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30221por Lee, Susan Shin-Jung, Lin, Hsi-Hsun, Tsai, Hung-Chin, Su, Ih-Jen, Yang, Chin-Hui, Sun, Hsin-Yun, Hung, Chien-Chin, Sy, Cheng-Len, Wu, Kuan-Sheng, Chen, Jui-Kuang, Chen, Yao-Shen, Fang, Chi-Tai“…We aimed to develop and validate a clinical algorithm, using baseline CD4 cell counts, HIV viral load (pVL), and interferon-gamma release assay (IGRA), to identify PLHIV who are at high risk for incident active TB in low-to-moderate TB burden settings where highly active antiretroviral therapy (HAART) is routinely provided. …”
Publicado 2015
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30222“…Patients’ kynurenine pathway metabolites correlated with the levels of inflammatory markers, including that of the major IDO-inducer, interferon-gamma. Indications are that the rate of de novo synthesis of nicotinamide in the kynurenine pathway correlates with increases in quinolinic acid levels up to a point where saturation of the enzyme quinolinate phosphoribosyl transferase occurs. …”
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30223“…HS was associated with significantly more intraoperative bleeding (mean difference [MD] 57.15, 95% confidence interval [CI] 18.83–95.46, P=0.003), and CD4/CD8 ratio (MD 0.69, 95% CI 0.61–0.77, P<0.00001), CD4 subset, platelet count (MD 213.06, 95% CI 202.59–223.53, P<0.0001), white blood cell count (MD 4.85, 95% CI 4.58–5.13, P<0.0001), interferon-gamma levels (MD 18.52, 95% CI 13.93–23.11, P<0.00001), and interleukin-2 levels (MD 20.73, 95% CI 16.05–25.41, P<0.0001). …”
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30224por Kim, Dong-Kyu, Jin, Hong Ryul, Eun, Kyoung Mi, Mutusamy, Somasundran, Cho, Seong H., Oh, Sohee, Kim, Dae Woo“…Tissue samples were analyzed for total IgE levels and for mRNA expression levels of interleukin (IL)-4, IL–5, IL–13, interferon (IFN)-γ, tumor necrosis factor (TNF)-α, IL-17A, IL–22, IL-23p19, transforming growth factor (TGF)-β1, TGF-β2, TGF-β3, and periostin. …”
Publicado 2015
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30225por Jia, Wei, Song, Liu-Wei, Fang, Yu-Qing, Wu, Xiao-Feng, Liu, Dan-Yang, Xu, Chun, Wang, Xiao-Mei, Wang, Wen, Lv, Dong-Xia, Li, Jun, Deng, Yong-Qiong, Wang, Yan, Huo, Na, Yu, Min, Xi, Hong-Li, Liu, Dan, Zhou, Yi-Xing, Wang, Gui-Qiang, Xia, Ning-Shao, Zhang, Ming-Xiang“…Previous studies have revealed antibody to hepatitis B core antigen (anti-HBc) levels as a predictor of treatment response in hepatitis B early antigen (HBeAg)-positive chronic hepatitis B (CHB) patients in both interferon and nucleos(t)ide analog therapy cohorts. …”
Publicado 2014
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30226por Lima, Jessica, Siqueira, Mariana, Pedro, Thaíze, Ponte, Carlos, Peres, Leandro, Marinho, Suelen, Castello-Branco, Luíz R., Antas, Paulo R. Z.“…CM was also assayed for nitric oxide (NO), prostaglandin E2 (PGE(2)), leukotriene B4 (LTB(4)), interferon (IFN)-β, and transforming growth factor (TGF)-β1 levels. …”
Publicado 2015
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30227por Miramontes, Roque, Hill, Andrew N., Yelk Woodruff, Rachel S., Lambert, Lauren A., Navin, Thomas R., Castro, Kenneth G., LoBue, Philip A.“…METHODS: Civilian, noninstitutionalized U.S. population survey participants aged 6 years and older were interviewed regarding their TB history and eligibility for the tuberculin skin test (TST) and interferon gamma release assay (IGRA) blood test. Once eligibility was confirmed, both tests were conducted. …”
Publicado 2015
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30228por Inácio, Ana R., Liu, Yawei, Clausen, Bettina H., Svensson, Martina, Kucharz, Krzysztof, Yang, Yiyi, Stankovich, Totte, Khorooshi, Reza, Lambertsen, Kate L., Issazadeh-Navikas, Shohreh, Deierborg, Tomas“…BACKGROUND: Interferon (IFN)-β exerts anti-inflammatory effects, coupled to remarkable neurological improvements in multiple sclerosis, a neuroinflammatory condition of the central nervous system. …”
Publicado 2015
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30229por Matsuda, Monique, Bonatti, Rodolfo, Marquezini, Mônica V., Garcia, Maria L. B., Santos, Ubiratan P., Braga, Alfésio L. F., Alves, Milton R., Saldiva, Paulo H. N., Monteiro, Mário L. R.“…Exposure to ambient PM(2.5) (particulate matter equal or smaller than 2.5 μm) was 24 hour individually collected and the collection of tears was performed to measure interleukins (IL) 2, 4, 5 and 10 and interferon gamma (IFN-γ) levels. Data from both groups were compared using Student’s t test or Mann- Whitney test for cytokines. …”
Publicado 2015
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30230por Getahun, Haileyesus, Matteelli, Alberto, Abubakar, Ibrahim, Aziz, Mohamed Abdel, Baddeley, Annabel, Barreira, Draurio, Den Boon, Saskia, Borroto Gutierrez, Susana Marta, Bruchfeld, Judith, Burhan, Erlina, Cavalcante, Solange, Cedillos, Rolando, Chaisson, Richard, Chee, Cynthia Bin-Eng, Chesire, Lucy, Corbett, Elizabeth, Dara, Masoud, Denholm, Justin, de Vries, Gerard, Falzon, Dennis, Ford, Nathan, Gale-Rowe, Margaret, Gilpin, Chris, Girardi, Enrico, Go, Un-Yeong, Govindasamy, Darshini, D. Grant, Alison, Grzemska, Malgorzata, Harris, Ross, Horsburgh Jr, C. Robert, Ismayilov, Asker, Jaramillo, Ernesto, Kik, Sandra, Kranzer, Katharina, Lienhardt, Christian, LoBue, Philip, Lönnroth, Knut, Marks, Guy, Menzies, Dick, Migliori, Giovanni Battista, Mosca, Davide, Mukadi, Ya Diul, Mwinga, Alwyn, Nelson, Lisa, Nishikiori, Nobuyuki, Oordt-Speets, Anouk, Rangaka, Molebogeng Xheedha, Reis, Andreas, Rotz, Lisa, Sandgren, Andreas, Sañé Schepisi, Monica, Schünemann, Holger J., Sharma, Surender Kumar, Sotgiu, Giovanni, Stagg, Helen R., Sterling, Timothy R., Tayeb, Tamara, Uplekar, Mukund, van der Werf, Marieke J., Vandevelde, Wim, van Kessel, Femke, van't Hoog, Anna, Varma, Jay K., Vezhnina, Natalia, Voniatis, Constantia, Vonk Noordegraaf-Schouten, Marije, Weil, Diana, Weyer, Karin, Wilkinson, Robert John, Yoshiyama, Takashi, Zellweger, Jean Pierre, Raviglione, Mario“…In prisoners, healthcare workers, immigrants from high TB burden countries, homeless persons and illicit drug users, systematic testing and treatment of LTBI is conditionally recommended, according to TB epidemiology and resource availability. Either commercial interferon-gamma release assays or Mantoux tuberculin skin testing could be used to test for LTBI. …”
Publicado 2015
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30231por Aulicino, Anna, Dinan, Adam M., Miranda-CasoLuengo, Aleksandra A., Browne, John A., Rue-Albrecht, Kévin, MacHugh, David E., Loftus, Brendan J.“…The core response is type I Interferon (IFN)-driven, involving the NF-κB and MAPK signaling pathways with concomitant pro-inflammatory cytokine production, and network analysis identified STAT1, EGR1, and SRC as key hub and bottleneck genes. …”
Publicado 2015
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30232por Wagstaff, J., Jones, R., Hawkins, R., Porfiri, E., Pickering, L., Bahl, A., Brown, J., Buchan, S.“…Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. …”
Publicado 2016
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30233por Aboulnasr, Fatma, Hazari, Sidhartha, Nayak, Satyam, Chandra, Partha K., Panigrahi, Rajesh, Ferraris, Pauline, Chava, Srinivas, Kurt, Ramazan, Song, Kyongsub, Dash, Asha, Balart, Luis A., Garry, Robert F., Wu, Tong, Dash, Srikanta“…Activation of Jak-Stat signaling, interferon stimulated gene (ISG) expression, and miRNA-122 transcription in S3-GFP and R4-GFP cells were examined. …”
Publicado 2015
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30234por Mazzola, Maria Antonietta, Raheja, Radhika, Murugaiyan, Gopal, Rajabi, Hasan, Kumar, Deepak, Pertel, Thomas, Regev, Keren, Griffin, Russell, Aly, Lilian, Kivisakk, Pia, Nejad, Parham, Patel, Bonny, Gwanyalla, Nguendab, Hei, Hillary, Glanz, Bonnie, Chitnis, Tanuja, Weiner, Howard L., Gandhi, Roopali“…Luciferase assays were performed to test the direct regulation of interferon gamma (IFN-γ) and granzyme B (GZMB) by TCF-1. …”
Publicado 2015
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30235por Surtees, Rebecca, Ariza, Antonio, Punch, Emma K., Trinh, Chi H., Dowall, Stuart D., Hewson, Roger, Hiscox, Julian A., Barr, John N., Edwards, Thomas A.“…In contrast HAZV is not associated with serious human disease, although infection of interferon receptor knockout mice with either CCHFV or HAZV results in similar disease progression. …”
Publicado 2015
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30236por Li, Hui, Stoddard, Mark B., Wang, Shuyi, Giorgi, Elena E., Blair, Lily M., Learn, Gerald H., Hahn, Beatrice H., Alter, Harvey J., Busch, Michael P., Fierer, Daniel S., Ribeiro, Ruy M., Perelson, Alan S., Bhattacharya, Tanmoy, Shaw, George M.“…IMPORTANCE Despite the recent development of highly effective, interferon-sparing anti-hepatitis C virus (HCV) drugs, the global burden of this pathogen remains immense. …”
Publicado 2015
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30237por GAO, QIYUE, LIU, YANG, WU, YAN, ZHAO, QIANG, WANG, LIJUN, GAO, SHANSHAN, WEN, WEN, ZHANG, WEIPING, GUO, NING, ZHOU, JUAN, YUAN, ZUYI“…Previous research has indicated that IL-17 plays a proinflammatory role by exacerbating interferon-γ (IFN-γ)-induced inflammation. However, prior to this study, it was not known whether inducible nitric oxide synthase (iNOS or NOS2), a signature molecule of inflammation, could be intensified by IL-17 when combined with IFN-γ. …”
Publicado 2016
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30238por Weber, Kathryn T., Alipui, D. Olivier, Sison, Cristina P., Bloom, Ona, Quraishi, Shaheda, Overby, M. Chris, Levine, Mitchell, Chahine, Nadeen O.“…Serum samples were collected before treatment and were assayed by multiplex assays for levels of interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, interferon-γ, tumor necrosis factor-α, MMP-1, MMP-3, and MMP-9. …”
Publicado 2016
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30239por STICCHI, L., DI BIAGIO, A., RAPPAZZO, E., SETTI, M., DE ROSA, G., DE HOFFER, L., NICOLINI, L., PRINAPORI, R., BRUZZONE, B.“…Genome-wide association studies have shown that single nucleotide polymorphisms (SNPs) near IL 28B gene on chromosome 19 are strong predictors of sustained virologic response (SVR) to pegylated interferon and ribavirin. This study was aimed at analyzing the co-prevalence of two common and clinically significant SNPs in a cohort of Ligurian patients. …”
Publicado 2013
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30240por Tham, Manuela, Schlör, Gabriele R., Yerly, Daniel, Mueller, Christina, Surbek, Daniel, Villiger, Peter M., Förger, Frauke“…In all subjects, peripheral Vδ1 and Vδ2 T cells were analyzed for cell frequencies, the activation marker CD69, the cytotoxicity markers NKG2D and NKG2A, and the intracellular cytokines tumor necrosis factor (TNF)α, interferon (IFN)γ, interleukin (IL)-17 and IL-10. RESULTS: Pregnant patients showed a decreased Vδ2/Vδ1 ratio in the third trimester, which resulted from a slightly reduced proportion of Vδ2 cells. …”
Publicado 2016
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