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29521por Yu, Wenqing, Ji, Ningfei, Gu, Chengjing, Yao, Juan, Ding, Mingdong, Zhou, Daming, Huang, Mao, Zhang, Mingshun“…METHODS: The percentage of CD4(+)CD25(+)Foxp3(+)Helios(+) and RORγt(+)Foxp3(+) Tregs from peripheral blood and pleural effusion mononuclear cells were measured. The level of interferon regulatory factor 4 (IRF4) mRNA expression was detected by quantitative real-time reverse transcription polymerase chain reaction. …”
Publicado 2021
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29522por Sato, Shunsuke, Tsuzura, Hironori, Kita, Yuji, Ikeda, Yuji, Kabemura, Daishi, Sato, Sho, Amano, Nozomi, Yatagai, Noboru, Murata, Ayato, Shimada, Yuji, Genda, Takuya“…METHODS AND RESULTS: We examined the association between WFA(+)‐M2BP and HCC development in 522 HCV patients who achieved an SVR (Interferon [IFN]‐based therapy, n = 228; IFN‐free therapy, n = 294). …”
Publicado 2021
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29523por Sima, Livia Elena, Chen, Siqi, Cardenas, Horacio, Zhao, Guangyuan, Wang, Yinu, Ivan, Cristina, Huang, Hao, Zhang, Bin, Matei, Daniela“…In response to the more robust immune response caused by loss of TG2, cancer cells growing intraperitoneally exhibited an interferon-γ (IFN-γ) responsive gene signature and underwent apoptosis. …”
Publicado 2021
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29524por Niedziela, Dagmara A., Naranjo-Lucena, Amalia, Molina-Hernández, Verónica, Browne, John A., Martínez-Moreno, Álvaro, Pérez, José, MacHugh, David E., Mulcahy, Grace“…Significantly overrepresented biological pathways at 2 wpi included role of PKR in interferon induction and anti-viral response, death receptor signalling and RIG-I-like receptor signalling, which suggested that an activation of innate response to intracellular nucleic acids and inhibition of cellular apoptosis were taking place. …”
Publicado 2021
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29525“…The following parameters were assessed: catalase (CAT), glutathione peroxidase (GSHpx) and superoxide dismutase (SOD) activities, plasma fluoride, serum interferon gamma (IFN-γ), serum interleukin 2 (IL2), serum interleukin 4 (IL4) and plasma thiobarbituric acid reactive substances (TBARS). …”
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29526por Yang, Jinyoung, Ko, Jae-Hoon, Baek, Jin Yang, Hong, Jinyeong, Ha, Soyoung, Lee, Beomki, Huh, Kyungmin, Cho, Sun Young, Kang, Cheol-In, Chung, Doo Ryeon, Kim, Yae-Jean, Kang, Eun-Suk, Peck, Kyong Ran“…The immunogenicity was measured three weeks after vaccination using quantitative anti-SARS-CoV-2 spike protein (S) antibody electrochemiluminescence immunoassay and interferon gamma (IFN-γ) release assay. A total of 67 HCWs comprising 24 ChAd, 29 BNT, and 14 ChAdPd was included. …”
Publicado 2021
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29527por Attallah, Abdelfattah M., Omran, Dalia, Abdelrazek, Mohamed A., Hassany, Mohamed, Saif, Sameh, Farid, Aza, El Essawey, Riham, Ghaffar, Muhammad Abdel, Aabdelghany, Marwa, Yosry, Ayman“…RESULTS: Three hundred patients on anti-HCV treatments were equally categorized into patients treated with dual therapy (sofosbuvir/ribavirin) for 24 weeks, triple therapy (sofosbuvir/ribavirin+pegylated interferon-alpha) for 12 weeks, dual therapy plus oral zinc and with triple therapy plus oral zinc. …”
Publicado 2021
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29528“…BACKGROUND: DNA-sensing receptor cyclic GMP–AMP synthase (cGAS) and its downstream signaling effector stimulator of interferon genes (STING) present a novel role in anti-tumor immunity. …”
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29529“…Also, it reduced the levels of inflammation factors: tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin (IL)-1β, and IL-6. …”
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29530por Schiffner, Julia, Backhaus, Insa, Rimmele, Jens, Schulz, Sören, Möhlenkamp, Till, Klemens, Julia Maria, Zapf, Dorinja, Solbach, Werner, Mischnik, Alexander“…We conducted a prospective, cross-sectional analysis in COVID-19 recovered patients at various time points over a 10-month period in order to investigate how circulating antibody levels and interferon-gamma (IFN-γ) release by peripheral blood cells change over time following natural infection. …”
Publicado 2021
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29531por Zhang, Yan, Cheng, Bo, Wu, Zhong-Wei, Cui, Zong-Chao, Song, Yao-Dong, Chen, San-Yang, Liu, Yan-Na, Zhu, Chang-Ju“…The serum levels of sST2, C-reactive protein (CRP) and Th1- and Th2-related cytokines, including interferon (IFN)-γ, tumor necrosis factor (TNF)-α, IL-2, IL-4, IL-5 and IL-13, were measured by highly sensitive ELISA, and the severity of AP in patients was evaluated by the 2012 Atlanta Classification Criteria. …”
Publicado 2021
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29532por Gadani, Sachin P., Reyes-Mantilla, Maria, Jank, Larissa, Harris, Samantha, Douglas, Morgan, Smith, Matthew D., Calabresi, Peter A., Mowry, Ellen M., Fitzgerald, Kathryn C., Bhargava, Pavan“…We also measured T cell responses using FluoroSpot assay for interferon gamma (IFN-γ) (Mabtech, Sweden) using cryopreserved rested PBMCs and then incubated in cRPMI with 1µg/ml of pooled peptides spanning the entire spike glycoprotein (Genscript, 2 pools; 158 peptides each). …”
Publicado 2021
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29533“…RESULTS: The results indicated that SARS-CoV-2-related DEmRNAs were associated with the interferon signaling pathway and other antiviral processes, such as IFNL3, IFNL1 and CH25H. …”
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29534por Park, Hyung Soon, Kim, Yoo Min, Kim, Sewha, Lee, Won Suk, Kong, So Jung, Yang, Hannah, Kang, Beodeul, Cheon, Jaekyung, Shin, Su-Jin, Kim, Chan, Chon, Hong Jae“…In addition, HEV-high GC demonstrated increased immune-modulating chemokines, type I or II interferon pathway, and immune checkpoints, all of which indicate the inflamed tumor microenvironment (TME). …”
Publicado 2021
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29535por Leb-Reichl, Victoria M, Kienzl, Melanie, Kaufmann, Anna, Stoecklinger, Angelika, Tockner, Birgit, Kitzmueller, Sophie, Zaborsky, Nadja, Steiner, Markus, Brachtl, Gabriele, Trattner, Lisa, Kreideweiss, Patrick, Reinsch, Christian, Panzner, Steffen, Greil, Richard, Strunk, Dirk, Bauer, Johann W, Gratz, Iris K, Guttmann-Gruber, Christina, Piñón Hofbauer, Josefina“…Vaccination generated MeV cytotoxic T lymphocyte (CTL) immunity in mice as demonstrated by enhanced interferon gamma production, antigen-specific T cell proliferation, and CTL-mediated specific killing of antigen-pulsed target cells. …”
Publicado 2021
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29536por Cheng, Chun-Chia, Chang, Yi-Fang, Ho, Ai-Sheng, Sie, Zong-Lin, Chang, Jung-Shan, Peng, Cheng-Liang, Chang, Chun-Chao“…Irradiation-broken DNA fragments increase type I interferon and chemokines secretion in tumor cells. …”
Publicado 2021
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29537por Liang, Frank, Rezapour, Azar, Szeponik, Louis, Alsén, Samuel, Wettergren, Yvonne, Bexe Lindskog, Elinor, Quiding-Järbrink, Marianne, Yrlid, Ulf“…Our attempt to model CRC treatment-induced T cell activation in vitro showed less interferon (IFN)-γ production by TILs than colonic T cells. …”
Publicado 2021
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29538por Anderson, Erik W, Fishbein, Joanna, Hong, Joseph, Roeser, Julien, Furie, Richard A, Aranow, Cynthia, Volpe, Bruce T, Diamond, Betty, Mackay, Meggan“…OBJECTIVES: Interferon-alpha, an important contributor to SLE pathogenesis, induces the enzyme indoleamine 2,3-dioxygenase in the kynurenine/tryptophan (KYN/TRP) pathway. …”
Publicado 2021
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29539por Tilston-Lunel, Natasha L., Welch, Stephen R., Nambulli, Sham, de Vries, Rory D., Ho, Gregory W., Wentworth, David E., Shabman, Reed, Nichol, Stuart T., Spiropoulou, Christina F., de Swart, Rik L., Rennick, Linda J., Duprex, W. Paul“…Defective interfering (DI) genomes restrict viral replication and induce type I interferon. Since DI genomes have been proposed as vaccine adjuvants or therapeutic antiviral agents, it is important to understand their generation, delineate their mechanism of action, develop robust production capacities, assess their safety and in vivo longevity, and determine their long-term effects. …”
Publicado 2021
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29540por Li, Jing, Cheng, Lisha, Jia, Haoyu, Liu, Chun, Wang, Siqi, Liu, Yun, Shen, Yue, Wu, Shengdi, Meng, Fanli, Zheng, Beishi, Yang, Changqing, Jiang, Wei“…Moreover, CD161(+)CD4(+) T cells as compared to homologous CD161(‐)CD4(+) T cells produced more pro‐inflammatory cytokines including interleukin (IL)‐17 and interferon (IFN)‐γ and expressed higher levels of liver‐homing chemokine receptors including CCR6, CXCR6 and CX3CR1. …”
Publicado 2021
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