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30121por Cappuzzello, Claudia, Di Vito, Luca, Melchionna, Roberta, Melillo, Guido, Silvestri, Lorena, Cesareo, Eleonora, Crea, Filippo, Liuzzo, Giovanna, Facchiano, Antonio, Capogrossi, Maurizio C, Napolitano, Monica“…In contrast, IL-7, IL-5, and Interferon (IFN)-γ were decreased in both ICM and NIDCM groups as compared to controls. …”
Publicado 2011
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30122“…HCV infectivity was inhibited by pre-incubation of the particles with anti-HCV antibodies and by a treatment of the target cells with leukocyte interferon plus ribavirin. The production of authentic infectious HCV particles of virtually any genotype without the adaptive mutations associated with in vitro HCV replication represents a new paradigm to decipher the requirements for HCV assembly, release, and entry, amenable to analyses of wild type and genetically modified viruses of the most clinically significant HCV genotypes.…”
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30123por Whitfield-Larry, Fatima, Young, Ellen F., Talmage, Garrick, Fudge, Elizabeth, Azam, Anita, Patel, Shipra, Largay, Joseph, Byrd, Warren, Buse, John, Calikoglu, Ali S., Shultz, Leonard D., Frelinger, Jeffrey A.“…In addition, many of the infiltrating CD8(+) T cells are epitope-specific and produce interferon-γ after in vitro peptide stimulation. This indicates that NOD-scid/γc(null)/A2 mice transferred with HLA-A2–matched PBMCs from type 1 diabetic patients may serve as a useful tool for studying epitope-specific T-cell–mediated responses in patients with type 1 diabetes.…”
Publicado 2011
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30124por O'Hanlon, Terrance P, Rider, Lisa G, Gan, Lu, Fannin, Rick, Paules, Richard S, Umbach, David M, Weinberg, Clarice R, Shah, Ruchir R, Mav, Deepak, Gourley, Mark F, Miller, Frederick W“…Differentially expressed genes involved several overlapping pathways including immune responses (16%), signaling pathways (24%), transcription/translation regulators (26%), and metabolic functions (15%). Interferon (IFN)-response genes (IFI27, OASF, PLSCR1, EIF2AK2, TNFAIP6, and TNFSF10) were up-regulated in probands compared to unrelated controls. …”
Publicado 2011
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30125por Cravens, Petra D, Hussain, Rehana Z, Zacharias, Tresa E, Ben, Li-Hong, Herndon, Emily, Vinnakota, Ramya, Lambracht-Washington, Doris, Nessler, Stefan, Zamvil, Scott S, Eagar, Todd N, Stüve, Olaf“…The ability of LNC to transfer disease was associated with the presence of inflammatory infiltrates in the CNS at day 12. Interferon gamma (IFNγ) was produced at comparable levels in cell cultures prepared from mice at both day 6 and day 12 post immunization. …”
Publicado 2011
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30126por Minassian, Angela M, Rowland, Rosalind, Beveridge, Natalie E R, Poulton, Ian D, Satti, Iman, Harris, Stephanie, Poyntz, Hazel, Hamill, Matthew, Griffiths, Kristin, Sander, Clare R, Ambrozak, David R, Price, David A, Hill, Brenna J, Casazza, Joseph P, Douek, Daniel C, Koup, Richard A, Roederer, Mario, Winston, Alan, Ross, Jonathan, Sherrard, Jackie, Rooney, Guy, Williams, Nicola, Lawrie, Alison M, Fletcher, Helen A, Pathan, Ansar A, McShane, Helen“…Vaccine immunogenicity was assessed by ex vivo interferon γ (IFN-γ) ELISpot assays and flow-cytometric analysis. …”
Publicado 2011
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30127por Yang, You-Lan, Hsu, Hsin-Te, Wang, Kuo-Hsien, Han, Cheng-Ying, Chen, Chien-Ming, Chen, Chi-Ming, Ko, Wun-Chang“…It also significantly suppressed the increases in the numbers of total inflammatory cells, macrophages, lymphocytes, neutrophils, and eosinophils, and levels of cytokines, including interleukin (IL)-2, IL-4, IL-5, interferon-γ, and tumor necrosis factor-α in bronchoalveolar lavage fluid (BALF) of these mice. …”
Publicado 2011
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30128por Nyland, Jennifer F., Fillion, Myriam, Barbosa, Fernando, Shirley, Devon L., Chine, Chiameka, Lemire, Melanie, Mergler, Donna, Silbergeld, Ellen K.“…Proinflammatory [interleukin (IL)-6 and interferon (IFN)-©], anti-inflammatory (IL-4), and IL-17 cytokine levels were increased with MeHg exposure; however, in the subset of the population with elevated ANA, proinflammatory IL-1®, IL-6, IFN-©, and tumor necrosis factor (TNF)-〈 and anti-inflammatory (IL-4) cytokine levels were decreased with MeHg exposure. …”
Publicado 2011
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30129por Lee, Kai Syin, Kalantzis, Anastasia, Jackson, Cameron B., O'Connor, Louise, Murata-Kamiya, Naoko, Hatakeyama, Masanori, Judd, Louise M., Giraud, Andrew S., Menheniott, Trevelyan R.“…Inhibition of the gp130-related SHP2-(Ras)-ERK pathway did not affect CagA-dependent REG3γ induction, but strengthened STAT3 activation as well as augmenting transcription of mucosal innate immune regulators, IL-6, IL-8 and interferon-response factor (IRF)1. CONCLUSIONS/SIGNIFICANCE: Our results support a model of CagA-directed REG3γ expression in gastric epithelial cells via activation of the IL-11/gp130/STAT3 pathway. …”
Publicado 2012
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30130por Chiang, Cheryl L-L, Maier, Dawn A, Kandalaft, Lana E, Brennan, Andrea L, Lanitis, Evripidis, Ye, Qunrui, Levine, Bruce L, Czerniecki, Brian J, Powell Jr, Daniel J, Coukos, George“…Different culture parameters for clinical-scale DC preparation were investigated, including: 1) culture media; 2) culture surface; 3) duration of activating DCs with lipopolysaccharide (LPS) and interferon (IFN)-gamma; 4) method of DC harvest; and 5) cryomedia and final DC product formulation. …”
Publicado 2011
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30131por Singh, Jagbir, Michel, Deborah, Chitanda, Jackson M, Verrall, Ronald E, Badea, Ildiko“…RESULTS: Nanoparticles were incubated with Sf 1 Ep cells in the presence of different endocytic inhibitors and gene expression (interferon-γ) was measured using ELISA. Clathrin-mediated and caveolae-mediated uptake were found to be equally contributing to cellular internalization of both P/12-7NH-12/L (parent gemini surfactant) and P/12-7NGK-12/L (amino acid-substituted gemini surfactant) nanoparticles. …”
Publicado 2012
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30132“…RESULTS: The results demonstrated a higher expression of interleukin (IL)-6 and IL-1α in OP, and interferon (IFN)-γ in OA (p < 0.0005). Negative correlations of total hip BMD with tumor necrosis factor-α (TNF-α) in OA and with RANKL/RANK in OP were found (p < 0.05). …”
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30133por Li, Jonathan Z., Brumme, Chanson J., Lederman, Michael M., Brumme, Zabrina L., Wang, Hongying, Spritzler, John, Carrington, Mary, Medvik, Kathleen, Walker, Bruce D., Schooley, Robert T., Kuritzkes, Daniel R.“…HIV-1 Gag-specific CD4+ interferon-γ responses were not associated with initial virologic suppression and no evidence of vaccine-driven HIV sequence evolution was detected. …”
Publicado 2012
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30134por Uchiyama, Masateru, Jin, Xiangyuan, Zhang, Qi, Hirai, Toshihito, Amano, Atsushi, Bashuda, Hisashi, Niimi, Masanori“…Proliferation of splenocytes, interleukin (IL)-2 and interferon (IFN)-γ production was suppressed in opera-exposed mice, and production of IL-4 and IL-10 from opera-exposed transplant recipients increased compared to that from splenocytes of untreated recipients. …”
Publicado 2012
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30135por Sharma-Walia, N, Patel, K, Chandran, K, Marginean, A, Bottero, V, Kerur, N, Paul, A G“…Kaposi's sarcoma herpesvirus (KSHV) latent oncoprotein viral FLICE (FADD-like interferon converting enzyme)-like inhibitory protein (v-FLIP) or K13, a potent activator of NF-κB, has well-established roles in KSHV latency and oncogenesis. …”
Publicado 2012
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30136por Brusés, Juan L“…RESULTS: Maternal exposure to poly(I:C) at gestational day 16 induced a significant increase in cytokines interleukin (IL)-1β, IL-7 and IL-13; chemokines monocyte chemoattractant protein 1 (MCP-1), macrophage inflammatory protein (MIP)-1α, interferon gamma-induced protein (IP)-10 and monokine induced by IFN-gamma (MIG); and in the colony stimulating factor vascular endothelial growth factor (VEGF) in the fetal brain. …”
Publicado 2012
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30137por Wang, Bei, Zaidi, Neeha, He, Li-Zhen, Zhang, Li, Kuroiwa, Janelle MY, Keler, Tibor, Steinman, Ralph M“…Vaccine-induced T cell immunity was determined by analyzing the ability of CD4(+)/CD8(+ )T cell to produce interferon (IFN)-gamma and proliferate upon antigen rechallenge. …”
Publicado 2012
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30138por Vidal, Francesc, López-Dupla, Miguel, Laguno, Montserrat, Veloso, Sergi, Mallolas, Josep, Murillas, Javier, Cifuentes, Carmen, Gallart, Lluis, Auguet, Teresa, Sampériz, Gloria, Payeras, Antoni, Hernandez, Pilar, Arnedo, Mireia, Gatell, Josep Ma, Richart, Cristóbal“…BACKGROUND AND AIMS: This was a safety and efficacy pharmacogenetic study of a previously performed randomized trial which compared the effectiveness of treatment of hepatitis C virus infection with pegylated interferon alpha (pegIFNα) 2a vs. 2b, both with ribavirin, for 48 weeks, in HCV-HIV coinfected patients. …”
Publicado 2012
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30139por Giannini, Marta, Portaccio, Emilio, Ghezzi, Angelo, Hakiki, Bahia, Pastò, Luisa, Razzolini, Lorenzo, Piscolla, Elisa, De Giglio, Laura, Pozzilli, Carlo, Paolicelli, Damiano, Trojano, Maria, Marrosu, Maria Giovanna, Patti, Francesco, La Mantia, Loredana, Mancardi, Gianluigi, Solaro, Claudio, Totaro, Rocco, Tola, Maria Rosaria, De Luca, Giovanna, Lugaresi, Alessandra, Moiola, Lucia, Martinelli, Vittorio, Comi, Giancarlo, Amato, Maria Pia“…Following a previous study assessing the safety of interferon beta (IFNB) pregnancy exposure in multiple sclerosis (MS), we aimed to assess pregnancy and fetal outcomes after in utero exposure to GA, using the same dataset, with a specific focus on the risk of spontaneous abortion. …”
Publicado 2012
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30140por Oreja-Guevara, Celia, Ramos-Cejudo, Jaime, Aroeira, Luiz Stark, Chamorro, Beatriz, Diez-Tejedor, Exuperio“…We determined serum levels of Th1 and Th2 cytokines (interleukin [IL]-1a, IL-1b, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-13, monocyte chemotactic protein [MCP]-1, tumor-necrosis factor [TNF]-α, interferon [IFN]-γ and granulocyte macrophage colony stimulating factor [GM-CSF]) by flow cytometry. …”
Publicado 2012
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