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29181por Walker, Joshua M, Rolig, Annah S, Charych, Deborah H, Hoch, Ute, Kasiewicz, Melissa J, Rose, Daniel C, McNamara, Michael J, Hilgart-Martiszus, Ian F, Redmond, William L“…RT is known to increase antigen presentation, type I/II interferon responses, and immune cell trafficking to irradiated tumors. …”
Publicado 2020
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29182por Raaijmakers, Tonke K, van den Bijgaart, Renske J E, den Brok, Martijn H, Wassink, Melissa, de Graaf, Annemarie, Wagenaars, Jori A, Nierkens, Stefan, Ansems, Marleen, Scheffer, Gert Jan, Adema, Gosse J“…Most strikingly, CpG/saponin-based adjuvant exposed DCs potentiate antigen-specific T-cell proliferation resulting in multipotent T cells with increased capacity to produce interferon (IFN)γ, IL-2 and tumor necrosis factor-α in vitro. …”
Publicado 2020
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29183por Archer, Todd M., Mulligan, Charlee, Narayanan, Lakshmi, Riggs, Caitlin, Fellman, Claire, Thomason, John M., Wills, Robert W., Boothe, Dawn M., Cruz‐Espindola, Crisanta, Harmon, Roy, Mackin, Andrew J.“…HYPOTHESIS/OBJECTIVES: To determine the effects of 5 medications (prednisone, cyclosporine, azathioprine, mycophenolate mofetil, and leflunomide) on activated T‐cell expression of the cytokines IL‐2 and interferon‐gamma (IFN‐γ). ANIMALS: Eight healthy dogs. …”
Publicado 2020
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29184por Brock, Rebecca M., Beitel-White, Natalie, Coutermarsh-Ott, Sheryl, Grider, Douglas J., Lorenzo, Melvin F., Ringel-Scaia, Veronica M., Manuchehrabadi, Navid, Martin, Robert C. G., Davalos, Rafael V., Allen, Irving C.“…Gene expression analysis revealed that IRE treatment resulted in an increase in biological pathway signaling associated with interferon gamma signaling, necrosis and mitochondria dysfunction, suggesting potential co-therapy targets. …”
Publicado 2020
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29185por Creary, Susan, Shrestha, Chandra L., Kotha, Kavitha, Minta, Abena, Fitch, James, Jaramillo, Lisa, Zhang, Shuzhong, Pinto, Swaroop, Thompson, Rohan, Ramilo, Octavio, White, Peter, Mejias, M. Asuncion, Kopp, Benjamin T.“…Top canonical pathways during ACS episodes were related to interferon signaling, neuro-inflammation, pattern recognition receptors, and macrophages. …”
Publicado 2020
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29186por Wattegedera, Sean R., Livingstone, Morag, Maley, Stephen, Rocchi, Mara, Lee, Susan, Pang, Yvonne, Wheelhouse, Nick M., Aitchison, Kevin, Palarea-Albaladejo, Javier, Buxton, David, Longbottom, David, Entrican, Gary“…By analysing cytokines associated with the major CD4(+ve) T(helper) (T(h)) cell subsets (Interferon-gamma (IFN-γ)/T(h)1; Interleukin (IL)-4/T(h)2; IL-17A/T(h)17; IL-10/T(regulatory)), we show that there is selective activation of PBMC producing IFN-γ and/or IL-10 during the latent phase following infection. …”
Publicado 2020
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29187por Key, Jana, Maletzko, Antonia, Kohli, Aneesha, Gispert, Suzana, Torres-Odio, Sylvia, Wittig, Ilka, Heidler, Juliana, Bárcena, Clea, López-Otín, Carlos, Lei, Yuanjiu, West, A. Phillip, Münch, Christian, Auburger, Georg“…Mostly in mouse fibroblasts and human endothelial cells, the Rnf213 levels showed prominent upregulation upon Poly(I:C)-triggered TLR3-mediated responses to dsRNA toxicity, as well as upon interferon gamma treatment. Only partial suppression of Rnf213 induction was achieved by C16 as an antagonist of PKR (dsRNA-dependent protein kinase). …”
Publicado 2020
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29188por Yap, Gracemary L. R., Sachaphibulkij, Karishma, Foo, Sok Lin, Cui, Jianzhou, Fairhurst, Anna-Marie, Lim, Lina H. K.“…ANXA1 deletion delays the phosphorylation of IRF3 and STAT1, leading to lower expression of interferon-stimulated genes, such as IFIT1, and silencing IFIT1 inhibited RIG-I-induced cell death. …”
Publicado 2020
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29189por Magatti, Marta, Masserdotti, Alice, Bonassi Signoroni, Patrizia, Vertua, Elsa, Stefani, Francesca Romana, Silini, Antonietta Rosa, Parolini, Ornella“…We observed the strong inhibition of B cell terminal differentiation into CD138(+) plasma cells, as further shown by a significant decrease of the expression of interferon regulatory factor 4 (IRF-4), PR/SET domain 1(PRDM1), and X-box binding protein 1 (XBP-1) genes. …”
Publicado 2020
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29190por Gao, Chao, Wang, Xiaodong, Lu, Jian, Li, Zhilin, Jia, Haowen, Chen, Minghao, Chang, Yuchen, Liu, Yanhong, Li, Peiyuan, Zhang, Baotong, Du, Xuezhi, Qi, Feng“…Besides, the sFgl2-MSCs significantly enhanced the migration and phagocytosis ability of macrophages stimulated with interferon-γ (IFN-γ) and lipopolysaccharide (LPS). Further, the application potential of sFgl2-MSCs in AR treatment was demonstrated by heterotopic cardiac transplantation in mice. …”
Publicado 2020
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29191por Xiong, Jie, Jiang, Binglei, Luo, Yong, Zou, Jianzhong, Gao, Xuan, Xu, Die, Du, Yan, Hao, Lan“…In particular, the nanoparticles upregulated the expression of MHC-II, CD80 and CD86 on cocultured DCs in vitro, followed by declining phagocytic function and enhanced interleukin (IL)-12 and interferon (INF)-γ production. Furthermore, they boosted the production of tumor necrosis factor (TNF)-α, IFN-γ, IL-4, IL-10, and IgG1 (P< 0.001) but not IgG2a. …”
Publicado 2020
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29192por Hassany, Sahar M, Hassan, Wesam, Abo-alam, Hany, Khalaf, Marwa, Nafeh, Amany M, Nasr-eldin, Eman, Mostafa, Ehab F“…PURPOSE: In interferon-free era, direct-acting antiviral agents (DAAs) have achieved high eradication rates with an excellent safety profile since revolutionized the management of hepatitis c virus (HCV) patients. …”
Publicado 2020
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29193por Ellis, Ronald J., Peterson, Scott N., Li, Yueling, Schrier, Rachel, Iudicello, Jenny, Letendre, Scott, Morgan, Erin, Tang, Bin, Grant, Igor, Cherner, Mariana“…METHODS: We measured a panel of proinflammatory cytokines (interleukin [IL]-16, C-reactive protein [CRP], IL-6, interferon gamma-induced protein [IP]-10, soluble CD14, and soluble tumor necrosis factor receptor type II [sTNFRII]) in CSF and blood plasma in PWH and HIV− individuals who did or did not use cannabis at various levels of exposure. …”
Publicado 2020
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29194por Inamo, Jun, Suzuki, Katsuya, Takeshita, Masaru, Kassai, Yoshiaki, Takiguchi, Maiko, Kurisu, Rina, Okuzono, Yuumi, Tasaki, Shinya, Yoshimura, Akihiko, Takeuchi, Tsutomu“…RESULTS: Expression of the long non-coding RNA LINC00487 was significantly upregulated in all B cell subsets, as was that of HLA and interferon (IFN) signature genes. Moreover, the normalized intensity value of LINC00487 significantly correlated with the disease activity score of all pSS B cell subsets. …”
Publicado 2020
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29195por Basu Roy, Robindra, Thee, Stephanie, Blázquez-Gamero, Daniel, Falcón-Neyra, Lola, Neth, Olaf, Noguera-Julian, Antoni, Lillo, Cristina, Galli, Luisa, Venturini, Elisabetta, Buonsenso, Danilo, Götzinger, Florian, Martinez-Alier, Nuria, Velizarova, Svetlana, Brinkmann, Folke, Welch, Steven B., Tsolia, Maria, Santiago-Garcia, Begoña, Krüger, Renate, Tebruegge, Marc“…Only limited data exist on the performance of interferon-γ release assays (IGRA) and molecular assays in children with TBM in routine clinical practice, particularly in the European setting. …”
Publicado 2020
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29196por Liu, Haoran, Yang, Xiaoqi, Tang, Kun, Ye, Tao, Duan, Chen, Lv, Peng, Yan, Libin, Wu, Xiaoliang, Chen, Zhiqiang, Liu, Jianhe, Deng, Yaoliang, Zeng, Guohua, Xing, Jinchun, Ye, Zhangqun, Xu, Hua“…Intrarenal calcium oxalate (CaOx) crystals induce renal tubular epithelial cells (TECs) injury and inflammation, which involve Toll-like receptor 4 (TLR4)/interferon regulatory factor 1 (IRF1) signaling. Additionally, infiltrating macrophages (Mϕs) might influence intrarenal CaOx crystals and CaOx-induced renal injury. …”
Publicado 2020
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29197por Romanowski, Kamila, Rose, Caren, Cook, Victoria J., Sekirov, Inna, Morshed, Muhammad, Djurdjev, Ognjenka, Levin, Adeera, Johnston, James C.“…In 2012, the Canadian province of British Columbia began systematically screening people initiating dialysis for latent TB using interferon-gamma release assay (IGRA), and treating when appropriate. …”
Publicado 2020
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29198por Borsini, Alessandra, Stangl, Doris, Jeffries, Aaron R., Pariante, Carmine M., Thuret, Sandrine“…Using transcriptomic analyses, we showed that both EPA and DHA regulated pathways involved in oxidative stress and immune response [e.g., nuclear factor (erythroid-derived 2)-like 2 (Nrf2), Signal transducer and activator of transcription 3 (STAT3), Interferon (IFN) and Interleukin (IL)-1 signaling], whereas DHA also regulated pathways involved in cell development and neuronal formation [e.g., cAMP-response element binding protein (CREB) signaling]. …”
Publicado 2020
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29199por Arrieta-Villegas, Claudia, Infantes-Lorenzo, José Antonio, Bezos, Javier, Grasa, Miriam, Vidal, Enric, Mercader, Irene, Singh, Mahavir, Domingo, Mariano, de Juan, Lucía, Pérez de Val, Bernat“…In this study, the performance of a new diagnostic platform, based on the P22 antigenic complex, was assessed for skin test (ST), interferon-gamma release assay (IGRA), and serology under different TB scenarios. …”
Publicado 2020
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29200por Butsashvili, Maia, Gvinjilia, Lia, Kamkamidze, George, Metreveli, David, Dvali, Shorena, Rukhadze, Tamar, Gamkrelidze, Amiran, Nasrullah, Muazzam, Shadaker, Shaun, Morgan, Juliette, Averhoff, Francisco“…Of those who received sofosbuvir/ribavirin (SOF/RBV) for 24 weeks, 79.3% achieved SVR, while 96.5% who received sofosbuvir/pegylated interferon/ribavirin (SOF/PEG/RBV) for 12 weeks achieved SVR (p < 0.01). …”
Publicado 2020
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