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29501por Wang, Qi, Liu, Liang, Cao, Jiangang, Abula, Muhetidier, Yimingjiang, Yasen, Feng, Shiqing“…Furthermore, C-X-C motif chemokine ligand 10 (CXCL10), myxovirus (influenza virus) resistance 1 (MX1), signal transducer and activator of transcription 1 (STAT1), interferon regulatory factor 7 (IRF7) and radical S-adenosyl methionine domain containing 2 (RSAD2) were identified as the hub genes in the PPI and Venn diagram network, and verified by qRT-PCR. …”
Publicado 2021
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29502por Calvo-Barreiro, Laura, Eixarch, Herena, Cornejo, Thais, Costa, Carme, Castillo, Mireia, Mestre, Leyre, Guaza, Carmen, Martínez-Cuesta, María del Carmen, Tanoue, Takeshi, Honda, Kenya, González-López, Juan José, Montalban, Xavier, Espejo, Carmen“…Transcriptome studies also highlighted increased antiinflammatory responses related to interferon beta in the periphery and lower immune responses in the CNS. …”
Publicado 2021
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29503por Maletzko, Antonia, Key, Jana, Wittig, Ilka, Gispert, Suzana, Koepf, Gabriele, Canet-Pons, Júlia, Torres-Odio, Sylvia, West, A. Phillip, Auburger, Georg“…Elevated expression was observed not only for the transcription factors Stat1/2, but also for two interferon-stimulated genes (Ifi44, Gbp3). Inflammatory responses were strongest for the RLR pattern recognition receptors (Ddx58, Ifih1, Oasl2, Trim25) and several cytosolic nucleic acid sensors (Ifit1, Ifit3, Oas1b, Ifi204, Mnda). …”
Publicado 2021
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29504por Dong, Chuanpeng, Cesarano, Annamaria, Bombaci, Giuseppe, Reiter, Jill L., Yu, Christina Y., Wang, Yue, Jiang, Zhaoyang, Zaid, Mohammad Abu, Huang, Kun, Lu, Xiongbin, Walker, Brian A., Perna, Fabiana, Liu, Yunlong“…Further analyses revealed that poor outcome in MM patients with high IR-neoAg load was associated with high expression levels of T-cell co-inhibitory molecules and elevated interferon signaling activity. We also found that MM cells exhibiting high IR levels had lower MHC-II protein abundance and treatment of MM cells with a spliceosome inhibitor resulted in increased MHC-I protein abundance. …”
Publicado 2021
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29505por Simon, David, Tascilar, Koray, Schmidt, Katja, Manger, Bernhard, Weckwerth, Leonie, Sokolova, Maria, Bucci, Laura, Fagni, Filippo, Manger, Karin, Schuch, Florian, Ronneberger, Monika, Hueber, Axel, Steffen, Ulrike, Mielenz, Dirk, Herrmann, Martin, Harrer, Thomas, Kleyer, Arnd, Krönke, Gerhard, Schett, Georg“…METHODS: Antibody responses (tested using enzyme‐linked immunosorbent assay) and T cell responses (tested using interferon‐γ enzyme‐linked immunospot assay) against the SARS–CoV‐2 spike S1 and nucleocapsid proteins were assessed in a limited number of previously infected (n = 6) and vaccinated (n = 8) autoimmune disease patients with B cell depletion, as well as previously infected (n = 30) and vaccinated (n = 30) healthy controls. …”
Publicado 2021
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29506por Li, Hua, Chen, Xinping, Zhu, Yaoyao, Liu, Rongrong, Zheng, Linlin, Shan, Shijuan, Zhang, Fumiao, An, Liguo, Yang, Guiwen“…BACKGROUND: Interferon regulatory factor 2 (IRF2) is an important transcription factor, which can regulate the IFN response and plays a role in antiviral innate immunity in teleost. …”
Publicado 2021
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29507por Khadka, Sudip, Williams, Caroline G., Sweeney-Gibbons, Joyce, Basler, Christopher F.“…In addition, the parental NP 3′ UTR, but not the edited or deletion mutant NP 3′ UTRs, induces a type I interferon (IFN) response upon transfection into cells. …”
Publicado 2021
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29508“…Similar to ICP22-null virus, the KOS-ICP22Δ40 mutant virus increased CD80 expression in dendritic cells (DCs) and interferon gamma (IFN-γ) expression in CD8(+) T cells but not CD4(+) T cells in infected mouse corneas. …”
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29509“…As a part of the cellular antiviral defense strategy, PML NB components are crucial restriction factors for many viruses and a mutual positive correlation has been found to exist between PML NBs and the interferon response. Viruses, in turn, have developed counterstrategies for disarming PML NB associated immune defense measures. …”
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29510por Sjöwall, Johanna, Azharuddin, Mohammad, Frodlund, Martina, Zhang, Yuming, Sandner, Laura, Dahle, Charlotte, Hinkula, Jorma, Sjöwall, Christopher“…Similarly to SLE, severe SARS-CoV-2 infection includes risks for thromboembolism, an unbalanced type I interferon response, and complement activation. Herein, SARS-CoV-2 antibodies in longitudinal samples collected prior to vaccination were analyzed and compared with SLE progression and antinuclear antibody (ANA) levels. …”
Publicado 2021
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29511por Shi, Qin, Li, Tongqiang, Huang, Songjiang, Bai, Yaowei, Wang, Yingliang, Liu, Jiacheng, Zhou, Chen, Chen, Yang, Xiong, Bin“…In addition, immune modulatory cytokines included interleukin (IL)-6, tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and biochemical hepatorenal function were measured. …”
Publicado 2021
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29512por Yamaguchi, Akihiro, Teratani, Toshiaki, Chu, Po‐sung, Suzuki, Takahiro, Taniki, Nobuhito, Mikami, Yohei, Shiba, Shunsuke, Morikawa, Rei, Amiya, Takeru, Aoki, Ryo, Kanai, Takanori, Nakamoto, Nobuhiro“…Twelve hours after ConA administration, inulin‐supplemented diet‐fed mice demonstrated significantly alleviated hepatic damage histologically and serologically, with down‐regulation of hepatic interferon‐γ and tumor necrosis factor and reduced myeloperoxidase (MPO)‐producing neutrophil infiltration. …”
Publicado 2021
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29513“…In addition, in vitro experiments showed that hsa_circ_0002202 inhibition suppressed the type I interferon (IFN-I)-induced macrophage inflammation. …”
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29514por Sun, Shulan, Zhou, Wei, Li, Xiaoxi, Peng, Fei, Yan, Min, Zhan, Yajing, An, Fan, Li, Xiaoyan, Liu, Yunyong, Liu, Quentin, Piao, Haozhe“…PD‐L1 overexpression mostly reversed AURKA silencing‐induced expression of immune effector molecules, including interleukin‐ (IL‐2), interferon‐γ (IFN‐γ), and perforin. Moreover, AURKA expression was negatively correlated with the enrichment and activity of tumor‐infiltrating CD8(+) T cells in 4T1 engrafted BALB/c mouse model. …”
Publicado 2021
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29515por Cruciani, Carolina, Puthenparampil, Marco, Tomas-Ojer, Paula, Jelcic, Ivan, Docampo, Maria Jose, Planas, Raquel, Manogaran, Praveena, Opfer, Roland, Wicki, Carla, Reindl, Markus, Jelcic, Ilijas, Lutterotti, Andreas, Martin, Roland, Sospedra, Mireia“…METHODS: The proliferative response and interferon gamma (IFN-γ) release of CSF-infiltrating CD4(+) T cells from patients with MS against several autoantigens was used to identify patients with different intrathecal T-cell specificities. …”
Publicado 2021
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29516“…CD8+ T cells recognize non-self antigen by MHC class I molecules and kill the target cells by the release of proinflammatory cytokines such as interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α). …”
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29517por Young, Kate, Lawlor, Rita T, Ragulan, Chanthirika, Patil, Yatish, Mafficini, Andrea, Bersani, Samantha, Antonello, Davide, Mansfield, David, Cingarlini, Sara, Landoni, Luca, Pea, Antonio, Luchini, Claudio, Piredda, Liliana, Kannan, Nagarajan, Nyamundanda, Gift, Morganstein, Daniel, Chau, Ian, Wiedenmann, Bertram, Milella, Michele, Melcher, Alan, Cunningham, David, Starling, Naureen, Scarpa, Aldo, Sadanandam, Anguraj“…The MLP-1 subtype (26%–31% samples across three cohorts) was strongly associated with elevated levels of immune-related genes, poor prognosis and a cascade of tumour evolutionary events: larger hypoxic and necroptotic tumours leading to increased damage-associated molecular patterns (viral mimicry), stimulator of interferon gene pathway, T cell-inflamed genes, immune checkpoint targets, and T cell-mediated and M1 macrophage-mediated immune escape mechanisms. …”
Publicado 2021
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29518por Martínez-Gallo, Mónica, Esperalba, Juliana, Pujol-Borrell, Ricardo, Sandá, Víctor, Arrese-Muñoz, Iria, Fernández-Naval, Candela, Antón, Andrés, Cardona, Victoria, Labrador-Horrillo, Moisés, Pumarola, Tomás, Hernandéz-González, Manuel“…Antibody test to SARS-CoV-2 N and S-proteins in parallel with a commercially available whole-blood-interferon-gamma-release-assay (IGRA) to S-peptides and two detection methods, CLIA and ELISA were determined. …”
Publicado 2022
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29519por Pralle, Ryan S., Li, Wenli, Murphy, Brianna N., Holdorf, Henry T., White, Heather M.“…The inferred metabolism of differentially expressed genes suggested a role of immune response (i.e., interferon-inducible proteins and major histocompatibility complex molecules). …”
Publicado 2021
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29520por Long, Shenfei, Ma, Jiayu, Piao, Xiangshu, Li, Yuxin, Rasmussen, Simone Husballe, Liu, Li“…These pigs had increased (p < 0.05) contents of glutathione peroxidase, catalase, superoxide dismutase, IgG, interleukin-10, and ferric reducing ability of plasma, as well as decreased (p < 0.05) malondialdehyde, IL-6, IL-1β, tumor necrosis factor (TNF-α), interferon-γ, thiobarbituric acid-reactive substances, and diamine oxidase level in serum and TNF-α level in the jejunal mucosa. …”
Publicado 2021
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