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29861por Sui, Laijian, Zeng, Jianyuan, Zhao, Huishan, Ye, Lin, Martin, Tracey A., Sanders, Andrew J., Ruge, Fiona, Jiang, Aihua, Dou, Q. Ping, Hargest, Rachel, Song, Xicheng, Jiang, Wen G.“…Death associated protein-3 (DAP3) was identified as a responsive protein to interferon-gamma-induced cell death which possibly exerts this regulation by interacting with DAP3 binding cell Death enhancer-1 (DELE1), a newly discovered mitochondrial stress protein in response to cell stress signals. …”
Publicado 2022
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29862por Kim, Jimin, Lee, Seul Ki, Jung, Minyoung, Jeong, Seon-Yeong, You, Haedeun, Won, Ji-Yeon, Han, Sang-Deok, Cho, Hye Jin, Park, Somi, Park, Joonghoon, Kim, Tae Min, Kim, Soo“…RESULTS: Proteome analysis showed that IFN-γ-iMSC-EVs are enriched with protein sets that are involved in regulating interferon responses and inflammatory pathways. In AD mice, expression of interleukin receptors for Th2 cytokines (IL-4Rα/13Rα1/31Rα) and activation of their corresponding intracellular signaling molecules was reduced. …”
Publicado 2022
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29863por Nistor, Gabriel I., Dillman, Robert O., Robles, Rockelle M., Langford, James L., Poole, Aleksandra J., Sofro, Muchlis A. U., Nency, Yetty M., Jonny, Jonny, Yana, Martina L., Karyana, Mahammad, Lestari, Endang S., Triwardhani, Ria, Mujahidah, Mujahidah, Sari, Retty K., Soetojo, Nur A., Wibisono, Djoko, Tjen, Daniel, Ikrar, Taruna, Sarkissian, Gregory, Winarta, Haryono, Putranto, Terawan A., Keirstead, Hans S.“…In Phase 2, in the 127 subjects who did not have high levels of gamma interferon-producing cells at baseline, 94.4% had increased by day 14 and 96.8% by day 28. …”
Publicado 2022
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29864por Li, Ping, Ke, Yuehua, Shen, Wenlong, Shi, Shu, Wang, Yahao, Lin, Kailin, Guo, Xinjie, Wang, Changjun, Zhang, Yan, Zhao, Zhihu“…Specifically, rs1799964 in the promoter of inflammation-related gene TNF, rs9975538 in the intron of interferon receptor gene IFNAR2, rs429358 in the exon of APOE, rs1886814 in the intron of FOXP4-AS1 and a list of variants in the widely reported 3p21.31 and ABO gene were confirmed. …”
Publicado 2022
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29865por Zhou, Bin, Sha, Shanshan, Tao, Juan, Li, Jun, Shen, Chen, Zhu, Jinjin, Tan, Lulu, Dong, Liyun, Huang, Changzheng“…Pyroptosis was also related to a better response of melanoma to interferon-α, paclitaxel, cisplatin and imatinib. Through Spearman correlation analysis of the 12 pyroptosis-related genes and 135 chemotherapeutic agents in the Genomics of Drug Sensitivity in Cancer database, we identified solute carrier family 31 member 2 (SLC31A2) and collagen type 4 alpha 5 chain (COL4A5) as being associated with resistance to most of these drugs. …”
Publicado 2022
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29866por Upmacis, Rita K, Becker, Wendy L, Rattendi, Donna M, Bell, Raven S, Jordan, Kelsey D, Saniei, Shayan, Mejia, Elena“…In macrophages, prostaglandin E(2) (PGE(2)) production following lipopolysaccharide (LPS) and interferon gamma (IFNγ) stimulation was COX2-dependent in both males and females, and data indicated that crosstalk between the nitric oxide (NO) and COX2 pathways may be sex specific. …”
Publicado 2022
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29867por Hart, Paulina M. B., Stephenson, Nikki L., Scime, Natalie V., Tough, Suzanne C., Slater, Donna M., Chaput, Kathleen H.“…Six cytokine levels were identified in the GDM CART: Interleukin-1 Receptor Antagonist (IL-1Ra; cut-off: <25pg/mL), Interleukin-5 (cut-off: ≥0.4pg/mL), Interferon-γ (cut-off: <4.9pg/mL), IL-1Ra (cut-off: ≥111pg/mL), Eotaxin (cut-off: ≥21pg/mL), and Interleukin-18 (cut-off: ≥155pg/mL). …”
Publicado 2022
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29868299. Systems immunology profiling of treatment-naïve children with multisystem inflammatory syndromepor Zheng, Hong, Yonker, Lael, Donado, Michele, Solomon, Ben, Boribong, Brittany, Gernez, Yael, Maecker, Holden, Sigal, Natalia, Kinane, Bernard, Arvin, Ann, Khatri, Purvesh, Weinacht, Katja“…Importantly, in PBMCs of MIS-C patients, we identified a distinct subset of proinflammatory monocytes, with increased expression of interferon gamma response genes combined with a signature of enhanced complement expression, antigen processing and presentation, which was not observed in post-treatment MIS-C samples. …”
Publicado 2022
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29869por Bark, Charles, Nsereko, Mary N, Kiwanuka, Noah, Whalen, Christopher C, Stein, Catherine M, Boom, Henry, Mayanja-Kizza, Harriet, Nalukwago, Sophie, Kakaire, Robert, Jingo, JohnPaul Kasule, Paramithiotis, Eustache“…Preventive therapy is an effective intervention but treating all individuals with latent TB infection (LTBI) based on current diagnostics, tuberculin skin test (TST) and interferon gamma release assay (IGRA), is not feasible. …”
Publicado 2022
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298701426. Characterization of Patients with Iatrogenic Mycobacterial Infections: A Hospital-Based Surveypor Mitra, Debdeep“…Tuberculin skin test(TST) and Interferon gamma release assay (IGRA) were used as additional diagnostic tests. …”
Publicado 2022
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29871“…The aim of the study was to evaluate serum levels of interleukin (IL)-6, IL-17A, IL-18, IL-23, regulated on activation, normal T cell expressed and secreted (RANTES) and interferon (IFN)-γ-inducible protein-10 (IP-10) in children with acute urticaria and exacerbation of chronic urticaria in comparison to healthy volunteers. …”
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29872por Kotsaki, Antigone, Pickkers, Peter, Bauer, Michael, Calandra, Thierry, Lupse, Mihaela, Wiersinga, W Joost, Meylan, Sylvain, Bloos, Frank, van der Poll, Tom, Slim, Marleen A, van Mourik, Niels, Müller, Marcella C A, van Vught, Lonneke, Vlaar, Alexander P J, de Nooijer, Aline, Bakkerus, Lieke, Weis, Sebastian, Antonakos, Nikolaos, Netea, Mihai G, Giamarellos-Bourboulis, Evangelos J“…In the active immunotherapy arm, patients with MALS will receive anakinra (recombinant interleukin-1 receptor antagonist) intravenously, and patients with immunoparalysis will receive subcutaneous recombinant human interferon-gamma. Τhe primary endpoint is the comparative decrease of the mean total Sequential Organ Failure Assessment score by at least 1.4 points by day 9 from randomisation. …”
Publicado 2022
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29873“…Our previous study on the liver transcriptome of Holstein cows found that acyl-CoA dehydrogenase (ACADVL) and interferon regulatory factor 6 (IRF6) are differentially expressed between dry and peak lactation periods, as well as that they are involved in lipid metabolism and the proliferation and differentiation of mammary epithelial cells. …”
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29874Assessment of Immune Status Using Inexpensive Cytokines: A Literature Review and Learning Approachespor Jamaludeen, Noor, Lehmann, Juliane, Beyer, Christian, Vogel, Katrin, Pierau, Mandy, Brunner-Weinzierl, Monika, Spiliopoulou, Myra“…We build machine-learning models to predict the values of other expensive cytokines such as Interferon-gamma (IFN- [Formula: see text]), IL-10, IL-2, IL-17A, IL-17F, IL-4 and IL-5 by relying on the identified inexpensive ones in addition to the age of the individual. …”
Publicado 2022
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29875“…This study aimed to assess the safety, tolerated, and prolonged retention of recombinant protein trefoil factor 2 (TFF2)- interferon (IFN) in the respiratory tract of healthy volunteers. …”
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29876por Wang, Guilin, Miao, Chen, Mo, Lijun, Kahlert, Ulf D., Wu, Jinfeng, Ou, Minglin, Huang, Renxiang, Feng, Ruifa, Pang, Weiyi, Shi, Wenjie“…Compared with MYCBP2-low patients, MYCBP2-high patients had higher expression of genes associated with B cells, CD8+ T cells, macrophages, plasmacytoid dendritic cells (pDCs), antigen processing and presentation, inflammatory stimulation, and interferon (IFN) responses. GSEA and ssGSEA also showed that MYCBP2-high patients had significantly increased activity of inflammatory factors and signaling pathways associated with immune responses.In addiation, Patients in our local cohort with high MYCBP2 expression always had a better prognosis and greater sensitivity to therapy while compared to patients with low MYCBP2 expression after six months clinic follow up. …”
Publicado 2022
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29877por Yu, Wei, Lu, Chang, Wang, Guoliang, Liang, Zhenghao, Jiang, Zizheng, Liu, Yanzhi, Yan, Jing“…Compared with XH administration, PX exhibited a stronger antitumor effect, such as smaller tumor volume, lower interleukin 17 (IL-17), IL-6 and tumor necrosis factor-alpha (TNFα) serum levels, and higher interferon-gamma (IFN-γ) concentration. Network pharmacology analysis demonstrated that both PX and XH targets were enriched in cancers and inflammatory responses. …”
Publicado 2022
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29878por Graciliano, Nayara Gomes, Tenório, Micaely Cristinados Santos, Fragoso, Marilene Brandão Tenório, Moura, Fabiana Andréa, Botelho, Rayane Martins, Tanabe, Eloiza Lopes Lira, Borbely, Karen Steponavicius Cruz, Borbely, Alexandre Urban, Oliveira, Alane Cabral Menezes, Goulart, Marília Oliveira Fonseca“…Colostrum samples were analysed for some enzymes and non-enzymatic oxidative stress markers (SOD, CAT, GPx, MDA, GSH, GSSG, H(2)O(2), MPO) and for IL-1β, IL-6, tumour necrosis factor (TNF)-α, protein induced by interferon gamma (IP)-10, IL-8, IFN-λ1, IL12p70, IFN-α2, IFN-λ2/3, granulocyte macrophage colony stimulating factor (GM-CSF), IFN-β, IL-10 and IFN-γ, along with IgA and IgG for the SARS-CoV-2 S protein. …”
Publicado 2022
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29879por Fernández-Ruiz, Mario, Andrés, Amado, Loinaz, Carmelo, Delgado, Juan F., López-Medrano, Francisco, San Juan, Rafael, González, Esther, Polanco, Natalia, Folgueira, María D., Lalueza, Antonio, Lumbreras, Carlos, Aguado, José M.“…Other antiviral regimens included hydroxychloroquine monotherapy (27.8%) and interferon-β (16.7%). As of April 4, the case-fatality rate was 27.8% (5/18). …”
Publicado 2020
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29880por Kumpunya, Sarinya, Thim-uam, Arthid, Thumarat, Chisanu, Leelahavanichkul, Asada, Kalpongnukul, Nuttiya, Chantaravisoot, Naphat, Pisitkun, Trairak, Pisitkun, Prapaporn“…INTRODUCTION: Type I interferon (IFN) plays a vital role in the pathogenesis of systemic lupus erythematosus. …”
Publicado 2022
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