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30561Publicado 2018“…METHODS: The BALB/c female SAA model mice were induced by interferon-gamma in combination with busulphan. The SAA model mice were intraperitoneal injection with RAPA at daily dose of 0.5 mg/kg for 5 days (the RAPA-treated group, n=15) in the SAA group (n=15) and the un-treated group (n=15) were control. …”
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30562por Gu, Yurong, Lian, Yifan, Zheng, Qiaolan, Huang, Zexuan, Gu, Lin, Bi, Yanhua, Li, Jing, Huang, Yanlin, Wu, Yuankai, Chen, Lubiao, Huang, Yuehua“…METHODS: We measured antiviral cytokines interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), and interleukin-2 (IL-2) produced by T, NK and natural killer T (NKT) cells, respectively, in a cohort with chronic hepatitis B virus (HBV) infection (CHB). …”
Publicado 2020
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30563A COVID-19 patient with multiple negative results for PCR assays outside Wuhan, China: a case reportpor Chen, Li-Da, Li, Hao, Ye, Yu-Ming, Wu, Zhi, Huang, Ya-Ping, Zhang, Wei-Liang, Lin, Li“…He was treated with lopinavir/ritonavir, recombinant human interferon alfa-2b inhalation, methylprednisolone. After 18 days of treatment, he was discharged with improved symptoms, lung lesions and negative results of nasopharyngeal swab. …”
Publicado 2020
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30564por Ma, Hui, Li, Ya-nan, Song, Lin, Liu, Rui, Li, Xiaolei, Shang, Qianwen, Wang, Ying, Shao, Changshun, Shi, Yufang“…The induced matured macrophages were then induced to undergo classically activated macrophage (M1) or alternatively activated macrophage (M2) polarization with Iipopolysaccharide (LPS)/interferon (IFN)-γ and interleukin (IL)-4/IL-13, respectively. …”
Publicado 2020
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30565por Kinder, Travis B., Heier, Christopher R., Tully, Christopher B., Van der Muelen, Jack H., Hoffman, Eric P., Nagaraju, Kanneboyina, Fiorillo, Alyson A.“…RESULTS: In mice with severe myositis, muscle tissue showed mononuclear cell infiltration along with elevated expression of type I interferon and NF‐κB–regulated genes, including Tlr7 (3.8‐fold increase, P < 0.05). …”
Publicado 2020
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30566por Hashii, Yoshiko, Oka, Yoshihiro, Kagawa, Naoki, Hashimoto, Naoya, Saitou, Hiroyuki, Fukuya, Syogo, Kanegae, Mizuki, Ikejima, Sayaka, Oji, Yusuke, Ozono, Keiichi, Tsuboi, Akihiro, Sugiyama, Haruo“…Modified WT1 tetramer staining revealed the WT1 peptide vaccine-induced production of WT1-specific cytotoxic T cells, and the interferon-γ (IFN-γ) ELISpot assay of peripheral blood mononuclear cells disclosed the production of IFN-γ. …”
Publicado 2020
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30567por Reichler, Mary R., Hirsch, Christina, Yuan, Yan, Khan, Awal, Dorman, Susan E., Schluger, Neil, Sterling, Timothy R.“…Blood was collected and stimulated with Mycobacterium tuberculosis culture filtrate protein, and tumor necrosis factor (TNF-α), interferon gamma (IFN-γ), and interleukin 10 (IL-10) concentrations were determined using immunoassays. …”
Publicado 2020
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30568por Zheng, Wenxiao, Klammer, Alissa M., Naciri, Jennifer N., Yeung, Jason, Demers, Matthew, Milosevic, Jadranka, Kinchington, Paul R., Bloom, David C., Nimgaonkar, Vishwajit L., D’Aiuto, Leonardo“…Here, we show that (i) NPCs can be efficiently infected by HSV-1, but infection does not result in cell death of most NPCs, even at high multiplicities of infection (MOIs); (ii) limited HSV-1 replication and gene expression can be detected in the infected NPCs; (iii) a viral silencing mechanism is established in NPCs exposed to the antivirals (E)-5-(2-bromovinyl)-2′-deoxyuridine (5BVdU) and alpha interferon (IFN-α) and when the antivirals are removed, spontaneous reactivation can occur at low frequency; (iv) HSV-1 impairs the ability of NPCs to migrate in a dose-dependent fashion in the presence of 5BVdU plus IFN-α; and (v) 3D cultures of NPCs are less susceptible to HSV-1 infection than 2D cultures. …”
Publicado 2020
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30569“…The mRNA expression of splenic and cecal tonsil interleukin 4 and interferon gamma was upregulated (p<0.001; linear, p<0.001) in the low-CP diets supplemented with AA (CP-1% and CP-2%). …”
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30570por Schulte-Schrepping, Jonas, Reusch, Nico, Paclik, Daniela, Baßler, Kevin, Schlickeiser, Stephan, Zhang, Bowen, Krämer, Benjamin, Krammer, Tobias, Brumhard, Sophia, Bonaguro, Lorenzo, De Domenico, Elena, Wendisch, Daniel, Grasshoff, Martin, Kapellos, Theodore S., Beckstette, Michael, Pecht, Tal, Saglam, Adem, Dietrich, Oliver, Mei, Henrik E., Schulz, Axel R., Conrad, Claudia, Kunkel, Désirée, Vafadarnejad, Ehsan, Xu, Cheng-Jian, Horne, Arik, Herbert, Miriam, Drews, Anna, Thibeault, Charlotte, Pfeiffer, Moritz, Hippenstiel, Stefan, Hocke, Andreas, Müller-Redetzky, Holger, Heim, Katrin-Moira, Machleidt, Felix, Uhrig, Alexander, Bosquillon de Jarcy, Laure, Jürgens, Linda, Stegemann, Miriam, Glösenkamp, Christoph R., Volk, Hans-Dieter, Goffinet, Christine, Landthaler, Markus, Wyler, Emanuel, Georg, Philipp, Schneider, Maria, Dang-Heine, Chantip, Neuwinger, Nick, Kappert, Kai, Tauber, Rudolf, Corman, Victor, Raabe, Jan, Kaiser, Kim Melanie, Vinh, Michael To, Rieke, Gereon, Meisel, Christian, Ulas, Thomas, Becker, Matthias, Geffers, Robert, Witzenrath, Martin, Drosten, Christian, Suttorp, Norbert, von Kalle, Christof, Kurth, Florian, Händler, Kristian, Schultze, Joachim L., Aschenbrenner, Anna C., Li, Yang, Nattermann, Jacob, Sawitzki, Birgit, Saliba, Antoine-Emmanuel, Sander, Leif Erik“…HLA-DR(hi)CD11c(hi) inflammatory monocytes with an interferon-stimulated gene signature were elevated in mild COVID-19. …”
Publicado 2020
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30571por Dikmen, Hasan Onur, Hemmerich, Marc, Lewen, Andrea, Hollnagel, Jan-Oliver, Chausse, Bruno, Kann, Oliver“…In contrast to priming with the cytokine IFN-γ (type II interferon), GM-CSF did not cause inflammatory neurodegeneration when paired with the TLR4 ligand LPS. …”
Publicado 2020
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30572por Manful, Adoma, Waller, Leslie, Katz, Ben, Cummins, Jason, Warkentin, Jon, Reagon, Billy, Shaw-Kaikai, Joanna, Zhu, Yuwei, van der Heijden, Yuri F.“…Male sex (Odds Ratio [OR]: 1.42; 95% Confidence Interval [CI]: 1.06, 1.89) and screening with interferon gamma release assay compared to tuberculin skin test (OR: 2.89; 95% CI: 1.59, 5.27) were associated with increased treatment initiation; living farther away from TB clinic was associated with decreased treatment initiation (OR: 0.91; 95% CI: 0.83, 0.99). …”
Publicado 2020
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30573por Häring, Dieter A., Kropshofer, Harald, Kappos, Ludwig, Cohen, Jeffrey A., Shah, Anuja, Meinert, Rolf, Leppert, David, Tomic, Davorka, Kuhle, Jens“…METHODS: This analysis included continuously fingolimod-treated patients with RRMS from the 24-month FTY720 Research Evaluating Effects of Daily Oral therapy in Multiple Sclerosis (FREEDOMS)/12-month Trial Assessing Injectable Interferon vs FTY720 Oral in Relapsing–Remitting Multiple Sclerosis (TRANSFORMS) phase 3 trials and their long-term extension, LONGTERMS. …”
Publicado 2020
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30574“…Several shared or specific DEGs response to different PAMPs were revealed in R. philippinarum, including pattern recognition receptors (PRRs), antimicrobial peptides (AMPs), interferon-induced proteins (IFI), and some other immune-related genes were found in the present work. …”
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30575por Lee, Jong-Uk, Lee, Hyeon Ju, Kim, Ji-Na, Kim, Min Kyung, Kim, Sung Roul, Chang, Hun-Soo, Park, Choon-Sik, Park, Jong-Sook“…Tumor necrosis factor (TNF)-α, interferon (IFN)-γ, interleukin (IL)-17, IL-1β, and caspase-1 were analyzed via western blotting. …”
Publicado 2020
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30576por Carpentier, Caroline, Verbanck, Sylvain, Schandené, Liliane, Heimann, Pierre, Trépant, Anne-Laure, Cogan, Elie, Roufosse, Florence“…Disease manifestations were mild and did not require maintenance therapy in roughly one third of the cohort, while two thirds required long-term oral corticosteroids and/or second-line agents. Among these, interferon-alpha was the most effective treatment option with a response observed in 8/8 patients, one of whom was cured of disease. …”
Publicado 2020
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30577por Chiappalupi, Sara, Sorci, Guglielmo, Vukasinovic, Aleksandra, Salvadori, Laura, Sagheddu, Roberta, Coletti, Dario, Renga, Giorgia, Romani, Luigina, Donato, Rosario, Riuzzi, Francesca“…In vitro experiments were performed using myotubes derived from C2C12 myoblasts or primary myoblasts isolated from C57BL/6 wild type and Ager (−/−) mice treated with the RAGE ligand, S100B (S100 calcium‐binding protein B), TNF (tumor necrosis factor)α±IFN (interferon) γ, and tumour cell‐ or masses‐conditioned media to analyse hallmarks of muscle atrophy. …”
Publicado 2020
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30578por Huang, Rui, Zhu, Li, Wang, Jian, Xue, Leyang, Liu, Longgen, Yan, Xuebing, Huang, Songping, Li, Yang, Yan, Xiaomin, Zhang, Biao, Xu, Tianmin, Li, Chunyang, Ji, Fang, Ming, Fang, Zhao, Yun, Cheng, Juan, Wang, Yinling, Zhao, Haiyan, Hong, Shuqin, Chen, Kang, Zhao, Xiang‐an, Zou, Lei, Sang, Dawen, Shao, Huaping, Guan, Xinying, Chen, Xiaobing, Chen, Yuxin, Wei, Jie, Zhu, Chuanwu, Wu, Chao“…Multivariate analysis showed that age over 50 years (odds ratio [OR], 2.077; 95% confidence interval [CI], 1.183, 3.648; P = 0.011) and concurrent NAFLD (OR, 2.956; 95% CI, 1.526, 5.726; P = 0.001) were independent risk factors of ALT elevation in patients with COVID‐19, while the atomized inhalation of interferon α‐2b (OR, 0.402; 95% CI, 0.236, 0.683; P = 0.001) was associated with a reduced risk of ALT elevation during hospitalization. …”
Publicado 2020
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30579“…Module 1 contained 35 genes related to cytokine associated functions, among which 14 genes, including chemokine receptors, interferon-induced proteins and Toll-like receptors, were identified as hub genes. …”
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30580por Lemos, Henrique, Ou, Rong, McCardle, Caroline, Lin, Yijun, Calver, Jessica, Minett, Jack, Chadli, Ahmed, Huang, Lei, Mellor, Andrew L“…BACKGROUND: Activating the Stimulator of Interferon Genes (STING) adaptor incites antitumor immunity against immunogenic tumors in mice, prompting clinical trials to test STING activators. …”
Publicado 2020
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