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29321“…We also found that cytokines, including interferon-gamma (IFNγ) and tumor necrosis factor-alpha (TNFα) secreted by activated T cells, damaged tumor cells in a cell contact-independent manner. …”
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29322por Ye, Lingna, Chapman, Thomas P., Wen, Zhenzhen, Lin, Lang, Qiu, Yun, Liu, Zhanju, Ran, Zhihua, Qian, Jiaming, Wu, Kaichun, Gao, Xiang, Hu, Pinjin, Chen, Minhu, Travis, Simon P. L., Cao, Qian“…TB screening prior to IFX was performed with chest X‐ray and/or computed tomography [CT] and immune reactivity testing (interferon‐γ release assay and/or tuberculin skin test). …”
Publicado 2020
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29323“…PURPOSE: MicroRNA-21 (miR-21) influences the Th2 immune pathway by suppressing the expressions of interleukin (IL)-12 and interferon (IFN)-γ. The effects of miR-21 suppression on alveolar macrophage polarization and airway inflammation are not known. …”
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29324por Funeshima, Natsumi, Miura, Ryotaro, Katoh, Taiga, Yaginuma, Hikari, Kitou, Takeshi, Yoshimura, Itaru, Konda, Kunitoshi, Hamano, Seizo, Shirasuna, Koumei“…As IDO is key for maternal immune tolerance and induced in response to interferon tau (IFNT, ruminant maternal recognition of pregnancy factor), we examined the responsiveness to IFNT on peripheral blood mononuclear cells (PBMC) isolated from healthy and repeat breeder cows. …”
Publicado 2021
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29325por Henning, Lisa, Endt, Kathrin, Steigerwald, Robin, Anderson, Michael, Volkmann, Ariane“…However, all vaccinated mice developed comparable interferon gamma T cell responses to the VEEV E2 peptide pools. …”
Publicado 2021
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29326por Lu-Culligan, Alice, Chavan, Arun R., Vijayakumar, Pavithra, Irshaid, Lina, Courchaine, Edward M., Milano, Kristin M., Tang, Zhonghua, Pope, Scott D., Song, Eric, Vogels, Chantal B.F., Lu-Culligan, William J., Campbell, Katherine H., Casanovas-Massana, Arnau, Bermejo, Santos, Toothaker, Jessica M., Lee, Hannah J., Liu, Feimei, Schulz, Wade, Fournier, John, Muenker, M. Catherine, Moore, Adam J., Konnikova, Liza, Neugebauer, Karla M., Ring, Aaron, Grubaugh, Nathan D., Ko, Albert I., Morotti, Raffaella, Guller, Seth, Kliman, Harvey J., Iwasaki, Akiko, Farhadian, Shelli F.“…Through single cell transcriptomic analyses, we found that the maternal-fetal interface of SARS-CoV-2-infected women exhibited markers associated with pregnancy complications, such as preeclampsia, and robust immune responses, including increased activation of placental NK and T cells and increased expression of interferon-related genes. Overall, this study suggests that SARS-CoV-2 is associated with immune activation at the maternal-fetal interface even in the absence of detectable local viral invasion. …”
Publicado 2021
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29327por Ho, Ming-Fen, Zhang, Cheng, Zhang, Lingxin, Wei, Lixuan, Zhou, Ying, Moon, Irene, Geske, Jennifer R., Choi, Doo-Sup, Biernacka, Joanna, Frye, Mark, Wen, Zhexing, Karpyak, Victor M., Li, Hu, Weinshilboum, Richard“…Knockdown of TSPAN5 also influenced the expression of genes associated with interferon signaling pathways. Finally, we determined that TSPAN5 SNPs were associated with acamprosate treatment outcomes in AUD patients. …”
Publicado 2020
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29328por Sakamoto, Shinya, Matsumura, Masaru, Tani, Keigo, Nemoto, Satoshi, Tsuchida, Kazuhito, Koga, Fumitaka, Seyama, Yasuji“…After discontinuing interferon therapy, he was followed up at his request without anticancer treatment. …”
Publicado 2021
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29329por Ding, Shaojie, Guo, Xinyue, Zhu, Libo, Wang, Jianzhang, Li, Tiantian, Yu, Qin, Zhang, Xinmei“…Lipopolysaccharide (LPS) and interferon gamma (IFN-γ) were used to stimulate human monocytic cell lines (THP-1) and rat alveolar macrophage-derived cell lines (NR8383) to induce M1 phenotype macrophages. …”
Publicado 2021
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29330por Fernández-Velasco, José I., Kuhle, Jens, Monreal, Enric, Meca-Lallana, Virginia, Meca-Lallana, José, Izquierdo, Guillermo, Gascón-Giménez, Francisco, Sainz de la Maza, Susana, Walo-Delgado, Paulette E., Maceski, Aleksandra, Rodríguez-Martín, Eulalia, Roldán, Ernesto, Villarrubia, Noelia, Saiz, Albert, Blanco, Yolanda, Sánchez, Pedro, Carreón-Guarnizo, Ester, Aladro, Yolanda, Brieva, Luis, Íñiguez, Cristina, González-Suárez, Inés, Rodríguez de Antonio, Luis A., Masjuan, Jaime, Costa-Frossard, Lucienne, Villar, Luisa M.“…We also observed a decrease in CD20(+) T-cell numbers (p < 0.0001) and percentages (p < 0.0001), and a clear remodeling of the T-cell compartment characterized by relative increases of the naive/effector ratios in CD4(+) (p = 0.002) and CD8(+) (p = 0.002) T cells and relative decreases of CD4(+) (p = 0.03) and CD8(+) (p = 0.004) T cells producing interferon-gamma. Total monocyte numbers increased (p = 0.002), but no changes were observed in those producing inflammatory cytokines. …”
Publicado 2021
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29331“…A lentivirus was used to overexpress SAMHD1 and stimulator of interferon genes (STING) in A549 cells; and RT-qPCR and western blot analysis were performed to verify their levels. …”
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29332por Naik, Shilpa, Alexander, Mallika, Kumar, Pavan, Kulkarni, Vandana, Deshpande, Prasad, Yadana, Su, Leu, Cheng-Shiun, Araújo-Pereira, Mariana, Andrade, Bruno B., Bhosale, Ramesh, Babu, Subash, Gupta, Amita, Mathad, Jyoti S., Shivakoti, Rupak“…LTBI status was assessed by interferon gamma release assay. Plasma was used to measure systemic inflammation markers using immunoassays: IFNβ, CRP, AGP, I-FABP, IFNγ, IL-1β, soluble CD14 (sCD14), sCD163, TNF, IL-6, IL-17a and IL-13. …”
Publicado 2021
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29333“…In addition, therapies based on the use of hydroxychloroquine, chloroquine, remdesvir, ribavirin, interferon or lopinavir-ritonavir were also initially used. …”
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29334por Slattery, Karen, Woods, Elena, Zaiatz-Bittencourt, Vanessa, Marks, Sam, Chew, Sonya, Conroy, Michael, Goggin, Caitriona, MacEochagain, Colm, Kennedy, John, Lucas, Sophie, Finlay, David K, Gardiner, Clair M“…METHODS: Single-cell analysis, metabolic flux and confocal analysis of NK cells from patients with metastatic breast cancer and healthy controls RESULTS: In addition to reduced interferon-γ production and cytotoxicity, peripheral blood NK cells from patients had clear metabolic deficits including reduced glycolysis and oxidative phosphorylation. …”
Publicado 2021
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29335por Goswami, Suranjana, Hu, Xiaojun, Chen, Qian, Qiu, Ju, Yang, Jun, Poudyal, Deepak, Sherman, Brad T., Chang, Weizhong, Imamichi, Tomozumi“…Anti-HIV effect was monitored by a p24 antigen enzyme-linked immunosorbent assay kit. interferon (IFN)-α, IFN-β, or IFN-λ production was quantified using each subtype-specific enzyme-linked immunosorbent assay kit. …”
Publicado 2021
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29336por Ferrer-Suay, Sara, Alonso-Iglesias, Eulalia, Tortajada-Girbés, Miguel, Carrasco-Luna, Joaquín, Codoñer-Franch, Pilar“…Routine biochemistry, serum levels of interleukin-6, tumor necrosis factor-α, interferon-γ, 8-isoprostaglandin F2α and nitrates were determined. …”
Publicado 2021
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29337por Cillo, Anthony R., Somasundaram, Ashwin, Shan, Feng, Cardello, Carly, Workman, Creg J., Kitsios, Georgios D., Ruffin, Ayana, Kunning, Sheryl, Lampenfeld, Caleb, Onkar, Sayali, Grebinoski, Stephanie, Deshmukh, Gaurav, Methe, Barbara, Liu, Chang, Nambulli, Sham, Andrews, Lawrence, Duprex, W. Paul, Joglekar, Alok V., Benos, Panayiotis V., Ray, Prabir, Ray, Anuradha, McVerry, Bryan J., Zhang, Yingze, Lee, Janet S., Das, Jishnu, Singh, Harinder, Morris, Alison, Bruno, Tullia C., Vignali, Dario A.A.“…Notably, monocytes exhibited bifurcated genomic states, with expression of a cytokine gene module exemplified by CCL4 (MIP-1β) associated with survival and an interferon signaling module associated with death. These gene modules were correlated with higher levels of MIP-1β and CXCL10 levels in plasma, respectively. …”
Publicado 2021
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29338por Nkurunungi, Gyaviira, Zirimenya, Ludoviko, Nassuuna, Jacent, Natukunda, Agnes, Kabuubi, Prossy N, Niwagaba, Emmanuel, Oduru, Gloria, Kabami, Grace, Amongin, Rebecca, Mutebe, Alex, Namutebi, Milly, Zziwa, Christopher, Amongi, Susan, Ninsiima, Caroline, Onen, Caroline, Akello, Florence, Sewankambo, Moses, Kiwanuka, Samuel, Kizindo, Robert, Kaweesa, James, Cose, Stephen, Webb, Emily, Elliott, Alison M“…Primary outcomes are BCG-specific interferon-γ ELISpot responses 8 weeks after BCG immunisation and for other vaccines, antibody responses to key vaccine antigens at 4 weeks after immunisation. …”
Publicado 2021
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29339por Crona Guterstam, Ylva, Strunz, Benedikt, Ivarsson, Martin A., Zimmer, Christine, Melin, Anna‐Sofia, Jonasson, Aino F., Björkström, Niklas K., Gidlöf, Sebastian Brusell“…In menstrual blood plasma, C5/C5a, interleukin‐6 (IL‐6), IL‐1β, and CXCL8 were detected in high concentrations, whereas IL‐2, IL‐12p70, XCL1/Lymphotactin, and interferon‐γ were low. The most pronounced median differences between menstrual and peripheral blood plasma were found for IL‐6, IL‐1β, and CXCL8. …”
Publicado 2020
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29340por Tummala, Raj, Abreu, Gabriel, Pineda, Lilia, Michaels, M Alex, Kalyani, Rubana N, Furie, Richard A, Morand, Eric F“…OBJECTIVE: In phase II and III trials, anifrolumab, a human monoclonal antibody that binds type I interferon receptor subunit 1, has shown efficacy in adults with moderate to severe SLE. …”
Publicado 2021
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