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29461por Borg, Danielle J., Faridi, Pouya, Giam, Kai Lin, Reeves, Peta, Fotheringham, Amelia K., McCarthy, Domenica A., Leung, Sherman, Ward, Micheal S., Harcourt, Brooke E., Ayala, Rochelle, Scheijen, Jean L., Briskey, David, Dudek, Nadine L., Schalkwijk, Casper G., Steptoe, Raymond, Purcell, Anthony W., Forbes, Josephine M.“…Indeed, ALT did not reduce interferon-γ production by leukocytes from ovalbumin-pre-immunised NODShiLt mice and NODscid recipients given diabetogenic ALT treated NOD splenocytes were not protected against T1D. …”
Publicado 2021
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29462“…Bioinformatics analysis revealed that most of these DEGs were mainly involved in the innate immune response, especially the interferon stimulated genes (ISGs). Gene Ontology (GO) enrichment analysis results indicated that the identified DEGs were significantly mainly enriched for response to virus, defense response to virus, response to biotic stimulus and regulation of innate immune response. …”
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29463por Pezzè, Laura, Meškytė, Erna Marija, Forcato, Mattia, Pontalti, Stefano, Badowska, Kalina Aleksandra, Rizzotto, Dario, Skvortsova, Ira-Ida, Bicciato, Silvio, Ciribilli, Yari“…By transcriptome profiling, we identified a signature of Interferon-responsive genes significantly repressed in cells over-expressing ETV7, which could be responsible for the increase in the breast CSCs population, as this could be partially reverted by the treatment with IFN-β. …”
Publicado 2021
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29464por Chebii, Vivien J., Mpolya, Emmanuel A., Oyola, Samuel O., Kotze, Antoinette, Entfellner, Jean-Baka Domelevo, Mutuku, J. Musembi“…We found copy number variable genes involved in defense response to viral infections (Cluster of Differentiation 48, UL16 binding protein 3, Natural Killer Group 2D ligand 1-like, and Interferon-induced transmembrane protein 3), possibly suggesting their roles in Nubian ibex adaptations to viral infections. …”
Publicado 2021
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29465por de Sousa, Eric, Lérias, Joana R., Beltran, Antonio, Paraschoudi, Georgia, Condeço, Carolina, Kamiki, Jéssica, António, Patrícia Alexandra, Figueiredo, Nuno, Carvalho, Carlos, Castillo-Martin, Mireia, Wang, Zhe, Ligeiro, Dário, Rao, Martin, Maeurer, Markus“…The quality and quantity of target recognition is determined by the repertoire of ‘neoepitope’-specific T-cell receptors (TCRs) in tumor-infiltrating lymphocytes (TIL), or peripheral T-cells. Interferon gamma (IFN-γ), produced by T-cells and other immune cells, is essential for controlling proliferation of transformed cells, induction of apoptosis and enhancing human leukocyte antigen (HLA) expression, thereby increasing immunogenicity of cancer cells. …”
Publicado 2021
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29466por Roessner, Philipp M., Llaó Cid, Laura, Lupar, Ekaterina, Roider, Tobias, Bordas, Marie, Schifflers, Christoph, Arseni, Lavinia, Gaupel, Ann-Christin, Kilpert, Fabian, Krötschel, Marit, Arnold, Sebastian J., Sellner, Leopold, Colomer, Dolors, Stilgenbauer, Stephan, Dietrich, Sascha, Lichter, Peter, Izcue, Ana, Seiffert, Martina“…The T(R)1 cell identity of these CD4(+) T cells was supported by their expression of interferon gamma and IL-10, as well as inhibitory receptors including PD-1. …”
Publicado 2021
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29467por Ager, Casey R, Boda, Akash, Rajapakshe, Kimal, Lea, Spencer Thomas, Di Francesco, Maria Emilia, Jayaprakash, Priyamvada, Slay, Ravaen B, Morrow, Brittany, Prasad, Rishika, Dean, Meghan A, Duffy, Colm R, Coarfa, Cristian, Jones, Philip, Curran, Michael A“…BACKGROUND: Intratumoral injection of cyclic dinucleotide (CDN) agonists of the stimulator of interferon genes (STING) pathway engages innate immune activation and priming of adaptive immune effectors to foster local and distal tumor clearance. …”
Publicado 2021
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29468“…Moreover, there were similar defense responses activated by IAV infection, including the interferon-regulated signaling pathway in different phagocyte types, although the differentially expressed genes in different phagocyte types showed a great difference. …”
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29469por Zheng, Yi, Xing, Hong-yi, Zhu, Zheng-Gang, Zhu, Hong-Hao, Zhang, Fang, Gao, Xia, Gao, Jun, Hu, Quan, Fang, Yuan“…At day 0, leprosy cured group have relatively high concentration of interleukin-6, interleukin-10, tumor necrosis factor, interferon-γ, and interleukin-17 compared to control group. …”
Publicado 2021
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29470por Spielmann, Julia, Naujoks, Wiebke, Emde, Matthias, Allweyer, Martin, Fänder, Johannes, Kielstein, Heike, Quandt, Dagmar, Bähr, Ina“…In contrast, restrictive feeding of a HFD compared to NFD led to significantly higher body weights, visceral fat mass and plasma interferon-γ concentrations which was associated with changes in the frequencies of granulocytes and NK cell subsets as well as in the surface expression of NK cell maturation markers. …”
Publicado 2021
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29471por Solanich, Xavier, Vargas-Parra, Gardenia, van der Made, Caspar I., Simons, Annet, Schuurs-Hoeijmakers, Janneke, Antolí, Arnau, del Valle, Jesús, Rocamora-Blanch, Gemma, Setién, Fernando, Esteller, Manel, van Reijmersdal, Simon V., Riera-Mestre, Antoni, Sabater-Riera, Joan, Capellá, Gabriel, van de Veerdonk, Frank L., van der Hoven, Ben, Corbella, Xavier, Hoischen, Alexander, Lázaro, Conxi“…Functional testing of this variant revealed decreased type I and II interferon responses in peripheral mononuclear blood cells upon stimulation with the TLR7 agonist imiquimod, confirming a loss-of-function effect. …”
Publicado 2021
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29472por Biciuşcă, Viorel, Popescu, Mihaela, Petrescu, Ileana Octavia, Stan, Ionelia Sorina, Durand, Patricia, Petrescu, Mihai, Velea, Rodica, Traşcă, Diana Maria, Popescu, Iulian Alin Silviu, Udriştoiu, Ion, Mărginean, Cristina Maria, Tudoraşcu, Diana Rodica, Petrescu, Florin“…Knowing the hepatic pathological features encountered in patients with chronic hepatitis C (CHC) and the fact that extrahepatic manifestations occur only in people with certain characteristics of the immune system, we tried to evaluate, qualitatively and semi-quantitatively, the liver pathological aspects encountered in 96 patients with CHC, previously untreated with Interferon (naïve), who showed or did not show signs of thyroid disorder (TD), hospitalized in the 2(nd) Medical Clinic of the Emergency County Hospital, Craiova, Romania, within a period of five years (2007–2012). …”
Publicado 2020
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29473“…The PD-L1 overexpression is an important event of immune escape and metastasis in triple-negative breast cancer (TNBC), but the molecular mechanism remains to be determined. Interferon gamma (IFNγ) represents a major driving force behind PD-L1 expression in tumor microenvironment, and histone deacetylase 2 (HDAC2) is required for IFN signaling. …”
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29474por Huwait, Etimad A., Saddeek, Salma Y., Al-Massabi, Rehab F., Almowallad, Sanaa J., Pushparaj, Peter Natesan, Kalamegam, Gauthaman“…Real-time gene expression assay for intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) was carried out following treatment with quercetin at 15 and 30 μM for 24 h either in the absence or presence of interferon (IFN-γ) for 3 h to induce inflammation. Monocyte migration and cholesterol efflux were also assessed. …”
Publicado 2021
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29475por Affandi, Alsya J., Olesek, Katarzyna, Grabowska, Joanna, Nijen Twilhaar, Maarten K., Rodríguez, Ernesto, Saris, Anno, Zwart, Eline S., Nossent, Esther J., Kalay, Hakan, de Kok, Michael, Kazemier, Geert, Stöckl, Johannes, van den Eertwegh, Alfons J. M., de Gruijl, Tanja D., Garcia-Vallejo, Juan J., Storm, Gert, van Kooyk, Yvette, den Haan, Joke M. M.“…In inflammatory conditions, monocytes frequently show increased expression of CD169/Siglec-1, a type-I interferon (IFN-I)-regulated protein. However, little is known about the phenotype and function of these CD169(+) monocytes. …”
Publicado 2021
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29476por Wibowo, Heri, Harbuwono, Dante S., Tahapary, Dicky L., Kartika, Rona, Pradipta, Saraswati, Larasati, Rahma A.“…The aim of the study was to measure the level of plasma butyrate in poorly controlled T2DM and normoglycemic participants and to compare the response of peripheral blood mononuclear cells (PBMCs) to sodium butyrate treatment between the groups by measuring production of the following cytokines: tumor necrosis factor (TNF)-α, interleukin (IL)-6, interferon (IFN)-γ, IL-13, and IL-10. The in vitro study examined the PBMCs of 15 participants with poorly controlled T2DM and 15 normoglycemic participants. …”
Publicado 2021
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29477por Carrión, Belinda, Liu, Yawei, Hadi, Mahdieh, Lundstrom, Jon, Christensen, Jeppe Romme, Ammitzbøll, Cecilie, Dziegiel, Morten Hanefeld, Sørensen, Per Soelberg, Comabella, Manuel, Montalban, Xavier, Sellebjerg, Finn, Issazadeh-Navikas, Shohreh“…Furthermore, hCII707-721–reactive iNKT cells did not upregulate interferon (IFN)-γ, interleukin (IL)-4, IL-10, IL-13, or IL-17 by RNA-seq or at the protein level, unlike the response to the glycolipid alpha-galactosylceramide. hCII707-721–reactive iNKT cells increased TNFα only at the protein level and suppressed autologous-activated T cells through FAS-FAS ligand (FAS-FASL) and TNFα-TNF receptor I signaling but not TNF receptor II. …”
Publicado 2021
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29478por Chapin, Catherine A, Taylor, Sarah A, Malladi, Padmini, Neighbors, Katie, Melin‐Aldana, Hector, Kreiger, Portia A, Bowsher, Nina, Schipma, Matthew J, Loomes, Kathleen M, Behrens, Edward M, Alonso, Estella M“…Most patients with IND‐PALF (94%) had dense/moderate CD8 staining and were characterized by Th1 immune analytes including tumor necrosis factor α, interferon γ (IFN‐γ), interleukin (IL) 1β, IL‐12, C‐X‐C motif chemokine ligand (CXCL) 9, and CXCL12. …”
Publicado 2021
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29479“…A total of 403 core genes were obtained from PPI network. The target gene interferon regulatory factor 7 (IRF7) was significantly associated with prognosis and clinical features of the tumor. …”
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29480“…RESULTS: Both pre-treatment and post-treatment of A549 cells with DATS resulted in reduced viral loads, increased expression of anti-viral genes (RIG-I, IRF-3, and interferon-β), and decreased expression of inflammatory cytokines (TNF-α and IL-6). …”
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