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29801por Lee, Je-Jung, Kim, So Young, Kim, Songhee H., Choi, Seoyeon, Lee, Bin, Shin, Jeon-Soo“…However, the relevance of PD-L1 targeting-induced senescence and the role of stimulator of interferon genes (STING) has not been reported. Therefore, we aimed to identify the role of PD-L1 in cancer progression and how it regulates cancer prevention. …”
Publicado 2022
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29802por Roccuzzo, Gabriele, Mastorino, Luca, Gallo, Giuseppe, Fava, Paolo, Ribero, Simone, Quaglino, Pietro“…Other therapy reported were based on Brentuximab Vedotin, Mogamulizumab, Carmustine, topical steroids, tazarotene and excimer laser, interferon, nitrogen mustard, imiquimod, systemic chemotherapy, extracorporeal photopheresis and stem cell transplantation. …”
Publicado 2022
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29803“…OBJECTIVE: This study determined the effects of chemical adjuvants, incomplete Freund's adjuvant (IFA) and aluminum hydroxide (Alum), mycobacteria, and a DNA plasmid as delivery systems on the induction of protective Th1 (interferon-gamma (IFN-γ)) and nonprotective Th2 (IL-5) and Treg (IL-10) cytokine responses to Rv3619c and its peptides. …”
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29804por Scholler, Nathalie, Perbost, Regis, Locke, Frederick L., Jain, Michael D., Turcan, Sarah, Danan, Corinne, Chang, Edmund C., Neelapu, Sattva S., Miklos, David B., Jacobson, Caron A., Lekakis, Lazaros J., Lin, Yi, Ghobadi, Armin, Kim, Jenny J., Chou, Justin, Plaks, Vicki, Wang, Zixing, Xue, Allen, Mattie, Mike, Rossi, John M., Bot, Adrian, Galon, Jérôme“…TME enriched for chemokines (CCL5 and CCL22), γ-chain receptor cytokines (IL-15, IL-7 and IL-21) and interferon-regulated molecules were associated with T cell infiltration and markers of activity. …”
Publicado 2022
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29805“…Flow cytometry was used to detect the levels of T lymphocyte subsets (CD4+, CD8+, and CD4+/CD8+) and serum inflammatory factor interleukin IL-6, IL-10, and interferon-γ(IFN-γ). The contents of serum immunoglobulin Ig E and 25-(OH) D(3) were detected by chemiluminescence. …”
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29806por Azamor, Tamiris, Horbach, Ingrid Siciliano, Brito e Cunha, Danielle, Melgaço, Juliana Gil, da Silva, Andréa Marques Vieira, Tubarão, Luciana Neves, Azevedo, Adriana de Souza, Santos, Renata Tourinho, Alves, Nathalia dos Santos, Machado, Thiago Lazari, Silva, Jane, de Souza, Alessandro Fonseca, Bayma, Camilla, Rocha, Vanessa Pimenta, Frederico, Ana Beatriz Teixeira, Dias, Brenda de Moura, Setatino, Bruno Pimenta, Denani, Caio Bidueira, Campos, Samir Pereira da Costa, Schwarcz, Waleska Dias, Sucupira, Michel Vergne, Mendes, Edinea Pastro, da Silva, Edimilson Domingos, Barbosa de Lima, Sheila Maria, Ano Bom, Ana Paula Dinis, Missailidis, Sotiris“…We investigated the immune response from ChAadOx1 nCoV-19 vaccination in naïve (noCOVID-19) and previously infected individuals (COVID-19) by analyzing levels of D-dimers, total IgG, neutralizing antibodies (Nabs), IFN-γ (interferon-γ) secretion, and immunophenotyping of memory lymphocytes. …”
Publicado 2022
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29807por Shao, Tihong, Leung, Patrick S. C., Zhang, Weici, Tsuneyama, Koichi, Ridgway, William M., Young, Howard A., Shuai, Zongwen, Ansari, Aftab A., Gershwin, M. Eric“…The interferon (IFN) signaling pathways are major immunological checkpoints with clinical significance in the pathogenesis of autoimmunity. …”
Publicado 2022
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29808por Wilkinson, Hannah, Leonard, Hugh, Robson, Michael G., Smith, Richard, Tam, ElLi, McVey, John H., Kirckhofer, Daniel, Chen, Daxin, Dorling, Anthony“…We have previously demonstrated PAR-1 signalling primes innate myeloid cells to be exquisitely sensitive to interferon-gamma (IFNγ). In this work we explored how TF mediated PAR-2 signalling modulated responsiveness to IFNγ and investigated the interplay between PAR-1/-2 signalling on macrophages. …”
Publicado 2022
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29809por Lin, Kuan-Yin, Yang, Chia-Jui, Sun, Hsin-Yun, Lee, Yuan-Ti, Liou, Bo-Huang, Hii, Ing-Moi, Chen, Tun-Chieh, Huang, Sung-Hsi, Lee, Chun-Yuan, Tsai, Chin-Shiang, Lin, Chi-Ying, Liu, Chun-Eng, Chang, Hsi-Yen, Cheng, Chien-Yu, Lu, Po-Liang, Hung, Chien-Ching“…This retrospective study included adult PLWH undergoing interferon-gamma release assay (IGRA)-based TBI screening during 2019–2021. …”
Publicado 2022
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29810por Li, Jiarui, Tao, Tianchang, Yu, Yingying, Xu, Ningda, Du, Wei, Zhao, Mingwei, Jiang, Zhengxuan, Huang, Lvzhen“…Furthermore, five gene sets (interferon-gamma response, Wnt beta-catenin signaling, oxidative phosphorylation, DNA repair, and MYC targets v2) were found only in our Chinese datasets. …”
Publicado 2022
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29811por Göschl, Lisa, Mrak, Daniel, Grabmeier-Pfistershammer, Katharina, Stiasny, Karin, Haslacher, Helmuth, Schneider, Lisa, Deimel, Thomas, Kartnig, Felix, Tobudic, Selma, Aletaha, Daniel, Burgmann, Heinz, Bonelli, Michael, Pickl, Winfried F., Förster-Waldl, Elisabeth, Scheinecker, Clemens, Vossen, Matthias Gerhard“…RESULTS: Our cohort included 11 individuals with common variable immunodeficiency (CVID), one patient with warts hypogammaglobulinemia immunodeficiency myelokathexis (WHIM) syndrome, two patients with X-linked agammaglobulinemia (XLA), one patient with Muckle Wells syndrome, two patients with cryopyrin-associated periodic syndrome, one patient with Interferon-gamma (IFN-gamma) receptor defect, one patient with selective deficiency in pneumococcal antibody response combined with a low MBL level and seven patients with severe MBL deficiency. …”
Publicado 2022
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29812“…METHODS: We measured interferon-gamma (IFN-γ) levels upon administering homologous adenovirus vector-based (ChAdOx1-S [AZ], Ad26.COV2.S [JAN]), mRNA-based (BNT162b2 [PF]; mRNA-1273 [MO]), and heterologous (AZ/PF) vaccines in healthy Korean individuals using two IFN-γ release assays: the Covi-FERON ELISA and T-SPOT Discovery SARS-CoV-2 assay. …”
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29813“…Compared with homologous booster group, geometric mean neutralizing titers (GMTs) of neutralizing antibody for different SARS-CoV-2 variants and response rate of antibody and gama interferon were higher in heterologous booster group. …”
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29814por Chen, Jinjin, Chen, Surong, Dai, Xichao, Ma, Liang, Chen, Yu, Bian, Weigang, Sun, Yunhao“…Pathway enrichment analysis showed that in Cluster2, the pathway of EMT, TNFα/NF-kB signaling, IL2/STAT5 signaling, inflammatory response, KRAS signaling, apical junction, complement, interferon-gamma response and allograft rejection were significantly activated. …”
Publicado 2022
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29815por Hong, Eun Hee, Hwang, Mina, Yu, Hyoseon, Park, Hyun-Hee, Cho, Heeyoon, Koh, Seong-Ho, Shin, Yong Un“…Bioinformatic analysis revealed a direct relationship among downregulated miRNAs, CRVO, and the following proteins: MMP-2, MMP-9, tumor necrosis factor, transforming growth factor beta-1, caspase-3, interleukin-6, interferon gamma, and interleukin-1-beta. Activities of MMP-2 and -9 in AH were detected using gelatin zymography, showing significant increase in the CRVO group compared to the control group (p < 0.01). …”
Publicado 2022
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29816por Mao, Jianbo, Chen, Nuo, Zhang, Shian, Fang, Yuyan, Zheng, Zicheng, Wu, Sulan, Ye, Xin, Chen, Yijing, Chen, Yiqi, Shen, Lijun“…Cytokines interleukin 6 (IL-6), IL-8, IL-10, interferon-inducible protein 10 (IP-10), monocyte chemotactic protein 1 (MCP-1), and VEGF were measured by multiplex bead assay. …”
Publicado 2022
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29817“…Extensive investigations were carried out, including an Interferon-gamma release assay (IGRA)- which was positive. …”
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29818por Klopp‐Schulze, Lena, Shaw, Jamie V., Dong, Jennifer Q., Khandelwal, Akash, Vazquez‐Mateo, Cristina, Goteti, Kosalaram“…Population pharmacokinetic/pharmacodynamic (PopPK/PD) model‐based simulations, using PK and PD (inhibition of ex vivo‐stimulated interleukin‐6 (IL‐6) and interferon‐α (IFN‐α) secretion) data from a phase I study of enpatoran in healthy participants, were leveraged to inform dose selection for lupus and repurposed for accelerated development in COVID‐19. …”
Publicado 2022
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29819por Derry-Vick, Heather M., Johnston, Carrie D., Brennan-Ing, Mark, Burchett, Chelsie O., Glesby, Nina, Zhu, Yuan-Shan, Siegler, Eugenia L., Glesby, Marshall J.“…Participants reported depressive symptoms (10-item Center for Epidemiological Studies Depression Scale) and then attended a biomedical visit in which they reported past-month pain (Medical Outcomes Study-HIV pain subscale), completed physical function assessments, and provided blood samples (assayed for interleukin 6, interferon-γ, tumor necrosis factor α, and C-reactive protein). …”
Publicado 2022
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29820por Van Royen, Tessa, Sedeyn, Koen, Moschonas, George D., Toussaint, Wendy, Vuylsteke, Marnik, Van Haver, Delphi, Impens, Francis, Eyckerman, Sven, Lemmens, Irma, Tavernier, Jan, Schepens, Bert, Saelens, Xavier“…Nonstructural protein NS1 of RSV modulates the host innate immune response by acting as an antagonist of type I and type III interferon (IFN) production and signaling in multiple ways. …”
Publicado 2022
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