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30661por Zhai, Xvwen, Feng, Min, Guo, Hui, Liang, Zhaojun, Wang, Yanlin, Qin, Yan, Wu, Yanyao, Zhao, Xiangcong, Gao, Chong, Luo, Jing“…The white blood cell (WBC), neutrophile granulocyte (NEUT), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6), IL-10, interferon-γ (IFN-γ), and tumor necrosis factor α (TNF-α) levels were significantly higher in bacteria-infected patients, while regulatory T (Treg) cells obviously decreased. …”
Publicado 2021
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30662por Chen, Ming-Ren, Kuo, Ho-Chang, Lee, Yann-Jinn, Chi, Hsin, Li, Sung Chou, Lee, Hung-Chang, Yang, Kuender D.“…The autoimmune vasculitis of KD, KD shock syndrome (KDSS), or MIS-C is mediated by a genetic variant of HLA, FcγR, and/or antibody-dependent enhancement (ADE) resulting in hyperinflammation with T helper 17 (Th17)/Treg imbalance with augmented Th17/Th1 mediators: interleukin-6 (IL-6), IL-10, inducible protein-10 (IP-10), Interferon (IFNγ), and IL-17A, and lower expression of Treg-signaling molecules, FoxP3, and transforming growth factor (TGF-β). …”
Publicado 2021
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30663por Caforio, Matteo, Sorino, Cristina, Caruana, Ignazio, Weber, Gerrit, Camera, Antonio, Cifaldi, Loredana, De Angelis, Biagio, Del Bufalo, Francesca, Vitale, Alessia, Goffredo, Bianca Maria, De Vito, Rita, Fruci, Doriana, Quintarelli, Concetta, Fanciulli, Maurizio, Locatelli, Franco, Folgiero, Valentina“…ELISA assay was used to quantify interferon-γ (IFNγ) secreted by NK and CAR T cells. …”
Publicado 2021
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30664Microwave ablation enhances tumor-specific immune response in patients with hepatocellular carcinomapor Leuchte, Katharina, Staib, Elena, Thelen, Martin, Gödel, Philipp, Lechner, Axel, Zentis, Peter, Garcia-Marquez, Maria, Waldschmidt, Dirk, Datta, Rabi Raj, Wahba, Roger, Wybranski, Christian, Zander, Thomas, Quaas, Alexander, Drebber, Uta, Stippel, Dirk Ludger, Bruns, Christiane, von Bergwelt-Baildon, Michael, Wennhold, Kerstin, Schlößer, Hans Anton“…This anti-tumor immune response was related to tumor control as Interferon-y and Interleukin-5 T cell responses against TAAs were more frequent in patients with a long-time remission (> 1 year) after MWA (7/16) compared to patients suffering from an early relapse (0/13 patients) and presence of tumor-specific T cell response (IFN-y and/or IL-5) was associated to longer progression-free survival (27.5 vs. 10.0 months). …”
Publicado 2020
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30665por Shimoda, Masafumi, Tanaka, Yoshiaki, Morimoto, Kozo, Okumura, Masao, Shimoda, Kiyomi, Takemura, Tamiko, Oka, Teruaki, Yoshiyama, Takashi, Yoshimori, Kozo, Ohta, Ken“…The pleural fluid test results revealed a total protein (TP) concentration of 6.60 g/dl, a lactate dehydrogenase (LDH) level of 383 IU/dl, and an ADA concentration of 54.5 U/L. An interferon gamma release assay showed a negative result. …”
Publicado 2021
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30666por Gong, Xiaoxiang, Liu, Lingjuan, Xiong, Jie, Li, Xingfang, Xu, Jie, Xiao, Yangyang, Li, Jian, Luo, Xuemei, Mao, Dingan, Liu, Liqun“…GSEA showed that interleukin-6 (IL-6)/Janus kinase (JAK)/signal transducer and activator of transcription (STAT3) signaling, interferon gamma (IFN-γ) response, angiogenesis, and coagulation were more highly enriched in the high-risk group and that oxidative phosphorylation was more highly enriched in the low-risk group. …”
Publicado 2021
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30667por Wang, Yun, Cui, Long, Georgiev, Peter, Singh, Latika, Zheng, Yanyan, Yu, Ying, Grein, Jeff, Zhang, Chunsheng, Muise, Eric S., Sloman, David L., Ferguson, Heidi, Yu, Hongshi, Pierre, Cristina St., Dakle, Pranal J, Pucci, Vincenzo, Baker, James, Loboda, Andrey, Linn, Doug, Brynczka, Christopher, Wilson, Doug, Haines, Brian B, Long, Brian, Wnek, Richard, Sadekova, Svetlana, Rosenzweig, Michael, Haidle, Andrew, Han, Yongxin, Ranganath, Sheila H.“…In vitro experiments demonstrated that MF-766 restored PGE(2)-mediated inhibition of lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α production in THP-1 cells and human blood, and PGE(2)-mediated inhibition of interleukin (IL)-2-induced interferon (IFN)-γ production in human NK cells. MF-766 reversed the inhibition of IFN-γ in CD8(+) T-cells by PGE(2) and impaired suppression of CD8(+) T-cells induced by myeloid-derived suppressor cells (MDSC)/PGE(2.) …”
Publicado 2021
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30668por Berke, Kimberly, Sun, Peter, Ong, Edison, Sanati, Nasim, Huffman, Anthony, Brunson, Timothy, Loney, Fred, Ostrow, Joseph, Racz, Rebecca, Zhao, Bin, Xiang, Zuoshuang, Masci, Anna Maria, Zheng, Jie, Wu, Guanming, He, Yongqun“…Using influenza as a model, live attenuated and killed inactivated influenza vaccines stimulate many shared pathways such as signaling of many interleukins (including IL-1, IL-4, IL-6, IL-13, IL-20, and IL-27), interferon signaling, MARK1 activation, and neutrophil degranulation. …”
Publicado 2021
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30669por Li, Chong, He, Jianchun, Yang, Yue, Gou, Yuting, Wang, Zhiying, Chen, Hong, Zhao, Xin“…WTSNF also reduced the inflammation-related levels of interleukin-6, interleukin-1 beta, tumor necrosis factor alpha (TNFα), and interferon gamma (IFN-γ) and increased the levels of interleukin-10 and interleukin-12. …”
Publicado 2021
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30670por Caldarale, Francesca, Giacomelli, Mauro, Garrafa, Emirena, Tamassia, Nicola, Morreale, Alessia, Poli, Piercarlo, Timpano, Silviana, Baresi, Giulia, Zunica, Fiammetta, Cattalini, Marco, Moratto, Daniele, Chiarini, Marco, Cannizzo, Elvira Stefania, Marchetti, Giulia, Cassatella, Marco Antonio, Taddio, Andrea, Tommasini, Alberto, Badolato, Raffaele“…CONCLUSIONS: Our results show a pattern of immune response which is suggestive of type I interferon activation in COVID-19 children, probably related to a recent interaction with the virus, while in MIS-C the immune response is characterized by elevation of the inflammatory cytokines/chemokines IL-6, CCL2, and CXCL8 and of the chemokines CXCL9 and CXL10, which are markers of an active Th1 type immune response. …”
Publicado 2021
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30671por Zhu, Jane, Tran, Ly, Zheng, Frank, James, Judith, Guthridge, Joel, Chong, Benjamin“…This approach was used to study gene expression in systemic lupus patients and subsequently identified a unique interferon signature. Thus, we aim to use the modular analysis approach to identify unique modules and genes of CLE patients in order to better understand their disease pathophysiology. …”
Publicado 2021
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30672por Guo, Guijie, Gao, Ming, Gao, Xiaochen, Zhu, Bibo, Huang, Jinzhou, Tu, Xinyi, Kim, Wootae, Zhao, Fei, Zhou, Qin, Zhu, Shouhai, Wu, Zheming, Yan, Yuanliang, Zhang, Yong, Zeng, Xiangyu, Zhu, Qian, Yin, Ping, Luo, Kuntian, Sun, Jie, Deng, Min, Lou, Zhenkun“…The RNA-sensing pathway contributes to type I interferon (IFN) production induced by DNA damaging agents. …”
Publicado 2021
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30673por Perez-Bercoff, Danielle, Laude, Hélène, Lemaire, Morgane, Hunewald, Oliver, Thiers, Valérie, Vignuzzi, Marco, Blanc, Hervé, Poli, Aurélie, Amoura, Zahir, Caval, Vincent, Suspène, Rodolphe, Hafezi, François, Mathian, Alexis, Vartanian, Jean-Pierre, Wain-Hobson, Simon“…Although four of them, A3A, A3B, A3F and A3G, are induced by type-1-interferon (IFN-I), their role in inflammatory conditions is unknown. …”
Publicado 2021
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30674por Zhao, Yao, Du, Xiaoyu, Duan, Yinkai, Pan, Xiaoyan, Sun, Yifang, You, Tian, Han, Lin, Jin, Zhenming, Shang, Weijuan, Yu, Jing, Guo, Hangtian, Liu, Qianying, Wu, Yan, Peng, Chao, Wang, Jun, Zhu, Chenghao, Yang, Xiuna, Yang, Kailin, Lei, Ying, Guddat, Luke W., Xu, Wenqing, Xiao, Gengfu, Sun, Lei, Zhang, Leike, Rao, Zihe, Yang, Haitao“…YM155 simultaneously targets three “hot” spots on PLpro, including the substrate-binding pocket, the interferon stimulating gene product 15 (ISG15) binding site and zinc finger motif. …”
Publicado 2021
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30675por Chen, Mochuan, Zhu, Bing, Chen, Dong, Hu, Xingzhong, Xu, Xueqin, Shen, Wen-Jun, Hu, Chenchan, Li, Jue, Qu, Shen“…Compared with the baseline results, patients had significantly elevated fasting C-peptide levels (0.35 ± 0.24 vs 2.36 ± 0.98 vs 2.52 ± 1.11 μg/L; P < .001), homeostasis model assessment for beta-cell function (0.42, interquartile range [IQR] 0.36-0.62 vs 2.54, IQR 1.95-3.42 vs 2.90, IQR 2.02-4.23; P < .001), and TyG indices (8.57 ± 0.47 vs 8.73 ± 0.60 vs 8.82 ± 0.62; P = .006) and decreased fasting glucose levels (5.84 ± 1.21 vs 4.95 ± 0.76 vs 5.40 ± 0.68 mmol/L; P = .003) at the 3- and 6-month follow-up. Male gender, age, interferon-alfa treatment during hospitalization, and changes in total cholesterol and high-density lipoprotein levels were significantly associated with changes in the TyG index. …”
Publicado 2021
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30676por Hu, Xiao-Xiao, Ma, Yan-Xiu, Lin, Yao-Xiang, Wu, Xiang-Ji, Wu, Jing, Ma, Hui, Lin, Sheng-Zhang, Chen, Gong-Yin, Pan, Xiao-Ben“…The effects of hepatitis B virus (HBV) replication or interferon on ACE2 and TMPRSS2 expression were tested in hepatic cell lines. …”
Publicado 2021
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30677“…In ophthalmology, advances in technology could be applied to examine tear or anterior chamber (AC) fluid for glucose, lactoferrin, interferon, or VEGF. These approaches could impact detection and care for diseases including diabetic mellitus, dry-eye disease, and age-related maculopathy. …”
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30678por Luo, Zhong-Wei, Xia, Kun, Liu, Yi-Wei, Liu, Jiang-Hua, Rao, Shan-Shan, Hu, Xiong-Ke, Chen, Chun-Yuan, Xu, Ran, Wang, Zhen-Xing, Xie, Hui“…This treatment elevated the proportion of granzyme B-positive (GZMB(+)) and interferon γ-positive (IFN-γ(+)) lymphocytes in CD8(+) T cells and caused macrophage recruitment, with increased tumor-killing M1 macrophages and decreased immunosuppressive M2 macrophages. …”
Publicado 2021
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30679por Zhang, Lanyu, Young, Juan I., Gomez, Lissette, Silva, Tiago C., Schmidt, Michael A., Cai, Jesse, Chen, Xi, Martin, Eden R., Wang, Lily“…TMEM39A is known to be involved in inflammation, dysregulated type I interferon responses, and other immune processes. TNXB encodes tenascin proteins, which are extracellular matrix glycoproteins demonstrated to modulate synaptic plasticity in the brain. …”
Publicado 2021
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30680por Hecht, J. Randolph, Lonardi, Sara, Bendell, Johanna, Sim, Hao-Wen, Macarulla, Teresa, Lopez, Charles D., Van Cutsem, Eric, Muñoz Martin, Andres J., Park, Joon Oh, Greil, Richard, Wang, Hong, Hozak, Rebecca R., Gueorguieva, Ivelina, Lin, Yong, Rao, Sujata, Ryoo, Baek-Yeol“…Exploratory analyses revealed increases in total IL-18, interferon (IFN)-γ, and granzyme B and decreases in transforming growth factor (TGF)-β with the addition of PEG. …”
Publicado 2021
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