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29741por Saetang, Jirakrit, Roongsawang, Niran, Sangkhathat, Surasak, Voravuthikunchai, Supayang Piyawan, Sangkaew, Natnaree, Prompat, Napat, Srichana, Teerapol, Tipmanee, Varomyalin“…Their activity was also investigated by treating NK-92MI cells with each IL-18 at concentrations of 75, 150, and 300 ng/ml with 0.5 ng/ml of human IL-12 and interferon-gamma (IFN-γ) levels in the supernatant were evaluated using ELISA. …”
Publicado 2022
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29742por Riestra, Sabino, Taxonera, Carlos, Zabana, Yamile, Carpio, Daniel, Chaparro, María, Barrio, Jesús, Rivero, Montserrat, López-Sanroman, Antonio, Esteve, María, de Francisco, Ruth, Bastida, Guillermo, García-López, Santiago, Mañosa, Miriam, Martin-Arranz, María Dolores, Pérez-Calle, José Lázaro, Guardiola, Jordi, Muñoz, Fernando, Arranz, Laura, Cabriada, José Luis, García-Sepulcre, Mariana Fe, Navarro, Mercè, Montoro-Huguet, Miguel Ángel, Ricart, Elena, Bermejo, Fernando, Calvet, Xavier, Piqueras, Marta, Garcia-Planella, Esther, Márquez, Lucía, Mínguez, Miguel, Van Domselar, Manuel, Bujanda, Luis, Aldeguer, Xavier, Sicilia, Beatriz, Iglesias, Eva, Alcaín, Guillermo, Pérez-Martínez, Isabel, Rolle, Valeria, Castaño-García, Andrés, P. Gisbert, Javier, Domènech, Eugeni“…The diagnostic yield of different strategies (dual screening with tuberculin skin test [TST] and interferon-ץ-release assay [IGRA], two-step TST, and early screening performed at least 12 months before starting biological treatment) was analyzed. (3) Results: Out of 7594 screened patients, 1445 (19%; 95% CI 18–20%) had LTBI. …”
Publicado 2022
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29743por Nguyen, Long C., Renner, David M., Silva, Diane, Yang, Dongbo, Parenti, Nicholas, Medina, Kaeri M., Nicolaescu, Vlad, Gula, Haley, Drayman, Nir, Valdespino, Andrea, Mohamed, Adil, Dann, Christopher, Wannemo, Kristin, Robinson-Mailman, Lydia, Gonzalez, Alan, Stock, Letícia, Cao, Mengrui, Qiao, Zeyu, Moellering, Raymond E., Tay, Savas, Randall, Glenn, Beers, Michael F., Rosner, Marsha Rich, Oakes, Scott A., Weiss, Susan R.“…Moreover, while IRE1α was dispensable for replication in human cells for all coronaviruses tested, it was required for maximal expression of genes associated with several key cellular functions, including the interferon signaling pathway, during SARS-CoV-2 infection. …”
Publicado 2022
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29744por Sanders, Jan-Stephan F, Messchendorp, A Lianne, de Vries, Rory D, Baan, Carla C, van Baarle, Debbie, van Binnendijk, Rob, Diavatopoulos, Dimitri A, Geers, Daryl, Schmitz, Katharina S, GeurtsvanKessel, Corine H, den Hartog, Gerco, Kho, Marcia M L, Koopmans, Marion P G, van der Molen, Renate G, Remmerswaal, Ester B M, Rots, Nynke, Gansevoort, Ron T, Bemelman, Frederike J, Hilbrands, Luuk B, Reinders, Marlies E J“…SARS-CoV-2 Spike S1 specific IgG antibodies were measured using fluorescent bead-based multiplex-immunoassay, neutralizing antibodies to ancestral, Delta, and Omicron (BA.1) variants by plaque reduction, and T-cell responses by interferon-γ release assay. RESULTS: At 6 months after vaccination, S1-specific antibodies were detected in 100% of controls, 98.7% of CKD G4/5 patients, 95.1% of dialysis patients, and 56.6% of KTRs. …”
Publicado 2022
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29745por Lipsky, Peter E, van Vollenhoven, Ronald, Dörner, Thomas, Werth, Victoria P, Merrill, Joan T, Furie, Richard, Petronijevic, Milan, Velasco Zamora, Benito, Majdan, Maria, Irazoque-Palazuelos, Fedra, Terbrueggen, Robert, Delev, Nikolay, Weiswasser, Michael, Korish, Shimon, Stern, Mark, Hersey, Sarah, Ye, Ying, Gaudy, Allison, Liu, Zhaohui, Gagnon, Robert, Tang, Shaojun, Schafer, Peter H“…Clinical efficacy was previously reported in patients with high IKZF3 expression and high type I interferon (IFN) signature at baseline and confirmed here in those with an especially high IFN signature. …”
Publicado 2022
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29746por Tang, Lirui, Wei, Xiaoting, Li, Caili, Dai, Jie, Bai, Xue, Mao, Lili, Chi, Zhihong, Cui, Chuanliang, Lian, Bin, Tang, Bixia, Du, Yu, Wang, Xuan, Lai, Yumei, Sheng, Xinan, Yan, Xieqiao, Li, Siming, Zhou, Li, Kong, Yan, Li, Zhongwu, Si, Lu, Guo, Jun“…A total of 100 patients received temozolomide (TMZ)-based adjuvant chemotherapy and 75 patients received high-dose interferon-α2b (HDI) adjuvant therapy. Compared with HDI, patients who received TMZ-based adjuvant chemotherapy had significantly superior RFS (21.0 vs. 9.6 months, P = 0.002). …”
Publicado 2022
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29747por Ali, Elrazi A, Abu-Tineh, Mohammad, Rozi, Waail, Ali, Bashir, Babiker, Anas, Hailan, Yousef, Al-Maharmeh, Qusai, Maat, Zakaria, Ismail, Abdellatif, Yassin, Mohamed A“…The treatment received included hydroxycarbamide (n=8), pegylated interferon 2 alpha (n=10), ruxolitinib (n=1), and phlebotomy (n=1). …”
Publicado 2022
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29748por Trugilho, Monique R. O., Azevedo-Quintanilha, Isaclaudia G., Gesto, João S. M., Moraes, Emilly Caroline S., Mandacaru, Samuel C., Campos, Mariana M., Oliveira, Douglas M., Dias, Suelen S. G., Bastos, Viviane A., Santos, Marlon D. M., Carvalho, Paulo C., Valente, Richard H., Hottz, Eugenio D., Bozza, Fernando A., Souza, Thiago Moreno L., Perales, Jonas, Bozza, Patrícia T.“…Significant changes in the expression of proteins related to platelet activation, cell death, and antiviral response through interferon type-I were found in all patients. Since the outcome of COVID-19 varies highly among individuals, we also performed a cross-comparison of proteins found in survivors and nonsurvivors. …”
Publicado 2022
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29749por Stumpf, Julian, Schwöbel, Jörg, Karger, Claudia, Schirutschke, Holger, Mauer, René, Klimova, Anna, Tonn, Torsten, Hugo, Christian“…One hundred sixty-six of 193 received a third vaccination between 3.5 and 5 months after the initial study enrollment and were always investigated 4 weeks later, exploring humoral immune response (ELISA) and specific cellular responses (interferon-γ release assay). Sixty-seven of 193 measurements in KTR were done immediately before the third vaccination or in KTR without further vaccination at 4.5–6 months. …”
Publicado 2022
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29750“…Placental SARS-CoV-2 and coronavirus-associated receptors and factors (SCARFs), including basigin (BSG/CD147), dipeptidyl peptidase-4 (DPP4/CD26), cathepsin B/L (CTL B/L), furin, interferon-induced transmembrane protein (IFITM1-3), and lymphocyte antigen 6E (LY6E) may increase or reduce the permissiveness of the placenta to SARS-CoV-2. …”
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29751por Kiyohara, Eiji, Tanemura, Atsushi, Sakura, Kazuma, Nakajima, Toshihiro, Myoui, Akira, Yamazaki, Naoya, Kiyohara, Yoshio, Katayama, Ichiro, Fujimoto, Manabu, Kaneda, Yasufumi“…The activity of NK cells and interferon-γ levels were increased in the circulation, indicating augmentation of antitumor immunity by GEN0101. …”
Publicado 2022
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29752por Nephew, Lauren D., Wang, Yumin, Mohamed, Kawthar, Nichols, Deborah, Rawl, Susan M., Orman, Eric, Desai, Archita P., Patidar, Kavish R., Ghabril, Marwan, Chalasani, Naga, Kasting, Monica L.“…Inflections in the Lowess curve defined four periods: (1) Interferon + DAA, (2) early direct‐acting antivirals, (3) Medicaid expansion/optimization and (4) Medicaid restrictions (fibrosis/prescriber) removed. …”
Publicado 2022
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29753“…We previously reported that pro-inflammatory cytokine signaling within peripheral blood mononuclear cells, elevated plasma interferon-gamma (IFNγ), and low birth weight correlated with vaccine-induced serum IgG titers in piglets that were below the threshold of detectable seroconversion (vaccine non-responders). …”
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29754por Plant, Darren, Maciejewski, Mateusz, Smith, Samantha, Nair, Nisha, Hyrich, Kimme, Ziemek, Daniel, Barton, Anne, Verstappen, Suzanne“…Pathway analysis of gene networks revealed significant overrepresentation of type I interferon signaling pathway genes in nonresponders at pretreatment (P = 2.8 × 10(−25)) and at 4 weeks after treatment initiation (P = 4.9 × 10(−28)). …”
Publicado 2019
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29755por Tang, Yongjun, Yang, Yaxiong, He, Ruohui, Huang, Rong, Zheng, Xiangrong, Liu, Chentao“…Then, we collected 52 children with wheezing diseases and 25 normal controls to detect the expression of interferon-γ (IFN-γ), interleukin-4 (IL-4), IFN-γ/IL-4, IL-17A, IL-17E, IgE, matrix metalloproteinase-3 (MMP-3), and MMP-9 in serum or plasma. …”
Publicado 2022
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29756por Jiang, Jie, Li, Junhui, Zhang, Yu, Zhou, Chen, Guo, Chen, Zhou, Zhaoqin, Ming, Yingzi“…Further analysis revealed that Sj SEA mediated regulation on cellular response to interferon-γ, activation of IL-17 signaling and chemokine signaling pathways, as well as cytokine–cytokine receptor interaction. …”
Publicado 2022
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29757por Hogg, Simon J., Motorna, Olga, Kearney, Conor J., Derrick, Emily B., House, Imran G., Todorovski, Izabela, Kelly, Madison J., Zethoven, Magnus, Bromberg, Kenneth D., Lai, Albert, Beavis, Paul A., Shortt, Jake, Johnstone, Ricky W., Vervoort, Stephin J.“…BACKGROUND: Interferon gamma (IFNγ) is a pro-inflammatory cytokine that directly activates the JAK/STAT pathway. …”
Publicado 2022
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29758por Bai, Lu, Dai, Jing, Xia, Yuxuan, He, Kaichuan, Xue, Hongmei, Guo, Qi, Tian, Danyang, Xiao, Lin, Zhang, Xiangjian, Teng, Xu, Wu, Yuming, Jin, Sheng“…Subsequently, we found that feeding choline or TMAO significantly increased the protein levels of cyclic GMP-AMP (cGAMP) synthase (cGAS), stimulator of interferon genes (STING), NOD-like receptor protein 3 (NLRP3), caspase-1, and interleukin-1β (IL-1β) as compared to the control, which indicated the activation of cGAS-STING-NLRP3 inflammasome axis. …”
Publicado 2022
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29759“…Expression levels of beta interferon (IFN-β) mRNA were detected using RT-qPCR. …”
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29760por Trung, Nguyen Bao, Nguyen, Tan-Phat, Hsueh, Hao-Yun, Loh, Jiun-Yan, Wangkahart, Eakapol, Wong, Alice Sui Fung, Lee, Po-Tsang“…The transcript levels of OnMyD88, OnTIRAP, OnTRIF, and downstream effectors, including interleukin (IL)-1β, IL-8, IL-12b and type I interferon (IFN)d2.13, were regulated conversely to the expression of OnSARM1 in the head kidney from Aeromonas hydrophila and Streptococcus agalactiae infected fish. …”
Publicado 2022
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