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30521por Robledo, Diego, Hamilton, Alastair, Gutiérrez, Alejandro P., Bron, James E., Houston, Ross D.“…Five QTL-region candidate genes showed differential expression, including a gene connected to interferon responses (GVINP1), a gene involved in systemic inflammation (MAP4K4), and a positive regulator of apoptosis (TRIM39). …”
Publicado 2020
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30522“…RESULTS: Around 50–60 genes were downregulated by HCoV-OC43 proteins, the most prominent genes being those critical for the activation of transcription factors involved in the antiviral response like interferon regulatory factors (IRFs) and activator protein 1 (AP-1). …”
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30523por Jain, Preeti, Singh, Rani, Saxena, V.K., Singh, K.B., Ahmed, K.A., Tiwari, A.K., Saxena, M., Sundaresan, N.R.“…Chicken orthologues of the T helper 1 (Th1) cytokines, interferon-γ (IFN-γ) and interleukin-2 (IL-2); a Th2 cytokine, IL-10; a pro inflammatory cytokine, IL-6; the CCL chemokines, chCCLi2, chCCLi4 and chCCLi7; colony stimulating factor, GM-CSF; and a anti-inflammatory cytokine, transforming growth factor β-2 (TGFβ-2) were quantified. …”
Publicado 2013
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30524por Sánchez‐Castellano, Carmen, Martín‐Aragón, Sagrario, Bermejo‐Bescós, Paloma, Vaquero‐Pinto, Nieves, Miret‐Corchado, Carmen, Merello de Miguel, Ana, Cruz‐Jentoft, Alfonso José“…No significant differences were found between groups in chymotrypsin‐like activity of the 20S proteasome, superoxide dismutase, glutathione peroxidase and butyrylcholinesterase activity, C‐terminal agrin fragment, interferon‐γ, or interleukin‐1β. CONCLUSIONS: The prevalence of sarcopenia in patients with hip fracture varies according to the definition and the muscle mass reference cut‐off points used. …”
Publicado 2020
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30525por Chan, Jasper Fuk-Woo, Zhu, Zheng, Chu, Hin, Yuan, Shuofeng, Chik, Kenn Ka-Heng, Chan, Chris Chung-Sing, Poon, Vincent Kwok-Man, Yip, Cyril Chik-Yan, Zhang, Xi, Tsang, Jessica Oi-Ling, Zou, Zijiao, Tee, Kah-Meng, Shuai, Huiping, Lu, Gang, Yuen, Kwok-Yung“…We evaluated the in vitro anti-ZIKV activity of AR-12, using cell protection and virus yield reduction assays, in multiple clinically relevant cell lines, and the in vivo treatment effects of AR-12 in a lethal mouse model using type I interferon receptor-deficient A129 mice. AR-12 inhibited ZIKV strains belonging to both the African and Asian/American lineages in Huh-7 and/or neuronal cells. …”
Publicado 2018
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30526“…Serum samples were collected on various days post-inoculation and analyzed by HerdChek* ELISA, PRRSV real time RT-PCR, gamma interferon (IFN-γ) ELISA, and nucleotide sequence analysis of the entire nsp2 coding region. …”
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30527por Omotani, Sachiko, Ishizaka, Toshihiko, Inoue, Miki, Nishida, Koji, Yasui, Yukako, Hatsuda, Yasutoshi, Mukai, Junji, Myotoku, Michiaki“…BACKGROUND: Interferon and ribavirin have been used as therapeutic agents for chronic hepatitis C infection or C-compensated cirrhosis in the conventional treatment. …”
Publicado 2020
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30528por Wattrang, Eva, McNeilly, Francis, Allan, Gordon M., Greko, Christina, Fossum, Caroline, Wallgren, Per“…In addition, 3-week-old piglets from three litters (n=24) farrowed close after the initial EE outbreak were closely monitored for clinical signs of skin disease, sampled for Staphylococcus hyicus, tested for antibodies to porcine parvovirus and in sequentially collected serum samples tested for interferon-α (IFN-α) and interleukin-6. The PVC-2 serology showed that animals in the herd were sero-negative at least until 2 months prior to the EE outbreak. …”
Publicado 2002
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30529por Hasslung, F., Wallgren, P., Ladekjær-Hansen, A.-S., Bøtner, A., Nielsen, J., Wattrang, E., Allan, G.M., McNeilly, F., Ellis, J., Timmusk, S., Belák, K., Segall, T., Melin, L., Berg, M., Fossum, C.“…All pigs inoculated with PPV, alone or in combination with PCV2, displayed interleukin-10 responses in serum while only pigs infected with PPV in combination with PCV2 showed interferon-α in serum on repeated occasions. Thus, the pathogenicity of S-PCV2 was confirmed and a role for cytokines in the etiology of PMWS was indicated.…”
Publicado 2005
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30530por Opriessnig, Tanja, Gauger, Phillip C., Faaberg, Kay S., Shen, Huigang, Beach, Nathan M., Meng, Xiang-Jin, Wang, Chong, Halbur, Patrick G.“…Blood samples were collected before inoculation and at day post-inoculation (dpi) 3, 6, 9 and 12 and tested for the presence of PRRSV antibody and RNA, PCV2 antibody and DNA, complete blood counts, and interferon gamma (IFN-γ) levels. Regardless of concurrent PCV2 infection, VR-2385 initially replicated at higher levels and reached peak replication levels at dpi 6. …”
Publicado 2012
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30531“…These surface molecules associated with immune function were either induced (Class II) or upregulated (Class I and ICAM-1) on cultured retinal glial cells in a dose- and time-dependent manner following exposure to recombinant Interferonγ (rIFN-γ). MHC Class I and II expression by passaged and primary cells was maximal (> 90% positive) after incubation with 100 U/ml of rlFN-y for 48 h. …”
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30532“…The cells of placenta express 10 Toll-like receptors a group of pattern recognition receptors responsible for innate immunity. The interferon level is also higher in the placental tissues than in the somatic fetal or maternal cells. …”
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30533por Lande, R., Palazzo, R., Gestermann, N., Jandus, C., Falchi, M., Spadaro, F., Riccieri, V., James, E. A., Butera, A., Boirivant, M., Feldmeyer, L., Surbeck, I., Di Lucca, J., Stuber, F., Spinelli, F. R., Botti, E., Marinari, B., Bianchi, L., Pica, R., Cerbelli, B., Giannakakis, K., Auteri, S. E., Daniels, I., Durrant, L. G., Horstman, S., Costanzo, A., Romero, P., Alessandri, C., Conti, F., Valesini, G., Gilliet, M., Chizzolini, C., Frasca, L.“…Bound to self-DNA/RNA, LL37 licenses autoreactivity by stimulating plasmacytoid dendritic cells-(pDCs)-Type I interferon (IFN-I) and acts as autoantigen for pathogenic Th17-cells. …”
Publicado 2020
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30534por Silverman, Robert H., Zhang, Rong, Jha, Babal K., Ogden, Kristen M., Dong, Beihua, Elliott, Ruth, Zhao, Ling, Patton, John T., Weiss, Susan R.“…Efficient and productive virus infection often requires viral countermeasures that block innate immunity. The interferon-inducible 2′,5-oligoadenylate (2-5A) synthetases (OAS) and ribonuclease L (RNase L) are components of a potent host antiviral pathway. …”
Publicado 2013
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30535por Tayyab, Ghias Un Nabi, Rasool, Shafqat, Nasir, Bilal, Rubi, Ghazala, Abou-Samra, Abdul-Badi, Butt, Adeel A.“…Treatment regimens used were: Sofosbuvir (SOF)/ribavirin (RBV)/pegylated interferon (PEG-IFN), 25.2%; SOF/RBV, 62.4%; SOF/RBV/daclatasavir (DCV), 10.6%; SOF/DCV, 2.0%. …”
Publicado 2020
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30536por Chuang, Wen Yang, Liu, Chu Ling, Tsai, Chia Fen, Lin, Wei Chih, Chang, Shen Chang, Shih, Hsin Der, Shy, Yi Ming, Lee, Tzu-Tai“…Toll-like receptor 4 was slightly increased in the 0.5% and 1% PWMC groups. Both interferon-γ (IFN-γ) and interleukin-1ß (IL-1ß) were significantly decreased, by about three to five times for IFN-γ (p < 0.0001) and 1.1 to 1.6 times for IL-1ß (p = 0.0002). …”
Publicado 2020
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30537por Klümper, Niklas, Ralser, Damian J, Bawden, Emma Grace, Landsberg, Jenny, Zarbl, Romina, Kristiansen, Glen, Toma, Marieta, Ritter, Manuel, Hölzel, Michael, Ellinger, Jörg, Dietrich, Dimo“…Furthermore, LAG3 methylation strongly correlated with signatures of distinct immune cell infiltrates, an interferon-y signature (TCGA cohort), and immunohistochemically quantified CD45(+), CD8(+), and CD4(+) immune cell infiltrates (UHB cohort). …”
Publicado 2020
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30538por Steinhardt, M. J., Wiercinska, E., Pham, M., Grigoleit, G. U., Mazzoni, A., Da-Via, M., Zhou, X., Meckel, K., Nickel, K., Duell, J., Krummenast, F. C., Kraus, S., Hopkinson, C., Weissbrich, B., Müllges, W., Stoll, G., Kortüm, K. M., Einsele, H., Bonig, H., Rasche, L.“…It enables the enrichment of JCV specific T cells via identification of stimulus-induced interferon gamma secretion. RESULTS: Despite low frequencies of responsive T cells, we succeeded in generating a product containing 20 000 JCV reactive T cells ready for patient infusion. …”
Publicado 2020
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30539“…The resulting signal cascades modulate the expression of KSHV latency genes (latency associated nuclear antigen-1 [LANA-1] and viral-Fas (TNFRSF6)-associated via death domain like interferon converting enzyme-like- inhibitory protein [vFLIP]). vFLIP was also shown to be crucial for the maintenance of COX-2 activation. …”
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30540por Raveendran Nair, P.K., Rodriguez, Sonia, Ramachandran, Reshma, Alamo, Arturo, Melnick, Steven J., Escalon, Enrique, Garcia, Pedro I., Wnuk, Stanislaw F., Ramachandran, Cheppail“…Immune activation by RR1 in normal lymphocytes elicited the synthesis of interleukin (IL)-1β (1080 pg/ml), IL-6 (21,833 pg/ml), IL-12 p70 (50.19 pg/ml), IL-12 p40 (918.23 pg/ml), IL-18 (27.47 pg/ml), IFN- γ (90.16 pg/ml), tumor necrosis factor (TNF)-α (2225 pg/ml) and monocyte chemoattractant protein (MCP)-1 (2307 pg/ml) at 100 μg/ml concentration, while it did not induce the production of IL-2, IL-4, IL-10, interferon (IFN)-α and TNF-β. The cytokine profile clearly demonstrates the Th1 pathway of T helper cell differentiation essential for cell mediated immunity, with a self-regulatory mechanism for the control of its overproduction. …”
Publicado 2004
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