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30641por Marcus, Nufar, Frizinsky, Shirly, Hagin, David, Ovadia, Adi, Hanna, Suhair, Farkash, Michael, Maoz-Segal, Ramit, Agmon-Levin, Nancy, Broides, Arnon, Nahum, Amit, Rosenberg, Elli, Kuperman, Amir Asher, Dinur-Schejter, Yael, Berkun, Yackov, Toker, Ori, Goldberg, Shmuel, Confino-Cohen, Ronit, Scheuerman, Oded, Badarneh, Basel, Epstein-Rigbi, Na‘ama, Etzioni, Amos, Dalal, Ilan, Somech, Raz“…It is also possible that only specific immune pathways (e.g. type I interferon signaling), may increase the risk for a more severe course of disease and these are not affected in many of the PID patients. …”
Publicado 2021
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30642por Lumlertgul, Nuttha, Hall, Anna, Camporota, Luigi, Crichton, Siobhan, Ostermann, Marlies“…We measured concentrations of 12 cytokines [Interleukin (IL) IL-1β, IL-1α, IL-2, IL-4, IL-6, IL-8, IL-10, interferon (IFN)-γ, tumour necrosis factor (TNF)-α, vascular endothelial growth factor, monocyte chemoattractant protein (MCP)-1, epidermal growth factor (EGF)] in plasma at baseline (T0) and pre- and post-dialyzer at 1, 6, 24, and 48 h after CVVHD initiation and in the effluent fluid at corresponding time points. …”
Publicado 2021
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30643por Lei, Yujie, Xu, Yushan, Jing, Peng, Xiang, Bingquan, Che, Keda, Shen, Junting, Ning, Minjie, Chen, Ying, Huang, Yunchao“…RESULTS: In the groups treated with TGF-β1 at different concentrations, the levels of Th1 cytokines interleukin-2 (IL-2), tumor necrosis factor (TNF), and interferon-γ (IFN-γ) were lower than those of normal group, while the levels of Th2 cytokines IL-6, IL-4 and IL-10 were higher than those of normal group. …”
Publicado 2021
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30644por Zhang, Xiaoling, van Rooij, Jeroen G. J., Wakabayashi, Yoshiyuki, Hwang, Shih-Jen, Yang, Yanqin, Ghanbari, Mohsen, Bos, Daniel, Levy, Daniel, Johnson, Andrew D., van Meurs, Joyce B. J., Kavousi, Maryam, Zhu, Jun, O’Donnell, Christopher J.“…Immune response, lipid metabolic process, and interferon regulatory factor were enriched in these 68 genes. …”
Publicado 2021
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30645por Shahsavari, Arash, Weeratunga, Prasanna, Ovchinnikov, Dmitry A., Whitworth, Deanne J.“…When stimulated with the canine pro-inflammatory cytokines tumor necrosis factor-α (cTNF-α), interferon-γ (cIFN-γ), or a combination of both, ciMSCs upregulated their expression of IDO, iNOS, GAL-9, HGF, TGF-β1, PTGER-2α, VEGF, COX-2, IL-1β and IL-8. …”
Publicado 2021
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30646por Ghanaie, Roxana Mansour, Karimi, Abdollah, Azimi, Leila, James, Seddon, Nasehi, Mahshid, Mishkar, Abolfazl Panahi, Sheikhi, Mahnaz, Fallah, Fatemeh, Tabatabaei, Sedigheh Rafiei, Hoseini-Alfatemi, Seyedeh Mahsan“…For LTBI diagnosis, tuberculin skin test (TST) and QuantiFERON®-TB Gold Plus (QFT-Plus) were performed at the time of the index TB case diagnosis, as well as, 3, 12, and 18 months, if the first results were negative. In addition, interferon-γ-induced protein-10(IP-10) concentrations were measured for all participants. …”
Publicado 2021
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30647por Isfordink, Cas J, van de Laar, Thijs J W, Rebers, Sjoerd P H, Wessels, Els, Molenkamp, Richard, Knoester, Marjolein, Baak, Bert C, van Nieuwkoop, Cees, van Hoek, Bart, Brakenhoff, Sylvia M, Blokzijl, Hans, Arends, Joop E, van der Valk, Marc, Schinkel, Janke“…METHODS: We performed a nationwide retrospective study including patients treated with interferon-free DAAs for an HCV genotype other than 1a/1b/2a/2b/3a/4a/4d. …”
Publicado 2021
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30648por Zhao, Yuan, Chen, Kun, Ramia, Nancy, Sahu, Sangeeta, Kumar, Achint, Naylor, Maria L., Zhu, Li, Naik, Himanshu, Butts, Cherié L.“…Prior studies with interferon beta-1a reported a lower frequency of ISRs with intramuscular (IM) administration than with SC administration. …”
Publicado 2021
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30649por Natukunda, Agnes, Nkurunungi, Gyaviira, Zirimenya, Ludoviko, Nassuuna, Jacent, Oduru, Gloria, Amongin, Rebecca, Kabuubi, Prossy N, Mutebe, Alex, Onen, Caroline, Amongi, Susan, Nakazibwe, Esther, Akello, Florence, Kiwanuka, Samuel, Kiwudhu, Fred, Sewankambo, Moses, Nsubuga, Denis, Kizindo, Robert, Staedke, Sarah G, Cose, Stephen, Webb, Emily, Elliott, Alison M“…Primary outcomes are BCG-specific interferon-γ ELISpot responses 8 weeks after BCG immunisation and for other vaccines, antibody responses to key vaccine antigens at 4 weeks after immunisation. …”
Publicado 2021
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30650por Odia, Trust, Malherbe, Stephanus T., Meier, Stuart, Maasdorp, Elizna, Kleynhans, Léanie, du Plessis, Nelita, Loxton, Andre G., Zak, Daniel E., Thompson, Ethan, Duffy, Fergal J., Kuivaniemi, Helena, Ronacher, Katharina, Winter, Jill, Walzl, Gerhard, Tromp, Gerard“…Gene enrichment over-representation analysis revealed that numerous biological processes were significantly enriched in the 639 genes, including several well known in TB transcriptomics such as platelet degranulation and response to interferon gamma, thus validating our novel approach. …”
Publicado 2021
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30651por Chaudhari, Sima, Dey Pereira, Satyajit, Asare-Warehene, Meshach, Naha, Ritam, Kabekkodu, Shama Prasada, Tsang, Benjamin K., Satyamoorthy, Kapaettu“…The upregulation of common inflammatory cytokines and chemokines such as tumor necrosis factor α (TNF-α), interleukin (IL)-1β, IL-2, IL-6, IL-10, interferon-γ-inducible protein 10 (IP-10), granulocyte colony-stimulating factor (G-CSF), monocyte chemoattractant protein-1 (MCP-1), macrophage colony-stimulating factor (M-CSF), among others in the sera of COVID-19 and OC subjects suggests potentially similar mechanism(s) involved in the hyper-inflammatory condition observed in both disease states. …”
Publicado 2021
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30652“…Single-nucleotide polymorphisms (SNPs) in several genes including solute-like carrier 11A1 (SLC11A1), interferon gamma (IFNγ), Toll-like receptor 4 (TLR4), nucleotide-binding oligomerization domain 2 gene (NOD2), and bovine peptidoglycan recognition protein 1 (PGLYRP1) have been implicated in influencing the infection outcome of MAP in cattle. …”
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30653por Tingting, Li, Wenhui, Li, Nianzhang, Zhang, Zigang, Qu, Ohiolei, John A, Li, Li, Hongbin, Yan, Wanzhong, Jia, Baoquan, Fu“…The kinetics of cytokines in the sera was detected by microarray, including interferon-γ (IFN-γ), interleukin (IL)-1β, IL-8, IL-12, IL-4, IL-6, IL-10, Granulocyte-macrophage Colony Stimulating Factor (GM-CSF), tumor necrosis factor (TNF)-α and transforming growth factor (TGF)-β1. …”
Publicado 2021
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30654por Keerqin, C., Rhayat, L., Zhang, Z.-H., Gharib-Naseri, K., Kheravii, S.K., Devillard, E., Crowley, T.M., Wu, S.-B.“…Compared with CtlrNE and contrary to AntNE, ProNE treatment exhibited upregulation of genes coding for tight junctions proteins (CLDN1, JAM2, TJP1), cytokines (IL12, interferon gamma, TGFβ), and Toll-like receptors (TLR5, TLR21) suggesting enhanced immunity and intestinal integrity. 16S NGS analysis of cecal microbiota at day 16 showed a decreased alpha diversity in challenged groups. …”
Publicado 2021
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30655“…In addition to the common interferon regulated genes (IRG), STAT1 GOF mutants up-regulated an additional set of genes, that were in part shared with other GOF mutants or mutation-specific. …”
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30656por Merola, Joseph F, Wang, Wenting, Wager, Carrie G, Hamann, Stefan, Zhang, Xueli, Thai, Alice, Roberts, Christopher, Lam, Christina, Musselli, Cristina, Marsh, Galina, Rabah, Dania, Barbey, Catherine, Franchimont, Nathalie, Reynolds, Taylor L“…Among these, we found an interferon (IFN)-dominant gene cluster that differentiated CLE-affected from HV (23-fold change; p<0.001) and CLE-unaffected skin (sevenfold change; p=0.002), respectively. …”
Publicado 2021
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30657por Zhang, Jingzhan, Yu, Shirong, Hu, Wen, Wang, Man, Abudoureyimu, Dilinuer, Luo, Dong, Li, Tingting, Long, Linglong, Zeng, Hui, Cheng, Chao, Lei, Zixian, Teng, Jianan, Kang, Xiaojing“…The TLR4 receptor pathway, interferon gamma-mediated signaling pathway and lipopolysaccharide-related pathway were positively correlated with CD4+ T cells. …”
Publicado 2021
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30658por Humam, Ali Merzza, Loh, Teck Chwen, Foo, Hooi Ling, Izuddin, Wan Ibrahim, Zulkifli, Idrus, Samsudin, Anjas Asmara, Mustapha, Noordin Mohamed“…However, no difference was observed in ileum claudin 1, ceruloplasmin, IL-6, IL-2, and interferon expression, but downregulation of occludin expression was observed as compared with the NC group. …”
Publicado 2020
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30659por Lin, Zhi, Huang, Ying, Jiang, Hua, Zhang, Di, Yang, Yanwei, Geng, Xingchao, Li, Bo“…Moreover, there were some differences in antigen processing and presentation, and the interferon gamma (INF-γ)–mediated signaling pathway in these species detected by gene expression profile study. …”
Publicado 2021
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30660por Sotoodehnejadnematalahi, Fattah, Moghadasali, Reza, Hajinasrollah, Mostafa, Ehsani, Ehsan, Hajizadeh-Saffar, Ensiyeh, Sodeifi, Niloofar, Saidi, Reza F., Zarrabi, Morteza, Farzanehkhah, Mohammad, Sadeghi, Bahareh, Baharvand, Hossein, Aghdami, Nasser“…Our results showed that human MSCs significantly decrease Th1 and Th17 cell proliferation by decreasing interleukin-17 (IL-17) and interferon-γ (INF-γ) production and significantly increase Treg cell proliferation by increasing FoxP3 production. …”
Publicado 2021
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