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29421por Schnittman, Samuel R, Byakwaga, Helen, Boum, Yap, Kabakyenga, Jerome, Matthews, Lynn T, Burdo, Tricia H, Huang, Yong, Tracy, Russell P, Haberer, Jessica E, Kembabazi, Annet, Kaida, Angela, Moisi, Daniela, Lederman, Michael M, Bangsberg, David R, Martin, Jeffrey N, Hunt, Peter W“…Plasma kynurenine/tryptophan (KT) ratio, soluble CD14 (sCD14), sCD163, sCD27, interferon-inducible protein 10 (IP-10), D-dimer, interleukin-6, and intestinal fatty-acid binding protein levels were assessed through the first year of ART and at 3-month intervals throughout pregnancy and 1 year postpartum. …”
Publicado 2021
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29422por Zheng, Guoxu, Guo, Zhangyan, Li, Weimiao, Xi, Wenjin, Zuo, Baile, Zhang, Rui, Wen, Weihong, Yang, An-Gang, Jia, Lintao“…Unless engaged by HLA-G, KIR2DL4 promotes antibody-dependent cell-mediated cytotoxicity and forms a regulatory circuit with the interferon-γ (IFN-γ) production pathway, in which IFN-γ upregulates KIR2DL4 via JAK2/STAT1 signaling, and then KIR2DL4 synergizes with the Fcγ receptor to increase IFN-γ secretion by NK cells. …”
Publicado 2021
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29423por Puray-Chavez, Maritza, LaPak, Kyle M., Schrank, Travis P., Elliott, Jennifer L., Bhatt, Dhaval P., Agajanian, Megan J., Jasuja, Ria, Lawson, Dana Q., Davis, Keanu, Rothlauf, Paul W., Liu, Zhuoming, Jo, Heejoon, Lee, Nakyung, Tenneti, Kasyap, Eschbach, Jenna E., Shema Mugisha, Christian, Cousins, Emily M., Cloer, Erica W., Vuong, Hung R., VanBlargan, Laura A., Bailey, Adam L., Gilchuk, Pavlo, Crowe, James E., Diamond, Michael S., Hayes, D. Neil, Whelan, Sean P.J., Horani, Amjad, Brody, Steven L., Goldfarb, Dennis, Major, M. Ben, Kutluay, Sebla B.“…Temporally resolved transcriptomic and proteomic profiling reveal alterations in cell cycle and the antiviral host cell response, including MDA5-dependent activation of type I interferon signaling. These findings establish an alternative SARS-CoV-2 host cell receptor for the E484D SARS-CoV-2 variant, which may impact tropism of SARS-CoV-2 and consequently human disease pathogenesis.…”
Publicado 2021
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29424por Beigmohammadi, Mohammad Taghi, Bitarafan, Sama, Abdollahi, Alireza, Amoozadeh, Laya, Salahshour, Faeze, Mahmoodi ali abadi, Maedeh, Soltani, Danesh, Motallebnejad, Zoya Asl“…Serum levels of inflammatory markers (erythrocyte sedimentation rate, C-reactive protein, interferon-gamma, tumor necrosis factor-alpha, interleukin-6), vitamins (A, B(9), B(12), C, D, E), and minerals (magnesium, zinc, iron) were measured. …”
Publicado 2021
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29425por Gewaily, Mahmoud S., Abdo, Safaa E., Moustafa, Eman M., AbdEl-kader, Marwa F., Abd El-Razek, Ibrahim M., El-Sharnouby, Mohamed, Alkafafy, Mohamed, Raza, Sayed Haidar Abbas, El Basuini, Mohammed F., Van Doan, Hien, Dawood, Mahmoud A. O.“…The results displayed upregulated transcription of catalase, glutathione peroxidase, and interferon (IFN-γ) genes caused by DMT exposure and synbiotic feeding when compared with the controls. …”
Publicado 2021
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29426por Schwertner, Barbara, Lindner, Georg, Toledo Stauner, Camila, Klapproth, Elisa, Magnus, Clara, Rohrhofer, Anette, Gross, Stefanie, Schuler-Thurner, Beatrice, Öttl, Veronika, Feichtgruber, Nicole, Drexler, Konstantin, Evert, Katja, Krahn, Michael P., Berneburg, Mark, Schmidt, Barbara, Schuster, Philipp, Haferkamp, Sebastian“…Our study aimed at characterizing surface receptors Nectin-1 and the herpes virus entry mediator (HVEM) in addition to intracellular molecules cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) as potential bio-markers for oncolytic virus treatment. …”
Publicado 2021
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29427por Zhou, Xiaoshuang, Li, Yidong, Ji, Yaqiu, Liu, Tian, Zhao, Ninghui, He, Jiefeng, Yao, Jia“…The functions of CD8(+) T lymphocytes in the ACLF+PD-1 group [using biomarkers of Ki67, CD69, IL-2, interferon-gamma, and tumor necrosis factor-alpha- were lower than in the ACLF group (all p<0.05). …”
Publicado 2021
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29428por Ross, Rebecca L, Corinaldesi, Clarissa, Migneco, Gemma, Carr, Ian M, Antanaviciute, Agne, Wasson, Christopher W, Carriero, Antonio, Distler, Jörg H W, Holmes, Steve, El-Sherbiny, Yasser M, McKimmie, Clive S, Del Galdo, Francesco“…RESULTS: RNAseq shows TLR9-induced activation of human pDC goes beyond type I interferon (IFN) secretion, which is functionally inactivated by BDCA2-targeting. …”
Publicado 2021
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29429“…An inflammatory lesion model was established by stimulating salivary gland epithelial cells (SGECs) with interferon-γ (IFN-γ). The apoptosis of SGECs was measured by using flow cytometry. …”
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29430por Gao, Huabin, Liang, Jiangtao, Duan, Jing, Chen, Lin, Li, Hui, Zhen, Tiantian, Zhang, Fenfen, Dong, Yu, Shi, Huijuan, Han, Anjia“…Further study showed that high expression of SLC2A3 was enriched in epithelial–mesenchymal transition (EMT) classical pathway, interferon-γ pathway by GSEA analysis enrichment, indicating that SLC2A3 may play a key role in the progression of CRC through EMT and immune response, which also has been validated by the global gene expression profiling of human CRC cell lines. …”
Publicado 2021
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29431por Gaitzsch, Erik, Passerini, Verena, Khatamzas, Elham, Strobl, Carolin D., Muenchhoff, Maximilian, Scherer, Clemens, Osterman, Andreas, Heide, Michael, Reischer, Anna, Subklewe, Marion, Leutbecher, Alexandra, Tast, Benjamin, Ruhle, Adrian, Weiglein, Tobias, Stecher, Stephanie-Susanne, Stemmler, Hans J., Dreyling, Martin, Girl, Philipp, Georgi, Enrico, Wölfel, Roman, Mateyka, Laura, D’Ippolito, Elvira, Schober, Kilian, Busch, Dirk H., Kager, Juliane, Spinner, Christoph D., Treiber, Matthias, Rasch, Sebastian, Lahmer, Tobias, Iakoubov, Roman, Schneider, Jochen, Protzer, Ulrike, Winter, Christof, Ruland, Jürgen, Quante, Michael, Keppler, Oliver T., von Bergwelt-Baildon, Michael, Hellmuth, Johannes, Weigert, Oliver“…Immune cell profiling and gene expression analysis of peripheral blood mononuclear cells revealed early activation of monocytes/macrophages, neutrophils, and the complement system in B-cell depleted lymphoma patients, with subsequent exacerbation of the inflammatory response and dysfunctional interferon signaling at the time of clinical deterioration of COVID-19. …”
Publicado 2021
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29432por Yang, Xiaochen, Lam, Wing, Jiang, Zaoli, Guan, Fulan, Han, Xue, Hu, Rong, Cai, Wei, Cheng, William, Liu, Shwu-Huey, Cheng, Peikwen, Cai, Yuping, Rattray, Nicholas J. W., Johnson, Caroline H., Chen, Lieping, Cheng, Yung-Chi“…YIV-906 could potentiate the action of interferon gamma (IFNg) to increase M1-like macrophage polarization while inhibiting IL4 action to decrease M2 macrophage polarization. …”
Publicado 2021
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29433por Brunner, Anna, Schuller, Simone, Hettlich, Bianca, Marti, Eliane, Lehmann, Anna, Peters, Laureen M., Adamik, Katja-Nicole“…Plasma concentrations of interleukin (IL)-6, IL-7, IL-8, IL-10, IL-15, IL-18, interferon gamma (IFN-γ), keratinocyte chemotactic-like, monocyte chemotactic protein (MCP)-1, Angiopoietin (Ang)-2, and C-reactive protein (CRP) were measured at admission (prior any therapeutic intervention, (T0), immediately after surgery (T1), 24 ± 4 h (T24), and 48 ± 4 h (T48) post-surgery. …”
Publicado 2021
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29434por Roca, Neus, Madrid, Alvaro, Lopez, Mercedes, Fraga, Gloria, Jatem, Elias, Gonzalez, Jorge, Martinez, Cristina, Segarra, Alfons“…Serum levels of soluble interleukin (IL)-1 receptor, tumoural necrosis factor alpha, Interferon gamma (IFNγ), IL-6, IL-17, IL-12, IL-23, IL-13, IL-4, IL-5, IL-6, haemopexin (Hx), haptoglobin (Hgl), soluble urokinase-type plasminogen activator receptor (suPAR) and urinary CD80 (uCD80) were measured with enzyme-linked immunosorbent assay or nephelometry. …”
Publicado 2020
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29435por Karaba, Andrew H, Zhou, Weiqiang, Hsieh, Leon L, Figueroa, Alexis, Massaccesi, Guido, Rothman, Richard E, Fenstermacher, Katherine Z J, Sauer, Lauren, Shaw-Saliba, Kathryn, Blair, Paul W, Robinson, Matthew L, Leung, Sherry, Wesson, Russell, Alachkar, Nada, El-Diwany, Ramy, Ji, Hongkai, Cox, Andrea L“…RESULTS: Interleukin-18 (IL-18), IL-1β, IL-6, and tumor necrosis factor-α (TNF-α) were significantly increased in COVID-19 versus influenza patients, whereas granulocyte macrophage colony-stimulating factor, interferon-γ (IFN-γ), IFN-λ1, IL-10, IL-15, and monocyte chemoattractant protein 2 were significantly elevated in the influenza group. …”
Publicado 2021
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29436“…Moreover, NCE had increased (P < 0.05) the contents of growth hormone, β-endorphin, 5-hydroxytryptamine, total antioxidant capacity, total superoxide dismutase, catalase, and IL-10, as well as decreased (P < 0.05) contents of malondialdehyde, tumor nuclear factor-α, interferon-γ, and interleukin-6 in serum on d 28 compared with CON and CTC. …”
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29437por Tian, Yun, Khwatenge, Collins N., Li, Jiuyi, De Jesus Andino, Francisco, Robert, Jacques, Sang, Yongming“…Our sequence analysis indicates that a fraction of these viral miRNAs is targeting the 3’-UTR regions of Xenopus genes involved in interferon (IFN)-dependent responses, including particularly those encoding IFN receptor subunits and IFN-regulatory factors (IRFs). …”
Publicado 2021
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29438por Dat, Ninh Quoc, Thuy, Le Thi Thanh, Hieu, Vu Ngoc, Hai, Hoang, Hoang, Dinh Viet, Thi Thanh Hai, Nguyen, Thuy, Tuong Thi Van, Komiya, Tohru, Rombouts, Krista, Dong, Minh Phuong, Hanh, Ngo Vinh, Hoang, Truong Huu, Sato‐Matsubara, Misako, Daikoku, Atsuko, Kadono, Chiho, Oikawa, Daisuke, Yoshizato, Katsutoshi, Tokunaga, Fuminori, Pinzani, Massimo, Kawada, Norifumi“…In addition, His‐CYGB induced interferon‐β secretion by HSCs that partly contributed to its antifibrotic function. …”
Publicado 2021
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29439por Samarkanova, Dinara, Cox, Steven, Hernandez, Diana, Rodriguez, Luciano, Pérez, Maria Luisa, Madrigal, Alejandro, Vilarrodona, Anna, Querol, Sergio, Casaroli-Marano, Ricardo P.“…When assessed in a lymphocyte culture, both favoured immune suppression reducing the cellular expression of NKG2D and CD107a as well as the production of interferon gamma (IFN-γ) in natural killer, NKT and T cells. …”
Publicado 2021
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29440por Adnan-Awad, Shady, Kim, Daehong, Hohtari, Helena, Javarappa, Komal Kumar, Brandstoetter, Tania, Mayer, Isabella, Potdar, Swapnil, Heckman, Caroline A., Kytölä, Soili, Porkka, Kimmo, Doma, Eszter, Sexl, Veronika, Kankainen, Matti, Mustjoki, Satu“…In contrast with p210(Bcr-Abl), p190(Bcr-Abl) exhibited specific transcriptional upregulation of interferon, interleukin-1 receptor, and P53 signaling pathways, associated with hyperphosphorylation of relevant signaling molecules including JAK1/STAT1 and PAK1 in addition to Src hyperphosphorylation. …”
Publicado 2020
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