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29601por Chen, Jia-Shiong, Chou, Cheng-Han, Wu, Yi-Hong, Yang, Mu-Hsuan, Chu, Sz-Hao, Chao, Ye-Su, Chen, Chia-Nan“…Analysis of the mouse tumor chip data using Gene Ontology enrichment analysis of biological processes revealed that the triple combination upregulated genes associated with responses to interferon-gamma. Our results demonstrated that CC-01 possessed potent TME regulatory properties, augmenting the antitumor effect when combined with ICIs. …”
Publicado 2022
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29602por Zhang, Guanglei, Liu, Wei, Gao, Zhan, Chang, Yanyan, Yang, Sicheng, Peng, Qian, Ge, Sudan, Kang, Bijing, Shao, Junjun, Chang, Huiyun“…Furthermore, OPMT elicited the highest levels of antigen-specific IgG responses, cytokines including interleukin-2, interferon-γ, and tumor necrosis factor-α, and proliferation of lymphocytes. …”
Publicado 2022
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29603por Yao, Fangyi, Zhao, Cui, Zhong, Fangmin, Qin, Tingyu, Li, Shuqi, Liu, Jing, Huang, Bo, Wang, Xiaozhong“…GSEA showed that these hub genes were related to the gamma-interferon immune response, inflammatory response, and allograft rejection. …”
Publicado 2022
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29604por Friedman, Claire F, Spencer, Christine, Cabanski, Christopher R, Panageas, Katherine S, Wells, Daniel K, Ribas, Antoni, Tawbi, Hussein, Tsai, Katy, Postow, Michael, Shoushtari, Alexander, Chapman, Paul, Karakunnel, Joyson, Bucktrout, Samantha, Gherardini, Pier, Hollmann, Travis J, Chen, Richard O, Callahan, Margaret, LaVallee, Theresa, Ibrahim, Ramy, Wolchok, Jedd“…In a pooled analysis, patients with clinical benefit (CB), defined as Response Evaluation Criteria in Solid Tumors response or progression-free for 6 months, showed increased circulating CD4+ T cells with higher polyfunctionality and interferon gamma production following treatment. Tumor profiling revealed enrichment of NRAS mutations and activation of transcriptional programs associated with innate and adaptive immunity in patients with CB. …”
Publicado 2022
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29605por Wedekind, Hanna, Walz, Kristina, Buchbender, Mayte, Rieckmann, Thorsten, Strasser, Erwin, Grottker, Fridolin, Fietkau, Rainer, Frey, Benjamin, Gaipl, Udo S, Rückert, Michael“…METHODS: Human monocytes were differentiated with the hematopoietic growth factors M‑CSF (m) or GM-CSF (g) and additionally pre-polarized with either interleukin (IL)-4 and IL-10 or interferon (IFN)-γ and lipopolysaccharides (LPS), respectively. …”
Publicado 2021
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29606por D’Onofrio, Valentino, Keulen, Lotte, Vandendriessche, Annelore, Dubois, Jasperina, Cartuyvels, Reinoud, Vanden Abeele, Marie-Elena, Fraussen, Judith, Vandormael, Patrick, Somers, Veerle, Achten, Ruth, Dendooven, Amélie, Driessen, Ann, Augsburg, Lukasz, Hellings, Niels, Lammens, Martin, Vanrusselt, Jan, Cox, Janneke“…Other organs with COVID-19 related histopathological changes were liver and heart. Interferon-γ levels were significantly higher in patients with severe-critical COVID-19 (P = 0.046). …”
Publicado 2022
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29607por Henriques-Pons, Andrea, Beghini, Daniela Gois, Silva, Vanessa dos Santos, Iwao Horita, Samuel, da Silva, Fabrício Alves Barbosa“…Then, IRF-1 was upregulated, one of the GAS target genes, leading to the interferon-stimulated response (ISR) and the overexpression of many signature target genes. …”
Publicado 2022
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29608por Weingartner, Michael, Stücheli, Simon, Jebbawi, Fadi, Gottstein, Bruno, Beldi, Guido, Lundström-Stadelmann, Britta, Wang, Junhua, Odermatt, Alex“…Furthermore, ABZ treatment reversed the elevated levels of interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α and interferon (IFN)-γ in the liver of infected mice. Similar to ABZ, αPD-L1 immune-treatment tended to reverse the increased CHOP and decreased ATF4 and IRE1α expression levels. …”
Publicado 2022
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29609por Dowsett, Joseph, Didriksen, Maria, von Stemann, Jakob Hjorth, Larsen, Margit Hørup, Thørner, Lise Wegner, Sørensen, Erik, Erikstrup, Christian, Pedersen, Ole Birger, Hansen, Morten Bagge, Eugen-Olsen, Jesper, Banasik, Karina, Ostrowski, Sisse Rye“…We additionally report that a high titer of autoantibodies specific against the cytokine interferon-alpha was associated with RLS. Our results support the existence of links between systemic inflammation and RLS, though further RLS studies on CRP, suPAR and c-aAb in larger cohorts are warranted to confirm our findings and further reveal the hitherto underexplored links between RLS and inflammation.…”
Publicado 2022
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29610por Wang, Haifeng, Bu, Lina, Shu, Fang, Bai, Yun, Xue, Feixiao, Shi, Shanshan, Sun, Daqing“…Secretion levels of IL-6, interferon β (IFN-β), chemokine (C-X-C motif) ligand 2 (CXCL2), and chemokine (C-C motif) ligand 2 (CCL20) increased in the model group versus blank control (P< 0.05). …”
Publicado 2021
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29611“…Previously, no drugs were available for HDV, and treatment relied on off-label use of interferon alpha/peginterferon alpha (IFNα/Peg-IFNα). …”
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29612por Fukuda, Yasunari, Bustos, Matias A., Cho, Sung-Nam, Roszik, Jason, Ryu, Suyeon, Lopez, Victor M., Burks, Jared K., Lee, Jeffrey E., Grimm, Elizabeth A., Hoon, Dave S. B., Ekmekcioglu, Suhendan“…Secretion of sCD74 was observed primarily in melanoma cell lines as well as a THP-1 line of macrophages from monocytes and primary macrophages, especially in response to interferon-γ (IFN-γ). A predominant form that showed clinical relevance was the 25-KDa sCD74, which originated from the 33-KDa isoform of CD74. …”
Publicado 2022
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29613por Yoo, Jiseon, Lee, Juyeon, Zhang, Ming, Mun, Daye, Kang, Minkyoung, Yun, Bohyun, Kim, Yong-An, Kim, Sooah, Oh, Sangnam“…We found that FAV significantly restored viability of mice splenocytes and immune promoting-related cytokines (interleukin [IL]-6, IL-10, inducible nitric oxide synthase [iNOS], interferon [IFN]-γ, and tumor necrosis factor [TNF]-α) were activated compared to non-fermented deer antlers. …”
Publicado 2022
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29614“…The iPSC-derived differentiated cells were susceptible to wild-type DENV infection and produced greater levels of type I interferon expression with increased passaging, despite similar levels of infection. …”
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29615por Marçal, Pedro Henrique Ferreira, de Souza, Márcio Luís Moreira, Gama, Rafael Silva, de Oliveira, Lorena Bruna Pereira, Gomes, Matheus de Souza, do Amaral, Laurence Rodrigues, Pinheiro, Roberta Olmo, Sarno, Euzenir Nunes, Moraes, Milton Ozório, Fairley, Jessica K, Martins-Filho, Olindo Assis, de Oliveira Fraga, Lucia Alves“…METHODS: A model of Mycobacterium leprae antigen-specific in vitro assay with subsequent cytokine measurements by enzyme-linked immunosorbent assay was employed to measure the levels of tumor necrosis factor (TNF), interferon-γ, interleukin 4, and interleukin 10 (IL-10) in culture supernatants of peripheral blood mononuclear cells from patients with leprosy, healthy controls, and household contacts. …”
Publicado 2022
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29616“…Additionally, LPS increased jejunal secretory IgA and interferon-γ (IFN-γ), and ileal secretory IgA, IgM, and interleukin-1β (IL-1β) concentrations, whereas COS reduced jejunal IFN-γ and IL-1β, and ileal IgM levels (P < 0.05). …”
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29617por Tumurkhuu, Gantsetseg, Laguna, Duygu Ercan, Moore, Richard E., Contreras, Jorge, Santos, Gabriela De Los, Akaveka, Luisa, Montano, Erica N., Wang, Yizhou, Ishimori, Mariko, Venuturupalli, Swamy, Forbess, Lindsy J., Stripp, Barry R., Wallace, Daniel J., Jefferies, Caroline A.“…Lastly, coculture experiments of human neutrophils and human lung epithelial cell line (BEAS-2b) showed neutrophils from SLE patients induced significantly more ER stress and interferon-stimulated genes in epithelial cells compared to healthy control neutrophils. …”
Publicado 2022
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29618por Yang, Qinglan, Zhang, Shuju, Wu, Shuting, Yao, Baige, Wang, Lili, Li, Yana, Peng, Hongyan, Huang, Minghui, Bi, Qinghua, Xiong, Peiwen, Li, Liping, Deng, Yafei, Deng, Youcai“…In this study, by using a commercially available metabolism-related compound library, we initially screened the capacity of compounds to activate NK cells by determining the ratio of interferon-gamma (IFN-γ)(+) NK cells by flow cytometry after the incubation of peripheral blood mononuclear cells (PBMCs) with IL-12 or IL-15 for 18 h. …”
Publicado 2022
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29619por Liu, Wei, Deng, Lisha, Xu, Anchun, Xiong, Xingcheng, Tao, Jing, Chang, Jian, Xu, Yiling, Zhou, Zhilin“…Abbreviations : CircRNA; Circular RNAPDAC; pancreatic ductal adenocarcinomaUHRF1; Ubiquitin-like with PHD and RING finger domain 1ARL4C; ADP Ribosylation Factor Like GTPase 4CRIP; RNA immunoprecipitationEDU; 5-Ethynyl-2ʹ-deoxyuridineEMT; epithelial to mesenchymal transitionAGO2; Argonaute RISC Catalytic Component 2CCK8; Cell counting Kit-8IRF3; Interferon Regulatory Factor 3…”
Publicado 2022
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29620por Huang, Yanping, Li, Xiangping, Sun, Xiangzhou, Yao, Jiahui, Gao, Fengxin, Wang, Zhenqing, Hu, Jiaying, Wang, Zhu, Ouyang, Bin, Tu, Xiangan, Zou, Xuenong, Liu, Wei, Lu, Mujun, Deng, Chunhua, Yang, Qiyun, Xie, Yun“…Furthermore, we highlighted Protein tyrosine phosphatase receptor type C (Ptprc), Lymphocyte protein tyrosine kinase (Lck), Microtubule associated protein tau (Mapt), and Interferon induced protein with tetratricopeptide repeats 3 (Ifit3) as critical molecules in the aging of initial segment, caput, caput, and cauda epididymidis, respectively. …”
Publicado 2022
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