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30601por Wu, Ruiyan, Wang, Caiqin, Li, Zhiming, Xiao, Jian, Li, Chunyan, Wang, Xuemin, Kong, Pengfei, Cao, Jianghua, Huang, Fuxue, Li, Zhiling, Huang, Yun, Chen, Yuhong, Li, Xuan, Yang, Dong, Zhang, Hailiang, Mai, Jia, Feng, Gongkan, Deng, Rong, Zhu, Xiaofeng“…Mechanistically, SOX2 inhibited phosphatases suppressor of cytokine signaling 3 (SOCS3) and protein tyrosine phosphatase non-receptor type 1 (PTPN1) transcription, induced duration activation of the JAK-STAT pathway and thereby overexpression of interferon stimulated genes resistance signature (ISG.RS). …”
Publicado 2020
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30602por Bortoluzzi, Alessandra, Chighizola, Cecilia Beatrice, Fredi, Micaela, Raschi, Elena, Bodio, Caterina, Privitera, Daniela, Gonelli, Arianna, Silvagni, Ettore, Govoni, Marcello, Cavazzana, Ilaria, Airò, Paolo, Meroni, Pier Luigi, Tincani, Angela, Franceschini, Franco, Piantoni, Silvia, Casciano, Fabio“…Flow cytometric analysis of endothelial progenitor cells (EPCs) and T(ang) subsets were performed and serum levels of interleukin (IL)-6, -8, matrix metalloproteinase (MMP)-9 and interferon (IFN)-γ were measured. Human umbilical vein endothelial cells (HUVECs) proliferation and pro-inflammatory phenotype in response to subjects’ serum stimulation were also evaluated. …”
Publicado 2020
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30603por Saavedra, Danay, Añé-Kourí, Ana Laura, Sánchez, Naivy, Filgueira, Lázaro Manuel, Betancourt, Julio, Herrera, Carlos, Manso, Leniel, Chávez, Elibet, Caballero, Armando, Hidalgo, Carlos, Lorenzo, Geydi, Cepeda, Meylan, Valenzuela, Carmen, Ramos, Mayra, León, Kalet, Mazorra, Zaima, Crombet, Tania“…Itolizumab is a humanized recombinant anti-CD6 monoclonal antibody (MAb), with the ability of reducing serum interferon gamma (INF-γ), tumour necrosis factor alpha (TNFα) and IL-6. …”
Publicado 2020
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30604por Cao, Mingzhuo, Zhan, Mengling, Wang, Zheng, Wang, Zeqian, Li, Xiu-Min, Miao, Mingsan“…Although ILQ-SMEDDS showed a slight less effective inhibitory effect on eotaxin-1 in human lung fibroblast (HFL-1) cells than free ILQ, in an ovalbumin-induced asthma model, ILQ-SMEDDS exhibited more efficacy than ILQ suspension in improving asthma-associated inflammation, including eosinophil production, ovalbumin-specific immunoglobulin E (OVA-sIgE), interleukin 4 (IL 4), interleukin 5 (IL 5) and interferon-γ (IFN-γ). Even the low dose of ILQ-SMEDDS group (10 mg/kg) showed better anti-asthma effect than that of the ILQ suspension group (20 mg/kg). …”
Publicado 2020
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30605por Qin, Yong, Bollin, Kathryn, de Macedo, Mariana Petaccia, Carapeto, Fernando, Kim, Kevin B, Roszik, Jason, Wani, Khalida M, Reuben, Alexandre, Reddy, Sujan T, Williams, Michelle D, Tetzlaff, Michael T, Wang, Wei-Lien, Gombos, Dan S, Esmaeli, Bita, Lazar, Alexander J, Hwu, Patrick, Patel, Sapna P“…A group of genes relevant to the interferon-γ signature was differentially up-expressed in the pre-treatment tumors of responders. …”
Publicado 2020
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30606por Danov, Olga, Wolff, Martin, Bartel, Sabine, Böhlen, Sebastian, Obernolte, Helena, Wronski, Sabine, Jonigk, Danny, Hammer, Barbara, Kovacevic, Draginja, Reuter, Sebastian, Krauss-Etschmann, Susanne, Sewald, Katherina“…Influenza H1N1-induced secretion of antiviral cytokines (IFN-α2a, IFN-λ, interferon-γ-induced protein 10 [IP-10]), pro-inflammatory cytokine IL-6, as well as T cell-associated cytokines (e.g., I-TAC) were completely suppressed in both Calu-3 cells and human PCLS after smoke exposure. …”
Publicado 2020
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30607por Taus, Francesco, Salvagno, Gianluca, Canè, Stefania, Fava, Cristiano, Mazzaferri, Fulvia, Carrara, Elena, Petrova, Varvara, Barouni, Roza Maria, Dima, Francesco, Dalbeni, Andrea, Romano, Simone, Poli, Giovanni, Benati, Marco, De Nitto, Simone, Mansueto, Giancarlo, Iezzi, Manuela, Tacconelli, Evelina, Lippi, Giuseppe, Bronte, Vincenzo, Minuz, Pietro“…Cytokines (IL [interleukin]-1α, IL-1β, IL-1RA, IL-4, IL-10, IL-13, IL, 17, IL-27, IFN [interferon]-α, and IFN-γ), chemokines (MCP-1/CCL2 [monocyte chemoattractant protein 1]), and growth factors (VEGF [vascular endothelial growth factor]-A/D) were released in significantly larger amounts upon stimulation of COVID-19 platelets. …”
Publicado 2020
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30608por Hauser, Stephen L., Kappos, Ludwig, Arnold, Douglas L., Bar-Or, Amit, Brochet, Bruno, Naismith, Robert T., Traboulsee, Anthony, Wolinsky, Jerry S., Belachew, Shibeshih, Koendgen, Harold, Levesque, Victoria, Manfrini, Marianna, Model, Fabian, Hubeaux, Stanislas, Mehta, Lahar, Montalban, Xavier“…METHODS: After 2 years of double-blind, controlled treatment, patients continued OCR (600 mg infusions every 24 weeks) or switched from interferon (IFN)-β-1a (44 μg 3 times weekly) to OCR when entering the OLE phase (3 years). …”
Publicado 2020
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30609por Jin, Won Jong, Erbe, Amy K., Schwarz, Ciara N., Jaquish, Abigail A., Anderson, Bryce R., Sriramaneni, Raghava N., Jagodinsky, Justin C., Bates, Amber M., Clark, Paul A., Le, Trang, Lan, Keng-Hsueh, Chen, Yi, Kim, KyungMann, Morris, Zachary S.“…Radiation enhanced the susceptibility of MOC1- and MOC2-huEGFR to ADCC, eliciting a type I interferon response and increasing expression of NKG2D ligands on these tumor cells. …”
Publicado 2020
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30610por Bernardes, Joana P., Mishra, Neha, Tran, Florian, Bahmer, Thomas, Best, Lena, Blase, Johanna I., Bordoni, Dora, Franzenburg, Jeanette, Geisen, Ulf, Josephs-Spaulding, Jonathan, Köhler, Philipp, Künstner, Axel, Rosati, Elisa, Aschenbrenner, Anna C., Bacher, Petra, Baran, Nathan, Boysen, Teide, Brandt, Burkhard, Bruse, Niklas, Dörr, Jonathan, Dräger, Andreas, Elke, Gunnar, Ellinghaus, David, Fischer, Julia, Forster, Michael, Franke, Andre, Franzenburg, Sören, Frey, Norbert, Friedrichs, Anette, Fuß, Janina, Glück, Andreas, Hamm, Jacob, Hinrichsen, Finn, Hoeppner, Marc P., Imm, Simon, Junker, Ralf, Kaiser, Sina, Kan, Ying H., Knoll, Rainer, Lange, Christoph, Laue, Georg, Lier, Clemens, Lindner, Matthias, Marinos, Georgios, Markewitz, Robert, Nattermann, Jacob, Noth, Rainer, Pickkers, Peter, Rabe, Klaus F., Renz, Alina, Röcken, Christoph, Rupp, Jan, Schaffarzyk, Annika, Scheffold, Alexander, Schulte-Schrepping, Jonas, Schunk, Domagoj, Skowasch, Dirk, Ulas, Thomas, Wandinger, Klaus-Peter, Wittig, Michael, Zimmermann, Johannes, Busch, Hauke, Hoyer, Bimba F., Kaleta, Christoph, Heyckendorf, Jan, Kox, Matthijs, Rybniker, Jan, Schreiber, Stefan, Schultze, Joachim L., Rosenstiel, Philip“…Coinciding with critical illness, we also identified an expansion of interferon-activated circulating megakaryocytes and increased erythropoiesis with features of hypoxic signaling. …”
Publicado 2020
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30611por Casagrande, Felipe Beccaria, Ferreira, Sabrina de Souza, de Sousa, Emanuella Sarmento Alho, Guimarães, João Pedro Tôrres, Romera, Lavínia Maria Dal’Mas, Tessaro, Fernando Henrique Galvão, de Almeida, Sandro Rogério, Rodrigues, Stephen Fernandes de Paula, Martins, Joilson O.“…Twenty-four hours after infection, infected diabetic mice showed reduced secretion of interferon (IFN)-γ and interleukine (IL)-12 p70 compared to infected nondiabetic controls. …”
Publicado 2020
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30612por Nebreda-Mayoral, Teresa, Miguel-Gómez, María Antonia, March-Rosselló, Gabriel Alberto, Puente-Fuertes, Lucía, Cantón-Benito, Elena, Martínez-García, Ana María, Muñoz-Martín, Ana Belén, Orduña-Domingo, Antonio“…The profiles of ICU patients (44%) included male, SARS-CoV-2 pneumonia, leukocytosis, elevated inteleukin-6, with interferon β-1b and tocilizumab and superinfection (p < 0.05). …”
Publicado 2022
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30613por Bonny, Tania S, Patel, Eshan U, Zhu, Xianming, Bloch, Evan M, Grabowski, M Kate, Abraham, Alison G, Littlefield, Kirsten, Shrestha, Ruchee, Benner, Sarah E, Laeyendecker, Oliver, Shoham, Shmuel, Sullivan, David, Quinn, Thomas C, Casadevall, Arturo, Pekosz, Andrew, Redd, Andrew D, Tobian, Aaron A R“…Compared with healthy blood donor controls, CCP donors had significantly higher plasma levels of interferon (IFN)-γ, interleukin (IL)-10, IL-15, IL-21, and macrophage-inflammatory protein-1, but lower levels of IL-1RA, IL-8, IL-16, and vascular endothelial growth factor-A (P < .0014). …”
Publicado 2020
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30614por Lai, Weiyi, Wu, Xiaohang, Wang, Dongni, Liu, Zhenzhen, Lin, Duoru, Zhao, Lanqin, Chen, Weirong, Lin, Haotian, Liu, Yizhi“…RESULTS: The concentrations of granulocyte colony stimulating factor (G-CSF), interferon (IFN)-α2, interleukin (IL)-1α and IL-7 were higher in the CC group than in the ARC group, while the concentrations of epidermal growth factor (EGF), granulocyte-macrophage colony stimulating factor (GM-CSF), IL-10, IL-12p70, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, and tumor necrosis factor (TNF)-α were more abundant in the ARC group (P<0.05). …”
Publicado 2020
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30615por Zhang, Zai-Li, Zhong, Han, Liu, Yang-Xi, Le, Ke-Jia, Cui, Min, Yu, Yue-Tian, Gu, Zhi-Chun, Gao, Yuan, Lin, Hou-Wen“…Randomised controlled trials (RCTs) and controlled cohort studies reporting antiviral therapies, including ribavirin, remdesivir, lopinavir/ritonavir, arbidol, chloroquine, hydroxychloroquine, and interferon, for SARS, MERS, and COVID-19 will be included. …”
Publicado 2020
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30616por Okoye, Isobel, Xu, Lai, Motamedi, Melika, Parashar, Pallavi, Walker, John W, Elahi, Shokrollah“…Also, we found an expansion of Gal-9+ but not TIGIT+ NK cells in patients with VASTs; however, dichotomous to TIGIT+ NK cells, Gal-9+ NK cells exhibited impaired cytotoxic molecules but higher Interferon gamma (IFN-γ) expression. CONCLUSION: Our data indicate that higher Gal-9-expressing CD8(+) T cells were associated with poor prognosis following immunotherapy with anti-Programmed death-ligand 1 (PD-L1) (avelumab) in our patients’ cohort. …”
Publicado 2020
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30617por Gómez, Luz Amparo, De Avila, Juliette, Castillo, Diana Marcela, Montenegro, Daniel Antonio, Trujillo, Tammy Gorety, Suárez, Lina J., Lafaurie, Gloria Inés“…Placental levels of interleukin IL-1β, IL-6, IL-10, IL-15, IL-17A, IL-17F, IL-21, IL-12p70, tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 α (MCP-1α), granzyme B, and interferon-γ (IFN-γ) were determined using a multiplex flow cytometry assay. …”
Publicado 2020
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30618por Weng, Senhui, Fan, Zhixin, Qiu, Guoyu, Liu, Fengbin, Huang, Linwen, Li, Jinghao, Jiang, Xiaotao, Song, Zhixuan, Gao, Yuxia, Zhong, Zhuotai, He, Long, Kang, Liping, Wu, Yunlong, Chen, Benshu, Jiang, Qilong“…The primary endpoints are quantitative myasthenia gravis (QMG) test; measurement of the amount of T(reg) cells and cytokines such as interferon-γ (IFN-γ), interleukin-4 (IL-4), interleukin-17A (IL-17A), and transforming growth factor-β (TGF-β); and corticosteroid or immunosuppressive agent dosage. …”
Publicado 2020
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30619por Choupoo, Nang S, Das, Saurabh K, Haldar, Rudrashish, Sarkar, Hillol, Tewari, Resma, Ray, Sumit“…RESULTS: Nine trials on hydroxychloroquine (HCQ), six studies on antiviral, four studies on monoclonal antibodies, two on corticosteroids, two on convalescent plasma (CP), and one on interferon-α2b were included in the systematic review. …”
Publicado 2020
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30620por Tsai, Pei-Chien, Chen, Chi-Yi, Kuo, Hsing-Tao, Hung, Chao-Hung, Tseng, Kuo-Chih, Lai, Hsueh-Chou, Peng, Cheng-Yuan, Wang, Jing-Houng, Chen, Jyh-Jou, Lee, Pei-Lun, Chien, Rong-Nan, Yang, Chi-Chieh, Lo, Gin-Ho, Kao, Jia-Horng, Liu, Chun-Jen, Liu, Chen-Hua, Yan, Sheng-Lei, Bair, Ming-Jong, Lin, Chun-Yen, Su, Wei-Wen, Chu, Cheng-Hsin, Chen, Chih-Jen, Tung, Shui-Yi, Tai, Chi-Ming, Lin, Chih-Wen, Lo, Ching-Chu, Cheng, Pin-Nan, Chiu, Yen-Cheng, Wang, Chia-Chi, Cheng, Jin-Shiung, Tsai, Wei-Lun, Lin, Han-Chieh, Huang, Yi-Hsiang, Yeh, Ming-Lun, Huang, Chung-Feng, Hsieh, Meng-Hsuan, Huang, Jee-Fu, Dai, Chia-Yen, Chung, Wan-Long, Ke, Chiao-Li Khale, Yu, Ming-Lung“…BACKGROUND: Chronic hepatitis C (CHC) has been associated with major psychoses, and interferon (IFN)-based therapy may cause psychiatric sequelae. …”
Publicado 2020
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