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29381por Coles, Makenly E., Forga, Aaron J., Señas-Cuesta, Roberto, Graham, Brittany D., Selby, Callie M., Uribe, Álvaro J., Martínez, Blanca C., Angel-Isaza, Jaime A., Vuong, Christine N., Hernandez-Velasco, Xochitl, Hargis, Billy M., Tellez-Isaias, Guillermo“…On d 25 of age, serum samples were collected to evaluate fluorescein isothiocyanate-dextran (FITC-d), superoxide dismutase (SOD), gamma interferon (IFN-γ), Immunoglobulin A (IgA). Group 3 showed a significant reduction of the harmful effects of induced infection/dysbiosis and a significant reduction in NE lesion scores, morbidity and mortality compared with the positive challenge control group (p < 0.05) compared with Group 2. …”
Publicado 2021
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29382Efficacy and safety of alemtuzumab over 6 years: final results of the 4-year CARE-MS extension trialpor Coles, Alasdair J., Arnold, Douglas L., Bass, Ann D., Boster, Aaron L., Compston, D. Alastair S., Fernández, Óscar, Havrdová, Eva Kubala, Nakamura, Kunio, Traboulsee, Anthony, Ziemssen, Tjalf, Jacobs, Alan, Margolin, David H., Huang, Xiaobi, Daizadeh, Nadia, Chirieac, Madalina C., Selmaj, Krzysztof W.“…BACKGROUND: In the 2-year CARE-MS I and II trials, alemtuzumab 12 mg administered on 5 consecutive days at core study baseline and on 3 consecutive days 12 months later significantly improved outcomes versus subcutaneous interferon beta-1a (SC IFNB-1a) in relapsing–remitting multiple sclerosis patients. …”
Publicado 2021
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29383“…Overall CCH or surgery treatment rate/year increased from 9.8% in 2014 to 15.5% in 2017, with <1% receiving verapamil or interferon. Initial treatment ratios of CCH to surgery increased from approximately 1:1 (2014) to 2:1 (2017). …”
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29384por Li, Yize, Renner, David M., Comar, Courtney E., Whelan, Jillian N., Reyes, Hanako M., Cardenas-Diaz, Fabian Leonardo, Truitt, Rachel, Tan, Li Hui, Dong, Beihua, Alysandratos, Konstantinos Dionysios, Huang, Jessie, Palmer, James N., Adappa, Nithin D., Kohanski, Michael A., Kotton, Darrell N., Silverman, Robert H., Yang, Wenli, Morrisey, Edward E., Cohen, Noam A., Weiss, Susan R.“…Coronaviruses are adept at evading host antiviral pathways induced by viral double-stranded RNA, including interferon (IFN) signaling, oligoadenylate synthetase–ribonuclease L (OAS-RNase L), and protein kinase R (PKR). …”
Publicado 2021
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29385por Datta, Syamal K.“…In Humans, similar potent Treg cells are generated by the histone peptide epitopes in vitro in lupus patients’ PBMC, inhibiting anti-dsDNA autoantibody and interferon production. Furthermore, the same types of Treg cells are generated in lupus patients who are in very long-term remission (2-8 years) after undergoing autologous hematopoietic stem cell transplantation. …”
Publicado 2021
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29386por Grembecka, Beata, Glac, Wojciech, Listowska, Magdalena, Jerzemowska, Grażyna, Plucińska, Karolina, Majkutewicz, Irena, Badtke, Piotr, Wrona, Danuta“…In this study, we examined the effects of unilateral DBS-STN applied in male Wistar rats with 6-hydroxydopamine PD model (DBS-6OHDA) and rats without nigral dopamine depletion (DBS) on corticosterone (CORT) plasma concentration, blood natural killer cell cytotoxicity (NKCC), leukocyte numbers, lymphocyte population and apoptosis numbers, plasma interferon gamma (IFN-γ), interleukin 6 (IL-6), and tumor necrosis factor (TNF-α) concentration. …”
Publicado 2020
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29387“…Additionally, polysaccharides enable a host-virus immune response, activate phagocytosis and stimulate interferon systems. Therefore, polysaccharides can be used as candidate drugs, adjuvants in vaccines or combination with other antivirals, antioxidants and immune-activating nutritional supplements and antiviral materials in healthcare products to prevent SARS-CoV-2 infection.…”
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29388por Yang, Lei, Wang, Jianhui, Hui, Pei, Yarovinsky, Timur O., Badeti, Saiaditya, Pham, Kien, Liu, Chen“…There are 13 human IFN-α subtypes that bind to the same receptor and induce different interferon-stimulated gene (ISG) expression, regulating various antiviral and immunoregulatory effects. …”
Publicado 2021
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29389por Qing, Pingying, Lu, Chenyang, Liu, Zhihui, Wen, Xiuzhen, Chen, Bo, Lin, Zhiguo, Ma, Yingbing, Zhao, Yi, Liu, Yi, Tan, Chunyu“…TB infection was evaluated by medical history, radiological examinations, sputum examinations, tubercular skin test (TST) and interferon gamma (IFN-γ) release assay test (IGRA). …”
Publicado 2021
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29390por Gray, Steven G.“…Other potential therapeutic avenues such CAR-T therapy or treatments like oncolytic viruses or agents that target the interferon pathway designed to recruit more immune cells to the tumor also hold great promise in this hard to treat cancer.…”
Publicado 2021
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29391“…Objective: To evaluate the value of combined interferon β (IFN-β) and platelet (PLT) detection for Kawasaki disease (KD) identification. …”
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29392por Carrasco-Leon, Arantxa, Ezponda, Teresa, Meydan, Cem, Valcárcel, Luis V., Ordoñez, Raquel, Kulis, Marta, Garate, Leire, Miranda, Estíbaliz, Segura, Victor, Guruceaga, Elisabeth, Vilas-Zornoza, Amaia, Alignani, Diego, Pascual, Marién, Amundarain, Ane, Castro-Labrador, Laura, Martín-Uriz, Patxi San, El-Omri, Halima, Taha, Ruba Y., Calasanz, Maria J., Planes, Francisco J., Paiva, Bruno, Mason, Christopher E., San Miguel, Jesús F., Martin-Subero, José I., Melnick, Ari, Prosper, Felipe, Agirre, Xabier“…Knockdown studies on one of these lncRNAs, SMILO (specific myeloma intergenic long non-coding RNA), resulted in reduced proliferation and induction of apoptosis of MM cells, and activation of the interferon pathway. We also showed that the expression of lncRNAs, together with clinical and genetic risk alterations, stratified MM patients into several progression-free survival and overall survival groups. …”
Publicado 2021
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29393por O’Rourke, Dennis, Wang, Danyi, Sanchez-Garcia, Jorge F., Cusano, Maria Perella, Miller, Waldemar, Cai, Ti, Scheuenpflug, Juergen, Feng, Zheng“…Four reference genes were analyzed in positive control cell line (A549 treated with interferon gamma, [IFN γ]) genomic DNA. The PD-L1 primer/probe sets were also evaluated in ddPCR for limit of blank, limit of detection, and precision. …”
Publicado 2021
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29394por Halle, Mari K., Sødal, Marte, Forsse, David, Engerud, Hilde, Woie, Kathrine, Lura, Njål G., Wagner-Larsen, Kari S., Trovik, Jone, Bertelsen, Bjørn I., Haldorsen, Ingfrid S., Ojesina, Akinyemi I., Krakstad, Camilla“…In gene set enrichment analyses, HLA-DQB1high tumours associated with immune activation and response to interferon-γ (IFN-γ). CONCLUSIONS: This study revealed a 10-gene signature with high prognostic power in cervical cancer. …”
Publicado 2021
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29395por Xia, Lu, Liu, Xu-hui, Zhao, Zhang-yan, Li, Tao, Xi, Xiu-hong, Liu, Ping, Huang, Wei, Fan, Xiao-yong, Wu, Xue-qiong, Lu, Shui-hua“…CONCLUSION: The RP22 skin test was well tolerated and safe, it could play a key role in screening for latent tuberculosis infection (LTBI) by providing a much-wanted alternative to the tuberculin skin test (TST) and interferon-γ release assays (IGRAs).…”
Publicado 2021
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29396por Ramez, Amany M., Elmahallawy, Ehab Kotb, Elshopakey, Gehad E., Saleh, Amira A., Moustafa, Samar M., Al-Brakati, Ashraf, Abdo, Walied, El-Shewehy, Dina M. M.“…Co-administration of SP and MGT reduced serum cytokine levels (tumor necrosis factor-alpha, interferon-gamma, and interleukin-13) and increased interleukin-10 levels after S. mansoni infection compared with the infected group. …”
Publicado 2021
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29397“…The anti-CD20 B cell depleting therapies (rituximab, ocrelizumab, and ofatumumab) have also demonstrated superiority in randomized clinical trials compared to their comparator group (placebo, interferon, and teriflunomide, respectively) and rituximab has shown in observational studies to be more effective than older injectable therapies and some of the oral therapies. …”
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29398por Gao, Xiaopan, Zhu, Kaixiang, Qin, Bo, Olieric, Vincent, Wang, Meitian, Cui, Sheng“…Our findings shed light on the mechanism underlying SARS-CoV-2 orf9b mediated suppression of interferon responses.…”
Publicado 2021
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29399por Du, Yanqin, Yan, Hu, Zou, Shi, Khera, Tanvi, Li, Jia, Han, Meihong, Yang, Xiaoli, Wang, Baoju, Liu, Jia, Sun, Shuilin, Zheng, Xin, Dittmer, Ulf, Lu, Mengji, Yang, Dongliang, Wedemeyer, Heiner, Wu, Jun“…We found that HI of DAP recruited conventional NK cells (cNK) into the liver and promoted tumor necrosis factor alpha (TNF‐α) and interferon‐gamma (IFN‐γ) production of NK cells in a chemokine (C‐X‐C motif) receptor 3 (CXCR3)‐dependent manner. …”
Publicado 2021
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29400por Rijsbergen, L. C., Lamers, M. M., Comvalius, A. D., Koutstaal, R. W., Schipper, D., Duprex, W. P., Haagmans, B. L., de Vries, R. D., de Swart, R. L.“…Epithelial cells from all anatomical locations were susceptible to HRSV infection despite the induction of a dominant type III interferon response. Subgroup A viruses disseminated and replicated faster than the subgroup B virus. …”
Publicado 2021
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