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29361“…TLR4 activates two distinct signaling pathways involving adaptors MyD88 and TRIF to produce proinflammatory cytokines and type-I interferon respectively. How Leishmania donovani suppresses these pathways is not well studied. …”
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29362“…By contrast, PM2.5 exposure decreased the protein and mRNA expression levels of Th1 cytokine interferon-γ and transcription factors Runx3 and T-bet, especially among asthmatic mice, different from OVA group, PM2.5 exposure only failed to influence the expression of T-bet. …”
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29363“…We hypothesize that the combination of STING agonists and IL-15 can additively increase NK and T cell activity as they act to increase type I interferons (IFNs) through STING activation and IFN-γ through IL-15. …”
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29364“…Other genes including cluster of differentiation 40 (CD40), the forkhead box P3 (FOXP3), the MHC Class I Polypeptide-Related Sequence A (MICA), insulin variable number of tandem repeats (INS-VNTR), the C-Type Lectin Domain Containing 16A (CLEC16A), the Erb-B2 Receptor Tyrosine Kinase 3 (ERBB3) gene, the interferon-induced helicase C domain-containing protein 1 (IFIH1), and various cytokine genes are also under suspicion to increase susceptibility to T1D and AITD. …”
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29365por Abo-Aziza, Faten A. M., Zaki, Abdel Kader A., Alajaji, Ahmed I., Al barrak, Saleh M.“…Significant elevation in the levels of tumor necrosis factor (TNF)-α and interferon (INF)-γ with a decline in interleukin (IL)-4 was observed in the untreated model (p<0.05). …”
Publicado 2021
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29366por Meier, Noemi Rebecca, Battegay, Manuel, Ottenhoff, Tom H. M., Furrer, Hansjakob, Nemeth, Johannes, Ritz, Nicole“…At T4 Rv2431c-induced and Rv3614/15c-induced interferon gamma-induced protein (IP)-10 responses and Rv2031c-induced and Rv2346/Rv2347c-induced tumor necrosis factor (TNF)-α responses were significantly higher in cases compared to controls (p < 0.004). …”
Publicado 2021
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29367por Muscarella, Peter, Bekaii-Saab, Tanios, McIntyre, Kristi, Rosemurgy, Alexander, Ross, Sharona B., Richards, Donald A., Fisher, William E., Flynn, Patrick J., Mattson, Alicia, Coeshott, Claire, Roder, Heinrich, Roder, Joanna, Harrell, Frank E., Cohn, Allen, Rodell, Timothy C., Apelian, David“…Immune responses were measured by interferon-γ (IFNγ) ELISpot assay and by regulatory T cell (Treg) frequencies on treatment. …”
Publicado 2021
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29368por Han, Ru, Liang, Shuyao, François, Clément, Aballea, Samuel, Clay, Emilie, Toumi, Mondher“…The model was designated with the objective function of minimizing liver-related deaths by varying the decision variables, representing the number of patients receiving each treatment (elbasvir-grazoprevir, ombitasvir-paritaprevir-ritonavir-dasabuvir, sofosbuvir-ledipasvir, and pegylated interferon-ribavirin) in each population (the general population, PWID, and MSM). …”
Publicado 2021
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29369por Ferreira-Gomes, Marta, Kruglov, Andrey, Durek, Pawel, Heinrich, Frederik, Tizian, Caroline, Heinz, Gitta Anne, Pascual-Reguant, Anna, Du, Weijie, Mothes, Ronja, Fan, Chaofan, Frischbutter, Stefan, Habenicht, Katharina, Budzinski, Lisa, Ninnemann, Justus, Jani, Peter K., Guerra, Gabriela Maria, Lehmann, Katrin, Matz, Mareen, Ostendorf, Lennard, Heiberger, Lukas, Chang, Hyun-Dong, Bauherr, Sandy, Maurer, Marcus, Schönrich, Günther, Raftery, Martin, Kallinich, Tilmann, Mall, Marcus Alexander, Angermair, Stefan, Treskatsch, Sascha, Dörner, Thomas, Corman, Victor Max, Diefenbach, Andreas, Volk, Hans-Dieter, Elezkurtaj, Sefer, Winkler, Thomas H., Dong, Jun, Hauser, Anja Erika, Radbruch, Helena, Witkowski, Mario, Melchers, Fritz, Radbruch, Andreas, Mashreghi, Mir-Farzin“…Before seroconversion in response to SARS-CoV-2 spike protein, peripheral plasmablasts display a type 1 interferon-induced gene expression signature; however, following seroconversion, plasmablasts lose this signature, express instead gene signatures induced by IL-21 and TGF-β, and produce mostly IgG1 and IgA1. …”
Publicado 2021
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29370por Attilio, Peter J., Snapper, Dustin M., Rusnak, Milan, Isaac, Akira, Soltis, Anthony R., Wilkerson, Matthew D., Dalgard, Clifton L., Symes, Aviva J.“…Among pathways that were differentially expressed at 3 dpi after CCI, candesartan treatment altered genes involved in angiogenesis, interferon signaling, extracellular matrix regulation including integrins and chromosome maintenance and DNA replication. …”
Publicado 2021
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29371por Zhou, Wenbin, Yu, Muxin, Pan, Hong, Qiu, Wen, Wang, Hui, Qian, Mengjia, Che, Nan, Zhang, Kai, Mao, Xinrui, Li, Li, Wang, Ruoxi, Xie, Hui, Ling, Lijun, Zhao, Yi, Liu, Xiaoan, Wang, Cong, Ding, Qiang, Wang, Shui“…Compared with surgery, MWA induced significantly increased levels of inducible co-stimulator (ICOS)+ activated CD4+ T cells and serum interferon gamma, indicating a shift in the Th1/Th2 balance toward Th1. …”
Publicado 2021
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29372por Didona, Dario, Scarsella, Luca, Fehresti, Milad, Solimani, Farzan, Juratli, Hazem A., Göbel, Manuel, Mühlenbein, Stefan, Holiangu, Lily, Pieper, Josquin, Korff, Vera, Schmidt, Thomas, Sitaru, Cassian, Eming, Rüdiger, Hertl, Michael, Pollmann, Robert“…For characterization of the autoreactive T cell response, peripheral blood mononuclear cells were stimulated ex vivo with recombinant BP180 proteins (NH(2)- and COOH-terminal domains) and the frequencies of BP180-specific T cells producing interferon-γ, interleukin (IL)-5 or IL-17 were subsequently determined by ELISpot assay. …”
Publicado 2021
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29373Interleukin-28A maintains the intestinal epithelial barrier function through regulation of claudin-1“…BACKGROUND: Interleukin-28A (IL-28A or interferon-λ2) is reported to maintain intestinal mucosal homeostasis. …”
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29374por Lin, Su-Ru, Yang, Ta-Yu, Peng, Cheng-Yuan, Lin, You-Yu, Dai, Chia-Yen, Wang, Hurng-Yi, Su, Tung-Hung, Tseng, Tai-Chung, Liu, I-Jung, Cheng, Huei-Ru, Shen, Yueh-Chi, Wu, Fang-Yi, Liu, Chun-Jen, Chen, Ding-Shinn, Chen, Pei-Jer, Yang, Hung-Chih, Kao, Jia-Horng“…METHODS: Fifty HBeAg-positive chronic hepatitis B patients, including 18 treatment-naïve and 32 interferon (IFN)-treated individuals, were recruited. …”
Publicado 2021
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29375por Martin-Sancho, Laura, Lewinski, Mary K., Pache, Lars, Stoneham, Charlotte A., Yin, Xin, Becker, Mark E., Pratt, Dexter, Churas, Christopher, Rosenthal, Sara B., Liu, Sophie, Weston, Stuart, De Jesus, Paul D., O’Neill, Alan M., Gounder, Anshu P., Nguyen, Courtney, Pu, Yuan, Curry, Heather M., Oom, Aaron L., Miorin, Lisa, Rodriguez-Frandsen, Ariel, Zheng, Fan, Wu, Chunxiang, Xiong, Yong, Urbanowski, Matthew, Shaw, Megan L., Chang, Max W., Benner, Christopher, Hope, Thomas J., Frieman, Matthew B., García-Sastre, Adolfo, Ideker, Trey, Hultquist, Judd F., Guatelli, John, Chanda, Sumit K.“…A deficient interferon (IFN) response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been implicated as a determinant of severe coronavirus disease 2019 (COVID-19). …”
Publicado 2021
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29376por Huang, Jianmei, Chen, Siying, Zhou, Zhouyang, Sun, Xiaoting, Haseeb, Muhammad, Lakho, Shakeel Ahmed, Zhang, Yang, Liu, Jiabin, Shah, Muhammad Ali A., Song, Xiaokai, Xu, Lixin, Yan, Ruofeng, Li, Xiangrui“…Poly (D, L-lactide-co-glycolide) encapsulated rEtTA4 nanoparticles–immunized chickens significantly induced higher levels of interferon gamma, IL-6, and IL-17 and a little bit higher proportion of CD8(+) T lymphocytes compared with rEtTA4 subunit vaccine–immunized chickens. …”
Publicado 2021
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29377por Castro de Moura, Manuel, Davalos, Veronica, Planas-Serra, Laura, Alvarez-Errico, Damiana, Arribas, Carles, Ruiz, Montserrat, Aguilera-Albesa, Sergio, Troya, Jesús, Valencia-Ramos, Juan, Vélez-Santamaria, Valentina, Rodríguez-Palmero, Agustí, Villar-Garcia, Judit, Horcajada, Juan P., Albu, Sergiu, Casasnovas, Carlos, Rull, Anna, Reverte, Laia, Dietl, Beatriz, Dalmau, David, Arranz, Maria J., Llucià-Carol, Laia, Planas, Anna M., Pérez-Tur, Jordi, Fernandez-Cadenas, Israel, Villares, Paula, Tenorio, Jair, Colobran, Roger, Martin-Nalda, Andrea, Soler-Palacin, Pere, Vidal, Francesc, Pujol, Aurora, Esteller, Manel“…These genes, such as the inflammasome component Absent in Melanoma 2 (AIM2) and the Major Histocompatibility Complex, class I C (HLA-C) candidates, were mainly involved in the response of interferon to viral infection. We used the EWAS-identified sites to establish a DNA methylation signature (EPICOVID) that is associated with the severity of the disease. …”
Publicado 2021
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29378por Hassan, Sk Sarif, Aljabali, Alaa A. A., Panda, Pritam Kumar, Ghosh, Shinjini, Attrish, Diksha, Choudhury, Pabitra Pal, Seyran, Murat, Pizzol, Damiano, Adadi, Parise, Abd El-Aziz, Tarek Mohamed, Soares, Antonio, Kandimalla, Ramesh, Lundstrom, Kenneth, Lal, Amos, Azad, Gajendra Kumar, Uversky, Vladimir N., Sherchan, Samendra P., Baetas-da-Cruz, Wagner, Uhal, Bruce D., Rezaei, Nima, Chauhan, Gaurav, Barh, Debmalya, Redwan, Elrashdy M., Dayhoff, Guy W., Bazan, Nicolas G., Serrano-Aroca, Ángel, El-Demerdash, Amr, Mishra, Yogendra K., Palu, Giorgio, Takayama, Kazuo, Brufsky, Adam M., Tambuwala, Murtaza M.“…This protein modulates the adaptive host immunity through down-regulation of MHC-1 (Major Histocompatibility Complex) molecules and innate immune responses by surpassing the host's interferon-mediated antiviral response. To understand the host's immune perspective in reference to the ORF8 protein, a comprehensive study of the ORF8 protein and mutations possessed by it have been performed. …”
Publicado 2021
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29379por Patel, Tejas K., Patel, Parvati B., Barvaliya, Manish, Saurabh, Manoj Kumar, Bhalla, Hira Lal, Khosla, Prem Parkash“…The included studies had five different control interventions: supportive care (n = 4), umifenovir (arbidol) (n = 2), navaferon (recombinant anti-tumour and anti-virus protein) (n = 1), lopinavir-ritonavir + novaferon (n = 1) and lopinavir-ritonavir + interferon beta 1b + ribavirin (n = 1). Lopinavir-ritonavir group did not show significant difference in mortality [RD: 0.00 (95% CI: −0.01, 0.02), I(2) = 0], virological cure [RR: 1.06 (95% CI: 0.85, 1.31), I(2) = 0%], radiological improvement [RR: 0.81 (95% CI: 0.62, 1.05)] and adverse events [RR: 2.59 (95% CI: 0.17, 38.90), I(2) = 75%] than supportive care. …”
Publicado 2021
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29380por Contreras-Magallanes, Yesenia Guadalupe, Durán-Aguilar, Marina, Sosa-Gallegos, Susana L., Álvarez, Ángel H., Andrade-Santillán, Fátima A., Bárcenas-Reyes, Isabel, González-Ruíz, Sara, Rodríguez-Hernández, Elba, Cantó-Alarcón, Germinal J., Milián-Suazo, Feliciano“…The vaccinated groups showed significantly higher Interferon-γ levels in the blood compared to the control, nonvaccinated group after vaccination, after boosting, and after the challenge with the wild-type Mycobacterium bovis strain.…”
Publicado 2021
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