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30421por Hojati, Seyed Amineh, Maserat, Elham, Ghorbani, Mohammad, Safarpour, Alireza, Fattehi, Mohammad Reza“…All patients infected with HCV treated by combination regimens of ribavirin, sofosbuvir and interferon. Patients received sofosbuvir (400mg once a day) in combination with peg-IFN-alpha (92a180m/w›92b1/5m/kg/w) and RBV (under 75 kg 1000mg, over 75 kg 12000kg) for 12 weeks. …”
Publicado 2018
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30422“…In Jersey cows, the lightsteelblue1 (MTR = − 0.57) module controlled by IFNG and IL10RA was involved in the positive regulation of interferon-gamma production, lymphocyte differentiation, natural killer cell-mediated cytotoxicity and primary immunodeficiency. …”
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30423por Zhang, Yuan-Yuan, Huang, Na-Na, Zhao, Yan-Xin, Li, Yan-Shuang, Wang, Dong, Fan, Yu-Chen, Li, Xiao-Hong“…The mRNA levels of TIPE2, interleukin(IL)-1β, IL-10, IL-6, nuclear factor(NF)-κβ, activator protein(AP)-1, interferon(IFN)-γ and tumor necrosis factor(TNF)-α from peripheral blood mononuclear cells were determined using real time quantitative reverse transcriptase polymerase chain reaction. …”
Publicado 2018
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30424por Ou, Guojin, Xu, Haixia, Yu, Hao, Liu, Xiao, Yang, Liu, Ji, Xin, Wang, Jue, Liu, Zhong“…Venous blood samples were subjected to DQB1 high-resolution typing and testing for interferon-gamma, interleukin-4 (IL-4), interleukin-10, and DQB1 mRNA expression. …”
Publicado 2018
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30425por Yang, Sien-Hung, Lin, Yi-Hsuan, Lin, Jr-Rung, Chen, Hsing-Yu, Hu, Sindy, Yang, Yi-Han, Yang, Yi-Hsun, Yang, Yin-Shuo, Fang, Yao-Fan“…For urticaria-related cytokines, interferon-γ seemed to decrease positively in the CHM group (about 30.8% reduction from baseline, trend analysis p = 0.013). …”
Publicado 2018
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30426por Landsberg, Christine D., Megger, Dominik A., Hotter, Dominik, Rückborn, Meike U., Eilbrecht, Mareike, Rashidi-Alavijeh, Jassin, Howe, Sebastian, Heinrichs, Stefan, Sauter, Daniel, Sitek, Barbara, Le-Trilling, Vu Thuy Khanh, Trilling, Mirko“…Our analysis confirmed several previously described interactions like the interaction of the MCMV-encoded interferon antagonist pM27 with STAT2. We extended known interactions to paralogous proteins like the interaction of the HBV-encoded HBx with different Spindlin proteins and documented interactions for the first time, which explain functional data like the interaction of the HIV-2-encoded Vpr with Bax. …”
Publicado 2018
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30427por Migita, Kiyoshi, Horai, Yoshiro, Kozuru, Hideko, Koga, Tomohiro, Abiru, Seigo, Yamasaki, Kazumi, Komori, Atsumasa, Fujita, Yuya, Asano, Tomoyuki, Sato, Shuzo, Suzuki, Eiji, Matsuoka, Naoki, Kobayashi, Hiroko, Watanabe, Hiroshi, Naganuma, Atsushi, Naeshiro, Noriaki, Yoshizawa, Kaname, Ohta, Hajime, Sakai, Hironori, Shimada, Masaaki, Nishimura, Hideo, Tomizawa, Minoru, Ario, Keisuke, Yamashita, Haruhiro, Kamitsukasa, Hiroshi, Kohno, Hiroshi, Nakamura, Minoru, Furukawa, Hiroshi, Takahashi, Atsushi, Kawakami, Atsushi, Ohira, Hiromasa, Yastuhashi, Hiroshi“…Among these cytokines and soluble adhesion molecules, soluble intercellular adhesion molecule-1 (sICAM-1) and interferon-γ-inducible protein 10 (IP-10) were most downregulated by steroid therapy in AIH patients. …”
Publicado 2018
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30428por Stöver, H., Meroueh, F., Marco, A., Keppler, K., Saiz de la Hoya, P., Littlewood, R., Wright, N., Nava, F., Alam, F., Walcher, S., Somaini, L.“…Direct-acting antiviral products with superior efficacy and safety compared to interferon-based regimens offer HCV cure. Many citizens in Europe have been treated, although few received therapy in prisons. …”
Publicado 2019
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30429“…Most belonged to immune responses, antigen processing and presentation, the interferon-gamma-mediated signaling pathway, and T cell co-stimulation. …”
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30430“…CSF from gram-positive and gram-negative shunt infections had similar levels of interferon gamma (INF-γ), tumor necrosis factor alpha (TNF-α), IL-6, and IL-8. …”
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30431“…BACKGROUND: ALRs (AIM2-like Receptors) are germline encoded PRRs that belong to PYHIN gene family of cytokines, which are having signature N-terminal PYD (Pyrin, PAAD or DAPIN) domain and C-terminal HIN-200 (hematopoietic, interferon-inducible nuclear protein with 200 amino acid repeat) domain joined by a linker region. …”
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30432por Ellis, Joanne, van Maurik, Andre, Fortunato, Lea, Gisbert, Sophie, Chen, Keguan, Schwartz, Ann, McHugh, Simon, Want, Andrew, Santos Franco, Sara, Oliveira, Joao‐Joaquim, Price, Jeffrey, Coles, Alasdair, Brown, Kim, Su, Donggang, Craigen, Jenny L., Yang, Jiansong, Brett, Sara, Davis, Bill, Cheriyan, Joseph, Kousin‐Ezewu, Onajite, Gray, Frank, Thompson, Paul W., Fernando, Disala“…No meaningful changes were observed in absolute numbers or proportions of immune cell populations or inflammatory cytokine profiles (IL‐6, tumour necrosis factor‐α, interferon‐γ, IL‐2). Persistent antidrug antibodies (ADAs) were detected in 5/6 subjects administered a dose of 0.6 mg kg(–1) (neutralizing in 2/6) and in 6/6 subjects administered 2.0 mg kg(–1) (neutralizing in 5/6). …”
Publicado 2018
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30433por Niezgoda, Anna, Winnicki, Andrzej, Kosmalski, Tomasz, Kowaliszyn, Bogna, Krysiński, Jerzy, Czajkowski, Rafał“…Multiple immunologic processes, including stimulation of the T-helper (Th)1 response, formation of autoreactive melanocyte-specific CD8(+) T lymphocytes, a decrease in the blood concentration of T regulatory (Treg) cells, and an increase in interleukin (IL)-17 and interferon (IFN) concentration, have been shown to contribute to vitiligo progression and maintenance. …”
Publicado 2019
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30434por Emerson, Sam R, Sciarrillo, Christina M, Kurti, Stephanie P, Emerson, Emily M, Rosenkranz, Sara K“…IL-8, VEGF-A, VEGF-C, and heparin-binding epidermal growth factor–like growth factor significantly increased, whereas granulocyte-macrophage colony-stimulating factor, interferon-γ, IL-1β, IL-5, IL-10, IL-12, IL-13, IL-17A, IL-23, TNF-α, leptin, angiopoietin-2, and follistatin significantly decreased after HFM consumption (P’s < 0.05). …”
Publicado 2018
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30435por Mariotti, Barbara, Servaas, Nila Hendrika, Rossato, Marzia, Tamassia, Nicola, Cassatella, Marco A., Cossu, Marta, Beretta, Lorenzo, van der Kroef, Maarten, Radstake, Timothy R. D. J., Bazzoni, Flavia“…Dysregulation of this process, collectively known as the “Interferon (IFN) Response,” represents a common molecular basis in the development of autoimmune and autoinflammatory disorders. …”
Publicado 2019
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30436por Liang, Yan, Chen, Chang, Xia, Baomei, Wu, Wei, Tang, Juanjuan, Chen, Qing, Tang, Lili, Yang, Hui, Zhang, Zhennian, Lu, Yan, Yang, Ye, Zhao, Yang“…Enzyme-linked immunosorbent assay (ELISA) method was used to detect the inflammatory cytokines in the serum, including TNF-α (Ttumor necrosis factor alpha) and IFN-γ (interferon gamma). Protein expressions of ionized calcium binding adaptor molecule 1 (IBA-1), TNF-α, Cleaved caspase-3, glial derived neurotrophic factor (GDNF), and phosphorylated and total extracellular signal-regulated kinase (p-ERK and ERK) in the anatomical region of substantia nigra (SN) were tested by protein immunoblot method (i.e., Western blotting). …”
Publicado 2019
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30437por Stougaard, Julie, Lomholt, Søren, Ommen, Pernille, Kelsen, Jens, Kragstrup, Tue W.“…RESULTS: PFD reduced the Ki67 expression 7.1-fold in untreated FLSs (p = 0.001) and 11.0-fold in FLSs stimulated with transforming growth factor beta (TGFβ), tumor necrosis factor alpha (TNFα), and interferon gamma (IFNγ) (p = 0.022). There were no statistically significant changes in membrane expression of alpha smooth muscle actin (αSMA), intercellular adhesion molecule 1 (ICAM-1), or human leukocyte antigen DR (HLA-DR). …”
Publicado 2018
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30438por Ge, Xuejun, Wang, Lixiang, Li, Mengdi, Xu, Na, Yu, Feiyan, Yang, Fang, Li, Ran, Zhang, Fang, Zhao, Bin, Du, Jie“…Herein, we identify lipopolysaccharide (LPS) is able to enhance interferon gamma (IFNγ) and interleukin-1 beta (IL-1β) productions in human oral keratinocytes (HOKs) dependent on hypoxia-inducible factor-1α (HIF-1α). …”
Publicado 2019
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30439por Liao, Songyan, Zhang, Yuelin, Ting, Sherwin, Zhen, Zhe, Luo, Fan, Zhu, Ziyi, Jiang, Yu, Sun, Sijia, Lai, Wing-Hon, Lian, Qizhou, Tse, Hung-Fat“…In vitro study showed that hiPSC-MSCs were insensitive to pro-inflammatory interferon-gamma-induced human leukocyte antigen class II expression compared with hESC-CMs. …”
Publicado 2019
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30440“…Other groups have observed a number of characteristics such as epigenetic remodelling, increased interferon signalling, cell cycle inhibition and apoptotic resistance that have also been reported by us suggesting these independent studies are investigating similar or identical phenomena. …”
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