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29641por Al Jurdi, Ayman, Gassen, Rodrigo B., Borges, Thiago J., Solhjou, Zhabiz, Hullekes, Frank E., Lape, Isadora T., Efe, Orhan, Alghamdi, Areej, Patel, Poojan, Choi, John Y., Mohammed, Mostafa T., Bohan, Brigid, Pattanayak, Vikram, Rosales, Ivy, Cravedi, Paolo, Kotton, Camille N., Azzi, Jamil R., Riella, Leonardo V.“…A cellular response against wild-type S1, measured by interferon-γ-ELISpot assay, developed in 38% of KTRs. …”
Publicado 2022
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29642“…Importantly, airway instillation of SLE-prone mice with crystalline silica elicits severe pulmonary pathology involving accumulation of particle-laden alveolar macrophages, dying and dead cells, nuclear and cytoplasmic debris, and neutrophilic inflammation that drive cytokine, chemokine, and interferon-regulated gene expression. Silica-induced immunogenic cell death and danger signal release triggers accumulation of T and B cells, along with IgG-secreting plasma cells, indicative of ectopic lymphoid tissue neogenesis, and broad-spectrum autoantibody production in the lung. …”
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29643por Guo-Parke, Hong, Linden, Dermot, Mousnier, Aurelie, Scott, Ian C., Killick, Helen, Borthwick, Lee A., Fisher, Andrew J., Weldon, Sinéad, Taggart, Clifford C., Kidney, Joseph C.“…A Th1/Th2 imbalance and a strong interferon and pro-inflammatory cytokine response was also observed in COPD cultures, characterized by increased levels of IFNγ, IFNβ, IP-10, IL-10 and decreased TSLP and IL-13 cytokine levels prior to HRV infection. …”
Publicado 2022
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29644por Xu, Xiao-Jun, Luo, Ze-Bin, Song, Hua, Xu, Wei-Qun, Henter, Jan-Inge, Zhao, Ning, Wu, Meng-Hui, Tang, Yong-Min“…Our previous studies indicated that cytokines such as interferon (IFN)-γ and interleukin (IL)-10 were helpful for the early diagnosis of HLH and were associated with disease severity. …”
Publicado 2022
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29645por Corbera-Bellalta, Marc, Alba-Rovira, Roser, Muralidharan, Sujatha, Espígol-Frigolé, Georgina, Ríos-Garcés, Roberto, Marco-Hernández, Javier, Denuc, Amanda, Kamberovic, Farah, Pérez-Galán, Patricia, Joseph, Alexandra, D’Andrea, Annalisa, Bondensgaard, Kent, Cid, Maria C, Paolini, John F“…Mavrilimumab reduced expression of molecules relevant to T cell activation (human leukocyte antigen-DR [HLA-DR]) and Th1 differentiation (interferon-γ), the pro-inflammatory cytokines: interleukin 6 (IL-6), tumour necrosis factor α (TNFα) and IL-1β, as well as molecules related to vascular injury (matrix metalloprotease 9, lipid peroxidation products and inducible nitric oxide synthase [iNOS]). …”
Publicado 2022
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29646por Zhai, Boyu, Liu, Lanlan, Li, Xiang, Lv, Xinru, Wu, Jinyan, Li, Jing, Lin, Shengze, Yin, Yuxiang, Lan, Jiaqi, Du, Jianan, Wu, Chenwei, Wen, Yi, Wang, Yajun, Wang, Yulong, Hou, Zhijun, Li, Yanbing, Chai, Hongliang, Zeng, Xiangwei“…In this study, we used two wild-bird-origin viruses, H5N8 and H4N6, to conduct duck infection experiments, and detect the load of the two viruses, and retinoic acid-inducible gene I (RIG-I) and interferon β (IFN-β) in the host’s natural immune response. …”
Publicado 2022
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29647por Ling, Xiao, Wang, Teng, Han, Chao, Wang, Pin, Liu, Xiaoli, Zheng, Chengyun, Bi, Jianzhong, Zhou, Xiaoyan“…Our previous study showed that interferon gamma (IFN-γ) might enhance the immunosuppressive properties of mesenchymal stem cells (MSCs) by upregulating the expression of indoleamine 2,3-dioxygenease. …”
Publicado 2022
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29648por Moll, Tobias, Odon, Valerie, Harvey, Calum, Collins, Mark O, Peden, Andrew, Franklin, John, Graves, Emily, Marshall, Jack N.G., Souza, Cleide dos Santos, Zhang, Sai, Azzouz, Mimoun, Gordon, David, Krogan, Nevan, Ferraiuolo, Laura, Snyder, Michael P, Shaw, Pamela J, Rehwinkel, Jan, Cooper-Knock, Johnathan“…OAS gene expression changes occurred independent of infection and in the absence of significant upregulation of other interferon-stimulated genes (ISGs). Targeted depletion or functional inhibition of EXOSC2 may be a safe and effective strategy to protect at-risk individuals against clinical COVID-19.…”
Publicado 2022
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29649por Chen, Juli, Wu, Lijuan, Lv, Yanghua, Liu, Tangyuheng, Guo, Weihua, Song, Jiajia, Hu, Xuejiao, Li, Jing“…The optimal model was the “LncRNA + EHR” model, which included the above two lncRNAs and eight EHR parameters (age, hemoglobin, lymphocyte count, gamma interferon release test, weight loss, night sweats, polymorphic changes, and calcified foci on imaging). …”
Publicado 2022
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29650por Zhu, Jun, Inomata, Takenori, Nakamura, Masahiro, Fujimoto, Keiichi, Akasaki, Yasutsugu, Fujio, Kenta, Yanagawa, Ai, Uchida, Koichiro, Sung, Jaemyoung, Negishi, Naoko, Nagino, Ken, Okumura, Yuichi, Miura, Maria, Shokirova, Hurramhon, Kuwahara, Mizu, Hirosawa, Kunihiko, Midorikawa-Inomata, Akie, Eguchi, Atsuko, Huang, Tianxiang, Yagita, Hideo, Habu, Sonoko, Okumura, Ko, Murakami, Akira“…Inflammatory cytokine levels in the culture supernatant were measured using an enzyme-linked immunosorbent assay. Interferon (IFN)-γ-producing CD4(+) T cell frequencies in the MLR were assessed using flow cytometry. …”
Publicado 2022
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29651por Marking, Ulrika, Havervall, Sebastian, Greilert-Norin, Nina, Ng, Henry, Blom, Kim, Nilsson, Peter, Phillipson, Mia, Hober, Sophia, Nilsson, Charlotta, Mangsbo, Sara, Christ, Wanda, Klingström, Jonas, Gordon, Max, Åberg, Mikael, Thålin, Charlotte“…T-cell responses were investigated using a whole blood interferon gamma (IFN-γ) release assay 2 weeks and 3 months post second vaccine dose. …”
Publicado 2022
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29652“…The serum levels of interleukin-4 (IL-4), interferon-γ (IFN-γ), and IL-17A were determined by the ELISA method. …”
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29653por Kuhle, Jens, Daizadeh, Nadia, Benkert, Pascal, Maceski, Aleksandra, Barro, Christian, Michalak, Zuzanna, Sormani, Maria Pia, Godin, Jean, Shankara, Srinivas, Samad, Tarek A, Jacobs, Alan, Chung, Luke, Rӧsch, Nora, Kaiser, Carina, Mitchell, Colin P, Leppert, David, Havari, Evis, Kappos, Ludwig“…OBJECTIVE: Evaluate serum neurofilament light chain (sNfL) in CARE-MS I patients and highly active disease (HAD) subgroup, over 7 and 2 years for alemtuzumab and subcutaneous interferon beta-1a (SC IFNB-1a), respectively. METHODS: Patients received SC IFNB-1a 44 µg 3×/week or alemtuzumab 12 mg/day at baseline and month 12, with further as-needed 3-day courses. sNfL was measured using single-molecule array (Simoa™). …”
Publicado 2021
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29654por Negm, Essamedin M.“…Antiviral treatment with interferon (IFN) in conjunction with ribavirin in patients with chronic hepatitis C reduces serum ACE activity and indirectly affects liver parenchyma fibrogenesis. …”
Publicado 2022
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29655por Loft, Josefine Amalie, Møller, Dina Leth, Thudium, Rebekka Faber, Knudsen, Jenny Dahl, Ostrowski, Sisse Rye, Andersen, Åse Bengård, Nielsen, Susanne Dam“…For each stimulus, the induced immune response was assessed by measuring the released concentration of Interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12p40, IL-17A, Interferon-γ (IFN-γ) and Tumor necrosis factor-α (TNF-α) in pg/mL. …”
Publicado 2022
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29656por Damas, Marcelo Silva Folhas, Mazur, Fernando Gabriel, Freire, Caio Cesar de Melo, da Cunha, Anderson Ferreira, Pranchevicius, Maria-Cristina da Silva“…In addition, HTL epitopes were able to induce interferon-gamma immune response. The selected peptides were used to design 4 multi-epitope vaccines constructs (SMV1, SMV2, SMV3 and SMV4) with immune-modulating adjuvants, PADRE sequence, and linkers. …”
Publicado 2022
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29657por Yalaz, Mehmet, Tanriverdi, Sema, Uygur, Özgün, Altun Köroğlu, Özge, Azarsiz, Elif, Aksu, Guzide, Kültürsay, Nilgün“…Total eosinophil count, inducible T Cell alpha chemoattractant (ITaC), macrophage inflammatory protein 3 beta (MIP3b), interleukins (IL) 5, 8, 9, 10, 13, immunoglobulin E (IgE), interferon gamma (IFN-γ), eotaxin and tumor necrosis factor beta-1 (TGF-β1) were measured from blood and tracheal aspirate samples. …”
Publicado 2022
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29658por McCann, Katy, von Witzleben, Adrian, Thomas, Jaya, Wang, Chuan, Wood, Oliver, Singh, Divya, Boukas, Konstantinos, Bendjama, Kaidre, Silvestre, Nathalie, Nielsen, Finn Cilius, Thomas, Gareth, Sanchez-Elsner, Tilman, Greenbaum, Jason, Schoenberger, Stephen, Peters, Bjoern, Vijayanand, Pandurangan, Savelyeva, Natalia, Ottensmeier, Christian“…Thereafter, we assessed the autologous T-cell reactivity to the candidate neoantigens using a long peptide approach in a cultured interferon gamma ELISpot and tracked the neoantigen-specific T-cells in the tumor by T-cell receptor (TCR) sequencing. …”
Publicado 2022
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29659“…The peripheral blood from the retroorbital venous plexus was collected to evaluate the levels of serum interferon-γ (IFN-γ) and interleukin 12 (IL-12). The comparisons of clinical signs, the disease score, CD8+ TRM cells, the serum IFN-γ, and IL-12 levels were performed among the three groups. …”
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29660“…The 1,000 and 2,000 mg/kg PAA reduced 21-d interleukin-1β and tumor necrosis factor-α (TNF-α) levels in serum and ileal mucosa and 42-d interferon-γ level in serum and jejunal mucosa (P < 0.05), which did not differ from antibiotic group (P > 0.05). …”
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