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29761por Lin, Yi-Fu, Lee, Tai-Fen, Wu, Un-In, Huang, Chun-Fu, Cheng, Aristine, Lin, Kuan-Yin, Hung, Chien-Ching“…BACKGROUND: Patients with adult-onset immunodeficiency syndrome due to anti-interferon-γ autoantibodies (AIGAs) are susceptible to disseminated Mycobacterium avium complex (MAC) infections. …”
Publicado 2022
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29762por Liu, Chen-Hua, Sun, Hsin-Yun, Peng, Cheng-Yuan, Hsieh, Szu-Min, Yang, Sheng-Shun, Kao, Wei-Yu, Shih, Yu-Lueng, Lin, Chih-Lin, Liu, Chun-Jen, Sheng, Wang-Hui, Lo, Yi-Chun, Liu, Wen-Chun, Wu, Jo-Hsuan, Su, Tung-Hung, Tseng, Tai-Chung, Chen, Pei-Jer, Hung, Chien-Ching, Kao, Jia-Horng“…METHODS: HIV/HCV-coinfected patients in Taiwan who achieved SVR(12) with interferon (IFN) or direct-acting antivirals (DAAs) between 2005 and 2021 underwent HCV RNA measurements at SVR(24) and then biannually. …”
Publicado 2022
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29763por Lai, Yimei, Zhao, Siyuan, Chen, Binfeng, Huang, Yuefang, Guo, Chaohuan, Li, Mengyuan, Ye, Baokui, Wang, Shuyi, Zhang, Hui, Yang, Niansheng“…CD4(+) T‐cells from patients with IIM was proinflammatory and iron chelation suppressed the differentiation of interferon gamma (IFNγ)‐ and interleukin (IL)‐17A‐producing CD4(+) T‐cells, which resulted in an increased percentage of regulatory T (Treg) cells. …”
Publicado 2022
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29764por L’Huillier, Arnaud G., Pagano, Sabrina, Baggio, Stephanie, Meyer, Benjamin, Andrey, Diego O., Nehme, Mayssam, Guessous, Idris, Eberhardt, Christiane S., Huttner, Angela, Posfay‐Barbe, Klara M., Yerly, Sabine, Siegrist, Claire‐Anne, Kaiser, Laurent, Vuilleumier, Nicolas“…ROC curve analyses and logistic regression models (LRM) were used to determine the prognostic accuracy of AAA1 and their association with patient‐reported COVID‐19 symptoms persistence at 12 months. Interferon (IFN)‐α and‐γ production by AAA1‐stimulated human monocyte‐derived macrophages (HMDM) was assessed in vitro. …”
Publicado 2022
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29765por Huijser, Erika, Bodewes, Iris L A, Lourens, Mirthe S, van Helden-Meeuwsen, Cornelia G, van den Bosch, Thierry P P, Grashof, Dwin G B, van de Werken, Harmen J G, Lopes, Ana P, van Roon, Joel A G, van Daele, Paul L A, Brkic, Zana, Dik, Willem A, Versnel, Marjan A“…Here we investigate the responsiveness of pSS monocytes and plasmacytoid dendritic cells (pDCs) to stimulator of interferon genes (STING) activation in relation to systemic IFN-I pathway activation and compare this with SLE. …”
Publicado 2022
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29766“…Antibodies were detected in 93% healthy controls (HCs), and 77% pwMS, with >93% responses in all DMTs (interferon‐beta, glatiramer acetate, cladribine, natalizumab, dimethyl fumarate, alemtuzumab, and teriflunomide) except for 72% sphingosine‐1‐phosphate modulators (S1PM) and 44% anti‐CD20 monoclonal antibodies (mAbs). …”
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29767por Lasagna, A., Bergami, F., Lilleri, D., Percivalle, E., Quaccini, M., Serra, F., Comolli, G., Sarasini, A., Sammartino, J.C., Ferrari, A., Arena, F., Secondino, S., Cicognini, D., Schiavo, R., Lo Cascio, G., Cavanna, L., Baldanti, F., Pedrazzoli, P., Cassaniti, I.“…Heparinized whole blood samples were used for the SARS-CoV-2 interferon-γ release assay (IGRA). RESULTS: Six months after the third dose only two patients (2.4%) showed negative spike-specific immunoglobulin G antibody levels (<33.8 BAU/ml). …”
Publicado 2022
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29768por Wang, Wen-Xin, Jia, Rui, Gao, Ying-Ying, Liu, Jia-Ye, Luan, Jun-Qing, Qiao, Fei, Liu, Li-Min, Zhang, Xiao-Ning, Wang, Fu-Sheng, Fu, Junliang“…BACKGROUND AND AIMS: Precise predictors are lacking for hepatitis B surface antigen (HBsAg) clearance under the combination therapy of nucleos(t)ide analogs (NA) and pegylated interferon-alpha (PEG-IFN-α) in patients with chronic hepatitis B (CHB). …”
Publicado 2022
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29769por Uzorka, Jonathan W., Bakker, Jaap A., van Meijgaarden, Krista E., Leyten, Eliane M.S., Delfos, Nathalie M., Hetem, David J., Kerremans, Jos, Zwarts, Mieke, Cozijn, Sandra, Ottenhoff, Tom H.M., Joosten, Simone A., Arend, Sandra M.“…Global testing revealed that the levels of 10 kDa interferon (IFN)-γ-induced protein (IP-10/CXCL10), monokine induced by IFN-γ (MIG/CXCL9) and interleukin-1 receptor antagonist in the antigen-stimulated tubes were each significantly higher in patients with a positive QFT result compared with low-negative QFT individuals (p<0.001). …”
Publicado 2022
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29770por Lin, Guizhen, Zhang, Lei, Yan, Zheng, Jiang, Wei, Wu, Beibei, Li, Dongsheng, Xiong, Xiaofang“…Results: C-X-C Motif Chemokine Receptor 3 (CXCR3), interleukin-17 receptor E (IL-17RE), CD200, and C-C Motif Chemokine Receptor 4 (CCR4) marked three subsets of aortic IL-17A-expressing T cells: CXCR3(+)IL-17RE(low)CD200(+)CCR4(-) T cells expressing T-box protein expressed in T cells (T-bet) and interferon-gamma (IFN-γ), CXCR3(+)IL-17RE(low)CD200(+)CCR4(+) T cells expressing T-bet but fewer IFN-γ, and CXCR3(−)IL-17RE(high)CD200(+)CCR4(+) T cells expressing very low T-bet and no IFN-γ. …”
Publicado 2022
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29771“…PURPOSE: Here, we analyzed the influence of lacidophilin vaginal capsules plus recombinant human interferon α-2b (rh-IFN-α2b) on efficacy, vaginal microecology, and safety of patients with HPV infection. …”
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29772por Srinivasan, Vasundara, Brognaro, Hévila, Prabhu, Prince R., de Souza, Edmarcia Elisa, Günther, Sebastian, Reinke, Patrick Y. A., Lane, Thomas J., Ginn, Helen, Han, Huijong, Ewert, Wiebke, Sprenger, Janina, Koua, Faisal H. M., Falke, Sven, Werner, Nadine, Andaleeb, Hina, Ullah, Najeeb, Franca, Bruno Alves, Wang, Mengying, Barra, Angélica Luana C., Perbandt, Markus, Schwinzer, Martin, Schmidt, Christina, Brings, Lea, Lorenzen, Kristina, Schubert, Robin, Machado, Rafael Rahal Guaragna, Candido, Erika Donizette, Oliveira, Danielle Bruna Leal, Durigon, Edison Luiz, Niebling, Stephan, Garcia, Angelica Struve, Yefanov, Oleksandr, Lieske, Julia, Gelisio, Luca, Domaracky, Martin, Middendorf, Philipp, Groessler, Michael, Trost, Fabian, Galchenkova, Marina, Mashhour, Aida Rahmani, Saouane, Sofiane, Hakanpää, Johanna, Wolf, Markus, Alai, Maria Garcia, Turk, Dusan, Pearson, Arwen R., Chapman, Henry N., Hinrichs, Winfried, Wrenger, Carsten, Meents, Alke, Betzel, Christian“…Beside the cysteine-protease activity, facilitating cleavage of the viral polypeptide chain, PLpro has the additional and vital function of removing ubiquitin and ISG15 (Interferon-stimulated gene 15) from host-cell proteins to support coronaviruses in evading the host’s innate immune responses. …”
Publicado 2022
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29773“…Eotaxin values were significantly higher in patients >18 years old (P = .03), and Macrophage Inflammatory Protein (MIP)-1alpha, MIP-1beta, Interleukine (IL)-1Ra, Interferon (IFN)-alpha2, IL-12, IL-13, IL-17A, IL-1beta, IL-2, IL-4, IL-5, IL-7, IL-9, Monocyte Chemoattractant Protein (MCP)-3, Transforming Growth Factor (TGF)-alpha, and Tumor necrosis factor (TNF)-beta were significantly higher in patients ≤18 years old (all P < .05). …”
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29774por Guti, Eliza, Regdon, Zsolt, Sturniolo, Isotta, Kiss, Alexandra, Kovács, Katalin, Demény, Máté, Szöőr, Árpád, Vereb, György, Szöllősi, János, Hegedűs, Csaba, Polgár, Zsuzsanna, Virág, László“…The drug suppressed NK cell activation as indicated by reduced granzyme B deposition on to the target cells and inhibition of interferon-γ production by the NK cells. Moreover, sunitinib induced downregulation of HER2 on the target cells' surface, changed the morphology and increased adherence of the target cells. …”
Publicado 2022
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29775“…OBJECTIVE: The aim of the present study was to investigate the association of single-nucleotide polymorphisms (SNPs) in the macrophage migration inhibiting factor (MIF), interferon-induced Helicase C domain 1 (IFIH1), interleukin-6 (IL6) genes, circulating levels with non-segmental vitiligo (NSV) susceptibility in the Chinese population, and to analyze the relationships between gene polymorphisms and clinical characteristics of vitiligo. …”
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29776por Zou, Tao, Gao, Shan, Yu, Zhaolan, Zhang, Fuyong, Yao, Lan, Xu, Mengyao, Li, Junxin, Wu, Zhigui, Huang, Yilan, Wang, Shurong“…Cell viability was not significantly changed when the concentration of Sal B was less than 200 μM, and Lipopolysaccharide (LPS) (100 ng/mL) + interferon-γ (IFN-γ) (2.5 ng/mL) successfully induced M1 polarization. …”
Publicado 2022
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29777por Bednarova, Kamila, Slatinska, Janka, Fabian, Ondrej, Wohl, Pavel, Kopecka, Emilia, Viklicky, Ondrej“…CONCLUSION: In this case, false negativity of interferon-γ release assays and possibly higher risk for intracellular infections in patients on costimulatory signal blockers are discussed. …”
Publicado 2022
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29778por Jin, Jenny C., Ananthanarayanan, Aparna, Brown, Julia A., Rager, Stephanie L., Bram, Yaron, Sanidad, Katherine Z., Amir, Mohammed, Baergen, Rebecca N., Stuhlmann, Heidi, Schwartz, Robert E., Perlman, Jeffrey M., Zeng, Melody Y.“…Newborn stool was evaluated for SARS-CoV-2 RNA, Spike protein, and induction of inflammatory cytokines interleukin-6 (IL-6) and interferon-γ (IFN-γ) in macrophages. RESULTS: Despite negative SARS CoV-2 nasal PCRs from all newborns, viral RNAs and Spike protein were detected in the stool of 11 out of 14 newborns as early as the first day of life and increased over time in 6. …”
Publicado 2022
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29779por James, Fiona, Goh, Michelle S Y, Mouhtouris, Effie, Vogrin, Sara, Chua, Kyra Y L, Holmes, Natasha E, Awad, Andrew, Copaescu, Ana-Maria, De Luca, Joseph F, Zubrinich, Celia, Gin, Douglas, Cleland, Heather, Douglas, Abby, Kern, Johannes S, Katelaris, Constance H, Thien, Francis, Barnes, Sara, Yun, James, Tong, Winnie, Smith, William B, Carr, Andrew, Anderson, Tara, Legg, Amy, Bourke, Jack, Mackay, Laura K, Aung, Ar Kar, Phillips, Elizabeth J, Trubiano, Jason“…To develop culprit drug identification and prevention, genomic testing will be performed to confirm human leukocyte antigen (HLA) type and ex vivo testing will be performed via interferon-γ release enzyme linked immunospot assay using collected peripheral blood mononuclear cells. …”
Publicado 2022
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29780por Martínez-Gallo, Mónica, Esperalba, Juliana, Pujol-Borrell, Ricardo, Sandá, Víctor, Arrese-Muñoz, Iria, Fernández-Naval, Candela, Antón, Andrés, Cardona, Victoria, Labrador-Horrillo, Moisés, Pumarola, Tomás, Hernandéz-González, Manuel“…Antibody test to SARS-CoV-2 N and S-proteins in parallel with a commercially available whole-blood-interferon-gamma-release-assay (IGRA) to S-peptides and two detection methods, CLIA and ELISA were determined. …”
Publicado 2022
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