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29621por Chen, Tianhang, Du, Haixia, Zhou, Huifen, Yang, Jiehong, Zhu, Jiaqi, Tong, Xin, Yang, Yuting, Wan, Jiayang, Fan, Yichen, Lu, Yiyu, He, Yu, Wan, Haitong“…Based on the maximum nontoxic concentration (TC(0)), half-maximal toxic concentration (TC(50)), half-maximal inhibitory concentration (IC(50)), and therapeutic index (TI), interferon-β (IFN-β) and interleukin-6 (IL-6) levels were measured using enzyme-linked immunosorbent assay (ELISA), and the gene expression of TLR7, MyD88, tumor necrosis factor receptor-associated factor 6 (TRAF6), c-Jun amino terminal kinase (JNK), p38 mitogen-activated protein kinase (p38 MAPK), and p65 nuclear transcription factor-kappa B (p65 NF-κB) was quantified using reverse transcription-polymerase chain reaction (RT-PCR). …”
Publicado 2022
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29622por Mogensen, Trine H.“…BACKGROUND: During the past 2 years, studies on patients with SARS-CoV-2 infection have revealed rare inborn errors of immunity (IEIs) in type interferon (IFN) pathways underlying critical COVID-19 pneumonia. …”
Publicado 2022
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29623“…In addition, the activity of natural killer (NK) cells decreased significantly, the levels of regulatory T cells (Tregs), interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) increased significantly and the levels of interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-17 (IL-17), interleukin-23 (IL-23), tumour necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) decreased significantly in the HO-1/BMMSC group compared with the BMMSC group. …”
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29624por Pekayvaz, Kami, Leunig, Alexander, Kaiser, Rainer, Joppich, Markus, Brambs, Sophia, Janjic, Aleksandar, Popp, Oliver, Nixdorf, Daniel, Fumagalli, Valeria, Schmidt, Nora, Polewka, Vivien, Anjum, Afra, Knottenberg, Viktoria, Eivers, Luke, Wange, Lucas E., Gold, Christoph, Kirchner, Marieluise, Muenchhoff, Maximilian, Hellmuth, Johannes C., Scherer, Clemens, Rubio-Acero, Raquel, Eser, Tabea, Deák, Flora, Puchinger, Kerstin, Kuhl, Niklas, Linder, Andreas, Saar, Kathrin, Tomas, Lukas, Schulz, Christian, Wieser, Andreas, Enard, Wolfgang, Kroidl, Inge, Geldmacher, Christof, von Bergwelt-Baildon, Michael, Keppler, Oliver T., Munschauer, Mathias, Iannacone, Matteo, Zimmer, Ralf, Mertins, Philipp, Hubner, Norbert, Hoelscher, Michael, Massberg, Steffen, Stark, Konstantin, Nicolai, Leo“…We see a distinct systemic rather than local immune state associated with viral containment, characterized by interferon stimulated gene (ISG) upregulation across circulating immune cell subsets in non-pneumonic SARS-CoV2 infection. …”
Publicado 2022
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29625por González-Mesa, Ernesto, García-Fuentes, Eduardo, Carvia-Pontiasec, Rafael, Lavado-Fernández, Ana I., Cuenca-Marín, Celia, Suárez-Arana, María, Blasco-Alonso, Marta, Benítez-Lara, Blanca, Mozas-Benítez, Laura, González-Cazorla, Ana, Egeberg-Neverdal, Herink, Jiménez-López, Jesús S.“…IgG and IgM SARS-CoV-2 antibodies, Interleukin 1b (IL1b), Interleukin 6 (IL6), and gamma-Interferon (IFN-γ), have been studied in the UCB samples. …”
Publicado 2022
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29626por Sangare, Kotou, Helmold Hait, Sabrina, Moore, Madison, Hogge, Christopher, Hoang, Tanya, Rahman, Mohammad Arif, Venzon, David J., LaBranche, Celia, Montefiori, David, Robert-Guroff, Marjorie, Thomas, Michael A.“…Rhesus macaques immunized with a ΔE4(1) Ad that expressed rhFLSC (HIV-1(BaL) gp120 linked to rhesus CD4 D1 and D2), exhibited higher levels of rhFLSC-specific interferon γ-producing memory T-cells, higher titers of rhFLSC-specific IgG1 binding antibody in serum, and antibodies able to mediate antibody-dependent cellular cytotoxicity (ADCC) with greater killing capacity than the ΔE1B Ad. …”
Publicado 2022
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29627por Mielcarska, Sylwia, Kula, Agnieszka, Dawidowicz, Miriam, Kiczmer, Paweł, Chrabańska, Magdalena, Rynkiewicz, Magdalena, Wziątek-Kuczmik, Daria, Świętochowska, Elżbieta, Waniczek, Dariusz“…Background and Objectives: Assessment of RANTES level and concentrations of inflammatory cytokines: programmed death ligand 1 (PD-L1), interferon gamma IFN-γ, tumor necrosis factor alpha (TNF-α), transforming growht factor β (TGF-β) (and angiogenesis factors: vascular endothelial growth factor A (VEGF-A) and vascular endothelial growth factor C (VEGF C) in tumor and margin tissues of colorectal cancer (CRC,) and evaluation of RANTES influence on histopathological parameters (microvessel density (MVD), budding, tumor-infiltrating lymphocytes (TILs)), in relation to patients’ clinical features. …”
Publicado 2022
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29628por Maulahela, Hasan, Simadibrata, Marcellus, Nelwan, Erni Juwita, Rahadiani, Nur, Renesteen, Editha, Suwarti, S. W. T., Anggraini, Yunita Windi“…Latest molecular-based diagnostic modalities such as GeneXpert, interferon-gamma (IFN-γ) release assays (IGRA), polymerase chain reaction (PCR), multiplex-PCR, and immunological markers are expected to help diagnose intestinal tuberculosis. …”
Publicado 2022
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29629por Domizio, Jeremy Di, Gulen, Muhammet F., Saidoune, Fanny, Thacker, Vivek V., Yatim, Ahmad, Sharma, Kunal, Nass, Théo, Guenova, Emmanuella, Schaller, Martin, Conrad, Curdin, Goepfert, Christine, de Leval, Laurence, Garnier, Christophe von, Berezowska, Sabina, Dubois, Anaëlle, Gilliet, Michel, Ablasser, Andrea“…COVID-19, which is caused by infection with SARS-CoV-2, is characterized by lung pathology and extrapulmonary complications(1,2). Type I interferons (IFNs) have an essential role in the pathogenesis of COVID-19 (refs (3–5)). …”
Publicado 2022
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29630por Versteven, Maarten, Flumens, Donovan, Campillo-Davó, Diana, De Reu, Hans, Van Bruggen, Laura, Peeters, Stefanie, Van Tendeloo, Viggo, Berneman, Zwi, Dolstra, Harry, Anguille, Sébastien, Hobo, Willemijn, Smits, Evelien, Lion, Eva“…Additionally, we validated that these DCs retain their specific characteristics, both at the level of phenotype and interferon gamma secretion. Evaluating their functional characteristics, we demonstrate that PD-L silencing does not affect the capacity to induce allogeneic proliferation. …”
Publicado 2022
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29631por Huang, Xiaochen, Guo, Jiaojiao, Li, Tao, Jia, Lizhou, Tang, Xiaojun, Zhu, Jin, Tang, Qi, Feng, Zhenqing“…All c-Met CARs were stably expressed on T cell membrane, and c-Met CAR-T cells aggregated around c-Met-positive HCC cells and specifically killed them in vitro. c-Met-28-137-3ζ CAR-T cells secreted more interferon-gamma (IFN-γ) and interleukin 2 (IL-2) than c-Met-28-3ζ CAR-T cells and c-Met-137-3ζ CAR-T cells. …”
Publicado 2022
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29632por Ruacho, Guillermo, Lira-Junior, Ronaldo, Gunnarsson, Iva, Svenungsson, Elisabet, Boström, Elisabeth A“…The levels of colony-stimulating factor (CSF)-1, interleukin (IL)-34, tumour necrosis factor (TNF)-α, interferon-γ-induced protein (IP)-10, monocyte chemoattractant protein (MCP)-1, calprotectin, macrophage inflammatory protein (MIP)-1α and MIP-1β were analysed by immunoassays and related to DA. …”
Publicado 2022
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29633por Yan, Yujie, Fu, Jiamei, Kowalchuk, Roman O., Wright, Christopher M., Zhang, Ran, Li, Xuefei, Xu, Yaping“…Different kinds of inflammatory and immune cells such as macrophages, fibroblasts, and T cells play key roles in the development of RILI, and transforming growth factor-β (TGF-β), interleukin-4 (IL-4), IL-13, and interferon-γ (IFN-γ) are also participants in this process. …”
Publicado 2022
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29634por Hope, Jacob M., Dombroski, Jenna A., Pereles, Rebecca S., Lopez-Cavestany, Maria, Greenlee, Joshua D., Schwager, Samantha C., Reinhart-King, Cynthia A., King, Michael R.“…The FSS treatment also enhanced the expression of the cytokines tumor necrosis factor alpha (TNF-α), interleukin 2 (IL-2), and interferon gamma (IFN-γ), which are necessary for sustained T cell activation and function. …”
Publicado 2022
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29635por Wu, Xionghui, Zhao, Sijun, Huang, Weiqing, Huang, Lihua, Huang, Min, Luo, Xinyou, Chang, Shuting“…For pediatric AR patients only, serum interferon‐gamma (IFN‐γ) and interleukin (IL)‐10 were measured by enzyme linked immunosorbent assay; meanwhile, T helper (Th) 1 and Th2 cells in CD4(+) T cells were analyzed by flow cytometry. …”
Publicado 2022
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29636por Lambert, Stacie L., Zhang, Chun, Guo, Claire, Turan, Tolga, Masica, David L., Englert, Stefan, Fang, Yuni, Sheridan, James, McLaughlin, Robert Tyler, Tribouley, Catherine, Vosganian, Greg, Afar, Daniel“…Treatment with budigalimab was associated with increases in multiple soluble biomarkers including interferon gamma-induced chemokines. Expanded overall T-cell counts, total CD8 T-cell counts, and percentages of CD8(+)CD45RA(–)CD62L(–) effector memory T cells were observed at cycle 1, day 15 in responders. …”
Publicado 2022
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29637“…In addition, serum interleukin 4 (IL-4), interferon-γ (IFN-γ), immunoglobulin E (IgE), IL-13, and TSLP levels were measured using enzyme-linked immunosorbent assay (ELISA), while tissue IL-13 and TSLP levels were assessed using ELISA, Western blotting, and immunohistochemical staining, and mast cell infiltration was assessed through toluidine blue (TBO) staining. …”
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29638por Durrant, Louise R., Bucca, Giselda, Hesketh, Andrew, Möller-Levet, Carla, Tripkovic, Laura, Wu, Huihai, Hart, Kathryn H., Mathers, John C., Elliott, Ruan M., Lanham-New, Susan A., Smith, Colin P.“…Surprisingly, gene expression associated with type I and type II interferon activity, critical to the innate response to bacterial and viral infections, differed following supplementation with either vitamin D(2) or vitamin D(3), with only vitamin D(3) having a stimulatory effect. …”
Publicado 2022
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29639“…A major advance has been achieved with the discovery of the next generation maturation protocol involving TLR-3 agonist (poly I:C), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, interferon (IFN)-γ, and IFN-α, and has since been known as α-type-1 maturation cocktail. …”
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29640por Ploeger, Carolin, Schreck, Johannes, Huth, Thorben, Fraas, Angelika, Albrecht, Thomas, Charbel, Alphonse, Ji, Junfang, Singer, Stephan, Breuhahn, Kai, Pusch, Stefan, Köhler, Bruno Christian, Springfeld, Christoph, Schirmacher, Peter, Mehrabi, Arianeb, Goeppert, Benjamin, Roessler, Stephanie“…Signal transducer and activator of transcription 1 (STAT1) and 3 (STAT3) are key transcription factors activated by pro-inflammatory cytokines such as interferon-γ (IFN-γ) and interleukin-6 (IL-6). In this study, we combined in vitro cell culture experiments and immunohistochemical analyses of human HCC (N = 124) and CCA (N = 138) specimens. …”
Publicado 2022
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