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30481por Ni, Ligang, Song, Chengyi, Wu, Xinsheng, Zhao, Xuting, Wang, Xiaoyan, Li, Bichun, Gan, Yuan“…Compared to Jiangquhai pigs, more chemokines, interferon response factors, and interleukins were specifically activated in Duroc pigs; CXCL10, CCL4, IL6 and IFNG genes were significantly up-regulated, which may help Duroc pigs enhance immune response and reduce Mhp susceptibility. …”
Publicado 2019
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30482por Lima, Joanna D.C.C., Simoes, Estefania, de Castro, Gabriela, Morais, Mychel Raony P.T., de Matos‐Neto, Emidio M., Alves, Michele J., Pinto, Nelson I., Figueredo, Raquel G., Zorn, Telma M.T., Felipe‐Silva, Aloísio S., Tokeshi, Flavio, Otoch, José P., Alcantara, Paulo, Cabral, Fernanda J., Ferro, Emer S., Laviano, Alessandro, Seelaender, Marilia“…RESULTS: Higher protein expression of inflammatory cytokines and growth factors such as epidermal growth factor, granulocyte–macrophage colony‐stimulating factor, interferon‐α, and interleukin (IL)‐8 was observed in the tumour and serum of cachectic cancer patients in comparison with weight‐stable counterparts. …”
Publicado 2019
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30483por Radley, Andrew, Robinson, Emma, Aspinall, Esther J., Angus, Kathryn, Tan, Lex, Dillon, John F.“…BACKGROUND: Direct Acting Antiviral (DAAs) drugs have a much lower burden of treatment and monitoring requirements than regimens containing interferon and ribavirin, and a much higher efficacy in treating hepatitis C (HCV). …”
Publicado 2019
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30484por Watari, Kei, Konnai, Satoru, Maekawa, Naoya, Okagawa, Tomohiro, Suzuki, Yasuhiko, Murata, Shiro, Ohashi, Kazuhiko“…Bovine CTLA-4-Ig significantly inhibited interferon-gamma (IFN-γ) production from bovine peripheral blood mononuclear cells (PBMCs) activated by Staphylococcus enterotoxin B (SEB). …”
Publicado 2019
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30485por Colussi, GianLuca, Donnini, Debora, Brizzi, Rosario Francesco, Maier, Silvia, Valenti, Luca, Catena, Cristiana, Cavarape, Alessandro, Sechi, Leonardo Alberto, Soardo, Giorgio“…The baseline anthropometric features, HCV viral load, severity of liver disease, presence of extra-hepatic complications, coinfection with HIV and/or HBV, alcohol consumption, previous interferon use, alpha-fetoprotein levels, and renal function were considered to be confounders. …”
Publicado 2019
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30486por Zhang, Yiwei, Jiang, Ning, Zhang, Ting, Chen, Ran, Feng, Ying, Sang, Xiaoyu, Yang, Na, Chen, Qijun“…Furthermore, the levels of interleukin (IL)-2, IL-4, IL-6, IL-22, and interferon (IFN)-γ, but not that of tumor necrosis factor alpha (TNF-α), IL-10, and IL-9, increased to their highest levels at day 4 post-infection and decreased thereafter. …”
Publicado 2019
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30487por Kim, Sehui, Jang, Ji-Young, Koh, Jaemoon, Kwon, Dohee, Kim, Young A., Paeng, Jin Chul, Ock, Chan-Young, Keam, Bhumsuk, Kim, Miso, Kim, Tae Min, Heo, Dae Seog, Chung, Doo Hyun, Jeon, Yoon Kyung“…By contrast, knocking-down PD-L1 in PD-L1(high) cells decreased HK2 expression and glycolysis by suppressing PI3K/Akt and Erk pathways. Interferon-γ (IFNγ) secretion and activation marker expression was decreased in stimulated Jurkat T-cells when co-cultured with HK2-overexpressing vector-transfected tumor cells rather than empty vector-transfected tumor cells. …”
Publicado 2019
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30488por Wang, Faxi, Sun, Fei, Luo, Jiahui, Yue, Tiantian, Chen, Longmin, Zhou, Haifeng, Zhang, Jing, Yang, Chunliang, Luo, Xi, Zhou, Qing, Zhu, He, Li, Jinxiu, Yang, Ping, Xiong, Fei, Yu, Qilin, Zhang, Huilan, Zhang, Wanguang, Xu, Aimin, Zhou, Zhiguang, Lu, Qianjin, Eizirik, Decio L., Zhang, Shu, Wang, Cong-Yi“…Mechanistically, Ubc9-mediated SUMOylation of interferon regulator factor 4 (IRF4) enhanced its nuclear localization and stability, thereby transcribing IL-4 and arginase 1 (Arg1) to promote the macrophage M2 program. …”
Publicado 2019
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30489por Passos, Vânia, Zillinger, Thomas, Casartelli, Nicoletta, Wachs, Amelie S., Xu, Shuting, Malassa, Angelina, Steppich, Katja, Schilling, Hildegard, Franz, Sergej, Todt, Daniel, Steinmann, Eike, Sutter, Kathrin, Dittmer, Ulf, Bohne, Jens, Schwartz, Olivier, Barchet, Winfried, Goffinet, Christine“…This modification enabled quantification of endogenous SERINC5 protein levels and demonstrated a predominant localization in lipid rafts. Interferon alpha (IFN-α) treatment enhanced cell surface levels of SERINC5 in a ruxolitinib-sensitive manner in the absence of modulation of mRNA and protein quantities. …”
Publicado 2019
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30490por Benson, Kathleen F., Stamets, Paul, Davis, Renee, Nally, Regan, Taylor, Alex, Slater, Sonya, Jensen, Gitte S.“…Both aqueous and solid fractions of FS triggered large and dose-dependent increases in immune-activating pro-inflammatory cytokines (IL-2, IL-6), anti-inflammatory cytokines Interleukin-1 receptor antagonist (IL-1ra) and Interleukin-10 (IL-10), anti-viral cytokines interferon-gamma (IFN-γ) and Macrophage Inflammatory Protein-alpha (MIP-1α), as well as Granulocyte-Colony Stimulating Factor (G-CSF) and Interleukin-8 (IL-8). …”
Publicado 2019
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30491por Gimenes-Junior, Joao, Owuar, Nicole, Vari, Hymavathi Reddy, Li, Wuyan, Xander, Nathaniel, Kotnala, Sudhir, Sajjan, Uma S.“…Airway epithelial cells express FOXO3a and play an important role in clearing rhinovirus (RV) by mounting antiviral type I and type III interferon (IFN) responses. To elucidate the role of FOXO3a in regulating antiviral responses, we generated airway epithelial cell-specific Foxo3a knockout (Scga1b1-Foxo3a−/−) mice and a stable FOXO3a knockout human airway epithelial cell line. …”
Publicado 2019
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30492por Menzel, Mandy, Ramu, Sangeetha, Calvén, Jenny, Olejnicka, Beata, Sverrild, Asger, Porsbjerg, Celeste, Tufvesson, Ellen, Bjermer, Leif, Akbarshahi, Hamid, Uller, Lena“…These present findings shed light on molecular mechanisms potentially causing reduced interferon responses to rhinovirus infection at exacerbations in asthma and COPD. …”
Publicado 2019
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30493“…The aim of the present study was to investigate the role and regulation of interferon regulatory factor-1 (IRF1) in modulating KPNA2 expression in lung adenocarcinoma (ADC). …”
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30494por Kantarci, Orhun H., Zeydan, Burcu, Atkinson, Elizabeth J., Conway, Brittani L., Castrillo-Viguera, Carmen, Rodriguez, Moses“…METHODS: We analyzed the double-blind, placebo-controlled interferon beta-1a 30 mc once a week in clinically isolated syndrome and 10-year-follow-up extension trial. …”
Publicado 2019
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30495por Peng, Yong, Zhu, Fei-Zhou, Chen, Zhi-Xing, Zhou, Jian-Xiong, Gan, Lu, Yang, Shan-Shan, Gao, Shuai, Liu, Qian-Qian“…These cells were stimulated by MOG(35–55) peptide and applied to proliferation assays. The interferon-gamma (IFN-γ) and interleukin (IL)-4 secretion of supernatant of cultured CD4(+) and CD8(+) T cells were measured by enzyme-linked immunosorbent assays (ELISA). …”
Publicado 2019
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30496por Friberg, Heather, Martinez, Luis J., Lin, Leyi, Blaylock, Jason M., De La Barrera, Rafael A., Rothman, Alan L., Putnak, J. Robert, Eckels, Kenneth H., Thomas, Stephen J., Jarman, Richard G., Currier, Jeffrey R.“…In addition, analysis of postvaccination cell culture supernatants demonstrated an increased rate of production of cytokines, including gamma interferon (IFN-γ), IL-5, and granulocyte-macrophage colony-stimulating factor (GM-CSF). …”
Publicado 2020
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30497“…We found that 40 Hz flicker leads to increases in the expression of cytokines which promote microglial phagocytic states, such as IL-6 and IL-4, and increased expression of microglial chemokines, such as macrophage-colony-stimulating factor and monokine induced by interferon-γ. Interestingly, cytokine effects differed as a function of stimulation frequency, revealing a range of neuroimmune effects of stimulation. …”
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30498por Mitwasi, Nicola, Feldmann, Anja, Arndt, Claudia, Koristka, Stefanie, Berndt, Nicole, Jureczek, Justyna, Loureiro, Liliana R., Bergmann, Ralf, Máthé, Domokos, Hegedüs, Nikolett, Kovács, Tibor, Zhang, Congcong, Oberoi, Pranav, Jäger, Elke, Seliger, Barbara, Rössig, Claudia, Temme, Achim, Eitler, Jiri, Tonn, Torsten, Schmitz, Marc, Hassel, Jessica C., Jäger, Dirk, Wels, Winfried S., Bachmann, Michael“…Redirected UniCAR NK-92 cells induced specific killing of GD2-expressing cells in vitro and in vivo, associated with enhanced production of interferon-γ. Analysis of radiolabelled proteins demonstrated that the IgG4-based format increased the in vivo half-life of the TM markedly in comparison to the scFv-based molecule. …”
Publicado 2020
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30499por Gurunathan, Sangiliyandi, Jeyaraj, Muniyandi, La, Hyeonwoo, Yoo, Hyunjin, Choi, Youngsok, Do, Jeong Tae, Park, Chankyu, Kim, Jin-Hoi, Hong, Kwonho“…A proinflammatory response to PtNPs was confirmed by significant upregulation of interleukin-1-beta (IL-1β), interferon γ (IFNγ), tumor necrosis factor alpha (TNFα), and interleukin (IL-6). …”
Publicado 2020
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30500por Zhao, Xiangjie, Yang, Rongling, Bi, Yanhong, Bilal, Muhammad, Kuang, Zheshi, Iqbal, Hafiz M. N., Luo, Qiulan“…The results revealed that the thymus and spleen indices were significantly increased (P < 0.05) in both MLT and MHT groups in comparison with the CT group, while the serum levels of immunoglobulin G (IgG), interleukin (IL)-1β, IL-2, IL-8, and interferon (IFN-γ) in the MLT group and IL-2, IL-6, and IFN-γ in the MHT group were also considerably greater (P < 0.05) than the corresponding levels in the CT group. …”
Publicado 2019
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