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30621por Konstantinus, Iyaloo N, Balle, Christina, Jaumdally, Shameem Z, Galmieldien, Hoyam, Pidwell, Tanya, Masson, Lindi, Tanko, Ramla F, Happel, Anna-Ursula, Sinkala, Musalula, Myer, Landon, Bosinger, Steven E, Gill, Katherine, Bekker, Linda-Gail, Jaspan, Heather B, Passmore, Jo-Ann S“…However, Th17-related cytokine concentrations (interleukin [IL]-21, IL-1β, tumor necrosis factor–α, interferon-γ) and CCR5, HLA-DR, CD38, and Th17 frequencies were significantly higher in CCVR than NET-EN and COCP. …”
Publicado 2019
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30622“…The model predicts that signal transducer and activator of transcription 1 (STAT1)/STAT4-dependent pathways, activated by cytokines such as interleukin 12 (IL12) and interferon gamma (IFNG), could improve the effect of ICI therapy via upregulation of Tbet, suggesting that the effect of the cytokines related to STAT3/STAT1 activity is dependent on the balance between STAT1 and STAT3 downstream signalling.…”
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30623por Baghaei, Parvaneh, Dastan, Farzaneh, Marjani, Majid, Moniri, Afshin, Abtahian, Zahra, Ghadimi, Somayeh, Valizadeh, Melika, Heshmatnia, Jalal, Sadat Mirenayat, Maryam, Abedini, Atefeh, Kiani, Arda, Eslaminejad, Alireza, MohammadReza Hashemian, Seyed, Jamaati, Hamidreza, Zali, Alireza, Akbar Velayati, Ali, Tabarsi, Payam“…Interferon Beta-1a (IFN-β1-a), an immunomodulatory mediator with antiviral effects, has shown in vivo and in vitro activities especially on coronavirus including SARS-CoV-2. …”
Publicado 2021
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30624“…Further, the levels of tumor necrosis factor α (TNF-α), Interleukin-6 (IL-6), Interleukin-12 (IL-12) and Interleukin-1β (IL-1β), malondialdehyde (MDA) content, and myeloperoxidase activity in the serum of UC mice treated with L. acidophilus XY27 significantly decreased, while the levels of Interferon-γ (IFN-γ), Interleukin-10 (IL-10), Catalase (CAT), and total superoxide dismutase (SOD) significantly increased. …”
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30625Interactions of the Nipah Virus P, V, and W Proteins across the STAT Family of Transcription Factorspor Keiffer, Timothy R., Ciancanelli, Michael J., Edwards, Megan R., Basler, Christopher F.“…The STAT1 and STAT2 interactions block interferon (IFN)-induced STAT tyrosine phosphorylation. …”
Publicado 2020
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30626por Sevenoaks, Tatum, Wedderburn, Catherine J., Donald, Kirsten A., Barnett, Whitney, Zar, Heather J., Stein, Dan J., Naudé, Petrus J.W.“…Serum inflammatory markers [granulocyte–macrophage colony-stimulating factor (GM-CSF), interferon-γ (IFN-γ), interleukin IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12p70, IL-13, tumor necrosis factor-α (TNF-α), neutrophil gelatinase-associated lipocalin (NGAL) and metalloproteinase-9 (MMP-9)] were analyzed with a multiplex bead array and ELISA assays. …”
Publicado 2021
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30627“…BACKGROUND: Endothelin-1 (ET-1) is increasingly recognized as an immune modulator; it exerts a pro-inflammatory effect by increasing the release of cytokines like interferon gamma. ET-1 is secreted by a variety of cells such as macrophages, neurons and endothelial cells. …”
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30628por Yang, Janet, Fritz, Carman, Kundu-Raychaudhuri, Smriti, Dailey, Jeffrey, Bang, Heejung, Nguyen, Hien, Maniar, Archana“…Contacts were offered interferon-gamma release-assay (IGRA). Staff contacts were tested by purified protein derivative (PPD). …”
Publicado 2020
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30629por Li, Yang, Li, Zhong-Xin, Xie, Chen-Yang, Fan, Jing, Lv, Ji, Xu, Xin-Jian, Lv, Jian, Kuai, Wen-Tao, Jia, Yi-Tao“…Levels of the cytokines tumor necrosis factor (TNF)-α, interferon (IFN)-γ, interleukin (IL)-2, IL-6, IL-10 and serotonin (5-hydroxytryptamine; 5-HT) in serum were assessed by enzyme-linked immunosorbent assay (ELISA). …”
Publicado 2020
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30630por Zhang, Shiyu, Song, Jiaxing, Yang, Yuyan, Miao, Huilei, Yang, Lu, Liu, Yuehua, Zhang, Xue, Liu, Yaping, Wang, Tao“…BACKGROUND: Type I interferonopathies are a group of rare autoimmune diseases characterised by excessive activation of type I interferon that leads to disturbances in immune function. …”
Publicado 2021
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30631por Wübbolding, Maximilian, Lopez Alfonso, Juan Carlos, Lin, Chun‐Yen, Binder, Sebastian, Falk, Christine, Debarry, Jennifer, Gineste, Paul, Kraft, Anke R.M., Chien, Rong‐Nan, Maasoumy, Benjamin, Wedemeyer, Heiner, Jeng, Wen‐Juei, Meyer Hermann, Michael, Cornberg, Markus, Höner zu Siederdissen, Christoph“…The combination of IL‐2, monokine induced by interferon γ (MIG)/chemokine (C‐C motif) ligand 9 (CCL9), RANTES/CCL5, stem cell factor (SCF), and TNF‐related apoptosis‐inducing ligand (TRAIL) was reliable in predicting VR (0.89; 95% confidence interval: 0.5‐1.0) and showed viable results in the validation cohort (0.63; 0.1‐0.99). …”
Publicado 2020
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30632por Aly, Rofyda H., Ahmed, Amr E., Hozayen, Walaa G., Rabea, Alaa Mohamed, Ali, Tarek M., El Askary, Ahmad, Ahmed, Osama M.“…All participants were tested for analysis of fasting plasma glucose and serum insulin, kidney function tests, C-reactive protein (CRP), and proinflammatory cytokines, including tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), and interleukin 6 (IL-6) as well as expression of TLR2 and TLR4 in peripheral blood (PB). …”
Publicado 2020
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30633por Chen, Qiang, Tian, Xiuying, Luo, Yarui, Liu, Jun, Jiang, Li, Feng, Xiaoqian, Chen, Zongwen“…The interleukin 4 (IL-4), IL-10, and IL-17 in 11 cases were normal; IL-6 was increased in 7 cases (64%); tumor necrosis factor-alpha (TNF-α) was increased in 1 case (9%); and interferon gamma (IFN-γ) was increased in 6 cases (55%). …”
Publicado 2020
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30634por Tanacan, Atakan, Yazihan, Nuray, Erol, Seyit Ahmet, Anuk, Ali Taner, Yucel Yetiskin, Fatma Didem, Biriken, Derya, Ozgu-Erdinc, A.Seval, Keskin, Huseyin Levent, Moraloglu Tekin, Ozlem, Sahin, Dilek“…Demographic features, clinical characteristics, laboratory parameters, interferon-gamma (IFN γ), interleukin (IL-2), IL-6, IL-10, and IL-17 levels were compared between the groups. …”
Publicado 2021
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30635por Ye, Lin-Lin, Peng, Wen-Bei, Niu, Yi-Ran, Xiang, Xuan, Wei, Xiao-Shan, Wang, Zi-Hao, Wang, Xu, Zhang, Si-Yu, Chen, Xin, Zhou, Qiong“…Consequently, the proportions of interferon gamma (IFN-γ)-producing cytotoxic T lymphocytes (CTLs) were significantly increased after TNFR2 blockade. …”
Publicado 2020
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30636por Mutala, Linda Bilonda, Deleine, Cécile, Karakachoff, Matilde, Dansette, Delphine, Ducoin, Kathleen, Oger, Romain, Rousseau, Olivia, Podevin, Juliette, Duchalais, Emilie, Fourquier, Pierre, Thomas, Wassila El Alami, Gourraud, Pierre-Antoine, Bennouna, Jaafar, Brochier, Camille, Gervois, Nadine, Bossard, Céline, Jarry, Anne“…Furthermore, unsupervised clustering identified three clusters of CRCs according to the caspase-1/IL-18/TIL density/interferon gamma (IFNγ) axis and microsatellite status. …”
Publicado 2021
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30637por Mortaz, Esmaeil, Bassir, Ali, Dalil Roofchayee, Neda, Dezfuli, Neda K., Jamaati, Hamidreza, Tabarsi, Payam, Moniri, Afshin, Rezaei, Mitra, Mehrian, Payam, Varahram, Mohammad, Marjani, Majid, Mumby, Sharon, Adcock, Ian M.“…Severe COVID-19 patients have elevated blood levels of interleukin-6 (IL-6), IL-1β, tumor necrosis factor (TNF)α, IL-8 and interferon (IFN)γ. OBJECTIVE: To investigate the effect of antiviral treatment serum cytokines in severe COVID-19 patients. …”
Publicado 2021
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30638por Lim, Ye Seon, Lee, Do-Young, Kim, Hye-Yoon, Ok, Yejin, Hwang, Seonyeong, Moon, Yuseok, Yoon, Sik“…Reverse transcription-polymerase chain reaction analysis revealed that EGFL8 knockdown upregulated the expression of cluster differentiation 74 (CD74), Fas ligand (FasL), C-X-C motif chemokine ligand 5 (CXCL5), CXCL10, CXCL16, C-C motif chemokine ligand 20 (CCL20), vascular endothelial growth factor-A (VEGF-A), interferon regulatory factor 7 (Irf7), insulin-like growth factor binding protein-4 (IGFBP-4), thrombospondin 1 (Thbs1) and nuclear factor κB subunit 2 (NF-κB2) genes, and downregulated the expression of angiopoietin-like 1 (Angptl1), and neuropilin-1 (Nrp1) genes. …”
Publicado 2021
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30639por Matsubara, Yosuke, Okuda, Hiroko, Harada, Kouji H., Youssefian, Shohab, Koizumi, Akio“…There was no significant change in the levels of interleukin-1β, interleukin-6, tumor necrosis factor-α, or interferon-γ in the plasma or spinal cords of WT and R222S mice after cold exposure. …”
Publicado 2020
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30640por Upadhyaya, Punit, Lahdenranta, Johanna, Hurov, Kristen, Battula, Sailaja, Dods, Rachel, Haines, Eric, Kleyman, Marianna, Kristensson, Julia, Kublin, Jessica, Lani, Rachid, Ma, Jun, Mudd, Gemma, Repash, Elizabeth, Van Rietschoten, Katerine, Stephen, Tom, You, Fanglei, Harrison, Helen, Chen, Liuhong, McDonnell, Kevin, Brandish, Philip, Keen, Nicholas“…An EphA2/CD137 TICA (BCY12491) efficiently costimulated human peripheral blood mononuclear cells in vitro in the presence of EphA2 expressing tumor cell lines as measured by the increased secretion of interferon γ and interleukin-2. Treatment of C57/Bl6 mice transgenic for the human CD137 extracellular domain (huCD137) bearing EphA2-expressing MC38 tumors with BCY12491 resulted in the infiltration of CD8+ T cells, elimination of tumors and generation of immunological memory. …”
Publicado 2021
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