-
29441por Vanderbeke, L., Van Mol, P., Van Herck, Y., De Smet, F., Humblet-Baron, S., Martinod, K., Antoranz, A., Arijs, I., Boeckx, B., Bosisio, F. M., Casaer, M., Dauwe, D., De Wever, W., Dooms, C., Dreesen, E., Emmaneel, A., Filtjens, J., Gouwy, M., Gunst, J., Hermans, G., Jansen, S., Lagrou, K., Liston, A., Lorent, N., Meersseman, P., Mercier, T., Neyts, J., Odent, J., Panovska, D., Penttila, P. A., Pollet, E., Proost, P., Qian, J., Quintelier, K., Raes, J., Rex, S., Saeys, Y., Sprooten, J., Tejpar, S., Testelmans, D., Thevissen, K., Van Buyten, T., Vandenhaute, J., Van Gassen, S., Velásquez Pereira, L. C., Vos, R., Weynand, B., Wilmer, A., Yserbyt, J., Garg, A. D., Matthys, P., Wouters, C., Lambrechts, D., Wauters, E., Wauters, J.“…We show that hypercytokinemia in COVID-19 differs from the interferon-gamma-driven cytokine storm in macrophage activation syndrome, and is more pronounced in critical versus mild-moderate COVID-19. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
29442por Owusu Sekyere, Solomon, Port, Kerstin, Deterding, Katja, Cornberg, Markus, Wedemeyer, Heiner“…INTRODUCTION: The risk of hepatocellular carcinoma persists in some patients despite achieving sustained virologic response with current interferon‐free direct‐acting antiviral therapy for hepatitis C. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
29443por Poles, Jillian, Karhu, Elisa, McGill, Megan, McDaniel, H. Reginald, Lewis, John E.“…Some of the noteworthy immune function and anti-inflammatory responses to these interventions included modulation of nuclear factor-Kappa B, tumor necrosis factor-a, interferon-g, interleukin-6, and CD4+ T cells, among others. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
29444por Oh, Sooyeon, Chun, Sukyung, Hwang, Sena, Kim, Jongseok, Cho, Yuri, Lee, Jooho, Kwack, KyuBum, Choi, Sang-Woon“…NKA was measured using the interferon-γ (IFN-γ) stimulation method. The association of NKA with 25-(OH)-vitamin D (25(OH)D) and other factors was investigated by multiple logistic regression analysis. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
29445por Sasson, Jennifer M., Campo, Joseph J., Carpenter, Rebecca M., Young, Mary K., Randall, Arlo Z., Trappl-Kimmons, Krista, Oberai, Amit, Hung, Christopher, Edgar, Joshua, Teng, Andy A., Pablo, Jozelyn V., Liang, Xiaowu, Yee, Angela, Petri, William A., Camerini, David“…Further characterization of these slow-low-responding individuals with cytokine analysis revealed significantly higher interleukin-10 (IL-10), IL-15, and interferon gamma-induced protein 10 (IP-10) levels and lower epidermal growth factor (EGF) and soluble CD40 ligand (sCD40L) levels than those of seroreactive patients in the cohort.…”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
29446por Cheng, Lijing, Yuan, Meiling, Li, Shu, Lian, Zhiying, Chen, Junjing, Lin, Weibiao, Zhang, Jianbo, Zhong, Shupeng“…While the introduction of β-interferon (IFN-β) regimen in the treatment of gliomas has significantly improved the outcome of patients; The mechanism by which IFN-β induces increased TMZ sensitivity has not been described. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
29447“…We also proposed that OAS1 expression enhancement can induce the anti-cancer effects of interferon-gamma, while suppression of CTSH hinders formation of focal adhesions. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
29448por Klein, Klara, Witalisz-Siepracka, Agnieszka, Gotthardt, Dagmar, Agerer, Benedikt, Locker, Felix, Grausenburger, Reinhard, Knab, Vanessa Maria, Bergthaler, Andreas, Sexl, Veronika“…RNA-seq analysis indicated a role of CDK6 in T cell metabolism and interferon (IFN) signaling. To investigate whether these CDK6 functions are T cell-intrinsic, we generated a T cell-specific CDK6 knockout mouse model (Cdk6 (fl/fl) CD4-Cre). …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
29449por Bauer, Lisa, Lendemeijer, Bas, Leijten, Lonneke, Embregts, Carmen W. E., Rockx, Barry, Kushner, Steven A., de Vrij, Femke M. S., van Riel, Debby“…However, this sparse infection did result in the production of type III interferons and interleukin-8 (IL-8). In contrast, H5N1 virus replicated and spread very efficiently in all cell types in all cultures. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
29450por Zawit, Misam, Swami, Umang, Awada, Hassan, Arnouk, Joyce, Milhem, Mohammed, Zakharia, Yousef“…Reviewed therapies include T-VEC, T-VEC with immune checkpoint inhibitors including ipilimumab and pembrolizumab or other agents, RP1, OrienX010, Canerpaturev (C-REV, HF10), CAVATAK (coxsackievirus A21, CVA21) alone or in combination with checkpoint inhibitors, oncolytic polio/rhinovirus recombinant (PVSRIPO), MAGE-A3-expressing MG1 Maraba virus, VSV-IFNbetaTYRP1, suicide gene therapy, ONCOS-102, OBP-301 (Telomelysin), Stimulation of Interferon Genes Pathway (STING agonists) including DMXAA, MIW815 (ADU-S100) and MK-1454, PV-10, toll-like receptors (TLRs) agonists including TLR-9 agonists (SD-101, CMP-001, IMO-2125 or tilsotolimod, AST-008 or cavrotolimod, MGN1703 or lefitolimod), CV8102, NKTR-262 plus NKTR-214, LHC165, G100, intralesional interleukin-2, Daromun (L19IL2 plus L19TNF), Hiltonol (poly-ICLC), electroporation including calcium electroporation and plasmid interleukin-12 electroporation (pIL-12 EP), IT ipilimumab, INT230-6 (cisplatin and vinblastine with an amphiphilic penetration enhancer), TTI-621 (SIRPαFc), CD-40 agonistic antibodies (ABBV-927 and APX005M), antimicrobial peptide LL37 and other miscellaneous agents.…”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
29451por Bazzi, Samer, El-Darzi, Emale, McDowell, Tina, Modjtahedi, Helmout, Mudan, Satvinder, Achkar, Marcel, Akle, Charles, Kadara, Humam, Bahr, Georges M.“…Here, we characterized cytokine/chemokine release patterns and transcriptomic profiles of lipopolysaccharide (LPS)/interferon γ (IFNγ)-activated human MDMs that were differentiated with HK M. obuense (Mob-MDM(LPS/IFNγ)), macrophage colony-stimulating factor M-MDM(LPS/IFNγ)), or granulocyte/macrophage colony-stimulating factor (GM-MDM(LPS/IFNγ)). …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
29452por Howard, Timothy R., Crow, Marni S., Greco, Todd M., Lum, Krystal K., Li, Tuo, Cristea, Ileana M.“…DNA sensors are critical components of innate immunity that enable cells to recognize infection by pathogens with DNA genomes. The interferon-inducible protein X (IFIX), a member of the PYHIN protein family, is a DNA sensor capable of promoting immune signaling after binding to double-stranded DNA (dsDNA) within either the nucleus or cytoplasm. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
29453por Zhu, Binghua, Tang, Jing, Fang, Rong, Fei, Xuejie, Wang, Qing, Wang, Wenqing, Wu, Xueqin, Liu, Chao, Wang, Qian“…Routine microbiological tests were performed, and tuberculosis interferon gamma release assays were positive. Mycobacterium tuberculosis polymerase chain reaction was also positive. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
29454por Goletti, Delia, Petrone, Linda, Manissero, Davide, Bertoletti, Antonio, Rao, Sonia, Ndunda, Nduku, Sette, Alessandro, Nikolayevskyy, Vladyslav“…OBJECTIVES: To provide an overview of the role of T-cell immunity in COVID-19, in the context of natural infection and post-vaccination, and discuss the potential utility of measuring SARS-CoV-2-specific T-cell responses, drawing on experience of the use of interferon-γ release assays (IGRAs) in tuberculosis (TB). …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
29455por Petrazzuolo, Adriana, Perez-Lanzon, Maria, Martins, Isabelle, Liu, Peng, Kepp, Oliver, Minard-Colin, Véronique, Maiuri, Maria Chiara, Kroemer, Guido“…ICD is characterized by a series of stereotyped changes that increase the immunogenicity of dying cells: exposure of calreticulin on the cell surface, release of ATP and high mobility group box 1 protein, as well as a type I interferon response. Here, we examined the possibility that inhibition of an oncogenic kinase, anaplastic lymphoma kinase (ALK), might trigger ICD in anaplastic large cell lymphoma (ALCL) in which ALK is activated due to a chromosomal translocation. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
29456por Espi, Maxime, Charmetant, Xavier, Barba, Thomas, Koppe, Laetitia, Pelletier, Caroline, Kalbacher, Emilie, Chalencon, Elodie, Mathias, Virginie, Ovize, Anne, Cart-Tanneur, Emmanuelle, Bouz, Christine, Pellegrina, Laurence, Morelon, Emmanuel, Fouque, Denis, Juillard, Laurent, Thaunat, Olivier“…To answer this, anti-spike receptor binding domain (RBD) IgG and interferon gamma-producing CD4(+) and CD8(+) specific-T cells were measured in the circulation 10-14 days after the second injection of BNT162b2 vaccine in 106 patients receiving MHD (14 with history of COVID-19) and compared to 30 healthy volunteers (four with history of COVID-19). …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
29457por Lim, Vanessa W, Wee, Hwee Lin, Lee, Phoebe, Lin, Yijun, Tan, Yi Roe, Tan, Mei Xuan, Lin, Lydia Wenxin, Yap, Peiling, Chee, Cynthia BE, Barkham, Timothy, Lee, Vernon, Chen, Mark, Ong, Rick Twee-Hee“…RESULTS: Of 3584 migrants surveyed, 20.4% had positive interferon-gamma release assay (IGRA) results, with the highest positivity in Filipinos (33.2%). …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
29458por Lai, Changchun, Liu, Xinglong, Yan, Qihong, Lv, Hualiang, Zhou, Lei, Hu, Longbo, Cai, Yong, Wang, Guoqiang, Chen, Yufeng, Chai, Renjie, Liu, Zhenwei, Xu, Yuhua, Huang, Wendong, Xiao, Fei, Hu, Linhui, Li, Yaocai, Huang, Jianhong, Zhou, Qiang, Li, Luqian, Peng, Tao, Zhang, Haiye, Zhang, Zhenhui, Chen, Ling, Chen, Chunbo, Ji, Tianxing“…The RP patient had lower interferon-, T cells- and B cell-related genes expression than non-RP patients with mild-to-moderate symptoms, and displayed lower cytokines and chemokines gene expression than severe patients. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
29459por Tang, Huai-ping, Huang, Chen, Hu, Chong-bin, Li, Hao, Shao, Tong, Ji, Jian-fei, Bai, Jun, Fan, Dong-dong, Lin, Ai-fu, Xiang, Li-xin, Shao, Jian-zhong“…This finding suggests that TcpAh extensively interferes with MyD88 and TIR domain-containing adapter inducing interferon (IFN)-β (TRIF) signaling pathways downstream of TLRs. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto -
29460por Wang, Kai, Hu, Chengjun, Tang, Wu, Azad, Md. Abul Kalam, Zhu, Qian, He, Qinghua, Kong, Xiangfeng“…The jejunal IL-10, interferon-α, and secretory IgA (sIgA) concentrations were increased (P < 0.05) in the probiotic and synbiotic groups, as well as the ileal sIgA concentration in the probiotic group. …”
Publicado 2021
Enlace del recurso
Enlace del recurso
Enlace del recurso
Online Artículo Texto