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29661A novel immunopeptidomic-based pipeline for the generation of personalized oncolytic cancer vaccinespor Feola, Sara, Chiaro, Jacopo, Martins, Beatriz, Russo, Salvatore, Fusciello, Manlio, Ylösmäki, Erkko, Bonini, Chiara, Ruggiero, Eliana, Hamdan, Firas, Feodoroff, Michaela, Antignani, Gabriella, Viitala, Tapani, Pesonen, Sari, Grönholm, Mikaela, Branca, Rui MM, Lehtiö, Janne, Cerullo, Vincenzo“…The generated list of candidates (26 in total) was further tested in a functional characterization assay using interferon-γ enzyme-linked immunospot (ELISpot), reducing the number of candidates to six. …”
Publicado 2022
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29662por Chen, Zibo, Zheng, Lin, Chen, Yulong, Liu, Xiuxia, Kawakami, Masanori, Mustachio, Lisa Maria, Roszik, Jason, Ferry-Galow, Katherine V., Parchment, Ralph E., Liu, Xin, Andresson, Thorkell, Duncan, Gerard, Kurie, Jonathan M., Rodriguez-Canales, Jaime, Liu, Xi, Dmitrovsky, Ethan“…This deubiquitinase (DUB) stabilized targeted proteins by removing the complex interferon-stimulated gene 15 (ISG15). This study explores if the loss of USP18 reduced lung cancer metastasis. …”
Publicado 2022
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29663“…Besides, Th1 and Th17 cells were measured in PBMCs from sepsis patients by flow cytometry; interleukin 17A (IL‐17A) and interferon gamma (IFN‐γ) were determined in serum from sepsis patients by ELISA. …”
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29664por López-Cortés, Andrés, Guerrero, Santiago, Ortiz-Prado, Esteban, Yumiceba, Verónica, Vera-Guapi, Antonella, León Cáceres, Ángela, Simbaña-Rivera, Katherine, Gómez-Jaramillo, Ana María, Echeverría-Garcés, Gabriela, García-Cárdenas, Jennyfer M., Guevara-Ramírez, Patricia, Cabrera-Andrade, Alejandro, Puig San Andrés, Lourdes, Cevallos-Robalino, Doménica, Bautista, Jhommara, Armendáriz-Castillo, Isaac, Pérez-Villa, Andy, Abad-Sojos, Andrea, Ramos-Medina, María José, León-Sosa, Ariana, Abarca, Estefanía, Pérez-Meza, Álvaro A., Nieto-Jaramillo, Karol, Jácome, Andrea V., Morillo, Andrea, Arias-Erazo, Fernanda, Fuenmayor-González, Luis, Quiñones, Luis Abel, Kyriakidis, Nikolaos C.“…The functional enrichment analysis of the 233 significantly expressed genes showed that the most relevant biological annotations were inflammatory response, innate immune response, cytokine production, interferon production, macrophage activation, blood coagulation, NLRP3 inflammasome complex, and the TLR, JAK-STAT, NF-κB, TNF, oncostatin M signaling pathways. …”
Publicado 2022
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29665por Giryes, Sami, Bragazzi, Nicola Luigi, Bridgewood, Charles, De Marco, Gabriele, McGonagle, Dennis“…Definitive, extrapulmonary clinically discernible vasculitis including cutaneous and cardiac vasculitis also emerged- namely a dysregulated interferon expression or “COVID toes” and an ill-defined systemic Kawasaki-like disease. …”
Publicado 2022
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29666“…METHODS: This study included 159 patients with TB without DM (TB-NDM) and 168 patients with TB-DM. Interferon-γ (IFN-γ) release assays (IGRAs) and TB-specific antibodies against 38kD+16kD proteins were used to detect humoral and cellular immune responses. …”
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29667por Liu, Zhangluxi, Xu, Jing, Li, Hongxi, Shu, Jia, Su, Guannan, Zhou, Chunjiang, Yang, Peizeng“…Interleukin-2 (IL-2)/interleukin-17A (IL-17A)/interferon-gamma (IFN-γ) producing cells were detected by FCM. …”
Publicado 2022
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29668por Schulze Lammers, Friederike C., Bonifacius, Agnes, Tischer-Zimmermann, Sabine, Goudeva, Lilia, Martens, Jörg, Lepenies, Bernd, von Karpowitz, Maria, Einecke, Gunilla, Beutel, Gernot, Skripuletz, Thomas, Blasczyk, Rainer, Beier, Rita, Maecker-Kolhoff, Britta, Eiz-Vesper, Britta“…Specifically, we determined the VST frequencies by interferon-gamma enzyme-linked immunospot assay and classified their distribution according to age and gender to allow for a more specific evaluation and prediction of antiviral immune responses. …”
Publicado 2022
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29669por Cheng, Li, Creasy, Todd, Pilataxi, Fernanda, Greenlees, Lydia, Vence, Luis, Sridhar, Sriram, Streicher, Katie“…All four tumors showed a robust increase in interferon gamma (IFN-γ) production (100–300% higher than isotype control) in both D- and D + T-treated tumors. …”
Publicado 2021
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29670por Ferreira, Wallax Augusto Silva, Vitiello, Glauco Akelinghton Freire, da Silva Medina, Tiago, de Oliveira, Edivaldo Herculano Correa“…Based on the analysis of biological functions, we found that GPX7 might be involved in immune mechanisms involving both innate and adaptive immunity, type I interferon production and regulation of synaptic transmission in LGG, whereas in GBM, it is mainly related to metabolic regulation of mitochondrial dynamics. …”
Publicado 2022
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29671por Wang, Lining, Dai, Bo, Gao, Wenhui, Wang, Jing, Wan, Ming, Wang, Runshu, Wang, Ling, Jiang, Jieling, Blaise, Didier, Hu, Jiong“…During the haplo-fever, there were significant increases in multiple cytokines, such as interferon gamma, interleukin (IL) 6, IL2, IL2 receptor, IL8, IL10, IL17, and tumor necrosis factor (TNF). …”
Publicado 2022
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29672por Liu, Zhaoli, Kilic, Gizem, Li, Wenchao, Bulut, Ozlem, Gupta, Manoj Kumar, Zhang, Bowen, Qi, Cancan, Peng, He, Tsay, Hsin-Chieh, Soon, Chai Fen, Mekonnen, Yonatan Ayalew, Ferreira, Anaísa Valido, van der Made, Caspar I., van Cranenbroek, Bram, Koenen, Hans J. P. M., Simonetti, Elles, Diavatopoulos, Dimitri, de Jonge, Marien I., Müller, Lisa, Schaal, Heiner, Ostermann, Philipp N., Cornberg, Markus, Eiz-Vesper, Britta, van de Veerdonk, Frank, van Crevel, Reinout, Joosten, Leo A. B., Domínguez-Andrés, Jorge, Xu, Cheng-Jian, Netea, Mihai G., Li, Yang“…However, subtle differences persist at the transcriptomic level in monocytes, with downregulation of the interferon pathway, while DNA methylation also displays minor changes in convalescent COVID-19 individuals. …”
Publicado 2022
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29673por Villanueva-Hernández, Sonia, Adib Razavi, Mahsa, van Dongen, Katinka A., Stadler, Maria, de Luca, Karelle, Beyersdorf, Niklas, Saalmüller, Armin, Gerner, Wilhelm, Mair, Kerstin H.“…For an in-depth study of porcine PCs, we identified cross-reactive antibodies against three key transcription factors: PR domain zinc finger protein-1 (Blimp-1), interferon regulatory factor 4 (IRF4), and paired box 5 (Pax5). …”
Publicado 2022
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29674por Cequier, Alina, Romero, Antonio, Vázquez, Francisco J., Vitoria, Arantza, Bernad, Elvira, Fuente, Sara, Zaragoza, Pilar, Rodellar, Clementina, Barrachina, Laura“…After co-culture, frequency and proliferation of T cell subsets and B cells were assessed by flow cytometry and interferon-ɣ (IFNɣ) secretion by ELISA. MSC-primed showed higher regulatory potential by decreasing proliferation of cytotoxic and helper T cells and B cells. …”
Publicado 2022
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29675“…We used PC cell lines (Penl1 and Penl2) and constructed a PC xenograft mice model to explore the effects of the silencing of BIRC5 on proliferation, migration, invasion and tumor growth, as well as survival of mice. Besides, interferon (IFN)-γ was utilized to mimic the ITM of PC cells. …”
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29676por Liu, Qingxiu, Li, Wenxiang, Zhang, Jiatu, Zhao, Lihong, Ji, Cheng, Zhang, Jianyun, Huang, Shimeng, Ma, Qiugang“…From the results, compared with the FO group, OFO significantly decreased the egg-laying rate, increased the contents of total protein (TP) and inflammatory factors [tumor necrosis factor α (TNF-α), interleukin (IL)-6, IL-8, and interferon γ (INF-γ)], and reduced the concentrations of anti-oxidation [total antioxidant (T-AOC), total superoxide dismutase (T-SOD), glutathione peroxidase (GSH-Px), glutathione (GSH), glutathione reductase (GR), catalase (CAT), and hydroxyl radical scavenging activity (HRSA)] in serum samples, as well as reduced the levels of anti-oxidation indexes in oviduct tissues (p < 0.05). …”
Publicado 2022
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29677por Mizutani, Taketoshi, Ishizaka, Aya, Koga, Michiko, Ikeuchi, Kazuhiko, Saito, Makoto, Adachi, Eisuke, Yamayoshi, Seiya, Iwatsuki-Horimoto, Kiyoko, Yasuhara, Atsuhiro, Kiyono, Hiroshi, Matano, Tetsuro, Suzuki, Yutaka, Tsutsumi, Takeya, Kawaoka, Yoshihiro, Yotsuyanagi, Hiroshi“…The abundance of the class Clostridia was inversely correlated with interferon-γ level and that of the phylum Actinobacteria, which was enriched in COVID-19, and was positively correlated with gp130/sIL-6Rb levels. …”
Publicado 2022
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29678por Xu, Ling-Dong, Zhang, Fei, Chen, Chu, Peng, Lei, Luo, Wen-Ting, Chen, Ruiai, Xu, Pinglong, Huang, Yao-Wei“…By treatment with two molecule inhibitors of TBK1, we also revealed a role of RIG-I like receptor-interferon regulatory factor 3 in host anti-HEV innate immune sensing in this in vivo model. …”
Publicado 2022
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29679por Xiao, Xun, Lu, Hao, Zhu, Wentao, Zhang, Yanqi, Huo, Xingchen, Yang, Chunrong, Xiao, Shaobo, Zhang, Yongan, Su, Jianguo“…Type I interferons (IFN-Is) are critical antiviral cytokine in innate immunity but with limited direct defense ability against bacterial infections in mammals. …”
Publicado 2022
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29680por Odera, Susan, Mureithi, Marianne, Aballa, Andrew, Onyango, Noel, Kazungu, Samwel, Ogolla, Simon, Kaiyare, George, Anzala, Omu, Oyugi, Julius“…Intravenous blood samples were drawn for interferon-gamma release assay (IGRA) to determine latent tuberculosis infection (LTBI) among HHCs, and for extraction of DNA used in typing of HLA-DQB1 and HLA-DRB1 alleles by PCR sequence specific primer amplification. …”
Publicado 2022
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