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30581por Sui, Baokun, Chen, Dong, Liu, Wei, Wu, Qiong, Tian, Bin, Li, Yingying, Hou, Jing, Liu, Shiyong, Xie, Juan, Jiang, Hao, Luo, Zhaochen, Lv, Lei, Huang, Fei, Li, Ruiming, Zhang, Chengguang, Tian, Yuling, Cui, Min, Zhou, Ming, Chen, Huanchun, Fu, Zhen F., Zhang, Yi, Zhao, Ling“…CONCLUSIONS: Our findings show that a neuronal lncRNA can exert an effective antiviral function via blocking a specific O-GlcNAcylation that determines EZH2 lysosomal degradation, rather than the traditional interferon-dependent pathway.…”
Publicado 2020
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30582“…The cytotoxicity of specific cytotoxic T lymphocytes (CTLs) on peptide-loaded T2 cells was initially verified using interferon IFN-γ detection and a calcein-acetoxymethyl (Cal-AM) release assay. …”
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30583por Borysewicz-Sańczyk, Hanna, Sawicka, Beata, Wawrusiewicz-Kurylonek, Natalia, Głowińska-Olszewska, Barbara, Kadłubiska, Anna, Gościk, Joanna, Szadkowska, Agnieszka, Łosiewicz, Aleksandra, Młynarski, Wojciech, Kretowski, Adam, Bossowski, Artur“…According to the literature genes encoding IL2RA (alpha subunit of Interleukin 2 receptor), IFIH1 (Interferon induced with helicase C domain 1) and CTLA-4 (cytotoxic T cell antigen 4) might be associated with autoimmune diseases pathogenesis. …”
Publicado 2020
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30584por Zheng, Shichao, Baak, Jan P., Li, Shuang, Xiao, Wenke, Ren, Hong, Yang, Huan, Gan, Yanxiong, Wen, Chuanbiao“…Six modules are enriched in leukocyte-mediated immunity, the interferon-gamma-mediated signaling pathway, immune response regulating signaling pathway, interleukin 23 mediated signaling pathway and Fc gamma receptor-mediated phagocytosis (GO analysis). …”
Publicado 2020
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30585por Sarohan, Aziz Rodan“…Despite compensatory mechanisms, causes such as high fever, serious catabolic process and excessively large viral genome (SARS-CoV-2), excessive use of RIG-I and Type I interferon synthesis pathway using retinoic acid causes emptying of retinoic acid stores. …”
Publicado 2020
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30586por Li, Lin, Yue, Hong Cheng, Han, Yun Wei, Liu, Wei, Xiong, Liang Geng, Zhang, Jian Wen“…Following this, the levels of interleukin-10 (IL-10), IL-12, and interferon-γ (IFN-γ) were detected by enzyme-linked immunosorbent assay. …”
Publicado 2020
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30587“…We aimed to explore the potential correlation of cytokine single nucleotide polymorphisms (SNPs) with HCV susceptibility and response rate of interferon (IFN)-based antiviral therapy in Chinese Han population. …”
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30588por Song, Yunejin, Lim, Jung-Yeon, Lim, Taekyu, Im, Keon-Il, Kim, Nayoun, Nam, Young-Sun, Jeon, Young-Woo, Shin, Jong Chul, Ko, Hyun Sun, Park, In Yang, Cho, Seok-Goo“…METHODS: To analyze soluble factors expressed by MSCs, such as indolamine 2,3-dioxygenase, cyclooxygenase-2, prostaglandin E2 and interleukin (IL)-6, inflammatory environments in vitro were reconstituted with combinations of interferon-gamma (IFN-γ), tumor necrosis factor alpha and IL-1β or with IFN-γ alone. …”
Publicado 2020
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30589por Mohan, Arjun, Neequaye, Nicole, Malur, Anagha, Soliman, Eman, McPeek, Matthew, Leffler, Nancy, Ogburn, David, Tokarz, Debra A., Knudson, Warren, Gharib, Sina A., Schnapp, Lynn M., Barna, Barbara P., Thomassen, Mary Jane“…Bronchoalveolar lavage (BAL) cells were analyzed 60 days after MWCNT instillation for expression of mediators thought to play a role in sarcoid granulomatosis: peroxisome proliferator-activated receptor-gamma (PPARγ), interferon-gamma (IFN-γ), and CCL2 (MCP-1). RESULTS: Pulmonary granuloma appearance at 10 days after MWCNT instillation showed no differences between wildtype and Mmp12 KO mice. …”
Publicado 2020
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30590por Oladipo, Elijah Kolawole, Ajayi, Ayodeji Folorunsho, Ariyo, Olumuyiwa Elijah, Onile, Samson Olugbenga, Jimah, Esther Moradeyo, Ezediuno, Louis Odinakaose, Adebayo, Oluwadunsin Iyanuoluwa, Adebayo, Emmanuel Tayo, Odeyemi, Aduragbemi Noah, Oyeleke, Marvellous Oluwaseun, Oyewole, Moyosoluwa Precious, Oguntomi, Ayomide Samuel, Akindiya, Olawumi Elizabeth, Olamoyegun, Bunmi Olayemi, Aremu, Victoria Oyetayo, Arowosaye, Abiola O., Aboderin, Dorcas Olubunmi, Bello, Habibat Bolanle, Senbadejo, Tosin Yetunde, Awoyelu, Elukunbi Hilda, Oladipo, Adio Abayomi, Oladipo, Bukola Bisola, Ajayi, Lydia Oluwatoyin, Majolagbe, Olusola Nathaniel, Oyawoye, Olubukola Monisola, Oloke, Julius Kola“…The steady rise in Th (T-helper) cell population with memory development was noticed, and IFN-g (Interferon gamma) was provoked after simulation. At this point, the vaccine candidate awaits animal trial to validate its efficacy and safety for use in the prevention of the novel COVID-19 (Coronavirus Disease 2019) infections.…”
Publicado 2020
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30591por Piao, Chun Hua, Bui, Thi Tho, Fan, Yan Jing, Van Nguyen, Thi, Shin, Dong-Uk, Song, Chang Ho, Lee, So-Young, Shin, Hee Soon, Kim, Hyoung Tae, Chai, Ok Hee“…DC treatment increased the level of T helper type 1 (Th1) cytokines (IL-10 and interferon (IFN)-γ) and decreased the levels Th2 cytokines (IL-4, IL-5 and IL-13) and proinflammatory cytokines (IL-6 and TNF-α). …”
Publicado 2020
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30592por Manh, Dao Huy, Weiss, Lan Nguyen, Thuong, Nguyen Van, Mizukami, Shusaku, Dumre, Shyam Prakash, Luong, Quang Chan, Thanh, Le Chi, Thang, Cao Minh, Huu, Pham Thanh, Phuc, Le Hong, Nhung, Cao Thi Hong, Mai, Nguyen Thi, Truong, Nguyen Quang, Ngu, Vu Thien Thu, Quoc, Do Kien, Ha, Tran Thi Ngoc, Ton, Tran, An, Tran Van, Halhouli, Oday, Quynh, Le Nhat, Kamel, Mohamed Gomaa, Karbwang, Juntra, Huong, Vu Thi Que, Huy, Nguyen Tien, Hirayama, Kenji“…On the other hand, Th2 cells increased during DENV infection until convalescent phase. Cytokines such as interferon-γ, IL-12p70, IL-5, IL-23, IL-17A showed tendency to decrease on day 0 and 1 compared with convalescence and only IL-5 showed significance indicating the production during acute phase was not systemic. …”
Publicado 2020
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30593por Starost, Laura, Lindner, Maren, Herold, Martin, Xu, Yu Kang T., Drexler, Hannes C. A., Heß, Katharina, Ehrlich, Marc, Ottoboni, Linda, Ruffini, Francesca, Stehling, Martin, Röpke, Albrecht, Thomas, Christian, Schöler, Hans R., Antel, Jack, Winkler, Jürgen, Martino, Gianvito, Klotz, Luisa, Kuhlmann, Tanja“…In particular, we identified CD4(+) T cells as mediators of impaired oligodendroglial differentiation; at least partly due to interferon-gamma secretion. Additionally, we observed that blocked oligodendroglial differentiation induced by PBMC supernatants could not be restored by application of oligodendroglial differentiation promoting drugs, whereas treatment of PBMCs with the immunomodulatory drug teriflunomide prior to supernatant collection partly rescued oligodendroglial differentiation. …”
Publicado 2020
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30594por Varchetta, Stefania, Mele, Dalila, Oliviero, Barbara, Mantovani, Stefania, Ludovisi, Serena, Cerino, Antonella, Bruno, Raffaele, Castelli, Alberto, Mosconi, Mario, Vecchia, Marco, Roda, Silvia, Sachs, Michele, Klersy, Catherine, Mondelli, Mario U.“…NK cell exhaustion was attested by increased frequencies of programmed cell death protein 1 (PD-1) positive cells and reduced frequencies of natural killer group 2 member D (NKG2D)-, DNAX accessory molecule-1 (DNAM-1)- and sialic acid-binding Ig-like lectin 7 (Siglec-7)-expressing NK cells, associated with a reduced ability to secrete interferon (IFN)γ. Patients with poor outcome showed a contraction of immature CD56(bright) and an expansion of mature CD57(+) FcεRIγ(neg) adaptive NK cells compared to survivors. …”
Publicado 2020
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30595por Rao, Huiying, Yang, Xingxiang, Tan, Youwen, Ning, Qin, Yang, Daokun, Wang, Jiefei, Yang, Yongfeng, Zheng, Sujun, Yang, Dongliang, Hou, Jinlin, Xie, Qing, Zhao, Caiyan, Zhang, Lunli, Mao, Xiaorong, Sun, Tong, Bai, Lang, Zhang, Fuchun, Jin, Jinglan, Zhao, Yingren, Wang, Maorong, Xie, Wen, Ma, Yingjie, Quan, Jun, Yan, Xuebing, An, Ping, Lin, Feng, Jia, Jidong, Hu, Xiaoxuan, Gong, Zuojiong, Wu, Jie, Chen, Yongping, Jia, Zhansheng, Lin, Minghua, Wang, Guiqiang, Zhu, Yueyong, Zhang, Yingjun, Xie, Hongming, Luo, Lin, Ren, Qingyun, Huang, Rui, Wei, Lai“…Conclusions: The 12 weeks of treatment with emitasvir-sofosbuvir was a highly efficient and safe treatment for a wide range of patients with HCV genotype 1b infection without cirrhosis, who had not been treated or who had been treated with interferon-based regimen previously.…”
Publicado 2020
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30596por Han, Huan, Xu, Zaichao, Cheng, Xiaoming, Zhong, Youquan, Yuan, Li, Wang, Fubing, Li, Yan, Liu, Fang, Jiang, Yingan, Zhu, Chengliang, Xia, Yuchen“…Cytokines, including gamma interferon (IFN-γ), tumor necrosis factor alpha (TNF-α), interleukin 2 (IL-2), IL-4, IL-6, and IL-10 were evaluated. …”
Publicado 2020
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30597por Steingo, Brian, Al Malik, Yaser, Bass, Ann D., Berkovich, Regina, Carraro, Matthew, Fernández, Óscar, Ionete, Carolina, Massacesi, Luca, Meuth, Sven G., Mitsikostas, Dimos D., Pardo, Gabriel, Simm, Renata Faria, Traboulsee, Anthony, Choudhry, Zia, Daizadeh, Nadia, Compston, D. Alastair S.“…BACKGROUND: In the phase 2 CAMMS223 trial (NCT00050778), alemtuzumab significantly improved clinical and MRI outcomes versus subcutaneous interferon beta-1a over 3 years in treatment-naive patients with relapsing–remitting MS. …”
Publicado 2020
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30598por Hasan, Amal, Kochumon, Shihab, Al-Ozairi, Ebaa, Tuomilehto, Jaakko, Al-Mulla, Fahd, Ahmad, Rasheed“…RESULTS: In individuals with normal glycemia, adipose tissue ST2 was directly correlated with chemokine (C-C motif) ligand (CCL)-2, CCL5, IL-12, fibrinogen-like protein 2 (FGL2) and interferon regulatory factor (IRF)-4, but inversely correlated with cytochrome C oxidase subunit 7A1. …”
Publicado 2020
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30599“…BACKGROUND: The T cell-inflamed tumor microenvironment, characterized by CD8 T cells and type I/II interferon transcripts, is an important cancer immunotherapy biomarker. …”
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30600por Jobe, Fatoumatta, Simpson, Jennifer, Hawes, Philippa, Guzman, Efrain, Bailey, Dalan“…Respiratory syncytial virus (RSV) is no exception, as it encodes two accessory proteins (NS1 and NS2) which are well established to block interferon signaling. However, RSV-encoded mechanisms for inhibiting NF-κB signaling are less well characterized. …”
Publicado 2020
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