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30081por Codarri, Laura, Vallotton, Laure, Ciuffreda, Donatella, Venetz, Jean-Pierre, Garcia, Miguel, Hadaya, Karine, Buhler, Leo, Rotman, Samuel, Pascual, Manuel, Pantaleo, Giuseppe“…The expanded CD4(+)CD25(+)CD45RO(+)IL-7Rα(high) cell population contained allospecific CD4 T cells and secreted effector cytokines such as tumor necrosis factor α and interferon γ, thus potentially contributing to the mechanisms of chronic rejection. …”
Publicado 2007
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30082Publicado 1991“…Analyses of the NK cell responses over a 2 wk period in control CB17 mice infected with MCMV indicated a sharp rise in serum interferon (IFN) and spleen NK cell activity early (days 3-5) in infection, followed by sharp declines at later stages. …”
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30083por Birmachu, Woubalem, Gleason, Raymond M, Bulbulian, Barbara J, Riter, Christie L, Vasilakos, John P, Lipson, Kenneth E, Nikolsky, Yuri“…BACKGROUND: Plasmacytoid Dendritic Cells (pDC) comprise approximately 0.2 to 0.8% of the blood mononuclear cells and are the primary type 1 interferon (IFN), producing cells, secreting high levels of IFN in response to viral infections. …”
Publicado 2007
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30084“…AK cells showed a similar selectivity pattern to NK cells, as demonstrated in cold target inhibition and direct cytotoxicity assays using variant or interferon-modulated YAC-1 cells with low expression of NK target structures. …”
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30085Publicado 1994“…Conversely, IGF-I-induced IgE and IgG4 production was blocked by anti-IGF-I Ab, but not by anti-GH Ab, anti-IL-4 Ab, or anti-IL-13 Ab. Moreover, interferon alpha (IFN-alpha) or IFN-gamma, which counteracted IL-4-and IL-13-induced IgE and IgG4 production, had no effect on induction by GH or IGF-I. …”
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30086Publicado 1996“…We studied the effects of various chemokines including neutrophil- activating peptide 2 (NAP-2), beta-thromboglobulin (beta-TG), platelet factor 4 (PF-4), melanoma growth stimulating activity (GRO), gamma interferon-induced protein (IP-10), regulated on activation, normal T expressed and secreted (RANTES), macrophage inflammatory protein 1 alpha (MIP-1 alpha), MIP-1 beta, and monocyte chemotactic protein 1 (MCP-1) on Immunoglobulin (IgE) and IgG4 production by human B cells. …”
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30087Publicado 1996“…In response to activation with exogenous peptide or immobilized anti-TCR mAB, iIELs from Ag- mice proliferated at high levels and produced interleukin (IL)- 2 and interferon (IFN)-gamma, while Tg+ iIELs from Ag+ mice proliferated at low levels and failed to produce detectable IL-2 or IFN- gamma. …”
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30088por Sempowski, Gregory D., Lee, David M., Scearce, Richard M., Patel, Dhavalkumar D., Haynes, Barton F.“…CD7-deficient animals develop normally but have antigen-specific defects in interferon (IFN)-γ production and CD8(+) CTL generation. …”
Publicado 1999
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30089por Verhagen, Claudia E., de Boer, Tjitske, Smits, Hermelijn H., Verreck, Frank A.W., Wierenga, Eddy A., Kurimoto, M., Lammas, D. Anthony, Kumararatne, Dinakanthe S., Sanal, Ozden, Kroon, Frank P., van Dissel, Jaap T., Sinigaglia, Francesco, Ottenhoff, Tom H.M.“…Genetic lack of interleukin 12 receptor β1 (IL-12Rβ1) surface expression predisposes to severe infections by poorly pathogenic mycobacteria or Salmonella and causes strongly decreased, but not completely abrogated, interferon (IFN)-γ production. To study IL-12Rβ1–independent residual IFN-γ production, we have generated mycobacterium–specific T cell clones (TCCs) from IL-12Rβ1–deficient individuals. …”
Publicado 2000
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30090por Ochi, Hiroshi, Hirani, W. Mona, Yuan, Qian, Friend, Daniel S., Austen, K. Frank, Boyce, Joshua A.“…In contrast, the prototypical Th1 cytokine, interferon γ, suppressed SCF-driven proliferation of both hPrMCs and hMCs. …”
Publicado 1999
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30091por Weir, Rosemary E, Gorak-Stolinska, Patricia, Floyd, Sian, Lalor, Maeve K, Stenson, Sally, Branson, Keith, Blitz, Rose, Ben-Smith, Anne, Fine, Paul EM, Dockrell, Hazel M“…Adolescents were tested for interferon-gamma (IFN-γ) response to Mycobacterium tuberculosis purified protein derivative (M.tb PPD) in a whole blood assay before, 3 months, 12 months (n = 148) and 3 years (n = 19) after receiving teenage BCG vaccination or 14 years after receiving infant BCG vaccination (n = 16). …”
Publicado 2008
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30092por Flori, Laurence, Rogel-Gaillard, Claire, Cochet, Marielle, Lemonnier, Gaetan, Hugot, Karine, Chardon, Patrick, Robin, Stéphane, Lefèvre, François“…Indeed, several genes involved in the SLA class I antigenic presentation pathway (SLA-Ia, TAP1, TAP2, PSMB8 and PSMB9), were down-regulated, thus contributing to viral immune escape from this pathway and other genes involved in apoptosis, nucleic acid metabolism, cytoskeleton signaling as well as interferon-mediated antiviral response were also modulated during PrV infection. …”
Publicado 2008
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30093por Mrowietz, U, Schwenk, U, Maune, S, Bartels, J, Küpper, M, Fichtner, I, Schröder, J-M, Schadendorf, D“…Tumour necrosis factor α (TNF-α), not, however, IL-2, interferon-γ (IFN-γ), or α-melanocyte-stimulating hormone (α-MSH) was able to up-regulate RANTES and interleukin 8 secretion. …”
Publicado 1999
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30094“…The aim of this study was to assess monocyte/macrophage function, as defined by lipopolysaccharide (LPS)-induced production of tumour necrosis factor (TNF)-α, interleukin (IL)-10 and interferon (IFN)-γ by stimulated whole blood cultures in patients with colorectal carcinoma before and after surgical resection. …”
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30095por O’Brien, M E R, Saini, A, Smith, I E, Webb, A, Gregory, K, Mendes, R, Ryan, C, Priest, K, Bromelow, K V, Palmer, R D, Tuckwell, N, Kennard, D A, Souberbielle, B E“…There was no detectable change in serum cytokine levels for gamma-interferon and TNF-α before and after treatment. In patients with NSCLC and mesothelioma, there may be a beneficial interaction when chemotherapy is administered in combination with SRL172. …”
Publicado 2000
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30096por Donskov, F, Bennedsgaard, K M, von der Maase, H, Marcussen, N, Fisker, R, Jensen, J J, Naredi, P, Hokland, M“…Twenty-six patients with metastatic renal cell carcinoma were treated with low dose s.c. interleukin-2, interferon-α and histamine. A total of 250 blood samples and 62 core needle biopsies from 23 and 19 of these patients, respectively, were analysed. …”
Publicado 2002
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30097por de Gast, G C, Batchelor, D, Kersten, M J, Vyth-Dreese, F A, Sein, J, van de Kasteele, W F, Nooijen, W J, Nieweg, O E, Waal, M A de, Boogerd, W“…The purpose of this study is to determine the toxicity and efficacy of temozolomide (TMZ) p.o. followed by subcutaneous (s.c.) low-dose interleukin-2 (IL2), granulocyte–monocyte colony stimulating factor (GM-CSF) and interferon-α 2b (IFNα) in patients with metastatic melanoma. …”
Publicado 2003
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30098“…This includes Interleukin 1-beta (IL1B) and Interferon-gamma receptor (IFNGR1) SNP analysis, and Interleukin-1 receptor antagonist (IL1RN) variable tandem repeats (VNTR) in intron 2. …”
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30099por Herasimtschuk, Anna A, Westrop, Samantha J, Moyle, Graeme J, Downey, Jocelyn S, Imami, Nesrina“…We assessed HIV-1-specific proliferative CD4(+ )and interferon-gamma (IFN-γ)-producing CD8(+ )T-cell responses, quantified thymic output and proviral HIV-1 DNA at the following time points: baseline; after 12 weeks of rhGH therapy; at 24 weeks, after randomization into three groups [placebo weeks 12–24 (Group A), alternate-day dosing weeks 12–24 (Group B), and twice-per-week dosing weeks 12–24 (Group C)]; and at 48 weeks after all patients had received HAART alone for the final 24 weeks. …”
Publicado 2008
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30100por Lahey, Timothy, Matee, Mecky, Mtei, Lillian, Bakari, Muhammad, Pallangyo, Kisali, von Reyn, C Fordham“…METHODS: HIV-infected subjects with bacille Calmette Guérin (BCG) scars and CD4 counts ≥ 200 cells/mm(3 )entering a TB booster vaccine trial in Tanzania had baseline in vivo and in vitro immune tests performed: tuberculin skin tests (TST), LPA and five day assays of interferon gamma (IFN-γ) release. Assay antigens were early secreted antigenic target 6 (ESAT-6), antigen 85 (Ag85), and Mycobacterium tuberculosis whole cell lysate (WCL). …”
Publicado 2009
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