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30021por Sun, Wei, Xu, Yu, Yan, WangJun, Wang, ChunMeng, Hu, Tu, Luo, ZhiGuo, Zhang, XiaoWei, Liu, Xin, Chen, Yong“…Among them, 115 (66.1%) patients received pembrolizumab or toripalimab monotherapy as adjuvant therapy; 22 (12.6%) patients received high‐dose interferon (IFN), and 37 (21.3%) patients were just for observation. …”
Publicado 2023
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30022“…At D21, NE challenge increased gut permeability (P < 0.001), decreased regulatory T cells (Tregs) in the cecal tonsil (CT) (P = 0.02), increased Tregs in the spleen (P = 0.02), decreased nitric oxide (NO) production in the spleen (P = 0.04) and decreased IL-10 expression in CT (P = 0.02), whereas synbiotic supplementation increased CD4+:CD8+ T cells in the spleen (P < 0.001) and decreased interferon (IFN)-γ expression in the jejunum (P = 0.07), however, synbiotic supplementation during NE challenge decreased mid-gut lesion score (P < 0.001), increased CD4+:CD8+ T cells in CT and decreased IgA production in bile (P < 0.001), compared to the control group. …”
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30023por Tanneti, Nikhila S, Patel, Anant K, Tan, Li Hui, Marques, Andrew D, Perera, Ranawaka A.P.M., Sherrill-Mix, Scott, Kelly, Brendan J, Collman, Ronald G, Rodino, Kyle, Lee, Carole, Bushman, Frederic D, Cohen, Noam A, Weiss, Susan R“…All VOCs overcame dsRNA-activated cellular responses including interferon signaling, oligoadenylate ribonuclease L (OAS-RNase L) degradation and protein kinase R (PKR) activation. …”
Publicado 2023
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30024“…PURPOSE: The mitochondrial DNA (mtDNA) activated cyclic guanosine monophosphate–adenosine monophosphate synthase—stimulator of interferon genes (cGAS-STING) signaling pathway is a key player in mediating immune responses in autoimmune disorders and cancer. …”
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30025por Koehm, Michaela, Klippstein, Maximilian, Dauth, Stephanie, Hallmann, Konstantin, Kohmer, Niko, Burkhardt, Harald, Ciesek, Sandra, Geisslinger, Gerd, Rabenau, Holger F, Behrens, Frank“…T-cell responses were assessed by an interferon gamma release assay (IGRA). RESULTS: Fifty patients with PID (n=6), treated with RTX therapy (n=13), or treated with csDMARDs/bDMARDs (n=31) were included. …”
Publicado 2023
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30026por Aquino, Yann, Bisiaux, Aurélie, Li, Zhi, O’Neill, Mary, Mendoza-Revilla, Javier, Merkling, Sarah Hélène, Kerner, Gaspard, Hasan, Milena, Libri, Valentina, Bondet, Vincent, Smith, Nikaïa, de Cevins, Camille, Ménager, Mickaël, Luca, Francesca, Pique-Regi, Roger, Barba-Spaeth, Giovanna, Pietropaoli, Stefano, Schwartz, Olivier, Leroux-Roels, Geert, Lee, Cheuk-Kwong, Leung, Kathy, Wu, Joseph T., Peiris, Malik, Bruzzone, Roberto, Abel, Laurent, Casanova, Jean-Laurent, Valkenburg, Sophie A., Duffy, Darragh, Patin, Etienne, Rotival, Maxime, Quintana-Murci, Lluis“…We show that SARS-CoV-2 induces weaker, but more heterogeneous, interferon-stimulated gene activity compared with influenza A virus, and a unique pro-inflammatory signature in myeloid cells. …”
Publicado 2023
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30027“…Data synthesis showed that the HPV clearance rate of HDCM groups was superior to both interferon and follow-up groups (RR = 1.40,95% CI:1.15, 1.71, P < 0.01) and (RR = 3.15, 95% CI:2.43,4.08, P < 0.01), respectively. …”
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30028por Martin-Valls, Gerard E., Cortey, Martí, Swam, Hanny, Jiménez, Marta, Mateu, Enric“…Animals were followed afterward for 42 days to examine the development of PCV2-specific antibodies and interferon-γ secreting cells (IFN-γ SC). RESULTS: The average titres of antibodies of the groups vaccinated in the presence of low or high MDA levels were similar at 28 and 42 days post-vaccination while in the controls the titres declined throughout the observation period. …”
Publicado 2023
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30029por Andrews, Daniel D. T., Vlok, Marli, Akbari Bani, Dorssa, Hay, Brenna N., Mohamud, Yasir, Foster, Leonard J., Luo, Honglin, Overall, Christopher M., Jan, Eric“…This pathway drives the production of antiviral molecules known as interferons, which are necessary to establish an antiviral state in the cellular environment. …”
Publicado 2023
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30030por Jani, Charul, Solomon, Sydney L., Peters, Joshua M., Pringle, Stephanie C., Hinman, Amelia E., Boucau, Julie, Bryson, Bryan D., Barczak, Amy K.“…We identified two axes of response: an NF-kB-dependent response similarly elicited by all Mtb pathogen-associated molecular patterns (PAMPs) and a type I interferon axis unique to cells infected with live Mtb. …”
Publicado 2023
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30031por Christensen, Sophie Hilario, Rom, Ane Lilleøre, Greve, Tine, Lewis, Jack Ivor, Frøkiær, Hanne, Allen, Lindsay H., Mølgaard, Christian, Renault, Kristina Martha, Michaelsen, Kim F.“…Maternal plasma inflammatory, lipid and metabolic markers included high-sensitive C-reactive protein (hs-CRP), tumor-necrosis factor-α (TNFα), interferon-γ (IFNγ), Interleukin (IL)-6, IL-8, high-, low-, and very-low-density lipoprotein (HDL, LDL, VLDL), total-cholesterol, triglycerides, leptin, adiponectin, insulin, C-peptide, the homeostasis model assessment of insulin resistance (HOMA-IR) and glucose concentration at t = 120 min following an oral glucose tolerance test. …”
Publicado 2023
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30032por Fernández-Ruiz, Mario, Almendro-Vázquez, Patricia, Redondo, Natalia, Ruiz-Merlo, Tamara, Abella, Sandra, Somoza, Adán, López-Medrano, Francisco, San Juan, Rafael, Loinaz, Carmelo, Andrés, Amado, Paz-Artal, Estela, Aguado, José María“…Cell-mediated immunity was measured by fluorescent ELISpot assay for interferon (IFN)-γ secretion, whereas the neutralizing IgG antibody response against the BA.4/BA.5 spike receptor-binding domain was quantified with a competitive ELISA. …”
Publicado 2023
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30033por Mohamed Mohamed, Kauzar, Álvarez-Hernández, María Paula, Jiménez García, Carlos, Guevara-Hoyer, Kissy, Freites, Dalifer, Martínez Prada, Cristina, Pérez-Sancristóbal, Inés, Fernández Gutiérrez, Benjamín, Mato Chaín, Gloria, Rodero, Maria, Rodríguez de la Peña, Antonia, Mulero, Teresa, Bravo, Cecilia, Toledano, Esther, Culebras López, Esther, Mediero Valeros, Beatriz, Pérez Segura, Pedro, Sánchez-Ramón, Silvia, Candelas Rodríguez, Gloria“…Specific anti-SARS-CoV-2 interferon-gamma (IFN-γ) production was evaluated between 8–12 weeks after the third dose of the SARS-CoV-2 vaccine. …”
Publicado 2023
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30034por Srivastava, Shriyansh, Sharma, Deepika, Kumar, Sachin, Sharma, Aditya, Rijal, Rishikesh, Asija, Ankush, Adhikari, Suraj, Rustagi, Sarvesh, Sah, Sanjit, Al-qaim, Zahraa Haleem, Bashyal, Prashant, Mohanty, Aroop, Barboza, Joshuan J., Rodriguez-Morales, Alfonso J., Sah, Ranjit“…MV can evade host immune response by inhibiting interferon type I (IFN-1) synthesis. This comprehensive investigation aims to enhance understanding of pathophysiology, cellular tropism, and injury sites in the host, aiding insights into MVD causes. …”
Publicado 2023
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30035por Sakai, Chiemi, Ueda, Keitaro, Goda, Kohei, Fujita, Rikuto, Maeda, Junji, Nakayama, Shinya, Sotomaru, Yusuke, Tashiro, Satoshi, Yoshizumi, Masao, Ishida, Takafumi, Ishida, Mari“…Inhibiting the cGAS-STING pathway reduced IL-6 mRNA level. Notably, interferon regulatory factor 3 (IRF3), a downstream effector of the cGAS-STING pathway, was activated, and the depletion of IRF3 also reduced IL-6 mRNA levels in the Ku80(+/−) cells. …”
Publicado 2023
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30036“…Marked induction of sulfhydration of interferon regulator factor 1 (IRF-1) as well as upregulation of mitochondrial transcription factor A (TFAM) (p < 0.05) and suppression of DNA methyltransferase3a (Dnmt-3a) (p < 0.05) were observed in NaNO(2) treated ischemic HF mice as compared with VEH. …”
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30037“…CONCLUSION: In conclusion, DAAs provide high SVR12 rates in cirrhotic/non-cirrhotic, pegylated interferon-naive/experienced patient groups and in patients infected with all genotypes. …”
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30038por Zedan, A. H., Nederby, L., Volmer, L. M., Madsen, C. V., Sørensen, B. E., Hansen, T. F.“…At the time of BR, interferon-gamma (IFNγ) decreased significantly compared to levels detected at baseline (z-score = 2.33, p = 0.019). …”
Publicado 2023
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30039por Rasmussen, Vinni Faber, Hirschberg Jensen, Verena, Thrysøe, Mathilde, Vestergaard, Esben Thyssen, Størling, Joachim, Kristensen, Kurt“…The adolescents with diabetes had significantly higher interferon-gamma, tumour necrosis factor-alpha (TNF-a), interleukin (IL)-10 and soluble urokinase plasminogen activator receptor (suPAR) compared with healthy controls (p values<0.05). …”
Publicado 2023
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30040por Groß-Albenhausen, Elina, Weier, Alicia, Velten, Markus, Heider, Thorsten, Chunder, Rittika, Kuerten, Stefanie“…PBMCs were also isolated from n = 19 age- and gender-matched healthy controls (HCs) after vaccination or infection with SARS-CoV-2, respectively. Interferon-γ (IFN-γ)/interleukin-2 (IL-2) and granzyme B (GzB)/perforin (PFN) double-color enzyme-linked immunospot (ELISPOT) assays or single-color ELISPOT assays were performed to measure SARS-CoV-2 antigen-specific T cell and B cell responses. …”
Publicado 2023
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