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29241por Yi, Ruokun, Tan, Fang, Zhou, Xianrong, Mu, Jianfei, Li, Lin, Du, Xiping, Yang, Zhennai, Zhao, Xin“…LF-CQPC04 can also decrease the levels of inflammatory cytokines, such as IL-6 (interleukin-6), IL-1β (interleukin-1 beta), TNF-α (tumor necrosis factor alpha), and IFN-γ (interferon gamma), and increase IL-4 and IL-10 levels in the serum of high-fat mice. …”
Publicado 2020
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29242por Chaban, Viktoriia, Clarke, Gerard J.B., Skandsen, Toril, Islam, Rakibul, Einarsen, Cathrine E., Vik, Anne, Damås, Jan K., Mollnes, Tom E., Håberg, Asta K., Pischke, Soeren E.“…Twelve cytokines were reliably detected. Plasma levels of interferon gamma (IFN-γ), interleukin 8 (IL-8), eotaxin, macrophage inflammatory protein-1-beta (MIP-1β), monocyte chemoattractant protein 1 (MCP-1), IL-17A, IL-9, tumor necrosis factor (TNF), and basic fibroblast growth factor (FGF-basic) were significantly increased at all time-points in patients compared with controls, whereas IFN-γ-inducing protein 10 (IP-10), platelet-derived growth factor (PDGF), and IL-1ra were not. …”
Publicado 2020
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29243por Ader, Florence“…METHODS AND ANALYSIS: DisCoVeRy is a phase III, open-label, adaptive, controlled, multicentre clinical trial in which hospitalised patients with COVID-19 in need of oxygen therapy are randomised between five arms: (1) a control group managed with SoC and four therapeutic arms with re-purposed antiviral agents: (2) remdesivir + SoC, (3) lopinavir/ritonavir + SoC, (4) lopinavir/ritonavir associated with interferon (IFN)-β−1a + SoC and (5) hydroxychloroquine + SoC. …”
Publicado 2020
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29244por Takeshima, Hideyuki, Yoda, Yukie, Wakabayashi, Mika, Hattori, Naoko, Yamashita, Satoshi, Ushijima, Toshikazu“…RESULTS: scRNA-seq revealed that DAC-treated cells had highly diverse expression profiles at the single-cell level, and tumor-suppressor genes, endogenous retroviruses, and interferon-stimulated genes were upregulated in random fractions of cells. …”
Publicado 2020
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29245por Liu, Ai-Ran, Du, Wen-Jing, Xie, Jian-Feng, Xu, Jing-Yuan, Huang, Ying-Zi, Qiu, Hai-Bo, Yang, Yi“…The Th cell polarization presented with pulmonary interleukin (IL)-4 and interferon (IFN)-γ level in response to the A. baumannii in CIA group were significantly depressed in comparison with in NIA group (IFN-γ: P = 0.003 at 6 h; P = 0.001 at 24 h; IL-4: P < 0.001 at 6 h; P < 0.001 at 24 h). …”
Publicado 2020
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29246por Powell, Allison B., Ren, Yanqin, Korom, Maria, Saunders, Devin, Hanley, Patrick J., Goldstein, Harris, Nixon, Douglas F., Bollard, Catherine M., Lynch, Rebecca M., Jones, R. Brad, Cruz, Conrad Russell Y.“…T cells retained specificity against Gag, Nef, and Pol peptides (218.55 ± 300.14 interferon γ [IFNγ] spot-forming cells [SFC]/1 × 10(5)) following transduction (38.92 ± 25.30) with the 10-1074 antibody constructs. …”
Publicado 2020
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29247por Metzger, Philipp, Kirchleitner, Sabrina V., Boehmer, Daniel F. R., Hörth, Christine, Eisele, Angelika, Ormanns, Steffen, Gunzer, Matthias, Lech, Maciej, Lauber, Kirsten, Endres, Stefan, Duewell, Peter, Schnurr, Max, König, Lars M.“…Several factors influence the development and function of MDSC including the transcription factor interferon regulatory factor 4 (IRF4). Here, we show that IRF4 deficiency accelerates tumor growth and reduces survival, accompanied with a dense tumor infiltration with PMN-MDSC and reduced numbers of CD8(+) T cells. …”
Publicado 2020
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29248por Kim, Kwang Il, Lee, Unn Hwa, Cho, Miyoung, Jung, Sung-Hee, Min, Eun Young, Park, Jeong Woo“…Among them, 9 genes changed expression by more than 2-fold and were commonly modulated by all three novirhabdoviruses. Interferon regulatory factor 8 (IRF8), C-X-C motif chemokine receptor 1 (CXCR1), Toll/interleukin-1 receptor domain-containing adapter protein (TIRAP), cholesterol 25-hydroxylase (CH25H), C-X-C motif chemokine ligand 11, duplicate 5 (CXCL11.5), and Toll-like receptor 2 (TLR2) were up-regulated, whereas C-C motif chemokine receptor 6a (CCR6a), interleukin-12a (IL12a), and Toll-like receptor 1 (TLR1) were down-regulated. …”
Publicado 2020
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29249“…The aim of this study was to investigate the efficacy and safety of subcutaneous injection of interferon alpha-2b (IFN alpha-2b) combined with lopinavir/ritonavir (LPV/r) in the treatment of COVID-19 infection, compared with that of using LPV/r alone. …”
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29250por Kochumon, Shihab, Al Madhoun, Ashraf, Al-Rashed, Fatema, Thomas, Reeby, Sindhu, Sardar, Al-Ozairi, Ebaa, Al-Mulla, Fahd, Ahmad, Rasheed“…Moreover, IL-2 correlated with toll-like receptors (TLR2, TLR8, TLR10), interferon regulatory factor 5 (IRF5) and cluster of differentiation CD11c (r = 0.282–0.357; p < 0.039). …”
Publicado 2020
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29251por Olagnier, David, Farahani, Ensieh, Thyrsted, Jacob, Blay-Cadanet, Julia, Herengt, Angela, Idorn, Manja, Hait, Alon, Hernaez, Bruno, Knudsen, Alice, Iversen, Marie Beck, Schilling, Mirjam, Jørgensen, Sofie E., Thomsen, Michelle, Reinert, Line S., Lappe, Michael, Hoang, Huy-Dung, Gilchrist, Victoria H., Hansen, Anne Louise, Ottosen, Rasmus, Nielsen, Camilla G., Møller, Charlotte, van der Horst, Demi, Peri, Suraj, Balachandran, Siddharth, Huang, Jinrong, Jakobsen, Martin, Svenningsen, Esben B., Poulsen, Thomas B., Bartsch, Lydia, Thielke, Anne L., Luo, Yonglun, Alain, Tommy, Rehwinkel, Jan, Alcamí, Antonio, Hiscott, John, Mogensen, Trine, Paludan, Søren R., Holm, Christian K.“…The inhibitory effect of 4-OI and DMF extends to the replication of several other pathogenic viruses including Herpes Simplex Virus-1 and-2, Vaccinia virus, and Zika virus through a type I interferon (IFN)-independent mechanism. In addition, 4-OI and DMF limit host inflammatory responses to SARS-CoV2 infection associated with airway COVID-19 pathology. …”
Publicado 2020
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29252por Tumurkhuu, Gantsetseg, Chen, Shuang, Montano, Erica N., Ercan Laguna, Duygu, De Los Santos, Gabriela, Yu, Jeong Min, Lane, Malcolm, Yamashita, Michifumi, Markman, Janet L., Blanco, Luz P., Kaplan, Mariana J., Shimada, Kenichi, Crother, Timothy R., Ishimori, Mariko, Wallace, Daniel J., Jefferies, Caroline A., Arditi, Moshe“…Systemic Lupus Erythematosus (SLE) is a chronic inflammatory autoimmune disease in which type I interferons (IFN) play a key role. The IFN response can be triggered when oxidized DNA engages the cytosolic DNA sensing platform cGAS-STING, but the repair mechanisms that modulate this process and govern disease progression are unclear. …”
Publicado 2020
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29253“…Results: We found more relationships in urogenital models as compared to ocular models, particularly those with interleukin 17 (IL17) mRNA expression compared to models with interferon gamma (IFNγ) expression. In the averaged model with IL17, urogenital chlamydial load was positively associated with disease and negatively associated with IL17 expression. …”
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29254por Barh, Debmalya, Tiwari, Sandeep, Weener, Marianna E., Azevedo, Vasco, Góes-Neto, Aristóteles, Gromiha, M. Michael, Ghosh, Preetam“…(ii) Viral process, mRNA splicing, cytokine and interferon signaling, and ubiquitin mediated proteolysis are important pathways in SARS-CoV-2 infection. …”
Publicado 2020
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29255por Han, Jiaochan, Li, Xing, Luo, Xiaoqing, He, Juan, Huang, Xuechan, Zhou, Qingyou, Han, Yanping, Jie, Hongyu, Zhuang, Jian, Li, Yehao, Yang, Fangyuan, Zhai, Zeqing, Wu, Shufan, He, Yi, Yang, Bin, Sun, Erwei“…In current study, we found that HCQ efficiently inhibited CD86, chemokine (C-X-C motif) receptor 4 (CXCR4) expression and interferon-α (IFN-α) secretion of healthy donor derived purified DCs stimulated by RA patient serum. …”
Publicado 2020
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29256por Kang, Qian, Chen, Jianhong, Luo, Hao, Tan, Ning, Gao, Hui, Zhang, Xiaxia, Yu, Min, Liu, Dan, Xi, Hongli, An, Yaoyu, Han, Yifan, Cheng, Ran, Xu, Xiaoyuan“…In this investigation, we used CHI3L1 as a surrogate marker to compare dynamic hepatic fibrosis variations following the elimination of HCV among cases receiving sofosbuvir (SOF)-based regimens and pegylated interferon/ribavirin (PR) treatments. METHODS: The study enrolled 105 patients, including 46 SOF-based regimens treated patients, 34 PR-experienced patients, and 25 untreated patients. …”
Publicado 2020
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29257“…Between 2017 and 2019, a total of 85 cases of interferon-γ release assays (IGRAs)-proven LTBI, and 170 control subjects were selected from a hospital (two controls per case). …”
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29258por Gu, Shengqing Stan, Wang, Xiaoqing, Hu, Xihao, Jiang, Peng, Li, Ziyi, Traugh, Nicole, Bu, Xia, Tang, Qin, Wang, Chenfei, Zeng, Zexian, Fu, Jingxin, Meyer, Cliff, Zhang, Yi, Cejas, Paloma, Lim, Klothilda, Wang, Jin, Zhang, Wubing, Tokheim, Collin, Sahu, Avinash Das, Xing, Xiaofang, Kroger, Benjamin, Ouyang, Zhangyi, Long, Henry, Freeman, Gordon J., Brown, Myles, Liu, X. Shirley“…We further identify several cancer cell-intrinsic gene expression signatures associated with ICB resistance, including increased interferon response genes and glucocorticoid response genes. …”
Publicado 2020
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29259por Wu, Jie, Wang, Yu-Chen, Xu, Wen-Hao, Luo, Wen-Jie, Wan, Fang-Ning, Zhang, Hai-Liang, Ye, Ding-Wei, Qu, Yuan-Yuan, Zhu, Yi-Ping“…EMT, IL-2/STAT5, inflammatory response, interferon gamma and KRAS hallmark gene sets were identified as CD39-related signaling pathway. …”
Publicado 2020
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29260por Lee, Koon H, Gowrishankar, Kavitha, Street, Janine, McGuire, Helen M, Luciani, Fabio, Hughes, Brendan, Singh, Mandeep, Clancy, Leighton E, Gottlieb, David J, Micklethwaite, Kenneth P, Blyth, Emily“…Re‐exposure to PRAME peptide mixture showed enrichment of CD4 cells expressing interferon (IFN)‐γ (mean: 12.2%) and TNF‐α (mean: 19.7%). …”
Publicado 2020
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