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29921por Jud, Philipp, Verheyen, Nicolas, Stradner, Martin H., Dejaco, Christian, Szolar, Dieter, Thonhofer, René, Schweiger, Leyla, Brodmann, Marianne, Hafner, Franz“…Cross-sectional study on 20 GCA patients with AD, 20 GCA patients without AD, and 20 non-GCA controls without AD measuring leukocytes, neutrophils, lymphocytes, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), serum amyloid A (SAA), interferon (IFN)-α, IFN-γ, IFN-γ-induced protein 10 (IP-10), interleukin (IL) 5, IL-8, IL-10, IL-17A, IL-18, IL-1 receptor antagonist, tumor necrosis factor (TNF)-α, platelet-derived growth factor (PDGF), L-selectin, P-selectin, and soluble intercellular adhesion molecule 1 (sICAM-1). …”
Publicado 2022
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29922por Firouzi, Javad, Hajifathali, Abbas, Azimi, Masoumeh, Parvini, Neda, Ghaemi, Fatemeh, Shayan Asl, Niloufar, Hedayati Asl, Amir Abbas, Safa, Majid, Ebrahimi, Marzieh“…The cytotoxic effect of NK cells increased in all groups, especially in IL-15+PD-1 blocker besides increasing interferon-gamma (IFN-γ), Granzymes, and perforin expression (P<0.05). …”
Publicado 2023
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29923por Buonsenso, Danilo, Delogu, Giovanni, del Carmen Pereyra Boza, Maria, De Maio, Flavio, Palucci, Ivana, Martino, Laura, Pata, Davide, Sanguinetti, Maurizio, Valentini, Piero, Sali, Michela“…Commercially available Interferon-γ release assays (IGRAs), including the last-generation QuantiFERON TB-Plus (QFT-Plus), are effective in aiding the diagnosis of tuberculosis (TB) infection but cannot distinguish latent TB subjects from active TB patients. …”
Publicado 2023
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29924por Yang, Hannah, Kang, Beodeul, Ha, Yeonjung, Lee, Sung Hwan, Kim, Ilhwan, Kim, Hyeyeong, Lee, Won Suk, Kim, Gwangil, Jung, Sanghoon, Rha, Sun Young, Gaillard, Vincent E., Cheon, Jaekyung, Kim, Chan, Chon, Hong Jae“…Participants with high IL-6 levels showed reduced interferon-γ and tumour necrosis factor-α secretion from CD8(+) T cells. …”
Publicado 2023
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29925por Chen, Sheng, Tang, Yuhang, Zhang, Zhou, Zheng, Jichang, He, Yuliang, Wang, Zhen, Mai, Kangsen, Ai, Qinghui“…The transcription of hepatic proinflammatory cytokine genes (interleukin-6 (il-6); tumor necrosis factor-α (tnf-α); and interferon-γ (ifn-γ)) in the DCP20 and DCP40 groups was significantly upregulated compared with that in the control group (P < 0.05). …”
Publicado 2022
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29926por Grimm, Lauren, Onyeukwu, Chinyere, Kenny, Grace, Parent, Danielle M., Fu, Jia, Dhingra, Shaurya, Yang, Emily, Moy, James, Utz, PJ, Tracy, Russell, Landay, Alan“…Analysis of autoantibodies against type 1 interferon was not shown to be statistically significant between disease severity groups. …”
Publicado 2023
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29927por Xiong, Jie, Li, Zhaoyue, Tang, Hao, Duan, Yuchen, Ban, Xiaofang, Xu, Ke, Guo, Yutong, Tu, Yingfeng“…Further analysis demonstrated that these cells manifested high heterogeneity at the levels of tissue preferences, genetic perturbations, functional variations, immune dynamics, transcriptional regulators, metabolic changes, and communication patterns. Of the T cells, interferon-induced CD8(+) T cells were involved in the progression of atherosclerosis. …”
Publicado 2023
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29928“…In the dose-dependent test, piglets immunized with the low dose (100 µg) of rSly had increased antigen-specific total IgG, interferon (IFN)-γ gene expression, and CD4(+) and CD8(+) T-cell populations. …”
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29929por Amin, Nada Sherif, Abd El-Aziz, Mostafa K., Hamed, Mohamed, Moustafa, Ramez Reda, El Tayebi, Hend M.“…OBJECTIVE: Very limited research is available around the long intergenic non-coding RNA (linc)00513, recently being reported as a novel positive regulator of the type-1 interferon (IFN) pathway, following its overexpression in the presence of two polymorphisms: rs205764 and rs547311 in the promoter region of this gene. …”
Publicado 2023
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29930por Xu, Huikang, Fu, Jiamin, Chen, Lijun, Zhou, Sining, Fang, Yangxin, Zhang, Qi, Chen, Xin, Yuan, Li, Li, Yifei, Xu, Zhenyu, Xiang, Charlie“…MiR-24-3p was proved to target and downregulate interferon regulatory factor 1 (IRF1) expression in the murine colon and then promoted the polarization of M2 macrophages. …”
Publicado 2023
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29931“…Some of the identified candidate genes; Oxysterol Binding Protein Like 6, Cysteine and Serine Rich Nuclear Protein 3, and the Coiled-Coil Domain Containing 92 regulate cellular cholesterol trafficking and efflux, apoptosis, and interferon production, respectively. Taken together, our results define a heritable and distinct immunogenetic profile in MAP-infected macrophages designed to limit bacterial load early after infection.…”
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29932por Guo, Yifei, Han, Jiajia, Zhang, Yongmei, Jin, Chengmeng, Zhang, Yao, He, Jingjing, Chen, Shiqi, Guo, Yue, Lin, Yanxue, Li, Fahong, Yang, Feifei, Shen, Zhongliang, Mao, Richeng, Zhu, Haoxiang, Zhang, Jiming“…BACKGROUND: Hepatitis B surface antigen (HBsAg) loss, namely, the functional cure, can be achieved through the pegylated interferon (PEG-IFN)-based therapy. However, it is an unignorable fact that a small proportion of patients who achieved functional cure develop HBsAg reversion (HRV) and the related factors are not well described. …”
Publicado 2023
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29933Publicado 2012“…Ampligen® [polyI:polyC12U] is a mismatched double-stranded RNA that acts by inducing interferon production (immunomodulator) and by activating an intracellular enzyme (RNase-L) against viral RNA transcripts (antiviral). …”
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29934por Qiu, Zongsheng, Xu, Qiyou, Xie, Dazhang, Zhao, Jiantao, Yamamoto, Fernando Y., Xu, Hong, Zhao, Jianhua“…The expression of the intestinal interleukin 10 (IL-10) gene was significantly down-regulated in the PBM10 group and the PBM15 group (p < 0.05), the expression of the intestinal interferon-γ (IFN-γ), interleukin-8 (IL-8), and liver toll-like receptor 4 (TLR4) and toll-like receptor 5 (TLR5) genes were significantly up-regulated in the PBM5 group (p < 0.05). …”
Publicado 2023
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29935por Li, Changqing, Chen, Jie, Wang, Jiajie, Whelan, Rose, Bütz, Daniel E., Ramuta, Mitchell D., Wang, Wentao, Li, Jiachen, Yang, Xin, Liu, Yanli, Yang, Xiaojun, Cook, Mark E., Crenshaw, Thomas D., Ren, Zhouzheng“…Compared to PBS-gavaged broilers and regardless of dietary SID M+C levels, the Eimeria-gavaged broilers had 1) decreased gain-to-feed ratio (15–21 d, P = 0.002; 11–21 d, P = 0.011); 2) increased fecal oocysts (P < 0.001); 3) increased plasma anti-Eimeria IgY (P = 0.033); and 4) increased intestinal luminal interleukin-10 (IL-10; duodenum, P = 0.039; jejunum, P = 0.018) and gamma interferon (IFN-γ; duodenum, P < 0.001; jejunum, P = 0.017). …”
Publicado 2023
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29936por Chen, Si, Chen, Yuanyuan, Jiao, Zizhuo, Wang, Chengqiang, Zhao, Dantong, Liu, Yongbin, Zhang, Wenguang, Zhao, Shihua, Yang, Bin, Zhao, Qinan, Fu, Shaoyin, He, Xiaolong, Chen, Qiaoling, Man, Churiga, Liu, Guoying, Wei, Xuefeng, Du, Li, Wang, Fengyang“…Body temperature, serum Brucella antibodies, serum cytokines (IL-12p70 and interferon [IFN]-γ), and bacterial load in the mandibular lymph nodes (LN), superficial cervical LN, superficial inguinal LN, and spleen were investigated to determine the safety and efficacy of the vaccine. …”
Publicado 2023
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29937por Yao, Ninghua, Jiang, Wei, Wang, Yilang, Song, Qianqian, Cao, Xiaolei, Zheng, Wenjie, Zhang, Jie“…Additionally, for immunological characteristics and enriched pathways, a low-IGS score was correlated with IL-6/JAK/STAT3 signaling, inflammatory response and interferon α/γ response pathways, low TP53 mutation rate, high infiltration level, and more benefit from ICI therapy. …”
Publicado 2023
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29938por Kim, Soyeon, Hesseling, Anneke C., Wu, Xingye, Hughes, Michael D., Shah, N. Sarita, Gaikwad, Sanjay, Kumarasamy, Nishi, Mitchell, Erika, Leon, Mey, Gonzales, Pedro, Badal-Faesen, Sharlaa, Lourens, Madeleine, Nerette, Sandy, Shenje, Justin, de Koker, Petra, Nedsuwan, Supalert, Mohapi, Lerato, Chakalisa, Unoda A., Mngqbisa, Rosie, Escada, Rodrigo Otávio da Silva, Ouma, Samuel, Heckman, Barbara, Naini, Linda, Gupta, Amita, Swindells, Susan, Churchyard, Gavin“…Among HHCs who were not already diagnosed with current active TB disease by the TB program, Mycobacterium tuberculosis infection was determined by interferon-gamma release assay (IGRA). TB disease was adjudicated centrally. …”
Publicado 2023
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29939por Sun, Yu, Hu, Haoran, Liu, Zheng, Xu, Jian, Gao, Yiyun, Zhan, Xinyu, Zhou, Shun, Zhong, Weizhe, Wu, Dongming, Wang, Ping, Rao, Zhuqing, Kong, Lianbao, Zhou, Haoming“…Global or myeloid stimulator of interferon gene (STING)-deficient mice, myeloid NOD-like receptor protein 3 (NLRP3)-deficient mice, and wild-type (WT) mice were subjected to a mouse model of CRC liver metastasis by intrasplenic injection of murine colon carcinoma cells (MC38). …”
Publicado 2023
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29940por Martins, Paulo, Vandewalle, Björn, Félix, Jorge, Capela, Carlos M., Cerqueira, João J., Salgado, António V., Ferreira, Diana G., Monteiro, Isabel“…RESULTS: For RMS patients, ocrelizumab was estimated to maximize the expected time (years) without progression to SPMS (10.50) relative to natalizumab (10.10), dimethyl fumarate (8.64), teriflunomide (8.39), fingolimod (8.38), interferon β-1a (8.33) and glatiramer acetate (8.18). …”
Publicado 2022
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