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  1. 29261
    “…Twentyeight patients (8.3%) cleared the infection, and 59/308 (19.1%) had received interferon-based treatment regimens before 2015. Among 249 patients eligible, 111 (44.6%) received DAAs. …”
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    Monitoring hepatitis C virus treatment rates in an Opioid Treatment Program: A longitudinal study
  2. 29262
    “…Although weight was not a risk factor for in-hospital death, overweight patients showed different responses to medications compared with normal weight patients. Intravenous interferon-α, intravenous glucocorticoids, and antifungal drugs were associated with reduced mortality in overweight patients. …”
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    The importance of overweight in COVID-19: A retrospective analysis in a single center of Wuhan, China
  3. 29263
    “…Future research directions should include proof-of-mechanism studies to better understand organ injuries and large-scale collaborative clinical studies to evaluate the efficacy and safety of antivirals, antibiotics, interleukin 6 receptor blockers, and interferon. The current established predictive models require further verification in other regions outside China.…”
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    Clinical Characteristics, Treatment, and Outcomes of Critically Ill Patients With COVID-19: A Scoping Review
  4. 29264
    “…Regardless of dietary SID M+C levels, compared to PBS gavaged broilers, the Eimeria-challenged broilers had (1) decreased (P < 0.05) body weight gain (BWG), feed intake (FI), and gain-to-feed ratio (G:F); (2) increased (P < 0.05) intestinal lesion scores and fecal oocyst counts; (3) increased (P < 0.05) plasma anti-Eimeria IgG, and intestinal luminal total IgA and anti-Eimeria IgA concentrations; and (4) increased (P < 0.05) levels of duodenum luminal gamma interferon (IFN-γ) and interleukin-10 (IL-10), as well as jejunum and cecum luminal IFN-γ concentrations. …”
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    Effects of dietary methionine plus cysteine levels on growth performance and intestinal antibody production in broilers during Eimeria challenge
  5. 29265
    “…Additionally, both 0.04 and 0.06% quercetin supplementation significantly increased expression of TNF-α, TNF receptor associated factor-2 (TRAF-2), TNF receptor superfamily member 1B (TNFRSF1B), nuclear factor kappa-B p65 subunit (NF-κBp65), and interferon-γ (IFN-γ) mRNA (P < 0.05), and expression of NF-κB inhibitor-alpha (IκB-α) mRNA were significantly decreased (P < 0.05). …”
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    Quercetin improves immune function in Arbor Acre broilers through activation of NF-κB signaling pathway
  6. 29266
    “…Given the functions of interleukin-18 in regulating the quiescence of hematopoietic stem/progenitor cells, our findings may be explained by Interferon gamma-independent inhibitory effects of interleukin-18 on stem cell proliferation and hematopoietic reconstitution in allografted patients. …”
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    Interleukin-18 and Hematopoietic Recovery after Allogeneic Stem Cell Transplantation
  7. 29267
    “…BACKGROUND: Cancer immunotherapy has evolved from interferon-alpha (IFNα) and interleukin-2 in the 1980s to CTLA-4 and PD-1/PD-L1 checkpoint inhibitors (CPIs), the latter highlighting the importance of enhancing T-cell functions. …”
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    Autoimmunity linked protein phosphatase PTPN22 as a target for cancer immunotherapy
  8. 29268
    “…All severe patients received oxygen support. 95.8% of them received antivirals, and the most frequent therapy was lopinavir and ritonavir plus human interferon-α2b. Moxifloxacin was used in 70.8% severe patients. …”
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    Combined Interventions for Severe Novel Coronavirus Disease (COVID-19): Experience from 350 Patients
  9. 29269
    “…We used pentamer staining, interferon (IFN)-γ enzyme-linked immunospot (ELISpot), intracellular cytokine staining (ICS), cytotoxicity assays, co-cultures, and cytokine secretion assays for the in vitro characterization. …”
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    Transgenic CD8αβ co-receptor rescues endogenous TCR function in TCR-transgenic virus-specific T cells
  10. 29270
    “…This study aims to describe interferon-γ release assay (IGRA) results in severe COVID-19 patients eligible for immunosuppressive treatment. …”
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    Preliminary observations on IGRA testing for TB infection in patients with severe COVID-19 eligible for immunosuppressive therapy
  11. 29271
    “…The results indicated that interferon (IFN)-β and tumor necrosis factor-α gene transcriptions were significantly upregulated, while interleukin (IL)-2 and Bcl2 mRNA levels were significantly decreased during 22 immunopotentiators treatment. …”
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    Effects of immunopotentiators on biochemical parameters, proinflammatory cytokine, and nonspecific immune responses in Shaoxing ducklings
  12. 29272
    “…The patient’s clinical condition stabilized after cytoreductive therapy with interferon-α (IFN-α), even though endovascular and antiplatelet treatments were restricted because of the simultaneous presence of intracerebral hemorrhage (ICH) and ischemic stroke. …”
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    Complex intracranial vascular complications caused by essential thrombocythemia: a critical case report
  13. 29273
    “…Notably, in vitro experimental results demonstrated that FDCs derived from splenic tissues of chronic HBV patients facilitated interferon-γ and interleukin-21 production from autologous intrasplenic CD4(+) T cells and promoted the proliferation of autologous intrasplenic CD19(+) B cells. …”
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    Expanded circulating follicular dendritic cells facilitate immune responses in chronic HBV infection
  14. 29274
    “…GSK2245035, a selective toll-like receptor-7 agonist, preferentially stimulates the induction of type 1 interferon alpha, reducing type 2 responses. OBJECTIVE: This study investigated whether intranasal GSK2245035 reduced allergen-induced bronchial reactivity in mild allergic asthma. …”
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    Intranasal GSK2245035, a Toll-like receptor 7 agonist, does not attenuate the allergen-induced asthmatic response in a randomized, double-blind, placebo-controlled experimental medicine study
  15. 29275
    por Hoang, Timothy N., Pino, Maria, Boddapati, Arun K., Viox, Elise G., Starke, Carly E., Upadhyay, Amit A., Gumber, Sanjeev, Nekorchuk, Michael, Busman-Sahay, Kathleen, Strongin, Zachary, Harper, Justin L., Tharp, Gregory K., Pellegrini, Kathryn L., Kirejczyk, Shannon, Zandi, Keivan, Tao, Sijia, Horton, Tristan R., Beagle, Elizabeth N., Mahar, Ernestine A., Lee, Michelle Y.H., Cohen, Joyce, Jean, Sherrie M., Wood, Jennifer S., Connor-Stroud, Fawn, Stammen, Rachelle L., Delmas, Olivia M., Wang, Shelly, Cooney, Kimberly A., Sayegh, Michael N., Wang, Lanfang, Filev, Peter D., Weiskopf, Daniela, Silvestri, Guido, Waggoner, Jesse, Piantadosi, Anne, Kasturi, Sudhir P., Al-Shakhshir, Hilmi, Ribeiro, Susan P., Sekaly, Rafick P., Levit, Rebecca D., Estes, Jacob D., Vanderford, Thomas H., Schinazi, Raymond F., Bosinger, Steven E., Paiardini, Mirko
    Publicado 2021
    “…Viral shedding measured from nasal and throat swabs, bronchoalveolar lavages, and tissues was not reduced with baricitinib. Type I interferon (IFN) antiviral responses and SARS-CoV-2-specific T cell responses remained similar between the two groups. …”
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    Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques
  16. 29276
    por Vadillo, Eduardo, Taniguchi-Ponciano, Keiko, Lopez-Macias, Constantino, Carvente-Garcia, Roberto, Mayani, Hector, Ferat-Osorio, Eduardo, Flores-Padilla, Guillermo, Torres, Javier, Gonzalez-Bonilla, Cesar Raul, Majluf, Abraham, Albarran-Sanchez, Alejandra, Galan, Juan Carlos, Peña-Martínez, Eduardo, Silva-Román, Gloria, Vela-Patiño, Sandra, Ferreira-Hermosillo, Aldo, Ramirez-Renteria, Claudia, Espinoza-Sanchez, Nancy Adriana, Pelayo-Camacho, Rosana, Bonifaz, Laura, Arriaga-Pizano, Lourdes, Mata-Lozano, Carlos, Andonegui-Elguera, Sergio, Wacher, Niels, Blanco-Favela, Francisco, De-Lira-Barraza, Roberto, Villanueva-Compean, Humberto, Esquivel-Pineda, Alejandra, Ramírez-Montes-de-Oca, Rubén, Anda-Garay, Carlos, Noyola-García, Maura, Guizar-García, Luis, Cerbulo-Vazquez, Arturo, Zamudio-Meza, Horacio, Marrero-Rodríguez, Daniel, Mercado, Moises
    Publicado 2021
    “…While the gene ontology showed myeloid cell activation in immune response, DNA and RNA processing, defense response to the virus, and response to type 1 interferon. Lymphoid lineage was scarce. Expression of genes such as C/EBPβ, IRF1and FOSL2 potentially suggests the induction of trained immunity. …”
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    A Shift Towards an Immature Myeloid Profile in Peripheral Blood of Critically Ill COVID-19 Patients
  17. 29277
    por Boudewijns, Robbert, Thibaut, Hendrik Jan, Kaptein, Suzanne J. F., Li, Rong, Vergote, Valentijn, Seldeslachts, Laura, Van Weyenbergh, Johan, De Keyzer, Carolien, Bervoets, Lindsey, Sharma, Sapna, Liesenborghs, Laurens, Ma, Ji, Jansen, Sander, Van Looveren, Dominique, Vercruysse, Thomas, Wang, Xinyu, Jochmans, Dirk, Martens, Erik, Roose, Kenny, De Vlieger, Dorien, Schepens, Bert, Van Buyten, Tina, Jacobs, Sofie, Liu, Yanan, Martí-Carreras, Joan, Vanmechelen, Bert, Wawina-Bokalanga, Tony, Delang, Leen, Rocha-Pereira, Joana, Coelmont, Lotte, Chiu, Winston, Leyssen, Pieter, Heylen, Elisabeth, Schols, Dominique, Wang, Lanjiao, Close, Lila, Matthijnssens, Jelle, Van Ranst, Marc, Compernolle, Veerle, Schramm, Georg, Van Laere, Koen, Saelens, Xavier, Callewaert, Nico, Opdenakker, Ghislain, Maes, Piet, Weynand, Birgit, Cawthorne, Christopher, Vande Velde, Greetje, Wang, Zhongde, Neyts, Johan, Dallmeier, Kai
    Publicado 2020
    “…Our results reveal the importance of STAT2-dependent interferon responses in the pathogenesis and virus control during SARS-CoV-2 infection and may help rationalizing new strategies for the treatment of COVID-19 patients.…”
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    STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters
  18. 29278
    “…Compared with other viral ARIs, COVID-19 is characterized by a pronounced interferon response but attenuated activation of other innate immune pathways, including toll-like receptor, interleukin and chemokine signaling. …”
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    Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses
  19. 29279
    “…All isolates with variant SH sequences replicated in interferon-competent cells with no evidence of attenuation. …”
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    Functional Characterization of Circulating Mumps Viruses with Stop Codon Mutations in the Small Hydrophobic Protein
  20. 29280
    “…BACKGROUND: Interferon (IFN) regulatory factors (IRFs), as transcriptional regulatory factors, play important roles in regulating the expression of type I IFN and IFN- stimulated genes (ISGs) in innate immune responses. …”
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    Identification of an IRF10 gene in common carp (Cyprinus carpio L.) and analysis of its function in the antiviral and antibacterial immune response
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