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30401por Syed, Taseen, Fazili, Javid, Ali, Ijlal Akbar, Zhao, Daniel, Hughes, Diane, Mahmood, Sultan“…Methods We analyzed 497 HCV-infected patients who were treated with DAAs, or a combination of DAA with interferon, from January 2014 to April 2017 at the Veterans Medical Center, Oklahoma City. …”
Publicado 2018
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30402por Vinh, Dao Nguyen, Ha, Dang Thi Minh, Hanh, Nguyen Thi, Thwaites, Guy, Boni, Maciej F., Clapham, Hannah E., Thuong, Nguyen Thuy Thuong“…In order to estimate the parameters governing transmission we fit this model in a maximum likelihood framework to both reported TB cases and data from samples tested with Interferon Gamma Assay from Ho Chi Minh City - a city with high TB transmission and strong synchronization between HIV/AIDS and TB dynamics. …”
Publicado 2018
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30403por de la Cruz, Maria Luisa, Branscum, Adam J., Nacar, Jesus, Pages, Enrique, Pozo, Pilar, Perez, Andres, Grau, Anna, Saez, Jose Luis, de Juan, Lucia, Diaz, Rosa, Minguez, Olga, Alvarez, Julio“…In Spain, the national bovine tuberculosis (bTB) eradication program is based on yearly skin testing of every ≥6 weeks old animal using the single or comparative tuberculin test and parallel use of the interferon-gamma (IFN-γ) assay as an ancillary diagnostic test in infected herds. …”
Publicado 2018
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30404por Ahmed, Mohamed I. M., Ntinginya, Nyanda E., Kibiki, Gibson, Mtafya, Bariki A, Semvua, Hadija, Mpagama, Stellah, Mtabho, Charles, Saathoff, Elmar, Held, Kathrin, Loose, Rebecca, Kroidl, Inge, Chachage, Mkunde, von Both, Ulrich, Haule, Antelmo, Mekota, Anna-Maria, Boeree, Martin J., Gillespie, Stephen H., Hoelscher, Michael, Heinrich, Norbert, Geldmacher, Christof“…Methods: Peripheral blood mononuclear cells from subjects with latent MTB infection (n = 16) and aTB (n = 39) at baseline, weeks 9, 12, and 26 (end of treatment) were analyzed after intracellular interferon gamma staining and overnight stimulation with tuberculin. …”
Publicado 2018
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30405“…Patients who received interferon therapy have shown a sharper reduction of HBsAg level than those who received nucleoside drug (NAs) therapy. …”
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30406por Haubruck, Patrick, Solte, Anja, Heller, Raban, Daniel, Volker, Tanner, Michael, Moghaddam, Arash, Schmidmaier, Gerhard, Fischer, Christian“…Serum chemokine expression (CCL-2, CCL-3, CCL-4, CXCL-10, CCL-11, and interferon gamma (IFN-γ)) was analyzed using Luminex assays. …”
Publicado 2018
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30407por Behera, Manas Kumar, Shukla, Sunit Kumar, Dixit, Vinod Kumar, Nath, Preetam, Abhilash, V. B., Asati, Pankaj Kumar, Jain, Ashok Kumar“…The patients were randomized into two groups: Vitamin D supplemented group received pegylated (PEG)-interferon α-2a 180 μg per week plus ribavirin (RBV) (1000-1200 mg/d) together with vitamin D3 (2000 IU/d) and control group received identical therapy without vitamin D (32 patients). …”
Publicado 2018
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30408“…METHODS: DCs were first obtained from the mononuclear cells of peripheral blood. The interferon (IFN)-γ and dexamethasone (Dex) were used to stimulate DCs. …”
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30409por Thomas, M, Ponce-Aix, S, Navarro, A, Riera-Knorrenschild, J, Schmidt, M, Wiegert, E, Kapp, K, Wittig, B, Mauri, C, Dómine Gómez, M, Kollmeier, J, Sadjadian, P, Fröhling, K -P, Huber, R M, Wolf, M“…Lefitolimod exhibited a favorable safety profile and pharmacodynamic assessment confirmed the mode-of-action showing a clear activation of monocytes and production of interferon-gamma-induced protein 10 (IP-10). While in the intent-to-treat (ITT) population no relevant effect of lefitolimod on progression-free and overall survival (OS) could be observed, two predefined patient subgroups indicated promising results, favoring lefitolimod with respect to OS: in patients with a low frequency of activated CD86(+) B cells (hazard ratio, HR 0.53, 95% CI: 0.26–1.08; n = 38 of 88 analyzed) and in patients with reported chronic obstructive pulmonary disease (COPD) (HR 0.48, 95% CI: 0.20–1.17, n = 25 of 103). …”
Publicado 2018
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30410por Hjorton, Karin, Hagberg, Niklas, Israelsson, Elisabeth, Jinton, Lisa, Berggren, Olof, Sandling, Johanna K., Thörn, Kristofer, Mo, John, Eloranta, Maija-Leena, Rönnblom, Lars“…RESULTS: In healthy individuals, RNA-IC induced interferon (IFN)-α, tumor necrosis factor (TNF)-α, IL-6, IL-8, IFN-γ, macrophage inflammatory protein (MIP)1-α, and MIP1-β production in pDC and NK cell cocultures. …”
Publicado 2018
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30411por Wimer, Christine L., Schnabel, Christiane L., Perkins, Gillian, Babasyan, Susanna, Freer, Heather, Stout, Alison E., Rollins, Alicia, Osterrieder, Nikolaus, Goodman, Laura B., Glaser, Amy, Wagner, Bettina“…Ab4ΔORF1/71 infection had reduced nasal shedding (1/5 vs. 5/5) and, simultaneously, decreased intranasal interferon (IFN)-α, interleukin (IL)-10 and soluble CD14 secretion. …”
Publicado 2018
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30412por Fraslin, Clémence, Dechamp, Nicolas, Bernard, Maria, Krieg, Francine, Hervet, Caroline, Guyomard, René, Esquerré, Diane, Barbieri, Johanna, Kuchly, Claire, Duchaud, Eric, Boudinot, Pierre, Rochat, Tatiana, Bernardet, Jean-François, Quillet, Edwige“…Integration of the QTL results with results of a previous transcriptomic analysis of response to F. psychrophilum infection resulted in a list of potential candidate immune genes that belong to four relevant functional categories (bacterial sensors, effectors of antibacterial immunity, inflammatory factors and interferon-stimulated genes). CONCLUSIONS: These results provide new insights into the genetic determinism of rainbow trout resistance to F. psychrophilum and confirm that some QTL with large effects are involved in this trait. …”
Publicado 2018
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30413por Lai, Ning-Sheng, Yu, Hui-Chun, Tung, Chien-Hsueh, Huang, Kuang-Yung, Huang, Hsien-Bin, Lu, Ming-Chi“…Increased expression of miR-29b-1-5p or miR-211-3p could enhance interferon-γ expression. CONCLUSIONS: Among the miRNAs regulated by IL-23, expression levels of five miRNAs were increased in T cells from patients with AS. …”
Publicado 2018
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30414por Smith, Christiana, Moraka, Natasha, Ibrahim, Maryanne, Moyo, Sikhulile, Mayondi, Gloria, Kammerer, Betsy, Leidner, Jean, Gaseitsiwe, Simani, Shapiro, Roger, Lockman, Shahin, Weinberg, Adriana“…T-cell expression of interferon (IFN)-γ and interleukin (IL)-2 were measured at 6 months using FluoroSpot after stimulation with tetanus toxoid or PPD. …”
Publicado 2018
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30415“…LTBI was diagnosed through tuberculin skin testing or interferon-γ release assay. 9H treatment was self administered while 3HP was under DOT. …”
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30416por Howard, Leigh, Goll, Johannes, Jensen, Travis, Hill, Heather, Gelber, Casey, Creech, C Buddy, Edwards, Kathryn“…Multiple innate immune signaling pathways were activated, including the interferon, JAK-STAT, and TNF pathways, and FC gamma receptor (Fc_R) mediated phagocytosis. …”
Publicado 2018
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30417por Zheng, Rui, Wang, Dan, Wang, Kai, Gao, Wen-Xiang, Yang, Qin-Tai, Jiang, Li-Jie, Zhou, Min, Cao, Yu-Jie, Shi, Jianbo, Sun, Yueqi“…The mRNA expression of cytokines, including TSLP, IL-25 and IL-33, as well as interferon (IFN)-γ, IL-4, IL-5, IL-13 and IL-17A in NP and control tissues was examined by qualitative polymerase chain reaction (qPCR). …”
Publicado 2018
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30418“…In addition, TNF and LPS, but not IL-1β, increased the abundance of several interferon-stimulated gene products. Finally, TNF and IL-1β similarly upregulated the secretion of several cytokines and chemokines, whereas LPS only induced a moderate increase in IL-8, IFN-γ, and IL-1β secretion. …”
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30419por Yu, Zhang, Wenyan, Tang, Xuewen, Su, Baixiang, Dong, Qian, Wang, Zhaoyan, Wang, Yinxiang, Yang, Suqing, Qu, Zuo, Luan“…Allo-ADMSCs evoked significantly stronger protein expression of interleukin-2 and interferon-gamma, as well as the local accumulation of CD4+ T lymphocytes, CD8+ T lymphocytes, and microglial cells. …”
Publicado 2018
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30420por Corbett, Yolanda, D’Alessandro, Sarah, Parapini, Silvia, Scaccabarozzi, Diletta, Kalantari, Parisa, Zava, Stefania, Giavarini, Flavio, Caruso, Donatella, Colombo, Irma, Egan, Timothy J., Basilico, Nicoletta“…RESULTS: Haemozoin synergizes in vitro with interferon-gamma to produce nitric oxide. However, when mouse macrophages were stimulated with haemozoin, a proportional increase of nitric oxide was observed up to 25 μM of haemozoin, followed by a decrease with doses up to 100 μM, when nitric oxide release was completely abrogated. …”
Publicado 2018
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