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29961por Zhu, Xiaoya, Guo, Ruirui, Su, Xiayu, Shang, Kun, Tan, Conglian, Ma, Junheng, Zhang, Yuemeng, Lin, Dan, Ma, Yueran, Zhou, Min, Yang, Jiale, Wu, Qiqi, Sun, Jiale, Wang, Zhuoling, Guo, Yuyue, Su, Ruifan, Cui, Xiangyi, Han, Jiming, Lü, Yuhong, Yue, Changwu“…To assess the effect of the drugs on cytokine secretion by immune cells and immune recovery in immunocompromised mice, the expression of interleukin (IL)-2, IL-6, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α were examined at the cellular and animal levels. …”
Publicado 2023
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29962por Goenka, Anshika, Khan, Fatima, Verma, Bhupender, Sinha, Priyanka, Dmello, Crismita C., Jogalekar, Manasi P., Gangadaran, Prakash, Ahn, Byeong‐Cheol“…These include both intrinsic and non‐autonomous tumor cell signaling pathways in the TME: protein kinase C (PKC) signaling, Notch, and transforming growth factor (TGF‐β) signaling, Endoplasmic Reticulum (ER) stress response, lactate signaling, Metabolic reprogramming, cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) and Siglec signaling pathways. …”
Publicado 2023
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29963“…METHODS: We performed post hoc analysis of pooled Treatment of Uncontrolled Lupus via the Interferon Pathway (TULIP-1) (NCT02446912) and TULIP-2 (NCT02446899) anifrolumab phase 3 trial data in patients with moderate to severe SLE receiving standard therapy. …”
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29964por Huang, Liuying, Yin, Yuan, Qian, Danqi, Cao, Yulin, Wang, Duo, Wu, Xiaohan, Ming, Liang, Huang, Zhaohui, Zhou, Leyuan“…Further experiments showed that interferon regulatory factor 7 (IRF7) and interferoninduced protein with tetratricopeptide repeats 2 (IFIT2) were differentially expressed between LUSC and LUAD tumors. …”
Publicado 2023
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29965por Liu, Pen-Ju, Yang, Ting-Ting, Fan, Ze-Xin, Yuan, Guo-Bin, Ma, Lin, Wang, Ze-Yi, Lu, Jian-Feng, Yuan, Bo-Yi, Zou, Wen-Long, Zhang, Xing-Hu, Liu, Guang-Zhi“…METHODS: The myelin oligodendrocyte glycoprotein (MOG)-specific CD8(+) memory T cell subsets and their related cytokines (perforin, granzyme B, interferon (IFN)-γ) and negative co-stimulatory molecules (programmed cell death protein 1 (PD-1), T- cell Ig and mucin domain 3 (Tim-3)) were analyzed by flow cytometry and real-time PCR in peripheral blood of patients with relapsing-remitting MS. …”
Publicado 2023
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29966por Rashid, Muzamil, Narang, Anmol, Thakur, Shubham, Jain, Subheet Kumar, Kaur, Sukhraj“…E. faecium Smr18 administration significantly increased the sera levels of nitrate by 1.63-fold and 3.22-fold in pre- and post-administration group, respectively. Sera levels of interferon-γ was highest (tenfold) in the untreated-infected group, whereas the levels of interleukin-10 was highest in the post-infection E. faecium-treated group thereby indicating the resolution of infection in the probiotic-treated group, plausibly due to the increased production of reactive nitrogen intermediates.…”
Publicado 2023
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29967por Choi, Seong-Ho, Park, Ji Young, Kweon, Oh Joo, Park, Joung Ha, Kim, Min-Chul, Lim, Yaeji, Chung, Jin-Won“…METHODS: The two groups were compared using quantification of the surrogate virus neutralization test for wild type severe acute respiratory syndrome coronavirus 2 (SVNT-WT), the omicron variant (SVNT-O), spike-specific IgG, and interferon-gamma (IFN-γ), as well as the omicron breakthrough infection cases. …”
Publicado 2023
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29968“…BACKGROUND: NFX1-type zinc finger-containing 1 (ZNFX1) is an interferon-stimulated double-stranded RNA sensor that restricts the replication of RNA viruses in mice. …”
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29969por Ma, Ru-xue, Hu, Jia-qian, Fu, Wei, Zhong, Jian, Cao, Can, Wang, Chang-chang, Qi, Shi-quan, Zhang, Xiao-Lian, Liu, Guang-hui, Gao, Ya-dong“…While no significant association was observed in interferon (IFN)-γ, tumor necrosis factor (TNF)-α, IL-6, IL-2 levels. …”
Publicado 2023
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29970por Dwyer, Liam J., Maheshwari, Saumya, Levy, Emily, Poznansky, Mark C., Whalen, Michael J., Sîrbulescu, Ruxandra F.“…In the presence of B cells, significantly more infiltrating myeloid cells produced IL-10, TGFβ, and IL-35, and fewer produced TNFα, interferon-γ and IL-6 as compared to controls, up to 2 months post-TBI. …”
Publicado 2023
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29971por Yang, Pu, Yuan, Yuncong, Sun, Yidan, Lv, Bonan, Du, Hang, Zhou, Zhou, Yang, Zhuang, Liu, Xuemei, Duan, Huimin, Shen, Chao“…These results revealed a unique means of counteracting the virus in BHK-21 cells lacking the interferon (IFN) signaling pathway. In conclusion, our study provides some potential targets for the development of drugs against FMDV.…”
Publicado 2023
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29972por Palmer, Christine D., Scallan, Ciaran D., Kraemer Tardif, Lauren D., Kachura, Melissa A., Rappaport, Amy R., Koralek, Daniel O., Uriel, Alison, Gitlin, Leonid, Klein, Joshua, Davis, Matthew J., Venkatraman, Harshni, Hart, Meghan G., Jaroslavsky, Jason R., Kounlavouth, Sonia, Marrali, Martina, Nganje, Charmaine N., Bae, Kyounghwa, Yan, Tiffany, Leodones, Katharyn, Egorova, Milana, Hong, Sue-Jean, Kuan, Jenchun, Grappi, Silvia, Garbes, Pedro, Jooss, Karin, Ustianowski, Andrew“…The secondary endpoint of immunogenicity was assessed via IgG binding assays, neutralization assays, interferon-gamma ELISpot, and intracellular cytokine staining. …”
Publicado 2023
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29973“…It is characterized mainly by early onset progressive encephalopathy, concomitant with an increase in interferon-α levels in the cerebrospinal fluid. Preimplantation genetic testing (PGT) is a procedure that could be used to choose unaffected embryos for transfer after analysis of biopsied cells, which prevents at-risk couples from facing the risk of pregnancy termination. …”
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29974por Pita-Martínez, Carlos, Pérez-García, Felipe, Virseda Berdices, Ana, Martin-Vicente, María, Castilla-García, Lucía, Hervás Fernández, Irene, González Ventosa, Victoria, Muñoz-Gómez, María José, Cuadros-González, Juan, Bermejo-Martin, Jesús F, Resino, Salvador, Martínez, Isidoro“…The gene expression of eight proinflammatory/antiviral genes (plasminogen activator urokinase receptor [PLAUR], interleukin [IL]-6, IL-8, interferon [IFN]-β, IFN-stimulated gene 15 [ISG15], retinoic acid-inducible gene I [RIG-I], C-C motif ligand 5 [CCL5], and chemokine C-X-C motif ligand 10 [CXCL10]) were quantified by real-time polymerase chain reaction. …”
Publicado 2023
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29975“…Previous reports have shown that SARS-CoV-2 infection antagonizes interferon (IFN)-dependent antiviral response, thereby preventing the expression of IFN-stimulated genes (ISGs). …”
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29976por Sweeney, Elizabeth E., Sekhri, Palak, Telaraja, Deepti, Chen, Jie, Chin, Samantha J., Chiappinelli, Katherine B., Sanchez, Carlos E., Bollard, Catherine M., Cruz, C. Russell Y., Fernandes, Rohan“…Upon co-culture with target U87 cells, these T cells secreted interferon-ɣ in a tumor-specific and dose-dependent manner (up to 647-fold over controls). …”
Publicado 2023
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29977por Wehner, Christian, Fürst, Gabor, Vaskovich, Tom, Andrukhov, Oleh, Vasak, Christoph, Moritz, Andreas, Rausch-Fan, Xiaohui“…Expression of C-reactive protein (CRP), interferon-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12A, IL-17A, macrophage inflammatory protein (MIP)-1α, matrix metalloproteinase (MMP)-13, osteopontin, osteoactivin, Receptor Activator of NF-κB (RANK), and TGF-β were analyzed using a multiplex ELISA kit. …”
Publicado 2022
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29978por Yang, Jing-Xing, Tseng, Jen-Chih, Tien, Chih-Feng, Lee, Chia-Yin, Liu, Yi-Ling, Lin, Jhe-Jhih, Tsai, Pei-Ju, Liao, Hung-Chun, Liu, Shih-Jen, Su, Yu-Wen, Hsu, Li-Chung, Chen, Jen-Kun, Huang, Ming-Hsi, Yu, Guann-Yi, Chuang, Tsung-Hsien“…In this study, we investigated the adjuvant activities of combinations of Toll-like receptor 9 (TLR9) and stimulator of interferon genes (STING) agonists in a SARS-CoV-2 receptor binding domain protein vaccine. …”
Publicado 2023
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29979por Viettri, Mercedes, Caraballo, Gerson, Sanchez, Maria Elena, Espejel-Nuñez, Aurora, Betanzos, Abigail, Ortiz-Navarrete, Vianney, Estrada-Gutierrez, Guadalupe, Nava, Porfirio, Ludert, Juan E.“…Finally, infection with ZIKV, but not DENV or YFV-17D, efficiently inhibited the interferon (IFN) and chemoattractant responses in both cell lines. …”
Publicado 2023
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29980por Qu, Yue, Haas de Mello, Aline, Morris, Dorothea R., Jones-Hall, Yava L., Ivanciuc, Teodora, Sattler, Rachel A., Paessler, Slobodan, Menachery, Vineet D., Garofalo, Roberto P., Casola, Antonella“…Reductions in cellular levels of NRF2 seem to be independent of proteasomal degradation and the interferon/promyelocytic leukemia (IFN/PML) pathway. …”
Publicado 2023
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