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30141por Zumbrun, Elizabeth E., Abdeltawab, Nourtan F., Bloomfield, Holly A., Chance, Taylor B., Nichols, Donald K., Harrison, Paige E., Kotb, Malak, Nalca, Aysegul“…In contrast, 10–30% lethality was observed in B6 and D2 mice exposed to aerosolized MA-EBOV, and 100% of SCID, Stat1 KO, interferon (IFN)-γ KO and Perforin KO mice became moribund between 7–14 dpe. …”
Publicado 2012
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30142por Ringpis, Gene-Errol E., Shimizu, Saki, Arokium, Hubert, Camba-Colón, Joanna, Carroll, Maria V., Cortado, Ruth, Xie, Yiming, Kim, Patrick Y., Sahakyan, Anna, Lowe, Emily L., Narukawa, Munetoshi, Kandarian, Fadi N., Burke, Bryan P., Symonds, Geoff P., An, Dong Sung, Chen, Irvin S. Y., Kamata, Masakazu“…No obvious cytotoxicity or interferon response was observed. Transplantation of combination vector-transduced HSPC into hu-BLT mice resulted in efficient engraftment and subsequent stable gene marking and CCR5 down-regulation in human CD4(+) T-cells within peripheral blood and systemic lymphoid tissues, including gut-associated lymphoid tissue, a major site of robust viral replication, for over twelve weeks. …”
Publicado 2012
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30143por Bian, Zhongqi, Xiao, An, Cao, Mingmei, Liu, Mingqiu, Liu, Shuang, Jiao, Ye, Yan, Weiyao, Qi, Zhongtian, Zheng, Zhaoxin“…CONCLUSIONS: Our combinational RNAi was sequence-specific, effective against wild-type and mutant drug-resistant HBV strains, without triggering interferon response or producing any side effects. These findings indicate that combinational RNAi has tremendous promise for developing innovative therapy against viral infection.…”
Publicado 2012
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30144“…CD4 depletion in B7-H1(−/−) mice also decreased inducible nitric oxide synthase expression by microglia and macrophages, consistent with decreased microglia/macrophage activation and reduced interferon (IFN)-γ. Enhanced production of IFN-γ, interleukin (IL)-10 and IL-21 mRNA was seen in CD4 T cells from infected B7-H1(−/−) compared with WT mice, suggesting that over-activated CD4 T cells primarily contribute to the increased pathology. …”
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30145por Meng, Min, He, Shenyi, Zhao, Guanghui, Bai, Yang, Zhou, Huaiyu, Cong, Hua, Lu, Gang, Zhao, Qunli, Zhu, Xing-Quan“…RESULTS: Mice vaccinated with pSAG1, p14-3-3 or pSAG1/14-3-3 developed high levels of IgG2a and gamma interferon (IFN-γ) and low levels of interleukin-4 (IL-4) and interleukin-10 (IL-10) compared to control groups (PBS or pBudCE4.1), which suggested a modulated Th1 type immune response (P<0.05). …”
Publicado 2012
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30146por Carmona, F. David, Martin, Jose-Ezequiel, Beretta, Lorenzo, Simeón, Carmen P., Carreira, Patricia E., Callejas, José Luis, Fernández-Castro, Mónica, Sáez-Comet, Luis, Beltrán, Emma, Camps, María Teresa, Egurbide, María Victoria, Airó, Paolo, Scorza, Raffaella, Lunardi, Claudio, Hunzelmann, Nicolas, Riemekasten, Gabriela, Witte, Torsten, Kreuter, Alexander, Distler, Jörg H. W., Madhok, Rajan, Shiels, Paul, van Laar, Jacob M., Fonseca, Carmen, Denton, Christopher, Herrick, Ariane, Worthington, Jane, Schuerwegh, Annemie J., Vonk, Madelon C., Voskuyl, Alexandre E., Radstake, Timothy R. D. J., Martín, Javier“…One of the strongest SSc association signals outside the human leukocyte antigen (HLA) region corresponds to interferon (IFN) regulatory factor 5 (IRF5), a major regulator of the type I IFN pathway. …”
Publicado 2013
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30147por Chuang, Dennis Y, Chan, Ming-Huan, Zong, Yijia, Sheng, Wenwen, He, Yan, Jiang, Jing Hua, Simonyi, Agnes, Gu, Zezong, Fritsche, Kevin L, Cui, Jiankun, Lee, James C, Folk, William R, Lubahn, Dennis B, Sun, Albert Y, Sun, Grace Y“…In this study, we investigate the ability of these isomers to suppress oxidative stress in neurons stimulated by the ionotropic glutamate receptor agonist N-methyl-D-aspartate (NMDA) and oxidative and inflammatory responses in microglial cells activated by interferon-γ (IFNγ) and lipopolysaccharide (LPS). We also attempt to elucidate the mechanism and signaling pathways involved in cytokine-induced production of reactive oxygen species (ROS) in microglial cells. …”
Publicado 2013
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30148“…In addition, eight weeks after the last immunization, maximum production of gamma interferon was detected in mice immunized with PLG-rSAG1 microparticles. …”
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30149por Richie, Thomas L., Charoenvit, Yupin, Wang, Ruobing, Epstein, Judith E., Hedstrom, Richard C., Kumar, Sanjai, Luke, Thomas C., Freilich, Daniel A., Aguiar, Joao C., Sacci, Jr., John B., Sedegah, Martha, Nosek, Jr., Ronald A., De La Vega, Patricia, Berzins, Mara P., Majam, Victoria F., Abot, Esteban N., Ganeshan, Harini, Richie, Nancy O., Banania, Jo Glenna, Baraceros, Maria Fe B., Geter, Tanya G., Mere, Robin, Bebris, Lolita, Limbach, Keith, Hickey, Bradley W., Lanar, David E., Ng, Jennifer, Shi, Meng, Hobart, Peter M., Norman, Jon A., Soisson, Lorraine A., Hollingdale, Michael R., Rogers, William O., Doolan, Denise L., Hoffman, Stephen L.“…The vaccine was safe and well-tolerated, inducing moderate antigen-specific, MHC-restricted T cell interferon-γ responses but no antibodies. Although no volunteers were protected, T cell responses were boosted post malaria challenge. …”
Publicado 2012
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30150por Jin, Young-Joo, Lee, Jin-Woo, Lee, Jung il, Park, Sang Hoon, Park, Choong Kee, Kim, Young Seok, Jeong, Sook-Hyang, Kim, Yun Soo, Kim, Ju Hyun, Hwang, Seong Gyu, Rim, Kyu Sung, Yim, Hyung Joon, Cheong, Jae Youn, Cho, Sung Won, Lee, June Sung, Park, Young Min, Jang, Jeong Won, Lee, Chun Kyon, Sohn, Joo Hyun, Yang, Jin Mo, Han, Seungbong“…BACKGROUND: Two recent Italian studies suggested that Pegylated-interferon (PEG-IFN) alfa-2a achieves a higher sustained virological response (SVR) rate than PEG-IFN alfa-2b. …”
Publicado 2013
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30151por Datau, Eulis A, Mewengkang, H, Matheos, JC, Purnawan, I, Wibisono, M, Wongdjaja, K, Wibowo, C, Surachmanto, E, Salim, FP“…The symptom score (SS) and drug score (DS), lung function, eosinophil blood count (EBC), total serum immunoglobulin E, interferon-γ (IFN-γ), interleukin 4, and transforming growth factor-β1 (TGF-β1) were examined on the first phase (before the treatment and at the 12th week) and on the second phase (on the sixth and ninth months after the third vaccination for thrice BCG group or after single BCG for control group) to monitor the efficacy. …”
Publicado 2008
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30152por Rullo, Ornella J, Woo, Jennifer MP, Parsa, Miriam F, Hoftman, Alice DC, Maranian, Paul, Elashoff, David A, Niewold, Timothy B, Grossman, Jennifer M, Hahn, Bevra H, McMahon, Maureen, McCurdy, Deborah K, Tsao, Betty P“…INTRODUCTION: Osteopontin (OPN) has been implicated as a mediator of Th17 regulation via type I interferon (IFN) receptor signaling and in macrophage activity at sites of tissue repair. …”
Publicado 2013
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30153por Batsalova, Tsvetelina, Lindh, Ingrid, Bäcklund, Johan, Dzhambazov, Balik, Holmdahl, Rikard“…T cells from draining lymph nodes were restimulated in vitro with CII peptides and interferon-gamma (IFN-γ) levels in culture supernatants were evaluated by ELISA. …”
Publicado 2012
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30154por Hall, Bruce M., Tran, Giang T., Verma, Nirupama D., Plain, Karren M., Robinson, Catherine M., Nomura, Masaru, Hodgkinson, Suzanne J.“…Specifically nT(reg) activated by IL-2 and antigen express the interferon-γ receptor (IFNGR) and IL-12p70 (IL-12Rβ2) receptor but not the IL-5 receptor (IL-5Rα). …”
Publicado 2013
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30155por Wahyuni, Tutik Sri, Tumewu, Lydia, Permanasari, Adita Ayu, Apriani, Evhy, Adianti, Myrna, Rahman, Abdul, Widyawaruyanti, Aty, Lusida, Maria Inge, Fuad, Achmad, Soetjipto, Nasronudin, Fuchino, Hiroyuki, Kawahara, Nobuo, Shoji, Ikuo, Deng, Lin, Aoki, Chie, Hotta, Hak“…Current standard treatment using pegylated interferon and ribavirin is effective in only 50% of the patients infected with HCV genotype 1, and is associated with significant side effects. …”
Publicado 2013
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30156por Potenza, Leonardo, Vallerini, Daniela, Barozzi, Patrizia, Riva, Giovanni, Forghieri, Fabio, Beauvais, Anne, Beau, Remi, Candoni, Anna, Maertens, Johan, Rossi, Giulio, Morselli, Monica, Zanetti, Eleonora, Quadrelli, Chiara, Codeluppi, Mauro, Guaraldi, Giovanni, Pagano, Livio, Caira, Morena, Giovane, Cinzia Del, Maccaferri, Monica, Stefani, Alessandro, Morandi, Uliano, Tazzioli, Giovanni, Girardis, Massimo, Delia, Mario, Specchia, Giorgina, Longo, Giuseppe, Marasca, Roberto, Narni, Franco, Merli, Francesco, Imovilli, Annalisa, Apolone, Giovanni, Carvalho, Agostinho, Comoli, Patrizia, Romani, Luigina, Latgè, Jean Paul, Luppi, Mario“…Aspergillus-specific T cells producing non-protective interleukin-10 (IL-10) and protective interferon-gamma (IFN-γ) have been detected to all the antigens only in IA patients. …”
Publicado 2013
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30157“…BACKGROUND: Chronic hepatitis B is a primary cause of liver-related death. Interferon alpha (IFN-α) is able to inhibit the replication of hepadnavirus, and the sustained and stable expression of IFN-α at appropriate level may be beneficial to HBV clearance. …”
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30158por Fan, Peihu, Wei, Yanwu, Guo, Longjun, Wu, Hongli, Huang, Liping, Liu, Jianbo, Liu, Changming“…The serum concentrations of interferon γ (IFN-γ), tumor necrosis factor α (TNF-α), interleukin 10 (IL-10), and macrophage granulocyte-colony stimulating factor (GM-CSF) were determined. …”
Publicado 2013
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30159“…METHODS: This systematic review and Bayesian mixed-treatment-comparison (MTC) aimed to compare the efficacy and safety of standard-therapy with pegylated-interferon-α/ribavirin (Peg-IFN-α/RBV (48 weeks), group A), FLT with TVR, Peg-IFN-α/RBV for 12 weeks with a long (+36 weeks, group B) or short (+12 weeks, group C) tail of Peg-IFN-α/RBV treatment, and RGT with 12 weeks of TVR, Peg-IFN-α/RBV followed by 12 weeks of Peg-IFN-α/RBV (group D) or no therapy (group E). …”
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30160por Schablon, Anja, Peters, Claudia, Diel, Roland, Diner, Genia, Anske, Ute, Pankow, Wulf, Ringshausen, Felix C., Nienhaus, Albert“…Background: Healthcare workers (HCW) are a risk group for tuberculosis (TB). That is why interferon-gamma release assay (IGRA) serial testing is performed on HCWs repeatedly exposed to infectious patients or materials. …”
Publicado 2013
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