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29561por Gnanagobal, Hajarooba, Cao, Trung, Hossain, Ahmed, Dang, My, Hall, Jennifer R., Kumar, Surendra, Van Cuong, Doan, Boyce, Danny, Santander, Javier“…Cytokines (il1β, il8a, il8b), pattern recognition receptors (tlr5a), interferon-induced effectors (rsad2, mxa, mxb, mxc), and iron regulation (hamp) and acute phase reactant (saa5) related genes were up-regulated at 28 dpi. …”
Publicado 2021
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29562por Li, Tian-Hao, Zhao, Bang-Bo, Qin, Cheng, Wang, Yuan-Yang, Li, Ze-Ru, Cao, Hong-Tao, Yang, Xiao-Ying, Zhou, Xing-Tong, Wang, Wei-Bin“…ABSTRACT: OBJECTIVES: Previously, Interferon-induced Protein with Tetratricopeptide Repeats 1 (IFIT1) has been shown to promote cancer development. …”
Publicado 2021
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29563por Wang, Yining, Li, Pengfei, Rajpoot, Sajjan, Saqib, Uzma, Yu, Peifa, Li, Yunlong, Li, Yang, Ma, Zhongren, Baig, Mirza S., Pan, Qiuwei“…Furthermore, combining favipiravir or remdesivir with the clinically used antiviral cytokine interferon-alpha resulted in synergistic effects. These findings provided a proof-of-concept that anti-SARS-CoV-2 drugs, in particular remdesivir, have the potential to be repurposed for treating HCoV-NL63 infection.…”
Publicado 2021
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29564por Li, Jie, Chen, Xiao-Ming, Zhou, Chun-Ze, Fang, Wei-Wei, Lv, Wei-Fu, Cheng, De-Lei“…The mRNA and protein levels of TLR4, NF-κB, tumor necrosis factor (TNF)-α, interleukin (IL)-2 and interferon (IFN)-γ were quantified. In addition, 60 patients with BCS and 30 healthy controls were enrolled, and their blood samples were analyzed. …”
Publicado 2021
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29565“…The TFAM-repressed genes were strongly enriched in cytokine-mediated signaling pathway, type I interferon- and INF-γ-mediated signaling pathways, and viral response pathways. …”
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29566por Narsinh, Kazim H., Narsinh, Kamileh, McCoy, David B., Sun, Zhengda, Halabi, Cathra, Meisel, Karl, Tihan, Tarik, Chaganti, Krishna, Amans, Matthew R., Halbach, Van V., Higashida, Randall T., Hetts, Steven W., Dowd, Christopher F., Winkler, Ethan A., Abla, Adib A., Nowakowski, Tomasz J., Cooke, Daniel L.“…A gene set enrichment analysis identified these ECs to have increased the expression of genes regulating the leukocyte-endothelial cell adhesion, major histocompatibility complex (MHC) class I, T cell receptor recycling, tumor necrosis factor alpha (TNFα) response, and interferon gamma signaling. A histopathologic analysis of a different intracranial aneurysm that was later resected yielded a diagnosis of polyarteritis nodosa and positive staining for TNFα. …”
Publicado 2021
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29567por Tleyjeh, Imad M., Saddik, Basema, AlSwaidan, Nourah, AlAnazi, Ahmed, Ramakrishnan, Rakhee K., Alhazmi, Deema, Aloufi, Ahmad, AlSumait, Fahad, Berbari, Elie, Halwani, Rabih“…Patients who were treated with interferon β-1b based triple antiviral therapy during hospital stay were less likely to experience new or persistent symptoms and more likely to return to their baseline health. …”
Publicado 2021
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29568“…Our results found that compared with PbANKA-infected mice (malarial mice), blockage of galectin-receptor interactions led to decreased host survival rate and increased peripheral blood parasitemia; exacerbated liver pathology, increased numbers of CD68(+) macrophages and apoptotic cells, and increased parasite burden in the livers on days 5 and 7 post infection (p.i.) as well as increased mRNA expression levels of galectin-9 (Gal-9) and its receptor, the T cell immunoglobulin domain and mucin domain protein 3 (Tim-3), interferon (IFN)α, IFNγ, and the triggering receptor expressed on myeloid cells (TREM)-1 in the livers or spleens of PbANKA-infected mice on day 7 p.i. …”
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29569por Gurevich, Michael, Zilkha-Falb, Rina, Sonis, Polina, Magalashvili, David, Menascu, Shay, Flechter, Shlomo, Dolev, Mark, Mandel, Mathilda, Achiron, Anat“…SARS-CoV-2 anti-spike IgG was determined by ELISA, MBC by SARS-CoV-2-specific receptor binding domain (RBD) ELISpot, and interferon gamma (IFN-γ)-, interleukin 2 (IL2)-, and IFN-γ+IL2-secreting MTC by IFN-γ and IL2 SARS-CoV-2 FluoroSpot. …”
Publicado 2022
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29570por Uraki, Ryuta, Imai, Masaki, Ito, Mutsumi, Shime, Hiroaki, Odanaka, Mizuyu, Okuda, Moe, Kawaoka, Yoshihiro, Yamazaki, Sayuri“…Moreover, we observed S1-specific CD4(+) T cells and CD8(+) T cells with interferon-γ production. Thus, captured S1 was successfully presented by DCs, including cross-presentation to CD8(+) T cells. …”
Publicado 2021
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29571por Li, Jiang, Liang, Xi, Jiang, Jing, Yang, Lingling, Xin, Jiaojiao, Shi, Dongyan, Lu, Yingyan, Li, Jun, Ren, Keke, Hassan, Hozeifa Mohamed, Zhang, Jianing, Chen, Pengcheng, Yao, Heng, Li, Jiaqi, Wu, Tianzhou, Jin, Linfeng, Ye, Ping, Li, Tan, Zhang, Huafen, Sun, Suwan, Guo, Beibei, Zhou, Xingping, Cai, Qun, Chen, Jiaxian, Xu, Xiaowei, Huang, Jianrong, Hao, Shaorui, He, Jinqiu, Xin, Shaojie, Wang, Di, Trebicka, Jonel, Chen, Xin, Li, Jun“…The analysis of 62 overlapping DEGs further linked the HBV-based immune-metabolism disorder to ACLF progression. The signatures of interferon-related, neutrophil-related and monocyte-related pathways related to the innate immune response were significantly upregulated. …”
Publicado 2022
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29572por Ouellette, Scot P., Hatch, Nathan D., Wood, Nicholas A., Herrera, Andrea L., Chaussee, Michael S.“…In the course of a natural immune response, both pathogens can be exposed to Trp-limiting conditions through the action of the interferon gamma-inducible IDO1 enzyme, which catabolizes Trp to N-formylkynurenine. …”
Publicado 2021
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29573por van Buuren, Nicholas, Ramirez, Ricardo, Turner, Scott, Chen, Diana, Suri, Vithika, Aggarwal, Abhishek, Moon, Christina, Kim, Sam, Kornyeyev, Dmytro, Bui, Nam, Bhardwaj, Neeru, Chan, Henry LY, Marcellin, Patrick, Buti, Maria, Wallin, Jeffrey, Gaggar, Anuj, Fletcher, Simon P., Diehl, Lauri, Li, Li, Mo, Hongmei, Feierbach, Becket“…Immune high patients showed elevated immune pathways, including interferon signaling pathways, and increase presence of immune cells. …”
Publicado 2021
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29574por Winkler, Aaron, Sun, Weiyong, De, Saurav, Jiao, Aiping, Sharif, M. Nusrat, Symanowicz, Peter T., Athale, Shruti, Shin, Julia H., Wang, Ju, Jacobson, Bruce A., Ramsey, Simeon J., Dower, Ken, Andreyeva, Tatyana, Liu, Heng, Hegen, Martin, Homer, Bruce L., Brodfuehrer, Joanne, Tilley, Mera, Gilbert, Steven A., Danto, Spencer I., Beebe, Jean J., Barnes, Betsy J., Pascual, Virginia, Lin, Lih‐Ling, Kilty, Iain, Fleming, Margaret, Rao, Vikram R.“…In a phase I clinical trial (NCT02485769), PF‐06650833 demonstrated in vivo pharmacologic action pertinent to SLE by reducing whole blood interferon gene signature expression in healthy volunteers. …”
Publicado 2021
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29575por Norheim, Katrine Brække, Imgenberg-Kreuz, Juliana, Alexsson, Andrei, Johnsen, Svein Joar Auglænd, Bårdsen, Kjetil, Brun, Johan Gorgas, Dehkordi, Rezvan Kiani, Theander, Elke, Mandl, Thomas, Jonsson, Roland, Ng, Wan-Fai, Lessard, Christopher J, Rasmussen, Astrid, Sivilis, Kathy, Ronnblom, Lars, Omdal, Roald“…RTP4 expression in pSS B cells was upregulated and positively correlated with the type I interferon score. Expression quantitative trait loci effects in whole blood for fatigue-associated variants at RTP4/MASP1 and levels of RTP4 and MASP1 expression were identified. …”
Publicado 2021
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29576“…In addition, changes in the levels of NLRP3, caspase-1, and caspase-3 were assessed by immunohistochemistry, while the levels of interleukin 17 (IL-17), interferon gamma (IFN-γ), and transforming growth factor β1 (TGF-β1) in peripheral blood were tested by enzyme-linked immunosorbent assay (ELISA). …”
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29577por Liu, Tianyan, Zhang, Yu, Cao, Yukai, Jiang, Shan, Sun, Rui, Yin, Jiechao, Gao, Zhenqiu, Ren, Guiping, Wang, Zhenzhong, Yu, Qingzhong, Sui, Guangchao, Sun, Xu, Sun, Wenying, Xiao, Wei, Li, Deshan“…We found that the levels of alpha-sialic acid acyltransferase were upregulated in MDA-MB-231 cells compared with MCF7 cells, and the interferon was downregulated. Second, to optimize the oncolytic capacity of the wild-type rClone30, a series of chimeric viruses rClone30-Anh(HN), rClone30-Anh(F), and rClone30-Anh(HN-F) were constructed by exchanging the HN gene, F gene or both of non-lytic rClone30 strain with lytic strain Anhinga. rClone30-Anh(F) and rClone30-Anh(HN-F) enhanced the oncolytic effect of the rClone30, and this enhancement is more obvious in the susceptible cells. …”
Publicado 2020
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29578“…BACKGROUND: Stomach adenocarcinoma (STAD) is one of the most prevalent malignances, ranking fifth in incidence and third in mortality among all malignances. Interferon regulatory factors (IRFs) play a vital role in immune response and tumor cellular biological process. …”
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29579por Jakimovski, Dejan, Awan, Samreen, Eckert, Svetlana P., Farooq, Osman, Weinstock-Guttman, Bianca“…First-line therapies not approved by the FDA for use in children (interferon-β and glatiramer acetate) are also commonly used and result in a significant reduction in inflammatory activity when compared with non-treated POMS patients. …”
Publicado 2021
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29580por Cumbo, Cosimo, Tarantini, Francesco, Anelli, Luisa, Zagaria, Antonella, Redavid, Immacolata, Minervini, Crescenzio Francesco, Coccaro, Nicoletta, Tota, Giuseppina, Ricco, Alessandra, Parciante, Elisa, Conserva, Maria Rosa, Specchia, Giorgina, Musto, Pellegrino, Albano, Francesco“…Interferon regulatory factor 4 (IRF4) is involved in the pathogenesis of various hematologic malignancies. …”
Publicado 2021
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