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30381por Main, Bradley J., Nicholson, Jay, Winokur, Olivia C., Steiner, Cody, Riemersma, Kasen K., Stuart, Jackson, Takeshita, Ryan, Krasnec, Michelle, Barker, Christopher M., Coffey, Lark L.“…We compared infection, dissemination, and transmission rates by measuring ZIKV RNA levels in cohorts of mosquitoes that ingested blood meals from type I interferon-deficient mice infected with either a Puerto Rican ZIKV strain from 2015 (PR15), a Brazilian ZIKV strain from 2015 (BR15), or an ancestral Asian-lineage Malaysian ZIKV strain from 1966 (MA66). …”
Publicado 2018
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30382por Retseck, Janet, Nasr, Alexis, Lin, Yan, Lin, Huang, Mendiratta, Prateek, Butterfield, Lisa H., Tarhini, Ahmad A.“…We detected evidence of type I (interferon-γ producing), activated (CD69+) CD4+ and CD8+ antigen-specific T cell immunity against cancer-testis (NY-ESO-1) as well as melanocytic lineage (MART-1, gp100) antigens in the absence of therapeutic vaccination. …”
Publicado 2018
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30383por Yaya, Issifou, Roux, Perrine, Marcellin, Fabienne, Wittkop, Linda, Esterle, Laure, Spire, Bruno, Dominguez, Stéphanie, Elegbe, Boni Armand, Piroth, Lionel, Sogni, Philippe, Salmon-Ceron, Dominique, Carrieri, Maria Patrizia“…This study aimed to compare the socio-behavioral characteristics of patients initiating pegylated-interferon (PEG-IFN)-based HCV treatment with those of patients initiating DAA-based treatment. …”
Publicado 2018
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30384por Mommert, Marine, Tabone, Olivier, Oriol, Guy, Cerrato, Elisabeth, Guichard, Audrey, Naville, Magali, Fournier, Paola, Volff, Jean-Nicolas, Pachot, Alexandre, Monneret, Guillaume, Venet, Fabienne, Brengel-Pesce, Karen, Textoris, Julien, Mallet, François“…HERV/MaLR expression was shown to be tightly modulated under several stimuli including high-dose and low-dose LPS and Interferon-γ (IFN-γ). HERV incorporation at the crossroads of immune response pathways paves the way for further functional studies and analyses of the HERV transcriptome in altered immune responses in vivo such as in sepsis. …”
Publicado 2018
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30385por Chavez, Michael, Silvestrini, Matthew T., Ingham, Elizabeth S., Fite, Brett Z., Mahakian, Lisa M., Tam, Sarah M., Ilovitsh, Asaf, Monjazeb, Arta M., Murphy, William J., Hubbard, Neil E., Davis, Ryan R., Tepper, Clifford G., Borowsky, Alexander D., Ferrara, Katherine W.“…Macrophages and DCs process and present this antigen to CD8(+) T-cells, increasing the number of unique T-cell receptor rearrangements in distant tumors. Second, type I interferon (IFN) release from tumor cells increased with the ablation-immunotherapy treatment as compared with ablation or immunotherapy alone. …”
Publicado 2018
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30386por Kustrimovic, Natasa, Comi, Cristoforo, Magistrelli, Luca, Rasini, Emanuela, Legnaro, Massimiliano, Bombelli, Raffaella, Aleksic, Iva, Blandini, Fabio, Minafra, Brigida, Riboldazzi, Giulio, Sturchio, Andrea, Mauri, Marco, Bono, Giorgio, Marino, Franca, Cosentino, Marco“…Naïve CD4+ T cells from peripheral blood of PD patients preferentially differentiate towards the Th1 lineage. Production of interferon-γ and tumor necrosis factor-α by CD4+ T cells from PD patients is increased and maintained in the presence of homologous Treg. …”
Publicado 2018
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30387por Qadir, Fatima, Aziz, Mohammad Arshad, Sari, Chrisdina Puspita, Ma, Hong, Dai, Haiyan, Wang, Xun, Raithatha, Dhiresh, Da Silva, Lucas Girotto Lagreca, Hussain, Muhammad, Poorkasreiy, Seyedeh P., Hutchison, Iain L., Waseem, Ahmad, Teh, Muy-Teck“…RESULTS: In recipient HNOK cells, we found that regardless of normal or cancer derived, exosomes altered molecular programmes involved in matrix modulation (MMP9), cytoskeletal remodelling (TUBB6, FEZ1, CCT6A), viral/dsRNA-induced interferon (OAS1, IFI6), anti-inflammatory (TSC22D3), deubiquitin (OTUD1), lipid metabolism and membrane trafficking (BBOX1, LRP11, RAB6A). …”
Publicado 2018
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30388“…AIM: We examined regulatory function of astaxanthin on mRNA expression of nuclear factor κB (NF-κB) p65, interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and interferon gamma (IFN-γ) in peripheral blood mononuclear cells in pre and postpartum Murrah buffaloes during summer (temperature-humidity index [THI]=86; relative humidity [RH]=24) and winter (THI=58.74; RH=73) seasons. …”
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30389por Dolcino, Marzia, Pelosi, Andrea, Fiore, Piera Filomena, Patuzzo, Giuseppe, Tinazzi, Elisa, Lunardi, Claudio, Puccetti, Antonio“…Such genes are involved in molecular pathways crucial for PsA pathogenesis, including immune response, glycolipid metabolism, bone remodeling, type 1 interferon, wingless related integration site, and tumor necrosis factor signaling. …”
Publicado 2018
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30390por Wang, Lefeng, Mehta, Sanjay, Ahmed, Yousuf, Wallace, Shelby, Pape, M. Cynthia, Gill, Sean E.“…To assess this hypothesis, human PMVECs cultured alone or in coculture with PMN were stimulated with PBS or cytomix (equimolar interferon γ, tumor necrosis factor α, and interleukin 1β) in the absence or presence of a pan-caspase inhibitor, Q-VD, or specific caspase inhibitors. …”
Publicado 2018
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30391por Niu, Guo chao, Liu, Lei, Zheng, Libo, Zhang, Hong, Shih, David Q., Zhang, Xiaolan“…Pro-inflammatory cytokines including tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), interleukin-17A (IL-17A), Toll receptor 4 (TLR4), TNF receptor-associated factor 6 (TRAF6) and nuclear factor kappa B (NF-κB) were detected by immunohistochemical staining, western blot analysis and real-time PCR, respectively. …”
Publicado 2018
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30392por Sikkema, Arend H., Stoffels, Josephine M. J., Wang, Peng, Basedow, Frederike J., Bulsink, Robbert, Bajramovic, Jeffrey J., Baron, Wia“…METHODS: Bone marrow-derived macrophages and microglia from newborn rats were exposed to (a) plasma fibronectin coatings; (b) coatings of deoxycholate-insoluble fibronectin aggregates; (c) interferon-γ (IFNγ) treatment, as an inducer of the pro-inflammatory classically activated phenotype; (d) interleukin-4 (IL-4) treatment, to promote the pro-regenerative anti-inflammatory alternatively activated phenotype; or (e) left unstimulated on uncoated plastic. …”
Publicado 2018
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30393por Mitra, Ankita, Vishweswaraiah, Sangeetha, Thimraj, Tania Ahalya, Maheswarappa, Mahendra, Krishnarao, Chaya Sindaghatta, Sundararaja Lokesh, Komarla, Biligere Siddaiah, Jayaraj, Ganguly, Koustav, Anand, Mahesh Padukudru“…METHODS: We assessed the serum concentrations [median (25th-75th percentile) pg/ml] of interleukin (IL)-2,4,6,8,10, granulocyte macrophage colony stimulating factor (GM-CSF), interferon gamma (IFN-γ), and tumor necrosis factor alpha (TNF-α) using a multiplexed immunoassay. …”
Publicado 2018
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30394por Kaneko, Kimihiko, Sato, Douglas Kazutoshi, Nakashima, Ichiro, Ogawa, Ryo, Akaishi, Tetsuya, Takai, Yoshiki, Nishiyama, Shuhei, Takahashi, Toshiyuki, Misu, Tatsuro, Kuroda, Hiroshi, Tanaka, Satoru, Nomura, Kyoichi, Hashimoto, Yuji, Callegaro, Dagoberto, Steinman, Lawrence, Fujihara, Kazuo, Aoki, Masashi“…MOG-IgG+ disease had significantly elevated levels of interleukin (IL)-6, IL-8, granulocyte-colony stimulating factor and granulocyte macrophage-colony stimulating factor, interferon-γ, IL-10, IL-1 receptor antagonist, monocyte chemotactic protein-1 and macrophage inflammatory protein-1α as compared with MS. …”
Publicado 2018
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30395por Chanouzas, Dimitrios, Sagmeister, Michael, Dyall, Lovesh, Sharp, Phoebe, Powley, Lucy, Johal, Serena, Bowen, Jessica, Nightingale, Peter, Ferro, Charles J., Morgan, Matthew D., Moss, Paul, Harper, Lorraine“…RESULTS: CD4(+)CD28(null) T cells were CMV-specific and expressed a T helper 1 (Th1) phenotype with high levels of interferon-gamma (IFN-γ) and tumour necrosis factor-alpha (TNF-α) secretion. …”
Publicado 2018
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30396por Romero-Masters, James C., Ohashi, Makoto, Djavadian, Reza, Eichelberg, Mark R., Hayes, Mitch, Bristol, Jillian A., Ma, Shidong, Ranheim, Erik A., Gumperz, Jenny, Johannsen, Eric C., Kenney, Shannon C.“…Unexpectedly, Δ3C-infected tumors had increased T-cell infiltration, increased expression of T-cell chemokines (CCL5, CCL20 and CCL22) and enhanced type I interferon response in comparison to WT tumors. Together, these results reveal that EBNA3C contributes to, but is not essential for, EBV-induced lymphomagenesis in CBH mice, and suggest potentially important immunologic roles of EBNA3C in vivo.…”
Publicado 2018
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30397por Lassner, Dirk, Siegismund, Christine S., Kühl, Uwe, Rohde, Maria, Stroux, Andrea, Escher, Felicitas, Schultheiss, Heinz-Peter“…Some patients with EV infection may spontaneously eliminate the virus and recover, whereas those with virus persistence deteriorate and progress to heart failure. Interferon-beta (IFN-β) therapy eliminates the virus, resulting in increased survival of treated patients. …”
Publicado 2018
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30398“…However, whereas phorbol 12-myristate 13-acetate/ionomycin stimulation induced the production of both interferon-γ and IL-17 by breast duct MAIT cells, bacterially exposed breast carcinoma cells elicited a strongly IL-17-biased response. …”
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30399por Dankers, Wendy, González-Leal, Claudia, Davelaar, Nadine, Asmawidjaja, Patrick S., Mus, Adriana M. C., Hazes, Johanna M. W., Colin, Edgar M., Lubberts, Erik“…RESULTS: 1,25(OH)(2)D(3), and to lesser extent DEX, reduced production of the pro-inflammatory cytokines IL-17A, IL-22, and interferon (IFN)γ in CCR6(+) memTh cells. Tumor necrosis factor (TNF)α was only inhibited by the combination of 1,25(OH)(2)D(3) and DEX. …”
Publicado 2018
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30400por Graziano, Francesca, Aimola, Giulia, Forlani, Greta, Turrini, Filippo, Accolla, Roberto S., Vicenzi, Elisa, Poli, Guido“…We have reported that short-term stimulation of primary human monocyte-derived macrophages (MDM) with interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α), i.e. …”
Publicado 2018
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