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30041por Li, Biao, Li, Juan, Wang, Li, Wei, Yong, Luo, Xiaolin, Guan, Jiuqiang, Zhang, Xiangfei“…Furthermore, the expressions of pro-inflammatory cytokines interleukin 1 beta (IL-1β), interleukin 6 (IL6), interleukin 8 (IL8) and interferon-α (TNF-α) were significantly increased (p < 0.05), but the expression of anti-inflammatory factor interleukin 10 (IL10) was significantly decreased (p < 0.05). …”
Publicado 2023
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30042por Röhl, Louisa, Wellhausen, Jana, Berszin, Michael, Krücken, Irene, Zebralla, Veit, Pirlich, Markus, Wiegand, Susanne, Dietz, Andreas, Wald, Theresa, Wichmann, Gunnar“…Concentrations of vascular endothelial growth factor A (VEGF), CCL2 (MCP-1), interleukin-6 (IL-6), IL-8, interferon-gamma (IFN-γ), and CXCL10 (IP-10) pre- and post-ICB in EDTA-anticoagulated plasma and serum were compared. …”
Publicado 2023
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30043por Bigelow, Rebecca A., Richeson, John T., McClurg, Molly, Valeris-Chacin, Robert, Morley, Paul S., Funk, Jenna L., Scott, Matthew A.“…There were no shared pathways or Gene Ontology (GO) terms among treatments at day 14, but TULA had 19 pathways and eight GO terms enriched related to NF- κβ activation, and interleukin/interferon signaling. Pathways related to cytokine signaling were enriched by TILD on day 21. …”
Publicado 2023
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30044“…Double-stranded DNA (dsDNA) has been evidenced to be a promising immunostimulatory agent to induce type I interferons (IFN-Is) production for innate immunity activation through the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway, yet the unsatisfactory delivery and susceptibility to nuclease degradation hindered its feasibility for further clinical applications. …”
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30045por Thirawatananond, Puchong, Brown, Matthew E., Sachs, Lindsey K., Arnoletti, Juan M., Yeh, Wen-I, Posgai, Amanda L., Shapiro, Melanie R., Chen, Yi-Guang, Brusko, Todd M.“…Moreover, NOD splenocytes treated with TIGIT-Fc fusion protein exhibited reduced T-cell proliferation and interferon-γ production following anti-CD3/CD28 stimulation. …”
Publicado 2023
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30046“…After stimulation with toll-like-receptor (TLR) agonists (lipopolysaccharides, Pam3CSK4), isolated NK cells showed increased interferon (IFN)-gamma secretion. To study the role of NK cells in a complex hepatic environment, these cells were integrated in the vascular compartment of a microfluidically supported liver-on-a-chip model in close interaction with endothelial and resident macrophages. …”
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30047por Joshi, Shivali S., Sadler, Matthew, Patel, Nishi H., Osiowy, Carla, Fonseca, Kevin, Coffin, Carla S.“…RESULTS: Of 16 HBV/HDV, 11 were HDV-RNA+ (HBV-DNA 0–1,040 IU/mL), 5/11 Interferon (IFN) + Nucleos/tide Analog (NA), 3/11 NA monotherapy, median ALT 77 U/L at the time of sample collection, median LSM of 9.8. …”
Publicado 2023
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30048por Dand, Nick, Stuart, Philip E, Bowes, John, Ellinghaus, David, Nititham, Joanne, Saklatvala, Jake R, Teder-Laving, Maris, Thomas, Laurent F, Traks, Tanel, Uebe, Steffen, Assmann, Gunter, Baudry, David, Behrens, Frank, Billi, Allison C, Brown, Matthew A, Burkhardt, Harald, Capon, Francesca, Chung, Raymond, Curtis, Charles J, Duckworth, Michael, Ellinghaus, Eva, FitzGerald, Oliver, Gerdes, Sascha, Griffiths, Christopher E M, Gulliver, Susanne, Helliwell, Philip, Ho, Pauline, Hoffmann, Per, Holmen, Oddgeir L, Huang, Zhi-ming, Hveem, Kristian, Jadon, Deepak, Köhm, Michaela, Kraus, Cornelia, Lamacchia, Céline, Lee, Sang Hyuck, Ma, Feiyang, Mahil, Satveer K, McHugh, Neil, McManus, Ross, Modalsli, Ellen H, Nissen, Michael J, Nöthen, Markus, Oji, Vinzenz, Oksenberg, Jorge R, Patrick, Matthew T, Perez-White, Bethany E, Ramming, Andreas, Rech, Jürgen, Rosen, Cheryl, Sarkar, Mrinal K, Schett, Georg, Schmidt, Börge, Tejasvi, Trilokraj, Traupe, Heiko, Voorhees, John J, Wacker, Eike Matthias, Warren, Richard B, Wasikowski, Rachael, Weidinger, Stephan, Wen, Xiaoquan, Zhang, Zhaolin, Barton, Anne, Chandran, Vinod, Esko, Tõnu, Foerster, John, Franke, Andre, Gladman, Dafna D, Gudjonsson, Johann E, Gulliver, Wayne, Hüffmeier, Ulrike, Kingo, Külli, Kõks, Sulev, Liao, Wilson, Løset, Mari, Mägi, Reedik, Nair, Rajan P, Rahman, Proton, Reis, André, Smith, Catherine H, Di Meglio, Paola, Barker, Jonathan N, Tsoi, Lam C, Simpson, Michael A, Elder, James T“…We conducted a transcriptome-wide association study to identify regulatory effects of psoriasis susceptibility variants and cross-referenced these against single cell expression profiles in psoriasis-affected skin, highlighting roles for the transcriptional regulation of haematopoietic cell development and epigenetic modulation of interferon signalling in psoriasis pathobiology.…”
Publicado 2023
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30049por Kroken, Abby R., Klein, Keith A., Mitchell, Patrick S., Nieto, Vincent, Jedel, Eric J., Evans, David J., Fleiszig, Suzanne M. J.“…While HeLa cells lacked a lytic death response to T3SS mutants, it was found to be enabled by interferon gamma treatment. Together, these results show that epithelial cells can activate the noncanonical inflammasome pathway to limit proliferation of intracellular P. aeruginosa, not fully dependent on bacterially driven vacuole escape. …”
Publicado 2023
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30050por Thind, Amara C., Mota, Caroline M., Gonçalves, Ana Paula N., Sha, Jihui, Wohlschlegel, James A., Mineo, Tiago W. P., Bradley, Peter J.“…Murine macrophages infected with ∆gra83 tachyzoites produced less interleukin-12 (IL-12) in vitro, which was confirmed with reduced IL-12 and interferon-gamma in vivo. This dysregulation of cytokines correlates with reduced nuclear translocation of the p65 subunit of the nuclear factor-κB (NF-κB) complex. …”
Publicado 2023
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30051por Cho, Yuri, Park, SeongBeom, Park, SeonYoung, Choi, WonJung, Kim, Book, Han, Helin“…Among CHB patients, 48.1% received ≥ 1 prescribed anti-HBV drug including interferon or nucleos(t)ide analogues and 64.4% had ≥ 1 hospitalization compared to 80.4% and 79.4% HBV/HDV patients. …”
Publicado 2023
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30052por Cai, Lisha, Xing, Yuan, Xia, Yahong, Zhang, Zihan, Luo, Zebin, Tang, Yongmin, Chen, Yan, Xu, Xiaojun“…When using the criteria of interleukin (IL)-10 > 89.6 pg/mL, interferon (IFN)-γ > 45.6 pg/mL, ferritin > 429 μg/L, D-dimer > 3.15 mg/L and triglycerides > 2.1 mmol/L, the sensitivity was 87.9%, 90.7%, 98.1%, 91.1% and 81.5% to predict EBV-HLH, while the specificity was 98.4%, 96.3%, 96.5%, 94.1% and 80.6%, respectively. …”
Publicado 2023
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30053por Mohamed, Eman E., Ahmed, Osama M., Zoheir, Khairy M. A., El-Shahawy, Ahmed A. G., Tamur, Shadi, Shams, Anwar, Burcher, Jack T., Bishayee, Anupam, Abdel-Moneim, Adel“…Naringin and Nar-Dx-NCs exerted anti-inflammatory actions manifested by a decrease in lung protein expression of tumor necrosis factor-α and interleukin-1β and mRNA expression of interleukin-6, interferon-γ, nuclear factor-κB, and inducible nitric oxide synthase, with a concurrent increase in interleukin-10 expression. …”
Publicado 2023
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30054por Neelamraju, Yaseswini, Gjini, Evisa, Chhangawala, Sagar, Fan, Hao, He, Shuning, Jing, Chang-Bin, Nguyen, Ashley T., Prajapati, Subhash, Sheridan, Caroline, Houvras, Yariv, Melnick, Ari, Look, A. Thomas, Garrett-Bakelman, Francine E.“…Gene expression analyses identified upregulation of genes associated with mTORC1 signaling and interferon gamma and alpha responses in tet2(m/m) HSPCs at 4 months of age when compared with the wild type. …”
Publicado 2023
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30055por Tanasescu, Radu, Frakich, Nanci, Chou, I.-Jun, Filippini, Perla, Podda, Giulio, Xin, Gao, Muraleedharan, Ranjithmenon, Jerca, Oltita, Onion, David, Constantinescu, Cris S.“…The effects of NTZ were compared to those obtained with 11 patients under interferon-beta-1a (IFN-β1a) treatment, and against 9 healthy volunteers. …”
Publicado 2023
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30056por Schleussner, Nikolai, Cauchy, Pierre, Franke, Vedran, Giefing, Maciej, Fornes, Oriol, Vankadari, Naveen, Assi, Salam A., Costanza, Mariantonia, Weniger, Marc A., Akalin, Altuna, Anagnostopoulos, Ioannis, Bukur, Thomas, Casarotto, Marco G., Damm, Frederik, Daumke, Oliver, Edginton-White, Benjamin, Gebhardt, J. Christof M., Grau, Michael, Grunwald, Stephan, Hansmann, Martin-Leo, Hartmann, Sylvia, Huber, Lionel, Kärgel, Eva, Lusatis, Simone, Noerenberg, Daniel, Obier, Nadine, Pannicke, Ulrich, Fischer, Anja, Reisser, Anja, Rosenwald, Andreas, Schwarz, Klaus, Sundararaj, Srinivasan, Weilemann, Andre, Winkler, Wiebke, Xu, Wendan, Lenz, Georg, Rajewsky, Klaus, Wasserman, Wyeth W., Cockerill, Peter N., Scheidereit, Claus, Siebert, Reiner, Küppers, Ralf, Grosschedl, Rudolf, Janz, Martin, Bonifer, Constanze, Mathas, Stephan“…It is caused by a recurrent somatic missense mutation c.295 T > C (p.Cys99Arg; p.C99R) targeting the center of the DNA-binding domain of Interferon Regulatory Factor 4 (IRF4), a key TF in immune cells. …”
Publicado 2023
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30057por Bakhshi, Parisa, Nourizadeh, Maryam, Sharifi, Laleh, Farajollahi, Mohammad M., Mohsenzadegan, Monireh“…Finally, CTLs were evaluated for their capacity to produce interferon-gamma (IFN-γ) and kill PCa cell lines (PC3 and LNCaP). …”
Publicado 2023
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30058por Borràs, Daniel Morales, Verbandt, Sara, Ausserhofer, Markus, Sturm, Gregor, Lim, Jinyeong, Verge, Gil Arasa, Vanmeerbeek, Isaure, Laureano, Raquel S., Govaerts, Jannes, Sprooten, Jenny, Hong, Yourae, Wall, Rebecca, De Hertogh, Gert, Sagaert, Xavier, Bislenghi, Gabriele, D’Hoore, André, Wolthuis, Albert, Finotello, Francesca, Park, Woong-Yang, Naulaerts, Stefan, Tejpar, Sabine, Garg, Abhishek D.“…This revealed that CRC CD8(+) T cell dynamics are underscored by complex interactions between interferon-γ signaling, tumor reactivity, TCR repertoire, (predicted) TCR antigen-specificities, and environmental cues like gut microbiome or colon tissue-specific ‘self-like’ features. …”
Publicado 2023
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30059por Yap, Desmond Yat-Hin, Fong, Carol Ho-Yan, Zhang, Xiaojuan, Ip, Jonathan Daniel, Chan, Wan-Mui, Chu, Allen Wing-Ho, Chen, Lin-Lei, Zhao, Yan, Chan, Brian Pui-Chun, Luk, Kristine Shik, Cheng, Vincent Chi-Chung, Chan, Tak-Mao, To, Kelvin Kai-Wang“…Adult CKD patients were recruited between August and October 2022. nAb against the SARS-CoV-2 (ancestral strains and four Omicron sublineages) and T cell response were measured using the live virus neutralization assay and interferon-gamma release assay (IGRA). The correlation between nAb/T-cell response and subsequent infection after recruitment were also determined. …”
Publicado 2023
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30060por Lee, Chrono K., Oliveira, Lorena V. N., Akalin, Ali, Specht, Charles A., Lourenco, Diana, Gomez, Christina L., Ramirez-Ortiz, Zaida G., Wang, Jennifer P., Levitz, Stuart M.“…Influenza-infected mice superinfected with A. fumigatus had increased levels of the pro-inflammatory cytokines and chemokines interleukin (IL)-6, tumor necrosis factor (TNF)α, interferon (IFN)β, IL-12p70, IL-1α, IL-1β, CXC motif chemokine ligand 1 (CXCL1), granulocyte-colony-stimulating factor (G-CSF), macrophage inflammatory protein (MIP)-1α, MIP-1β, regulated upon activation, normal T cell expressed and presumably secreted (RANTES), and monocyte chemoattractant protein (MCP)-1. …”
Publicado 2023
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