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29701por Larenas-Muñoz, Fernanda, Sánchez-Carvajal, José M., Galán-Relaño, Ángela, Ruedas-Torres, Inés, Vera-Salmoral, Eduardo, Gómez-Gascón, Lidia, Maldonado, Alfonso, Carrasco, Librado, Tarradas, Carmen, Luque, Inmaculada, Rodríguez-Gómez, Irene M., Gómez-Laguna, Jaime“…The diagnosis of bovine tuberculosis (bTB) is based on the single intradermal tuberculin test (SIT), interferon gamma, and compulsory slaughter of reactor animals. …”
Publicado 2022
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29702por Berghäll, Elisabeth, Hultström, Michael, Frithiof, Robert, Lipcsey, Miklos, Hahn-Strömberg, Victoria“…The expression levels of intracellular tumor necrosis factor alpha (TNFα) and IL-1 receptor type 2 in leukocytes were lower (p < 0.001), and the plasma levels of TNFα, IL-2, IL-6, IL-8, IL-10 (p < 0.001), interferon gamma (IFNγ) (p < 0.01), and granulocyte-macrophage colony-stimulating factor (GM-CSF) (p < 0.05) were higher in patients with severe COVID-19 than in the control group. …”
Publicado 2022
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29703“…SARS-CoV-2-specific T-cell responses were measured using an interferon-γ (IFN-γ) release assay (IGRA; Euroimmun Medical Laboratory Diagnostics, Lübeck, Germany). …”
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29704por Clark, Christopher, Richiardi, Jonas, Maréchal, Bénédicte, Bowman, Gene L., Dayon, Loïc, Popp, Julius“…RESULTS: NPS were associated with distinct inflammatory profiles in serum, involving eotaxin-3, interleukin (IL)-6 and C-reactive protein (CRP); and in CSF, including soluble intracellular cell adhesion molecule-1 (sICAM-1), IL-8, 10-kDa interferon-γ-induced protein, and CRP. AD pathology interacted with CSF sICAM-1 in association with NPS. …”
Publicado 2022
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29705“…In addition, higher infiltrating fractions of immune cells, such as activated CD8(+) T cells and Gamma delta T cells, mainly enriched immune-related signaling pathways, including the IL2-STAT3 signaling pathway and interferon-gamma response signaling pathway, and higher expression of immune checkpoints, including PDCD1, CTLA4, TIGIT, and CD83, were presented in patients with high FTL expression (p < 0.05). …”
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29706por Azad, Md. Abul Kalam, Jiang, Huijiao, Ni, Hengjia, Liu, Yating, Huang, Pan, Fang, Jun, Kong, Xiangfeng“…Dietary CR supplementation increased the levels of secretory immunoglobulin A (sIgA) in the intestine and liver, as well as jejunal interleukin (IL)-10, ileal tumor necrosis factor (TNF)-α, and hepatic interferon (IFN)-γ, whereas dietary CR or FCR supplementation decreased the jejunal IL-1β level and increased hepatic IL-10 level (P < 0.05). …”
Publicado 2022
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29707por Zhou, Xian, Münch, Gerald, Wohlmuth, Hans, Afzal, Sualiha, Kao, Ming-Hui (Tim), Al-Khazaleh, Ahmad, Low, Mitchell, Leach, David, Li, Chun Guang“…A Bioplex ProTM mouse cytokine 23-plex assay was utilized to assess the broad anti-cytokine activity of GT in LPS and interferon (IFN)-ɣ (both at 50 ng/mL)-activated RAW 264.7 cells. …”
Publicado 2022
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29708por Legebeke, Jelmer, Lord, Jenny, Penrice-Randal, Rebekah, Vallejo, Andres F., Poole, Stephen, Brendish, Nathan J., Dong, Xiaofeng, Hartley, Catherine, Holloway, John W., Lucas, Jane S., Williams, Anthony P., Wheway, Gabrielle, Strazzeri, Fabio, Gardner, Aaron, Schofield, James P. R., Skipp, Paul J., Hiscox, Julian A., Polak, Marta E., Clark, Tristan W., Baralle, Diana“…Additionally ribosomal, mitochondrial oxidative stress and interferon signalling pathways differentiated the cohorts. …”
Publicado 2022
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29709“…In RA patients, M1/Th1 activation occurs in an inflammatory environment dominated by Toll-like receptor (TLR) and interferon (IFN) signaling, and it promotes a massive production of pro-inflammatory cytokines [i.e., tumor necrosis factor-α (TNFα), interleukin (IL)-1, IL-12, IL-18, and IFNγ], chemotactic factors, and matrix metalloproteinases resulting in osteoclastogenesis, erosion, and progressive joint destruction. …”
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29710por Wu, Dai-Qing, Ding, Qiu-Ying, Tao, Na-Na, Tan, Ming, Zhang, Yuan, Li, Fan, Zhou, Yu-Jiao, Dong, Mei-Ling, Cheng, Sheng-Tao, Ren, Fang, Chen, Juan, Ren, Ji-Hua“…Although the major drugs against CHB including nucleos(t)ide analogs and PEG-interferon can effectively control human hepatitis B virus (HBV) infection, complete cure of HBV infection is quite rare. …”
Publicado 2022
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29711“…Pro-inflammatory cytokines including tumor necrosis factor-α, interleukin-1β, and interferon-γ in serum and hippocampal tissues were measured by enzyme-linked immunosorbent assays. …”
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29712por Shin, Duckhyang, Shin, Younchul, Kim, Eunmi, Nam, Hyojung, Nan, Haiyan, Lee, Jaewoo“…Glycoprotein enzyme-linked immunosorbent assay (gpELISA) was used to compare the degree of the antibody responses induced by the two available commercial VZV vaccines and the MAV/06 vaccine. Interferon-gamma enzyme-linked immunosorbent spot (IFN-γ ELISpot) assays and cytokine bead array (CBA) assays were conducted to investigate T cell immune responses. …”
Publicado 2022
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29713por Maekawa, Naoya, Konnai, Satoru, Asano, Yumie, Sajiki, Yamato, Deguchi, Tatsuya, Okagawa, Tomohiro, Watari, Kei, Takeuchi, Hiroto, Takagi, Satoshi, Hosoya, Kenji, Kim, Sangho, Ohta, Hiroshi, Kato, Yukinari, Suzuki, Yasuhiko, Murata, Shiro, Ohashi, Kazuhiko“…Indeed, PGE(2) suppressed IL-2 and interferon (IFN)-γ production by stimulated canine peripheral blood mononuclear cells (PBMCs), while inhibition of PGE(2) biosynthesis using the COX-2 inhibitor meloxicam in combination with c4G12 enhanced Th1 cytokine production by PBMCs. …”
Publicado 2022
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29714por Li, Xinhui, Yang, Wensong, Shen, Yiqing, Liu, Fangyu, Xiong, Xin, Wu, Qingyuan, Xiao, Zhongsong, Yang, Xun, Dang, Ruozhi, Manaenko, Anatol, Xie, Peng, Li, Qi“…We found aged mice exhibited increased brain inflammatory responses compared with young animals and ICH induced significant activation of the interferon-β (IFN-β) and IFN signaling pathways exclusively in aged mice. …”
Publicado 2022
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29715“…Besides, immunosuppressive effects of FB(1) were observed by the decreased concentrations of interleukin-2 (IL-2), IL-4, IL-12 and interferon-γ (IFN-γ) in the cell culture supernatant. …”
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29716“…The expression of two markers, interleukin-18 (IL-18) and interferon-γ (IFN-γ), were significantly different in cases showing improvement in the early stage of SMPP (P<0.05), and the cut-off values for IL-18 (218.19 pg/mL, AUC =0.581, sensitivity =0.909, 1-specificity =0.786) and IFN-γ (11.24 pg/mL, AUC =0.566, sensitivity =0.905, 1-specificity =0.795) were identified. …”
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29717por Liu, Junfeng, Liang, Qin, Wang, Tianyang, Ma, Bei, Wang, Xin, Li, Ping, Shaukat, Aftab, Guo, Xuefeng, Deng, Ganzhen“…Endometritis is the failure of embryo implantation and an important cause of infertility in dairy cows. IFN-τ is a type I interferon unique to ruminants. In regulating the process of inflammatory response, IFN-τ can be expressed through MicroRNAs (miRNAs) to regulate the process of inflammation. …”
Publicado 2022
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29718por Nchioua, Rayhane, Schundner, Annika, Kmiec, Dorota, Prelli Bozzo, Caterina, Zech, Fabian, Koepke, Lennart, Graf, Alexander, Krebs, Stefan, Blum, Helmut, Frick, Manfred, Sparrer, Konstantin M. J., Kirchhoff, Frank“…It has recently been shown that an early SARS-CoV-2 isolate (NL-02-2020) hijacks interferon-induced transmembrane proteins (IFITMs) for efficient replication in human lung cells, cardiomyocytes, and gut organoids. …”
Publicado 2022
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29719por Xiao, Yao, Yao, Wenxia, Lin, Mingzhen, Huang, Wei, Li, Ben, Peng, Bin, Ma, Qinhai, Zhou, Xinke, Liang, Min“…Most importantly, our results demonstrated that PLGA@Icaritin could activate the anti-tumor immunity via recruitment of infiltrating CD4+ cells, CD8+ T cells and increased secretion of cytokine immune factors, including interferon-γ (IFN-γ) tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1).(++) Our findings validate that the successful design of PLGA@Icaritin, which can effectively active ICD and facilitate tumor recruitment in GC through inducing mitoDNA oxidative damage.…”
Publicado 2022
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29720por Shirasaki, Takayoshi, Yamagoe, Satoshi, Shimakami, Tetsuro, Murai, Kazuhisa, Imamura, Ryu, Ishii, Kiyo-Aki, Takayama, Hiroaki, Matsumoto, Yukako, Tajima-Shirasaki, Natsumi, Nagata, Naoto, Shimizu, Ryogo, Yamanaka, Souma, Abe, Atsushi, Omura, Hitoshi, Kawaguchi, Kazunori, Okada, Hikari, Yamashita, Taro, Yoshikawa, Tomoki, Takimoto, Kazuhiro, Taharaguchi, Motoko, Takatsuka, Shogo, Miyazaki, Yoshitsugu, Tamai, Toshikatsu, Tanabe, Yamato, Kurachi, Makoto, Yamamoto, Yasuhiko, Kaneko, Shuichi, Matsumoto, Kunio, Takamura, Toshinari, Honda, Masao“…Retinoic acid-inducible gene (RIG)-I is an essential innate immune sensor that recognises pathogen RNAs and induces interferon (IFN) production. However, little is known about how host proteins regulate RIG-I activation. …”
Publicado 2022
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