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29581por Narayanaswamy, Vignesh, Pentecost, Brian, Alfandari, Dominique, Chin, Emily, Minor, Kathleen, Kastrinakis, Alyssa, Lieberman, Tanya, Arcaro, Kathleen F., Leftwich, Heidi“…All samples were tested for reactivity to the receptor binding domain (RBD) of the SARS-CoV-2 spike protein using an enzyme-linked immunosorbent assay that measures SARS-CoV-2 RBD-specific IgA, IgG, and IgM and for levels of 10 inflammatory cytokines (interferon-gamma [IFN-γ], tumor necrosis factor-alpha, interleukin [IL]-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13) using a multiplex electrochemiluminescent sandwich assay. …”
Publicado 2021
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29582por Zhang, Kailing, Lei, Na, Li, Meng, Li, Jijun, Li, Caijun, Shen, Yue, Guo, Peixin, Xiong, Lei, Xie, Yuhuan“…Expression levels of interleukin-6 (IL-6), interleukin-1beta (IL-1β), tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), interleukin-4 (IL-4), interleukin-10 (IL-10), kynurenine (KYN), quinolinic acid (QUIN), tryptophan (Trp), kynurenic acid (KYNA), serotonin (5-HT), and 5-hydroxyindole acetic acid (5-HIAA) in the prefrontal cortex of CUMS rats were determined by ELISA. …”
Publicado 2021
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29583por Aliaga-Gaspar, Pablo, Hurtado-Guerrero, Isaac, Ciano-Petersen, Nicolas Lundahl, Urbaneja, Patricia, Brichette-Mieg, Isabel, Reyes, Virginia, Rodriguez-Bada, Jose Luis, Alvarez-Lafuente, Roberto, Arroyo, Rafael, Quintana, Ester, Ramió-Torrentà, Lluis, Alonso, Ana, Leyva, Laura, Fernández, Oscar, Oliver-Martos, Begoña“…PURPOSE: Interferon beta receptor 2 subunit (IFNAR2) can be produced as a transmembrane protein, but also as a soluble form (sIFNAR2) generated by alternative splicing or proteolytic cleavage, which has both agonist and antagonist activities for IFN-β. …”
Publicado 2021
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29584por Liu, Yu-Chi, Setiawan, Melina, Chin, Jia Ying, Wu, Benjamin, Ong, Hon Shing, Lamoureux, Ecosse, Mehta, Jodhbir S.“…FLACS resulted in significantly higher aqueous PGE(2) (P < 0.01), interleukin (IL)-6 (P = 0.03), IL-8 (P = 0.03), and interferon (IFN)-γ (P = 0.04) concentrations and greater anterior chamber flare at 1 day (P = 0.02). …”
Publicado 2021
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29585por Bich, Tra Cao Thi, Quoc, Quang Luu, Choi, Youngwoo, Yang, Eun-Mi, Trinh, Hoang Kim Tu, Shin, Yoo Seob, Park, Hae-Sim“…In ovalbumin-induced asthma mice, Poly I-C treatment significantly increased SAA1 levels as well as IL-17A/interferon-gamma/IL-33 levels in bronchoalveolar lavage fluid (BALF), leading to airway hyperresponsiveness and inflammation. …”
Publicado 2021
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29586In vitro characterization of a small molecule PD-1 inhibitor that targets the PD-l/PD-L1 interactionpor Lu, Chih-Hao, Chung, Wei-Min, Tsai, Chun-Hao, Cheng, Ju-Chien, Hsu, Kai-Cheng, Tzeng, Huey-En“…Investigations into CH-4 analogs revealed that CH-4.7 effectively blocked the PD-1/sPD-L1 interaction, but sustained the secretion of interleukin-2 and interferon-γ by Jurkat cells. Our experiments revealed a novel small molecule inhibitor that blocks the interaction of PD-1/sPD-L1 and potentially offers an alternative PD-1 target for immune checkpoint therapy.…”
Publicado 2022
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29587por Fan, Linyuan, Liu, Zhaohui, Zhang, Zhan, Li, Ting, Li, Hua, Chen, Jing, Zong, Xiaonan, Zhang, Xu, Chen, Xi, Bai, Huihui, Wang, Fengjuan, Shang, Chenguang“…Infection-related factors in the blood were also significantly changed compared with the normal group, with obviously increased serum levels of C-reactive protein (CRP), interferon gamma (IFN-γ), and interleukin-4 (IL-4). …”
Publicado 2021
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29588por Wen, Hairuo, Huo, Guitao, Hou, Tiantian, Qu, Zhe, Sun, Juanjuan, Yu, Zhou, Kang, Liqing, Wang, Manhong, Lou, Xiaoyan, Yu, Lei, Huo, Yan“…Chimeric antigen receptor gene modified T cells (CAR-Ts) were detected in the peripheral blood with a significant increase in number beginning at approximately 3 weeks. ssCART-19 administration resulted in increased of interferon-gamma (IFN-γ), tumor necrosis factor (TNF), interleukin-2 (IL-2), and IL-17A and decreased IL-10 and IL-6 levels. ssCART-19 inhibited the proliferation of Raji-Luc cells in tumor-bearing NSG mice, and reduced the incidence of lymphomas in the liver, kidneys and spleen. …”
Publicado 2021
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29589por Kagoya, Ryoji, Toma-Hirano, Makiko, Yamagishi, Junya, Matsumoto, Naoyuki, Kondo, Kenji, Ito, Ken“…In addition, qPCR and ELISA revealed the elevated expression of interleukin-1 beta, interleukin-6, tumor necrosis factor-alpha, and interferon-gamma both in the OB and nasal tissue. CONCLUSIONS: Taken together, the decreased peripheral OSNs, OB microgliosis, and elevated proinflammatory cytokines suggest that immunological changes in the OB may be involved in the pathogenesis of PVOD.…”
Publicado 2022
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29590por Kim, Young-Il, Yu, Kwang-Min, Koh, June-Young, Kim, Eun-Ha, Kim, Se-Mi, Kim, Eun Ji, Casel, Mark Anthony B., Rollon, Rare, Jang, Seung-Gyu, Song, Min-Suk, Park, Su-Jin, Jeong, Hye Won, Kim, Eung-Gook, Lee, Ok-Jun, Kim, Yong-Dae, Choi, Younho, Lee, Shin-Ae, Choi, Youn Jung, Park, Su-Hyung, Jung, Jae U., Choi, Young Ki“…Transcriptome analysis of aged ferret lungs reveals strong enrichment of gene sets related to type I interferon, activated T cells, and M1 macrophage responses, mimicking the gene expression profile of severe COVID-19 patients. …”
Publicado 2022
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29591por Mohsen, Mona O, Speiser, Daniel E, Michaux, Justine, Pak, HuiSong, Stevenson, Brian J, Vogel, Monique, Inchakalody, Varghese Philipose, de Brot, Simone, Dermime, Said, Coukos, Georges, Bassani-Sternberg, Michal, Bachmann, Martin F“…RESULTS: As compared with short peptides, vaccination with long peptides was superior in the generation of neoantigen-specific CD4(+) and CD8(+) T cells, which readily produced interferon gamma (IFN-γ) and tumor-necrosis factor α (TNF-α). …”
Publicado 2022
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29592por Shi, Yuequan, Liu, Xiaoyan, Du, Juan, Zhang, Dongming, Liu, Jia, Chen, Minjiang, Zhao, Jing, Zhong, Wei, Xu, Yan, Wang, Mengzhao“…On the contrary, increased on‐treatment interleukin‐6 (IL‐6) was associated with a worse response (OR 0.015, 95% CI: 0.001–0.400, p = 0.012), worse PFS (HR 2.639, 95% CI: 1.163–5.991, p = 0.020) and worse OS (HR 2.742, 95% CI: 1.063–7.074, p = 0.037). Increased interferon‐γ (IFN‐γ) was found to be associated with better PFS (HR 0.336, 95% CI: 0.153–0.745, p = 0.007). …”
Publicado 2021
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29593por Narayanaswamy, Vignesh, Pentecost, Brian T., Schoen, Corina N., Alfandari, Dominique, Schneider, Sallie S., Baker, Ryan, Arcaro, Kathleen F.“…The immune response in milk also included significant elevation of interferon-γ. The immune response to maternal vaccination was reflected in breastfed infants: anti-RBD IgG and anti-RBD IgA were detected in 33% and 30% of infant stool samples, respectively. …”
Publicado 2022
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29594“…The levels of cell-associated HIV RNA (CA-HIV-RNA), HIV DNA, and inflammatory cytokines (including interferon [IFN]-α, IFN-γ, tumor necrosis factor [TNF]-α, interleukin [IL]-2, IL-4, IL-6, IL-10, and IL-17A) were assessed at each timepoint. …”
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29595por Zhang, Liang, Yang, Zhentao, Zhang, Shiyu, Zhou, Ke, Zhang, Wu, Ling, Sunbin, Sun, Ruiqi, Tang, Hong, Wen, Xue, Feng, Xiaowen, Song, Penghong, Xu, Xiao, Xie, Haiyang, Zheng, Shusen“…These two groups differed in abundance of infiltrative CD8(+) cytotoxic T cells and FoxP3(+) Treg cells, and PD-L1 expression, as well as circulating granulocyte–macrophage colony-stimulating factor, interferon-γ and interleukin-10 levels. HMP–HCC constituted an independent recurrence predictor and could improve the discriminative efficacy of clinical prediction models (Milan criteria, AFP model, and Metroticket 2.0 criteria). …”
Publicado 2022
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29596“…Serum was collected for JKAP, interferon‐gamma (IFN‐γ) (Th1 cytokine), and interleukin 17 (IL‐17) (Th17 cytokine) detection. …”
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29597por Allweiss, Lena, Giersch, Katja, Pirosu, Andrea, Volz, Tassilo, Muench, Robert C, Beran, Rudolf K, Urban, Stephan, Javanbakht, Hassan, Fletcher, Simon P, Lütgehetmann, Marc, Dandri, Maura“…We aimed to investigate the impact of small interferring RNA (siRNA) targeting all HBV transcripts or pegylated interferon-α (peg-IFNα) on the viral regulatory HBx protein and the structural maintenance of chromosome 5/6 complex (SMC5/6), a host factor suppressing cccDNA transcription. …”
Publicado 2022
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29598por Hu, Jiemiao, Yang, Qing, Zhang, Wendong, Du, Hongwei, Chen, Yuhui, Zhao, Qingnan, Dao, Long, Xia, Xueqing, Natalie Wall, Fowlkes, Zhang, Zhongting, Mahadeo, Kris, Gorlick, Richard, Kopetz, S, Dotti, Gianpietro, Li, Shulin“…Mechanistically, attIL12-T cells targeted tumor cells expressing cell-surface vimentin, enriching effector T cell and interferon γ production in tumors, which in turn stimulates dendritic cell maturation for activating secondary T-cell responses and tumor antigen spreading. …”
Publicado 2022
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29599por Zhang, Liwei, Li, Mingxing, Wang, Zhiwei, Sun, Peng, Wei, Shunbo, Zhang, Cong, Wu, Haoliang, Bai, Hualong“…Epigenetic changes in PBMC after COVID-19 infection are characterized by activation of the type I interferon pathway. MEK inhibitors are the promising compounds for the treatment of HIF-1 overactivation. …”
Publicado 2022
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29600por Rahmati Nezhad, Pegah, Riihilä, Pilvi, Knuutila, Jaakko S., Viiklepp, Kristina, Peltonen, Sirkku, Kallajoki, Markku, Meri, Seppo, Nissinen, Liisa, Kähäri, Veli-Matti“…FD production by cSCC cells was dependent on p38 mitogen-activated protein kinase activity, and it was induced by interferon-γ and interleukin-1β. Blocking FD activity by Danicopan inhibited activation of extracellular signal-regulated kinase 1/2 and attenuated proliferation of cSCC cells. …”
Publicado 2022
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