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29261por Sanvisens, Arantza, Rivas, Inmaculada, Faure, Eva, Espinach, Néstor, Hernandez-Rubio, Anna, Majó, Xavier, Colom, Joan, Muga, Robert“…Twentyeight patients (8.3%) cleared the infection, and 59/308 (19.1%) had received interferon-based treatment regimens before 2015. Among 249 patients eligible, 111 (44.6%) received DAAs. …”
Publicado 2020
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29262por Rao, Xinrui, Wu, Chuangyan, Wang, Sihua, Tong, Song, Wang, Geng, Wu, Gang, Zhou, Rui“…Although weight was not a risk factor for in-hospital death, overweight patients showed different responses to medications compared with normal weight patients. Intravenous interferon-α, intravenous glucocorticoids, and antifungal drugs were associated with reduced mortality in overweight patients. …”
Publicado 2020
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29263por Huang, Chanyan, Soleimani, Jalal, Herasevich, Svetlana, Pinevich, Yuliya, Pennington, Kelly M., Dong, Yue, Pickering, Brian W., Barwise, Amelia K.“…Future research directions should include proof-of-mechanism studies to better understand organ injuries and large-scale collaborative clinical studies to evaluate the efficacy and safety of antivirals, antibiotics, interleukin 6 receptor blockers, and interferon. The current established predictive models require further verification in other regions outside China.…”
Publicado 2021
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29264por Ren, Zhouzheng, Bütz, Daniel E., Whelan, Rose, Naranjo, Victor, Arendt, Maria K., Ramuta, Mitchell D., Yang, Xiaojun, Crenshaw, Thomas D., Cook, Mark E.“…Regardless of dietary SID M+C levels, compared to PBS gavaged broilers, the Eimeria-challenged broilers had (1) decreased (P < 0.05) body weight gain (BWG), feed intake (FI), and gain-to-feed ratio (G:F); (2) increased (P < 0.05) intestinal lesion scores and fecal oocyst counts; (3) increased (P < 0.05) plasma anti-Eimeria IgG, and intestinal luminal total IgA and anti-Eimeria IgA concentrations; and (4) increased (P < 0.05) levels of duodenum luminal gamma interferon (IFN-γ) and interleukin-10 (IL-10), as well as jejunum and cecum luminal IFN-γ concentrations. …”
Publicado 2019
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29265“…Additionally, both 0.04 and 0.06% quercetin supplementation significantly increased expression of TNF-α, TNF receptor associated factor-2 (TRAF-2), TNF receptor superfamily member 1B (TNFRSF1B), nuclear factor kappa-B p65 subunit (NF-κBp65), and interferon-γ (IFN-γ) mRNA (P < 0.05), and expression of NF-κB inhibitor-alpha (IκB-α) mRNA were significantly decreased (P < 0.05). …”
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29266por Radujkovic, Aleksandar, Kordelas, Lambros, Bogdanov, Rashit, Müller-Tidow, Carsten, Beelen, Dietrich W., Dreger, Peter, Luft, Thomas“…Given the functions of interleukin-18 in regulating the quiescence of hematopoietic stem/progenitor cells, our findings may be explained by Interferon gamma-independent inhibitory effects of interleukin-18 on stem cell proliferation and hematopoietic reconstitution in allografted patients. …”
Publicado 2020
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29267por Cubas, Rafael, Khan, Zia, Gong, Qian, Moskalenko, Marina, Xiong, Huizhong, Ou, Qinglin, Pai, Christine, Rodriguez, Ryan, Cheung, Jeanne, Chan, Andrew C“…BACKGROUND: Cancer immunotherapy has evolved from interferon-alpha (IFNα) and interleukin-2 in the 1980s to CTLA-4 and PD-1/PD-L1 checkpoint inhibitors (CPIs), the latter highlighting the importance of enhancing T-cell functions. …”
Publicado 2020
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29268Combined Interventions for Severe Novel Coronavirus Disease (COVID-19): Experience from 350 Patientspor Guo, Ting, Shen, Qinxue, Zhou, Zhiguo, Li, Jinhua, Guo, Wei, He, Wenlong, Wang, Yunnian, Xiang, Zhi, Huang, Peng, Zeng, Nanyang, Qin, Qingwu, Chen, Ping, Luo, Hong, Peng, Hong“…All severe patients received oxygen support. 95.8% of them received antivirals, and the most frequent therapy was lopinavir and ritonavir plus human interferon-α2b. Moxifloxacin was used in 70.8% severe patients. …”
Publicado 2020
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29269“…We used pentamer staining, interferon (IFN)-γ enzyme-linked immunospot (ELISpot), intracellular cytokine staining (ICS), cytotoxicity assays, co-cultures, and cytokine secretion assays for the in vitro characterization. …”
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29270por Torre, Alessandro, Aliberti, Stefano, Castellotti, Paola Francesca, Cirillo, Daniela Maria, Grisolia, Antonella, Mangioni, Davide, Marchetti, Giulia, Rossotti, Roberto, Santus, Pierachille, Besozzi, Giorgio, Villa, Simone, Codecasa, Luigi Ruffo“…This study aims to describe interferon-γ release assay (IGRA) results in severe COVID-19 patients eligible for immunosuppressive treatment. …”
Publicado 2020
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29271por Gu, Tiantian, Li, Guoqin, Wu, Xinsheng, Zeng, Tao, Xu, Qi, Li, Liumeng, Vladyslav, Spyrydonov, Chen, Guohong, Lu, Lizhi“…The results indicated that interferon (IFN)-β and tumor necrosis factor-α gene transcriptions were significantly upregulated, while interleukin (IL)-2 and Bcl2 mRNA levels were significantly decreased during 22 immunopotentiators treatment. …”
Publicado 2020
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29272“…The patient’s clinical condition stabilized after cytoreductive therapy with interferon-α (IFN-α), even though endovascular and antiplatelet treatments were restricted because of the simultaneous presence of intracerebral hemorrhage (ICH) and ischemic stroke. …”
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29273Expanded circulating follicular dendritic cells facilitate immune responses in chronic HBV infectionpor Li, Xiaoyi, Zhang, Qifan, Zhang, Wanyue, Ye, Guofu, Ma, Yanchen, Wen, Chunhua, Gu, Shuqin, Tang, Libo, Li, Yongyin“…Notably, in vitro experimental results demonstrated that FDCs derived from splenic tissues of chronic HBV patients facilitated interferon-γ and interleukin-21 production from autologous intrasplenic CD4(+) T cells and promoted the proliferation of autologous intrasplenic CD19(+) B cells. …”
Publicado 2020
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29274por Siddall, Hilary, Quint, Diana, Pandya, Hitesh, Powley, Will, Shabbir, Shaila, Hohlfeld, Jens M., Singh, Dave, Lee, Laurie“…GSK2245035, a selective toll-like receptor-7 agonist, preferentially stimulates the induction of type 1 interferon alpha, reducing type 2 responses. OBJECTIVE: This study investigated whether intranasal GSK2245035 reduced allergen-induced bronchial reactivity in mild allergic asthma. …”
Publicado 2020
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29275por Hoang, Timothy N., Pino, Maria, Boddapati, Arun K., Viox, Elise G., Starke, Carly E., Upadhyay, Amit A., Gumber, Sanjeev, Nekorchuk, Michael, Busman-Sahay, Kathleen, Strongin, Zachary, Harper, Justin L., Tharp, Gregory K., Pellegrini, Kathryn L., Kirejczyk, Shannon, Zandi, Keivan, Tao, Sijia, Horton, Tristan R., Beagle, Elizabeth N., Mahar, Ernestine A., Lee, Michelle Y.H., Cohen, Joyce, Jean, Sherrie M., Wood, Jennifer S., Connor-Stroud, Fawn, Stammen, Rachelle L., Delmas, Olivia M., Wang, Shelly, Cooney, Kimberly A., Sayegh, Michael N., Wang, Lanfang, Filev, Peter D., Weiskopf, Daniela, Silvestri, Guido, Waggoner, Jesse, Piantadosi, Anne, Kasturi, Sudhir P., Al-Shakhshir, Hilmi, Ribeiro, Susan P., Sekaly, Rafick P., Levit, Rebecca D., Estes, Jacob D., Vanderford, Thomas H., Schinazi, Raymond F., Bosinger, Steven E., Paiardini, Mirko“…Viral shedding measured from nasal and throat swabs, bronchoalveolar lavages, and tissues was not reduced with baricitinib. Type I interferon (IFN) antiviral responses and SARS-CoV-2-specific T cell responses remained similar between the two groups. …”
Publicado 2021
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29276por Vadillo, Eduardo, Taniguchi-Ponciano, Keiko, Lopez-Macias, Constantino, Carvente-Garcia, Roberto, Mayani, Hector, Ferat-Osorio, Eduardo, Flores-Padilla, Guillermo, Torres, Javier, Gonzalez-Bonilla, Cesar Raul, Majluf, Abraham, Albarran-Sanchez, Alejandra, Galan, Juan Carlos, Peña-Martínez, Eduardo, Silva-Román, Gloria, Vela-Patiño, Sandra, Ferreira-Hermosillo, Aldo, Ramirez-Renteria, Claudia, Espinoza-Sanchez, Nancy Adriana, Pelayo-Camacho, Rosana, Bonifaz, Laura, Arriaga-Pizano, Lourdes, Mata-Lozano, Carlos, Andonegui-Elguera, Sergio, Wacher, Niels, Blanco-Favela, Francisco, De-Lira-Barraza, Roberto, Villanueva-Compean, Humberto, Esquivel-Pineda, Alejandra, Ramírez-Montes-de-Oca, Rubén, Anda-Garay, Carlos, Noyola-García, Maura, Guizar-García, Luis, Cerbulo-Vazquez, Arturo, Zamudio-Meza, Horacio, Marrero-Rodríguez, Daniel, Mercado, Moises“…While the gene ontology showed myeloid cell activation in immune response, DNA and RNA processing, defense response to the virus, and response to type 1 interferon. Lymphoid lineage was scarce. Expression of genes such as C/EBPβ, IRF1and FOSL2 potentially suggests the induction of trained immunity. …”
Publicado 2021
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29277por Boudewijns, Robbert, Thibaut, Hendrik Jan, Kaptein, Suzanne J. F., Li, Rong, Vergote, Valentijn, Seldeslachts, Laura, Van Weyenbergh, Johan, De Keyzer, Carolien, Bervoets, Lindsey, Sharma, Sapna, Liesenborghs, Laurens, Ma, Ji, Jansen, Sander, Van Looveren, Dominique, Vercruysse, Thomas, Wang, Xinyu, Jochmans, Dirk, Martens, Erik, Roose, Kenny, De Vlieger, Dorien, Schepens, Bert, Van Buyten, Tina, Jacobs, Sofie, Liu, Yanan, Martí-Carreras, Joan, Vanmechelen, Bert, Wawina-Bokalanga, Tony, Delang, Leen, Rocha-Pereira, Joana, Coelmont, Lotte, Chiu, Winston, Leyssen, Pieter, Heylen, Elisabeth, Schols, Dominique, Wang, Lanjiao, Close, Lila, Matthijnssens, Jelle, Van Ranst, Marc, Compernolle, Veerle, Schramm, Georg, Van Laere, Koen, Saelens, Xavier, Callewaert, Nico, Opdenakker, Ghislain, Maes, Piet, Weynand, Birgit, Cawthorne, Christopher, Vande Velde, Greetje, Wang, Zhongde, Neyts, Johan, Dallmeier, Kai“…Our results reveal the importance of STAT2-dependent interferon responses in the pathogenesis and virus control during SARS-CoV-2 infection and may help rationalizing new strategies for the treatment of COVID-19 patients.…”
Publicado 2020
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29278por Mick, Eran, Kamm, Jack, Pisco, Angela Oliveira, Ratnasiri, Kalani, Babik, Jennifer M., Castañeda, Gloria, DeRisi, Joseph L., Detweiler, Angela M., Hao, Samantha L., Kangelaris, Kirsten N., Kumar, G. Renuka, Li, Lucy M., Mann, Sabrina A., Neff, Norma, Prasad, Priya A., Serpa, Paula Hayakawa, Shah, Sachin J., Spottiswoode, Natasha, Tan, Michelle, Calfee, Carolyn S., Christenson, Stephanie A., Kistler, Amy, Langelier, Charles“…Compared with other viral ARIs, COVID-19 is characterized by a pronounced interferon response but attenuated activation of other innate immune pathways, including toll-like receptor, interleukin and chemokine signaling. …”
Publicado 2020
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29279por Stinnett, Rita Czakó, Beck, Andrew S., Lopareva, Elena N., McNall, Rebecca J., Latner, Donald R., Hickman, Carole J., Rota, Paul A., Bankamp, Bettina“…All isolates with variant SH sequences replicated in interferon-competent cells with no evidence of attenuation. …”
Publicado 2020
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29280por Zhu, Yaoyao, Shan, Shijuan, Zhao, Huaping, Liu, Rongrong, Wang, Hui, Chen, Xinping, Yang, Guiwen, Li, Hua“…BACKGROUND: Interferon (IFN) regulatory factors (IRFs), as transcriptional regulatory factors, play important roles in regulating the expression of type I IFN and IFN- stimulated genes (ISGs) in innate immune responses. …”
Publicado 2020
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