020
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29170“…We hypothesize that patients with severe COVID-19 have a severely compromised innate immune response and could be treated via the use of Monalizumab, interferon α, chloroquine, and other antiviral agents.…”
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29171“…More importantly, the levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, and interferon (IFN)-γ were decreased. CONCLUSIONS: Remifentanil has significant potential as a therapeutic intervention strategy for ameliorating myocardial injury after MI and these findings provide the rationale for further clinical studies.…”
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29172por James, Rachel E., Schalks, Renee, Browne, Eleanor, Eleftheriadou, Ioanna, Munoz, Carmen Picon, Mazarakis, Nicholas D., Reynolds, Richard“…Analysis of isolated meninges and cerebrospinal fluid (CSF) of post-mortem MS cases has shown increased gene and protein expression for the pro-inflammatory cytokines: tumour necrosis factor (TNF) and interferon-γ (IFNγ). Here we tested the hypothesis that persistent production of these cytokines in the meningeal compartment and diffusion into underlying GM can drive chronic MS-like GM pathology. …”
Publicado 2020
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29173por Gilley, Kristen N., Wierenga, Kathryn A., Chauhuan, Preeti S., Wagner, James G., Lewandowski, Ryan P., Ross, Elizbeth A., Lock, A. L., Harkema, Jack R., Benninghoff, Abby D., Pestka, James J.“…Exposing lupus-prone female NZBWF1 mice to crystalline silica (cSiO(2)), a known human autoimmune trigger, mimics flaring by inducing interferon-related gene (IRG) expression, inflammation, ectopic lymphoid structure (ELS) development, and autoantibody production in the lung that collectively accelerate glomerulonephritis. cSiO(2)-triggered flaring in this model can be prevented by supplementing mouse diet with the ω-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA). …”
Publicado 2020
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29174por Müller, Sabrina, Heidler, Tobias, Fuchs, Andreas, Pfaff, Andreas, Ernst, Kathrin, Ladinek, Gunter, Wilke, Thomas“…Among all patients, 38.3% of those with CIS, 22.4% with PPMS, 69.6% with RRMS, and 33.9% with SPMS received a prescription of a disease-modifying immunomodulatory agent, with interferon beta-1a being the most frequently prescribed agent. …”
Publicado 2019
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29175por Sun, Jialei, Yogarajah, Thinesshwary, Lee, Regina Ching Hua, Kaur, Parveen, Inoue, Masafumi, Tan, Yong Wah, Chu, Justin Jang Hann“…In addition, the drug combination study of gemcitabine’s synergistic effects with interferon-β at 1:1 and 1:2 ratio enhanced inhibition against EV-A71 replication. …”
Publicado 2020
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29176por Sugiura, Ayumi, Joshita, Satoru, Yamashita, Yuki, Yamazaki, Tomoo, Fujimori, Naoyuki, Kimura, Takefumi, Matsumoto, Akihiro, Wada, Shuichi, Mori, Hiromitsu, Shibata, Soichiro, Yoshizawa, Kaname, Morita, Susumu, Furuta, Kiyoshi, Kamijo, Atsushi, Iijima, Akihiro, Kako, Satoko, Maruyama, Atsushi, Kobayashi, Masakazu, Komatsu, Michiharu, Matsumura, Makiko, Miyabayashi, Chiharu, Ichijo, Tetsuya, Takeuchi, Aki, Koike, Yuriko, Gibo, Yukio, Tsukadaira, Toshihisa, Inada, Hiroyuki, Nakano, Yoshiyuki, Usuda, Seiichi, Kiyosawa, Kendo, Tanaka, Eiji, Umemura, Takeji“…The retreatment group had a significantly more frequent history of interferon treatment (12.3% vs. 52.2%, p < 0.01) and the Y93H mutation (25.0% vs. 64.7%, p = 0.02). …”
Publicado 2020
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29177por Kazer, Samuel W., Aicher, Toby P., Muema, Daniel M., Carroll, Shaina L., Ordovas-Montanes, Jose, Miao, Vincent N., Tu, Ang A., Ziegler, Carly G. K., Nyquist, Sarah K., Wong, Emily B., Ismail, Nasreen, Dong, Mary, Moodley, Amber, Berger, Bonnie, Love, J. Christopher, Dong, Krista L., Leslie, Alasdair, Ndhlovu, Zaza M., Ndung’u, Thumbi, Walker, Bruce D., Shalek, Alex K.“…Beyond previously unappreciated individual- and cell-type-specific interferon-stimulated gene upregulation, we describe temporally aligned gene expression responses obscured in bulk analyses, including those involved in proinflammatory T cell differentiation, prolonged monocyte major histocompatibility complex II upregulation and persistent natural killer (NK) cell cytolytic killing. …”
Publicado 2020
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29178por Xu, Dachun, Ma, Mengqiu, Xu, Yanhua, Su, Yang, Ong, Sang-Bing, Hu, Xingdong, Chai, Min, Zhao, Maojun, Li, Hong, Chen, Yingjie, Xu, Xiaojiang“…To our surprise, we found that genes related to virus entry, virus replication and suppression of interferon-gamma(IFN-γ)signaling are all up-regulated in CMs in failing hearts, and the increases were significantly higher in ACE2+ CMs as compared with ACE2 negative (ACE2−) CMs, suggesting that these ACE2+ CMs may be more vulnerable to virus infection. …”
Publicado 2020
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29179por Zeng, Yongyi, Zhang, Wei, Li, Zhenli, Zheng, Youshi, Wang, Yingchao, Chen, Geng, Qiu, Liman, Ke, Kun, Su, Xiaoping, Cai, Zhixiong, Liu, Jingfeng, Liu, Xiaolong“…After six cycles of neoantigen-based vaccination and T-cell immunotherapy, the patient was reported with stable disease status in tumor burden and significant alleviation of bone pain. Ex vivo interferon-γ enzyme-linked immunospot assay proved the reactivity to 12 of 13 neoantigens in peripheral blood mononuclear cells collected after immunotherapy, and the preferential reactivity to mutant peptides compared with corresponding wild-type peptides was also observed for 3 of the neoantigens. …”
Publicado 2020
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29180por Han, Bobby Kwanghoon, Wysham, Katherine D, Cain, Kevin C, Tyden, Helena, Bengtsson, Anders A, Lood, Christian“…High NLR was associated with immune complex (IC)-driven disease with presence of antidouble-stranded DNA antibodies (p=0.006), circulating ICs (p=0.02) and type I interferon (IFN) activity (p=0.009). Further, high NLR was associated with neutrophil abnormalities, including enrichment for low-density granulocytes (LDGs) (p=0.001), and increased levels of the serum neutrophil activation marker, calprotectin (p=0.02). …”
Publicado 2020
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