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29221por Itakura, Jun, Kurosaki, Masayuki, Kakizaki, Satoru, Amano, Keisuke, Nakayama, Nobuaki, Inoue, Jun, Endo, Tetsu, Marusawa, Hiroyuki, Hasebe, Chitomi, Joko, Kouji, Wada, Shuichi, Akahane, Takehiro, Koushima, Youhei, Ogawa, Chikara, Kanto, Tatsuya, Mizokami, Masashi, Izumi, Namiki“…BACKGROUND & AIMS: We aimed to clarify the features of resistance-associated substitutions (RASs) after failure of multiple interferon (IFN)-free regimens in HCV genotype 1b infections. …”
Publicado 2020
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29222por Levanova, Alesia A., Kalke, Kiira M., Lund, Liisa M., Sipari, Nina, Sadeghi, Mohammadreza, Nyman, Marie C., Paavilainen, Henrik, Hukkanen, Veijo, Poranen, Minna M.“…Modest stimulation of innate immunity signaling, including induced expression of both type I and type III interferons, as well as interferon-stimulated gene 54, by 2′-F-cytidine and 2′-F-uridine modified siRNA swarms occurred at early time points after transfection while the 2′-F-adenosine-containing siRNA was similar to the unmodified antiviral siRNA swarm in this respect. …”
Publicado 2020
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29223“…Pathway enrichment and GO analysis conceded the enrichment of pathways associated with interferon signalling and antiviral-mechanism by IFN-stimulated genes. …”
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29224por Hoefflin, Rouven, Harlander, Sabine, Schäfer, Silvia, Metzger, Patrick, Kuo, Fengshen, Schönenberger, Désirée, Adlesic, Mojca, Peighambari, Asin, Seidel, Philipp, Chen, Chia-yi, Consenza-Contreras, Miguel, Jud, Andreas, Lahrmann, Bernd, Grabe, Niels, Heide, Danijela, Uhl, Franziska M., Chan, Timothy A., Duyster, Justus, Zeiser, Robert, Schell, Christoph, Heikenwalder, Mathias, Schilling, Oliver, Hakimi, A. Ari, Boerries, Melanie, Frew, Ian J.“…HIF-2α-deficient tumours are characterised by increased antigen presentation, interferon signalling and CD8(+) T cell infiltration and activation. …”
Publicado 2020
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29225por Bosso, Matteo, Prelli Bozzo, Caterina, Hotter, Dominik, Volcic, Meta, Stürzel, Christina M., Rammelt, Annika, Ni, Yi, Urban, Stephan, Becker, Miriam, Schelhaas, Mario, Wittmann, Sabine, Christensen, Maria H., Schmidt, Florian I., Gramberg, Thomas, Sparrer, Konstantin M. J., Sauter, Daniel, Kirchhoff, Frank“…While absent in melanoma 2 (AIM2) acts a cytosolic sensor of non-self DNA and plays a key role in inflammasome assembly, the γ-interferon-inducible protein 16 (IFI16) restricts retroviral gene expression by sequestering the transcription factor Sp1. …”
Publicado 2020
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29226“…The in vitro efficacy of the DC/T-cell vaccine formulations subjected to different immunogen treatments and co-cultured with glioma cells was evaluated based on glioma cell viability and monocyte chemoattractant protein (MCP)-2 and interferon (IFN)-γ secretion. Subsequently, the efficacy of the 9L + C6 hybrid vaccine was evaluated in 32 glioma rat models, randomly allocated to the following five treatment groups: blank control, tumor, vaccine treatment, thymosin treatment, and vaccine + thymosin treatment (combined treatment). …”
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29227por Wang, Hesong, Sun, Ye, Xin, Jinge, Zhang, Tao, Sun, Ning, Ni, Xueqin, Zeng, Dong, Bai, Yang“…L. johnsonii BS15 pretreatment modulated inflammatory factors, specifically tumor necrosis factor-alpha, interferon-gamma, and interleukin-10. L. johnsonii BS15 pretreatment improved their performance in two behavioral tests, namely the novel object and T-maze tests. …”
Publicado 2020
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29228“…Gene ontology analysis indicated that the biological functions of DEGs focused primarily on response to virus, type I interferon signaling pathway and negative regulation of viral genome replication. …”
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29229por Campeau, Anaamika, Mills, Robert H., Blanchette, Marie, Bajc, Kaja, Malfavon, Mario, Munji, Roeben N., Deng, Liwen, Hancock, Bryan, Patras, Kathryn A., Olson, Joshua, Nizet, Victor, Daneman, Richard, Doran, Kelly, Gonzalez, David J.“…In isolated brain microvessels, classical blood-brain barrier proteins were unaltered, but interferon signaling and leukocyte recruitment proteins were upregulated. …”
Publicado 2020
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29230por Beretta, Lorenzo, Barturen, Guillermo, Vigone, Barbara, Bellocchi, Chiara, Hunzelmann, Nicolas, De Langhe, Ellen, Cervera, Ricard, Gerosa, Maria, Kovács, László, Ortega Castro, Rafaela, Almeida, Isabel, Cornec, Divi, Chizzolini, Carlo, Pers, Jacques-Olivier, Makowska, Zuzanna, Lesche, Ralf, Kerick, Martin, Alarcón-Riquelme, Marta Eugenia, Martin, Javier“…Among replicated pathways, we found a deregulation in type-I interferon, Toll-like receptor cascade, tumour suppressor p53 protein function, platelet degranulation and activation. …”
Publicado 2020
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29231por Lei, Yao, Shen, Feihu, Zhu, Haimeng, Zhu, Laicheng, Chu, Ruilin, Tang, Jianxia, Yao, Wenxi, Zhu, Guoding, Zhang, Dengxin, Cao, Jun, Cheng, Yang“…Moreover, rPoAMA-1 s induced interferon (IFN)-gamma-secreting cells in mice and increased lymphocyte proliferation response. …”
Publicado 2020
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29232por Mühlig, Anne K., Keir, Lindsay S., Abt, Jana C., Heidelbach, Hannah S., Horton, Rachel, Welsh, Gavin I., Meyer-Schwesinger, Catherine, Licht, Christoph, Coward, Richard J., Fester, Lars, Saleem, Moin A., Oh, Jun“…The process of secretion in podocytes was stimulated with interferon gamma and located in the Golgi apparatus. …”
Publicado 2020
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29233por Sindhu, Sardar, Akhter, Nadeem, Wilson, Ajit, Thomas, Reeby, Arefanian, Hossein, Al Madhoun, Ashraf, Al-Mulla, Fahd, Ahmad, Rasheed“…The involvement of TLR4-downstream pathways, interferon regulatory factor (IRF)-3 or myeloid differentiation (MyD)-88 factor, was determined using IRF3-siRNA or MyD88-deficient cells. …”
Publicado 2020
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29234“…The protein expression levels of Interferon (IFN)-γ were down-regulated, but levels of IL-4 were increased. …”
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29235por Mallis, Panagiotis, Michalopoulos, Efstathios, Chatzistamatiou, Theofanis, Stavropoulos-Giokas, Catherine“…Severe acute respiratory distress syndrome is mostly accompanied by the secretion of proinflammatory cytokines, including interleukin (IL)-2, IL-6, IL-7, granulocyte colony-stimulating factor (GSCF), interferon-inducible protein 10 (IP10), monocyte chemotactic protein-1 (MCP1), macrophage inflammatory protein 1A (MIP1A), and tumor necrosis factor alpha (TNF-α), an event which is known as “cytokine storm”. …”
Publicado 2020
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29236por Rosani, Umberto, Abbadi, Miriam, Green, Timothy, Bai, Chang-Ming, Turolla, Edoardo, Arcangeli, Giuseppe, Wegner, K. Mathias, Venier, Paola“…RESULTS: The mRNA profiles of the naturally infected oysters were mostly governed by the transcriptional activity of OsHV-1, with several differentially expressed genes mapping to the interferon, toll, apoptosis, and pro-PO pathways. In contrast, miRNA profiles suggested more complex regulatory mechanisms, with 15 differentially expressed miRNAs (DE-miRNA) pointing to a possible modulation of the host response during OsHV-1 infection. …”
Publicado 2020
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29237por Hu, Yihuai, Xie, Chenyi, Yang, Hong, Ho, Joshua W. K., Wen, Jing, Han, Lujun, Chiu, Keith W. H., Fu, Jianhua, Vardhanabhuti, Varut“…The association of peritumoral area with response identification might be partially attributed to type I interferon–related biological process. CONCLUSIONS AND RELEVANCE: A combination of peritumoral radiomics features appears to improve the predictive performance of intratumoral radiomics to estimate pathological complete response after neoadjuvant chemoradiation in patients with esophageal squamous cell carcinoma. …”
Publicado 2020
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29238por Choi, Mi-Ra, Xu, Jun, Lee, Seulgi, Yeon, Sun-Hee, Park, Soo-Kyoung, Rha, Ki-Sang, Kim, Yong Min“…METHODS: The expression of type I interferons (IFNs) in human CRS tissues was evaluated using quantitative polymerase chain reaction (qPCR), western blotting, and immunofluorescence. …”
Publicado 2020
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29239“…Biological pathways such as interferon-alpha/beta signaling, molecules associated with elastic fibers, and synthesis of bile acids and bile salts were significantly enriched in CSCs. …”
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29240“…In this study, we compare MEIRLOP against other MEA methods in identifying binding motifs found enriched in differentially active regulatory regions after interferon-beta stimulus, finding that using logistic regression and covariates improves the ability to call enrichment of ISGF3 binding motifs from differential acetylation ChIP-seq data compared to other methods. …”
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