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30301Bacterial amyloid curli acts as a carrier for DNA to elicit an autoimmune response via TLR2 and TLR9por Tursi, Sarah A., Lee, Ernest Y., Medeiros, Nicole J., Lee, Michael H., Nicastro, Lauren K., Buttaro, Bettina, Gallucci, Stefania, Wilson, Ronald Paul, Wong, Gerard C. L., Tükel, Çagla“…Infection with curli-expressing bacteria or systemic exposure to purified curli-DNA complexes triggers autoimmunity via the generation of type I interferons (IFNs) and anti-double-stranded DNA antibodies. …”
Publicado 2017
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30302“…Abbreviations used: LPS: Lipopolysaccharide, IL: Interleukin; NF-κB: Nuclear factor kappa-B, TNF-α: Tumor necrosis factor alpha, MIP-1α: Macrophage inflammatory protein-1α, IFN-γ: Interferon, MTT: 3-(4,5-diamethyl-2-thiazolyl)-2, 5-diphenyl-2Htetrazolium), ELISA: Enzyme linked immune sorbent assay, ANOVA: Analysis of variance…”
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30303por Hinkula, Jorma, Devignot, Stéphanie, Åkerström, Sara, Karlberg, Helen, Wattrang, Eva, Bereczky, Sándor, Mousavi-Jazi, Mehrdad, Risinger, Christian, Lindegren, Gunnel, Vernersson, Caroline, Paweska, Janusz, van Vuren, Petrus Jansen, Blixt, Ola, Brun, Alejandro, Weber, Friedemann, Mirazimi, Ali“…Using the recently developed interferon alpha receptor knockout (IFNAR(−/−)) mouse model, which replicates human disease, we investigated the immunogenicity and protection of two novel CCHFV vaccine candidates: a DNA vaccine encoding a ubiquitin-linked version of CCHFV Gc, Gn, and N and one using transcriptionally competent virus-like particles (tc-VLPs). …”
Publicado 2017
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30304“…Both methods yielded microglia that were responsive to various stimuli such as IL-4, lipopolysaccharide (LPS), or interferon-γ (IFNγ). Although stimulated patterns of gene expression and cytokine release were generally similar, there were also significant differences in terms of absolute response. …”
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30305por Stewart, Linda D., Tort, Nuria, Meakin, Paul, Argudo, Jose M., Nzuma, Ruramayi, Reid, Neil, Delahay, Richard J., Ashford, Roland, Montgomery, W. Ian, Grant, Irene R.“…Subsequently, when 130 faeces samples from live captured, or captive, badgers of known infection status (on the basis of StatPak, interferon-γ and/or culture results) were tested, the IMS-LFD assay had higher relative diagnostic specificity (Sp 0.926), but poorer relative diagnostic sensitivity (Se 0.081), than IMS-qPCR (Sp 0.706, Se 0.581) and IMS-culture (Sp 0.794, Se 0.436). …”
Publicado 2017
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30306por Cento, Valeria, Nguyen, Thi Huyen Tram, Di Carlo, Domenico, Biliotti, Elisa, Gianserra, Laura, Lenci, Ilaria, Di Paolo, Daniele, Calvaruso, Vincenza, Teti, Elisabetta, Cerrone, Maddalena, Romagnoli, Dante, Melis, Michela, Danieli, Elena, Menzaghi, Barbara, Polilli, Ennio, Siciliano, Massimo, Nicolini, Laura Ambra, Di Biagio, Antonio, Magni, Carlo Federico, Bolis, Matteo, Antonucci, Francesco Paolo, Di Maio, Velia Chiara, Alfieri, Roberta, Sarmati, Loredana, Casalino, Paolo, Bernardini, Sergio, Micheli, Valeria, Rizzardini, Giuliano, Parruti, Giustino, Quirino, Tiziana, Puoti, Massimo, Babudieri, Sergio, D’Arminio Monforte, Antonella, Andreoni, Massimo, Craxì, Antonio, Angelico, Mario, Pasquazzi, Caterina, Taliani, Gloria, Guedj, Jeremie, Perno, Carlo Federico, Ceccherini-Silberstein, Francesca“…BACKGROUND: Intracellular HCV-RNA reduction is a proposed mechanism of action of direct-acting antivirals (DAAs), alternative to hepatocytes elimination by pegylated-interferon plus ribavirin (PR). We modeled ALT and HCV-RNA kinetics in cirrhotic patients treated with currently-used all-DAA combinations to evaluate their mode of action and cytotoxicity compared with telaprevir (TVR)+PR. …”
Publicado 2017
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30307“…The number of CD8(+) effector memory T-cells (Tem), expression of interferon (IFN)-γ, mTOR, and ribosomal protein S6 kinase (S6K), and the levels of IL-6, IL-10, galactomannan (GM), and soluble TREM-1 (sTREM-1) were measured. …”
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30308por Zhu, Lei, Li, Weihua, Qi, Gongjian, Liu, Na, Sheng, Liping, Shang, Lei, Qi, Boxiang“…Peripheral vein blood samples were collected from each individual, and used to isolate peripheral blood mononuclear cells (PBMCs) for mRNA extraction and sera for measuring levels of tumor necrosis factor (TNF)-α, interferon (IFN)-γ, interleukin (IL)-6 and IL-10. The average expression levels of TLR3, TLR4, TLR7 and TLR8 mRNA in PBMCs of children with severe HFMD were significantly higher than those in the other children, the lowest values were found in the healthy control group (P<0.05). …”
Publicado 2017
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30309por Bassano, Irene, Ong, Swee Hoe, Lawless, Nathan, Whitehead, Thomas, Fife, Mark, Kellam, Paul“…BACKGROUND: Interferon inducible transmembrane (IFITM) proteins are effectors of the immune system widely characterized for their role in restricting infection by diverse enveloped and non-enveloped viruses. …”
Publicado 2017
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30310“…Conversely, certain cytokines such as interferon gamma-inducible protein-10, IL-2, IL-13, IL-17, GM-CSF, and GRO were suppressed in BCG-vaccinated infants, while no increases in TNFα or IL-1β production were detected. …”
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30311por Saito, Emi, Suzuki, Dai, Kurotaki, Daisuke, Mochizuki, Ayako, Manome, Yoko, Suzawa, Tetsuo, Toyoshima, Yoichi, Ichikawa, Takahiro, Funatsu, Takahiro, Inoue, Tomio, Takami, Masamichi, Tamura, Tomohiko, Inagaki, Katsunori, Kamijo, Ryutaro“…Interferon regulatory factor 8 (Irf8) is a transcription factor that negatively regulates osteoclast differentiation and Irf8 global knockout (Irf8 (−/−)) mice have been shown to have reduced bone volume resulting from increased osteoclast numbers. …”
Publicado 2016
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30312por He, Libo, Zhang, Aidi, Pei, Yongyan, Chu, Pengfei, Li, Yongming, Huang, Rong, Liao, Lanjie, Zhu, Zuoyan, Wang, Yaping“…Most of the DEGs in Group I were also present in Group II, although the expression profiles differed, with most DEGs showing mild changes in Group I, while marked changes were observed in Group II, especially the interferon-related genes. Many of the genes involved in the complement pathway and coagulation cascades were significantly up-regulated at 7 days post-infection in Group II, suggesting activation of these pathways. …”
Publicado 2017
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30313por Zheng, Guoping, Qiu, Guanguan, Ge, Menghua, He, Jianping, Huang, Lanfang, Chen, Ping, Wang, Wei, Xu, Qi, Hu, Yaoqin, Shu, Qiang, Xu, Jianguo“…METHODS: For studies in vitro, ASCs were treated with interferon-γ (IFN-γ). For in vivo study, tracheas from BALB/c or C57BL/6 donors were transplanted into C57BL/6 recipients to create a HTT model. …”
Publicado 2017
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30314“…List of Abbreviations: AO: Acridine orange, AIDS: Acquired immunodeficiency syndrome, ACT: Artemisinin-based combination therapy, CM:Cerebral malaria, BCP:Benzothiocarboxypurine, DDT:Dichloro-diphenyl-trichloroethane, DNA:DeoxyriboNucleic Acid, ELAM-1: Endothelial leukocyte adhesion molecule, G6PD: Glucose-6-Phosphate Dehydrogenase, HIV: Human immuno deficiency virus, HRP 2: Histidine Rich Protein 2, ICAM -1: Inter cellular adhesion molecule1, ICER: Incremental cost effectiveness ratio, IL-1: Interleukin -1, IFN-g: Interferon-gamma, IgG: Immunoglobulin G, MP: Malaria parasite, NADP: Oxidised Nicotinamide Adenine Dinucleotide Phosphate, NADPH: Reduced Nicotinamide Adenine Dinucleotide Phosphate, PCV: Packed Cell Volume (haematocrit), P. falciparum: Plasmodium falciparum, PLDH: Plasmodium lactate dehydrogenase, PCR: Polymerase Chain Reaction, PPV: Positive predictive value, QBC: Quantitative Buffy Coat examination, TNF: Tumour necrosis factor, NPV: Negative predictive value, RDT: Rapid diagnostic test, SP: Sulphadoxine -Pyrimethamine, SMA: Severe malarial anaemia, UM: Uncomplicated malaria, USA:United States of America, VCAM-1: Vascular cell adhesion molecule, WBC: White Blood Cell, WHO: World Health Organization.…”
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30315por Bakari, Soale Majeed, Ofori, Jennifer Afua, Kusi, Kwadwo Asamoah, Aning, George Kwame, Awandare, Gordon Akanzuwine, Carrington, Mark, Gwira, Theresa Manful“…Levels of serum biochemical parameters, including creatinine, cholesterol, alkaline phosphatase (ALP), alanine aminotransferase (ALT), total bilirubin and total protein and cytokines (interleukin 10, interleukin 4, interleukin 12, interferon gamma and tumor necrosis factor alpha) were measured in serum samples and then compared between infected cattle and uninfected controls. …”
Publicado 2017
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30316“…Cell division is assumed to be asymmetric and regulated by the extracellular concentration of interleukin-2 (IL-2) and type I interferon (IFN), together controlling the balance between proliferation and differentiation. …”
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30317por Shino, Michael Y., Weigt, S. Samuel, Li, Ning, Palchevskiy, Vyacheslav, Derhovanessian, Ariss, Saggar, Rajan, Sayah, David M., Huynh, Richard H., Gregson, Aric L., Fishbein, Michael C., Ardehali, Abbas, Ross, David J., Lynch, Joseph P., Elashoff, Robert M., Belperio, John A.“…CONCLUSIONS: This study identifies OP, a relatively uncommon histopathologic finding after lung transplantation, as a major risk factor for CLAD development when considered in the context of increased allograft expression of interferon-γ inducible ELR- CXC chemokines. We further demonstrate for the first time, the prognostic importance of BALF CXCR3 ligand concentrations during OP on subsequent CLAD risk.…”
Publicado 2017
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30318por Deng, Yuanyuan, Tang, Qin, Zhang, Yan, Zhang, Ruifen, Wei, Zhencheng, Tang, Xiaojun, Zhang, Mingwei“….; ROS: reactive oxygen species; NO: nitric oxide; iNOS: inducible nitric oxide synthase; IL-1β: interleukin-1 beta; TNF-α: tumor necrosis factor alpha; IL-6: interleukin 6; IFN-γ: interferon gamma; VC: vitamin C; ALT: alanine transaminase; AST: aspartate aminotransferase; GSH: glutathione; GSH-PX: glutathione peroxidase; MDA: malondialdehyde; BCA: bicinchoninic acid; TBARS: thiobarbituric acid reactive substances; Trolox: 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid; JC-B: Janus Green B; DW: dry weight; FC: Folin–Ciocalteu; GAE: gallic acid equivalents; bw: body weight; NC: normal control group; Model: restraint stress model group; VC: positive control vitamin C group, 250 mg/kg bw; MWEL: Momordica charantia water extract low-dose group, 250 mg/kg bw; MWEM: Momordica charantia water extract middle-dose group, 500 mg/kg bw; MWEH: Momordica charantia water extract high-dose group, 750 mg/kg bw; HE: hematoxylin and eosin; ORAC: total oxygen radical absorbance capacity; ABAP: dihydrochloride; ATP: adenosine triphosphate…”
Publicado 2017
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30319por Liu, Zongjian, Ran, Yuanyuan, Huang, Shuo, Wen, Shaohong, Zhang, Wenxiu, Liu, Xiangrong, Ji, Zhili, Geng, Xiaokun, Ji, Xunming, Du, Huishan, Leak, Rehana K., Hu, Xiaoming“…In vitro studies using the BV2 microglial cell line confirmed that curcumin inhibited lipopolysaccharide (LPS) and interferon-γ (IFN-γ)-induced M1 polarization. Curcumin treatment concentration-dependently reduced the expression of pro-inflammatory cytokines, including TNF-α, IL-6 and IL-12p70, in the absence of any toxic effect on microglial cell survival. …”
Publicado 2017
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30320por Didié, Michael, Galla, Satish, Muppala, Vijayakumar, Dressel, Ralf, Zimmermann, Wolfram-Hubertus“…MHC class I and MHC class II expression in cardiomyocytes could only be observed after stimulation with interferon gamma (IFN-γ). PDL-1 was markedly upregulated under IFN-γ. …”
Publicado 2017
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