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30541por Cui, Min, Chen, Shuling, Zhang, Shaqiu, Cheng, Anchun, Pan, Yuhong, Huang, Juan, Hu, Zhiqiang, Zhang, Xingcui, Wang, Mingshu, Zhu, Dekang, Chen, Shun, Liu, Mafeng, Zhao, Xinxin, Wu, Yin, Yang, Qiao, Liu, Yunya, Zhang, Ling, Yu, Yanling, Yin, Zhongqiong, Jing, Bo, Rehman, Mujeeb Ur, Tian, Bin, Pan, Leichang, Jia, Renyong“…Transfection of miR-221-3p mimic significantly reduced interferon (IFN) β production, whereas transfection of miR-221-3p inhibitor conversely significantly increased the expression of IFN-β in DTMUV-infected DEF. …”
Publicado 2020
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30542“…It has been shown that Th17 cells can alter their gene expression to produce interferon-gamma (IFN-γ). Forkhead box P3 (Foxp3) is considered the master regulator of Treg cells that produce inhibitory cytokines like IL-10. …”
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30543por Ueno, Kazuko, Aiba, Yoshihiro, Hitomi, Yuki, Shimoda, Shinji, Nakamura, Hitomi, Gervais, Olivier, Kawai, Yosuke, Kawashima, Minae, Nishida, Nao, Kohn, Seik‐Soon, Kojima, Kaname, Katsushima, Shinji, Naganuma, Atsushi, Sugi, Kazuhiro, Komatsu, Tatsuji, Mannami, Tomohiko, Matsushita, Kouki, Yoshizawa, Kaname, Makita, Fujio, Nikami, Toshiki, Nishimura, Hideo, Kouno, Hiroshi, Kouno, Hirotaka, Ohta, Hajime, Komura, Takuya, Tsuruta, Satoru, Yamauchi, Kazuhiko, Kobata, Tatsuro, Kitasato, Amane, Kuroki, Tamotsu, Abiru, Seigo, Nagaoka, Shinya, Komori, Atsumasa, Yatsuhashi, Hiroshi, Migita, Kiyoshi, Ohira, Hiromasa, Tanaka, Atsushi, Takikawa, Hajime, Nagasaki, Masao, Tokunaga, Katsushi, Nakamura, Minoru“…The most significant common upstream regulators associated with PBC disease susceptibility identified were interferon‐gamma (IFNG) and CD40 ligand (CD40L). Hierarchical cluster analysis of data set 2 revealed two distinct groups of patients with PBC by disease activity. …”
Publicado 2020
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30544por Cicconi, Paola, Jones, Claire, Sarkar, Esha, Silva-Reyes, Laura, Klenerman, Paul, de Lara, Catherine, Hutchings, Claire, Moris, Philippe, Janssens, Michel, Fissette, Laurence A, Picciolato, Marta, Leach, Amanda, Gonzalez-Lopez, Antonio, Dieussaert, Ilse, Snape, Matthew D“…The median frequency of RSV-F–specific interferon γ–secreting T-cells after a ChAd155-RSV high dose was 108.3/10(6) PBMCs at D30, with no increase after the second dose. …”
Publicado 2020
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30545por Arnold, Douglas L, Banwell, Brenda, Bar-Or, Amit, Ghezzi, Angelo, Greenberg, Benjamin M, Waubant, Emmanuelle, Giovannoni, Gavin, Wolinsky, Jerry S, Gärtner, Jutta, Rostásy, Kevin, Krupp, Lauren, Tardieu, Marc, Brück, Wolfgang, Stites, Tracy E, Pearce, Gregory L, Häring, Dieter A, Merschhemke, Martin, Chitnis, Tanuja“…OBJECTIVE: PARADIGMS demonstrated superior efficacy and comparable safety of fingolimod versus interferon β-1a (IFN β-1a) in paediatric-onset multiple sclerosis (PoMS). …”
Publicado 2020
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30546por Nguyen, Dung Thanh, Tran, Thanh Thi Thanh, Nghiem, Ngoc My, Le, Phuong Thanh, Vo, Quang Minh, Day, Jeremy, Rahman, Motiur, Le, Hung Mạnh“…We found no evidence that patient’s age, gender, liver cirrhosis, diabetes, HBV or HIV coinfection, prior treatment failure with pegylated interferon therapy, body mass index (BMI), aspartate aminotransferase to platelet ratio index (APRI), or fibrosis 4 (FIB-4) index were associated with treatment failure. …”
Publicado 2020
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30547por Yang, Rui, Elsaadi, Samah, Misund, Kristine, Abdollahi, Pegah, Vandsemb, Esten Nymoen, Moen, Siv Helen, Kusnierczyk, Anna, Slupphaug, Geir, Standal, Therese, Waage, Anders, Slørdahl, Tobias S, Rø, Torstein Baade, Rustad, Even, Sundan, Anders, Hay, Carl, Cooper, Zachary, Schuller, Alwin G, Woessner, Richard, Borodovsky, Alexandra, Menu, Eline, Børset, Magne, Sponaas, Anne Marit“…Blocking the adenosine pathway in vivo with a combination of Sodium polyoxotungstate (POM-1), anti-CD73, and the A2AR antagonist AZD4635 activated immune cells, increased interferon gamma production, and reduced the tumor load in a murine model of MM. …”
Publicado 2020
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30548por Mhandire, Doreen Z., Mhandire, Kudakwashe, Magadze, Mulalo, Wonkam, Ambroise, Kengne, Andre P., Dandara, Collet“…Furthermore, allele frequencies of SNPs in TLR2, TLR4, TLR9, TLR7, IL-6, IL-10, IL-28B, IL-1A and interferon AR1 (IFNAR1) genes are being reported here for the first time in a Zimbabwean population. …”
Publicado 2020
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30549por Sun, Manman, Gao, Xiong, Zhao, Zihao, Li, An, Wang, Yali, Yang, Yankun, Liu, Xiuxia, Bai, Zhonghu“…The compatibility of these bicistronic vectors was further validated using six model proteins- aldehyde dehydrogenase (ALDH), alcohol dehydrogenase (ADH), RamA (regulator of acetate metabolism), Bovine interferon-α (BoIFN-α), glycoprotein D protein (gD) of infectious bovine rhinotracheitis virus (IBRV) and procollagen type Ι N-terminal peptide (PΙNP). …”
Publicado 2020
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30550por Bergamaschi, Cristina, Pandit, Hrishikesh, Nagy, Bethany A, Stellas, Dimitris, Jensen, Shawn M, Bear, Jenifer, Cam, Maggie, Valentin, Antonio, Fox, Bernard A, Felber, Barbara K, Pavlakis, George N“…Intratumoral NK and CD8(+) T cells showed activation features with enhanced interferon-γ (IFN-γ) production, proliferation (Ki67(+)), cytotoxic potential (Granzyme B(+)) and expression of the survival factor Bcl-2. …”
Publicado 2020
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30551por Matsushita, Hirokazu, Hasegawa, Kosei, Oda, Katsutoshi, Yamamoto, Shogo, Asada, Kayo, Karasaki, Takahiro, Yabuno, Akira, Nishijima, Akira, Nejo, Takahide, Kobayashi, Yukari, Sato, Sho, Ikeda, Yuji, Miyai, Manami, Takahashi, Yusuke, Yamaguchi, Rui, Fujiwara, Keiichi, Aburatani, Hiroyuki, Kakimi, Kazuhiro“…Gene set enrichment analysis demonstrated that the genes for effector memory CD8 T cells, TH1 T cells, the interferon-γ response, and other immune-related genes, were enriched in these patients. …”
Publicado 2020
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30552por Liu, Qin, Zhang, Dinghu, Qian, Hanqing, Chu, Yanhong, Yang, Yan, Shao, Jie, Xu, Qiuping, Liu, Baorui“…In order to effectively deliver immune cells into tumors, we encapsulated interferon-α2b (IFN-α2b) into macroporous hydrogels as an enhancement factor and utilized low-dose irradiation (LDI) as a tumoral attractor of T cells. …”
Publicado 2020
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30553“…In TH group, elevated expression was observed in the innate immune mediators, including retinoic acid-inducible gene I (RIG-I), interferon alpha (IFN-α), mitochondrial antiviral-signaling protein (MAVS), NLR family pyrin domain containing 3 (NLRP3), toll-like receptor (TLR) 4 and TLR7. …”
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30554por Feng, Kaichao, Liu, Yang, Zhao, Yongtian, Yang, Qingming, Dong, Liang, Liu, Jiejie, Li, Xiang, Zhao, Zhikun, Mei, Qian, Han, Weidong“…On-therapy changes in serum soluble FasL, MCP-1 and interferon-γ were correlated with prognosis. CONCLUSIONS: Nivolumab in combination with gemcitabine and cisplatin offers promising efficacy and a manageable safety profile for patients with advanced BTCs. …”
Publicado 2020
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30555por Almohaya, Abdulellah, Aldrees, Abdulwahab, Akkielah, Layan, Hashim, Alshaima Talal, Almajid, Fahad, Binmoammar, Turki, Barry, Mazin A.“…The prevalence of LTBI in HCW in Saudi Arabia has not been reported using the fourth-generation interferon gamma release assay QuantiFERON-TB Gold Plus (QFT-Plus). …”
Publicado 2020
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30556por Shi, Xinli, Li, Shenghao, Wang, Li, Li, Hui, Li, Zhen, Wang, Weiyi, Bai, Jing, Sun, Yajing, Li, Jianchun, Li, Xiaoming“…BACKGROUND: Interferon-inducible 16 (IFI16)/caspase-1 inflammasome activates and secretes IL-1β. …”
Publicado 2020
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30557por Jiang, Chun-Guo, Wang, Wen, Zhou, Qiong, Wu, Xiu-Zhi, Wang, Xiao-Juan, Wang, Zhen, Zhai, Kan, Shi, Huan-Zhong“…We sought to evaluate the influence of age on diagnostic values of pleural adenosine deaminase (ADA), interferon-gamma (IFN-γ), and interleukin 27 (IL-27) for tuberculous pleural effusion (TPE). …”
Publicado 2020
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30558por Sadeghi, Omid, Milajerdi, Alireza, Siadat, Seyed Davar, Keshavarz, Seyed Ali, Sima, Ali Reza, Vahedi, Homayoon, Adibi, Peyman, Esmaillzadeh, Ahmad“…Assessment of anthropometric measures and biochemical indicators including serum concentrations of high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interferon gamma (IFN-γ) will be done at the study baseline and end of trial. …”
Publicado 2020
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30559por Subhi, Ohoud, Schulten, Hans-Juergen, Bagatian, Nadia, Al-Dayini, Roa'a, Karim, Sajjad, Bakhashab, Sherin, Alotibi, Reem, Al-Ahmadi, Alaa, Ata, Manar, Elaimi, Aisha, Al-Muhayawi, Saad, Mansouri, Majid, Al-Ghamdi, Khalid, Hamour, Osman Abdel, Jamal, Awatif, Al-Maghrabi, Jaudah, Al-Qahtani, Mohammed Hussain“…The majority of the 71 DEGs were upregulated and the most upregulated DEGs included a number of immunoglobulin kappa variable genes, and other immune-related genes, e.g., CD86 molecule (CD86), interleukin 2 receptor gamma (IL2RG), and interferon, alpha-inducible protein 6 (IFI6). Upregulated genes preferentially associated with other gene ontologies (GO) were, e.g., STAT1, MMP9, TOP2A, and BRCA2. …”
Publicado 2020
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30560por Bösken, Björn, Hepner-Schefczyk, Monika, Vonderhagen, Sonja, Dudda, Marcel, Flohé, Stefanie B.“…CD56(bright) Natural killer (NK) cells play a key role in the defense against infection due to their rapid release of Interferon (IFN) γ in response to Interleukin (IL) 12. …”
Publicado 2020
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