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29481por Prasad, Sujata, Sheng, Wen S., Hu, Shuxian, Chauhan, Priyanka, Lokensgard, James R.“…Upon reactivation of quiescent neurotropic viruses antigen (Ag)-specific brain resident-memory CD8+ T-cells (bT(RM)) may respond to de novo-produced viral Ag through the rapid release of IFN-γ, which drives subsequent interferon-stimulated gene expression in surrounding microglia. …”
Publicado 2021
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29482“…In addition, mRNA expression of IL-1β, IL-6, TNF-α, TLR-2, NF-κB, CXCL8, CXCL6 and interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) genes was also significantly higher in the LPS group compared to the 0.05% TTO group. …”
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29483por Nabatanzi, Rose, Bayigga, Lois, Cose, Stephen, Canderan, Glenda, Rowland Jones, Sarah, Joloba, Moses, Nakanjako, Damalie“…We report that ILC1 frequencies (T-BET + CD127 + and CD161 +) were higher in cART-treated HIV-infected relative to age-matched health HIV-negative adults; P = 0.04 whereas ILC precursors (ILCP) were comparable in the two groups (P = 0.56). Interferon gamma (IFN-γ) secretion by ILC1 was higher among cART-treated HIV-infected relative to HIV-negative adults (P = 0.03). …”
Publicado 2021
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29484por Sarma, Aartik, Christenson, Stephanie A., Byrne, Ashley, Mick, Eran, Pisco, Angela Oliveira, DeVoe, Catherine, Deiss, Thomas, Ghale, Rajani, Zha, Beth Shoshana, Tsitsiklis, Alexandra, Jauregui, Alejandra, Moazed, Farzad, Detweiler, Angela M., Spottiswoode, Natasha, Sinha, Pratik, Neff, Norma, Tan, Michelle, Serpa, Paula Hayakawa, Willmore, Andrew, Ansel, K. Mark, Wilson, Jennifer G., Leligdowicz, Aleksandra, Siegel, Emily R., Sirota, Marina, DeRisi, Joseph L., Matthay, Michael A., Hendrickson, Carolyn M., Kangelaris, Kirsten N., Krummel, Matthew F., Woodruff, Prescott G., Erle, David J., Calfee, Carolyn S., Langelier, Charles R.“…Compared to ARDS due to other types of viral pneumonia, COVID-19 is characterized by impaired interferon-stimulated gene (ISG) expression. The relationship between SARS-CoV-2 viral load and expression of ISGs is decoupled in patients with COVID-19 ARDS when compared to patients with mild COVID-19. …”
Publicado 2021
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29485por Marcheteau, Elie, Farge, Thomas, Pérès, Michaël, Labrousse, Guillaume, Tenet, Julie, Delmas, Stéphanie, Chusseau, Maud, Duprez-Paumier, Raphaëlle, Franchet, Camille, Dalenc, Florence, Imbert, Caroline, Noujarède, Justine, Colacios, Céline, Prats, Hervé, Cabon, Florence, Ségui, Bruno“…In contrast, in tumors expressing low levels of TSP1, gene signatures of interferon gamma (IFN-γ) signaling and lymphocyte activation were enriched. …”
Publicado 2021
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29486por Oya, Kazumasa, Nakamura, Yoshiyuki, Zhenjie, Zhu, Tanaka, Ryota, Okiyama, Naoko, Ichimura, Yuki, Ishitsuka, Yosuke, Saito, Akimasa, Kubota, Noriko, Watanabe, Rei, Tahara, Hideaki, Fujimoto, Manabu, Fujisawa, Yasuhiro“…Topical IMQ significantly suppressed the tumor growth of MC38 in wildtype mice. IMQ upregulated interferon γ (IFN-γ) expression in CD8(+) T cells in both the lymph nodes and the tumor, and the antitumor effect was abolished in both Rag1-deficient mice and IFN-γ-deficient mice, indicating that IFN-γ produced by CD8(+) T cells play a crucial role in the IMQ-induced antitumor effect. …”
Publicado 2021
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29487por Liu, Pei-Feng, Shu, Chih-Wen, Lee, Cheng-Hsin, Sie, Huei-Cin, Liou, Huei-Han, Cheng, Jiin-Tsuey, Ger, Luo-Ping, Chen, Chun-Lin, Chen, Chien-Chou, Chen, Chun-Feng“…ABSTRACT: Guanylate binding protein 5 (GBP5) is the interferon (IFN)-inducible subfamily of guanosine triphosphatases (GTPases) and is involved in pathogen defense. …”
Publicado 2021
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29488por Lee, Jae-Hee, Lee, Dae-Young, Lee, Hyo-Jung, Im, Eunji, Sim, Deok-Yong, Park, Ji-Eon, Park, Woon-Yi, Shim, Bum-Sang, Kim, Sung-Hoon“…Furthermore, CK effectively abrogated the expression of p-STAT3 and PD-L1 in interferon-gamma (INF-γ)-stimulated DU145cells. Additionally, CK suppressed the expression of vascular endothelial growth factor (VEGF), transforming growth factor-β (TGF-β), interleukin 6 (IL-6) and interleukin 10 (IL-10) as immune escape-related genes in DU145 cells. …”
Publicado 2021
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29489“…In addition, saponarin (100 μM) significantly inhibited the expression of macrophage-derived chemokine, thymus and activation-regulated chemokine, IL-33, thymic stromal lymphopoietin, and the phosphorylation of signaling molecules (ERK, p38 and signal transducer and activator of transcription 1 [STAT1]) in TNF-α- and interferon (IFN)-γ-stimulated HaCaT (human immortalized keratinocyte) cells. …”
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29490por Gadani, Sachin P., Reyes-Mantilla, Maria, Jank, Larissa, Harris, Samantha, Douglas, Morgan, Smith, Matthew D., Calabresi, Peter A., Mowry, Ellen M., Fitzgerald, Kathryn C., Bhargava, Pavan“…We also measured T cell responses using FluoroSpot assay for interferon gamma (IFN-γ) (Mabtech, Sweden) using cryopreserved rested PBMCs and then incubated in cRPMI with 1μg/ml of pooled peptides spanning the entire spike glycoprotein (Genscript, 2 pools; 158 peptides each). …”
Publicado 2021
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29491“…Here we demonstrate that the prototypical Smac mimetic BV6 cooperates with the stimulator of interferon (IFN) genes (STING) ligand 2′,3′-cyclic guanosine monophosphate–adenosine monophosphate (2′3′-cGAMP) to trigger necroptosis in apoptosis-deficient PC cells. …”
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29492por Dhakal, Santosh, Ruiz-Bedoya, Camilo A., Zhou, Ruifeng, Creisher, Patrick S., Villano, Jason S., Littlefield, Kirsten, Ruelas Castillo, Jennie, Marinho, Paula, Jedlicka, Anne E., Ordonez, Alvaro A., Bahr, Melissa, Majewska, Natalia, Betenbaugh, Michael J., Flavahan, Kelly, Mueller, Alice R. L., Looney, Monika M., Quijada, Darla, Mota, Filipa, Beck, Sarah E., Brockhurst, Jacqueline, Braxton, Alicia M., Castell, Natalie, Stover, Mitchel, D’Alessio, Franco R., Metcalf Pate, Kelly A., Karakousis, Petros C., Mankowski, Joseph L., Pekosz, Andrew, Jain, Sanjay K., Klein, Sabra L.“…Virus titers in respiratory tissues, including nasal turbinates, trachea, and lungs, and pulmonary cytokine concentrations, including interferon-β (IFN-β) and tumor necrosis factor-α (TNF-α), were comparable between the sexes. …”
Publicado 2021
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29493por Zheng, Hong-Yi, He, Xiao-Yan, Li, Wei, Song, Tian-Zhang, Han, Jian-Bao, Yang, Xiang, Liu, Feng-Liang, Luo, Rong-Hua, Tian, Ren-Rong, Feng, Xiao-Li, Ma, Yu-Hua, Liu, Chao, Li, Ming-Hua, Zheng, Yong-Tang“…Quantitative analysis of multiplex immunofluorescence staining images of formalin-fixed paraffin-embedded (FFPE) sections showed that SARS-CoV-2 infection specifically induced elevated levels of apoptosis, autophagy, and nuclear factor kappa-B (NF-κB) activation of angiotensin-converting enzyme 2 (ACE2)+ cells, and increased interferon α (IFN-α)- and interleukin 6 (IL-6)-secreting cells and C-X-C motif chemokine receptor 3 (CXCR3)+ cells in lung tissue of old RMs. …”
Publicado 2021
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29494por Slavik, Kailey M., Morehouse, Benjamin R., Ragucci, Adelyn E., Zhou, Wen, Ai, Xianlong, Chen, Yuqiang, Li, Lihua, Wei, Ziming, Bähre, Heike, König, Martin, Seifert, Roland, Lee, Amy S. Y., Cai, Hua, Imler, Jean-Luc, Kranzusch, Philip J.“…A crystal structure of Drosophila stimulator of interferon genes (dSTING) in complex with 3′2′-cGAMP explains selective isomer recognition, and 3′2′-cGAMP induces an enhanced antiviral state in vivo that protects from viral infection. …”
Publicado 2021
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29495por Zhang, Yue Yue, Gu, Li Jie, Zhu, Nan, Wang, Ling, Cai, Min Chao, Jia, Jie Shuang, Rong, Shu, Yuan, Wei Jie“…However, inflammatory cytokines, such as interleukin (IL)-6, tumor necrosis factor (TNF)-α, interferon (INF)-γ and lipopolysaccharides upregulated CAPN6 expression, inhibited L6 myoblast autophagy and stabilized mTOR activity. …”
Publicado 2021
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29496por Krämer, Benjamin, Knoll, Rainer, Bonaguro, Lorenzo, ToVinh, Michael, Raabe, Jan, Astaburuaga-García, Rosario, Schulte-Schrepping, Jonas, Kaiser, Kim Melanie, Rieke, Gereon J., Bischoff, Jenny, Monin, Malte B., Hoffmeister, Christoph, Schlabe, Stefan, De Domenico, Elena, Reusch, Nico, Händler, Kristian, Reynolds, Gary, Blüthgen, Nils, Hack, Gudrun, Finnemann, Claudia, Nischalke, Hans D., Strassburg, Christian P., Stephenson, Emily, Su, Yapeng, Gardner, Louis, Yuan, Dan, Chen, Daniel, Goldman, Jason, Rosenstiel, Philipp, Schmidt, Susanne V., Latz, Eicke, Hrusovsky, Kevin, Ball, Andrew J., Johnson, Joe M., Koenig, Paul-Albert, Schmidt, Florian I., Haniffa, Muzlifah, Heath, James R., Kümmerer, Beate M., Keitel, Verena, Jensen, Björn, Stubbemann, Paula, Kurth, Florian, Sander, Leif E., Sawitzki, Birgit, Aschenbrenner, Anna C., Schultze, Joachim L., Nattermann, Jacob“…Here, we performed a detailed characterization of natural killer (NK) cells in 205 patients (403 samples; days 2 to 41 after symptom onset) from four independent cohorts using single-cell transcriptomics and proteomics together with functional studies. We found elevated interferon (IFN)-α plasma levels in early severe COVD-19 alongside increased NK cell expression of IFN-stimulated genes (ISGs) and genes involved in IFN-α signaling, while upregulation of tumor necrosis factor (TNF)-induced genes was observed in moderate diseases. …”
Publicado 2021
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29497por Langer, Kailey, Cohen, Ronald A., Porges, Eric C., Williamson, John B., Woods, Adam J.“…Blood data were collected to quantify 12 cytokines: interleukins (IL-) 2, 5, 6, 7, 8, 10, 12, 13, IL-1 β, tumor necrosis factor α (TNF-α), interferon γ (IFN-γ), and IL-17 α. Correlation analyses were performed to assess age relationships between each of these factors. …”
Publicado 2021
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29498por Brochado-Kith, Óscar, Martínez, Isidoro, Berenguer, Juan, González-García, Juan, Salgüero, Sergio, Sepúlveda-Crespo, Daniel, Díez, Cristina, Hontañón, Víctor, Ibañez-Samaniego, Luis, Pérez-Latorre, Leire, Fernández-Rodríguez, Amanda, Ángeles Jiménez-Sousa, María, Resino, Salvador“…We also found two upregulated (HAS1 and IRG1) and 15 downregulated (CXCL11, CCL8, CCL7, CCL2, ADARB2, RRAD, MX1, SIGLEC1, IFI44L, IFI44, IFI27, IFI6, IFIT3, IFIT1B, and IFIT1) genes at the end of follow-up, all interferon-stimulated genes (ISGs) grouped into four pathways (“cytokine-cytokine receptor interaction”, “viral protein interaction with cytokine and cytokine receptor”, “chemokine signaling pathway”, and “hepatitis C”). …”
Publicado 2021
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29499por Zhang, Tong, Wang, Yue, Chen, Yangyang, Jin, Shuo, Gao, Ying, Zhang, Dan, Wu, Yonghui“…Functional network analysis indicated GOLPH3 regulated T-cell receptor signaling pathway and interferon signaling pathway with kinase and transcription factor targets. …”
Publicado 2021
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29500por Wang, Yongqi, Wang, Xiaoqing, Zhang, Hong, Han, Biao, Ye, Yuanmei, Zhang, Mengjie, Wang, Yingbin, Xue, Jianjun, Wang, Chun’ai“…The current study sets out to investigate the molecular mechanism of transforming growth factor-β (TGFβ1) in the regulation of M1 alveolar macrophage polarization in ALI by modulating DNA methyltransferase 1 (DNMT1), along with the microRNA (miR)-124/Pellino 1 (PELI1)/interferon regulatory factor 5 (IRF5) axis. METHODS: First, ALI mouse models were established, and the proportion of M1 and M2 macrophages in mouse lung tissues was detected using flow cytometry. …”
Publicado 2021
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